Articles tagged with Albumin
Researchers uncover the placenta distinguishes between antibodies and albumin, allowing for the design of long-acting biologic medicines with reduced fetal exposure. Fusion of IgG antibodies to albumin inhibits transport across the placenta, enabling the development of safer treatments during pregnancy.
Researchers at Kyushu University develop a new tissue-clearing reagent, SeeDB-Live, enabling repeated, reversible, and real-time imaging of living brains at greater depth and clarity. This breakthrough allows scientists to visualize neural activity in living mice and brain slices, offering new insights into brain dynamics and function.
A new study published in Nature has identified albumin as a powerful defense against mucormycosis, a rare but often fatal fungal infection. Patients with mucormycosis have lower levels of albumin, which can predict poor outcomes and mortality.
The study found clear absolute benefits of SGLT2 inhibitors on kidney, hospitalization, and mortality outcomes regardless of diabetes status and level of urine albumin to creatinine ratio. This benefit suggests a potential therapeutic approach for patients with kidney disease.
A study published in Journal of Internal Medicine found that people with moderate to high levels of albumin in their urine have a higher risk of developing dementia. The researchers discovered an association between albuminuria and increased risk of dementia, independent of kidney function.
Researchers developed a new, three times more effective version of the antibothropic serum used to treat snake venom poisoning. The improved serum had increased neutralizing antibodies and fewer proteins associated with side effects, resulting in greater potency and reduced risk of adverse reactions.
Researchers at Institut Laue-Langevin and Aarhus University developed a new method to characterise foam structure, enabling the creation of plant-derived foaming ingredients in food. The technique uses small-angle neutron scattering, imaging, and electrical conductivity measurements to provide insights into pea albumin-based foams.
A novel ratiometric fluorescent probe was synthesized to detect native human albumin (HA) activity in patients with hepatitis B cirrhosis and hepatocellular carcinoma. Native HA activity levels were significantly higher in low albumin groups, correlating with increased severity of liver disease.
Scientists at RIKEN CPR created a method to change albumin's molecular ID card, allowing for targeted treatments against diseases like cancer. The new technology can transport proteins out of the body, mimicking drug delivery and removal.
A five-year randomized control trial found that diets high in fruits and vegetables lower blood pressure, reduce cardiovascular risk, and improve kidney health. The study also suggests that incorporating fruits and vegetables into treatment plans can be more effective than traditional medication approaches.
Researchers found that abnormal results from routine blood tests were linked to a higher risk of being diagnosed with cancer within a year. The study estimated that taking these results into account could lead to an extra six people with undiagnosed cancer being urgently referred for treatment.
A phase II clinical trial found that combining sEphB4-HSA with pembrolizumab improved outcomes in HPV-negative, EphrinB2-positive head and neck squamous cell carcinoma patients. The combination showed a favorable toxicity profile and activity, particularly among those with HNSCC.
Scientists have designed a synthetic antigen that can stimulate antibody production against cancer cells. The approach uses a natural protein called serum albumin to carry the antigen, reducing the need for bulky carriers and side effects.
A study found that structural racism is largely to blame for disparities in tuberculosis (TB) incidence among the U.S.-born population. Researchers analyzed national TB registry data and found that TB incidence ratios were higher for certain racial and ethnic groups, with greater relative disparities among females.
A team of researchers from Aarhus University has developed a simple measurement of protein in the urine that can predict which individuals are at high risk of rapid progression of chronic kidney disease. The study found that patients with newly diagnosed mild to moderate chronic kidney disease within three years have a 15% risk of rapi...
A long-acting biologic with transmucosal transport properties has been developed to block cellular infection of all SARS-CoV-2 variants. The biologic utilizes a soluble recombinant human ACE2 protein fused to an engineered human albumin variant, offering improved pharmacokinetic properties and delivery across selective barriers.
A clinical trial using DIALIVE, a novel liver dialysis device, demonstrated significant improvements in all main underlying pathophysiological mechanisms of acute-on-chronic liver failure. Treatment resulted in accelerated resolution of ACLF and sustained improvement in biomarkers.
The HALP score, a novel immune-nutritional marker, has been linked to prognostic ability in different cancer types. It integrates indicators of immune status and nutritional status, showing promise as a cost-effective biomarker.
Researchers have discovered that zinc ions tune the ability of human serum albumin to prevent α-synuclein aggregation, a process linked to Parkinson's disease. Zinc binding alters HSA's chaperone function, blunting fibril formation and slowing down protein deposition that can lead to neurodegeneration.
A novel study has identified metabolic defects, impaired protein secretion, and altered phosphoproteomic signatures in alcohol-associated cirrhosis and hepatitis. These findings may lead to the development of new diagnostic and therapeutic approaches for a disease with limited treatment options.
Researchers from China have developed a novel bioconjugate that can suppress the growth of K-Ras mutant pancreatic tumors. The conjugate, which targets folate receptors and macropinocytosis, was found to be highly cytotoxic and effective at suppressing tumor growth.
Researchers at the University of Illinois Chicago have identified two distinct subtypes of neutrophils, with one subtype being a drug target for treating inflammatory diseases. The discovery paves the way for more targeted therapies that address chronic inflammation without suppressing anti-infection functions.
A new study by Dr. Brian Stansfield and Dr. Jessica Gancar found a clear linear relationship between mortality and red blood cell transfusion volume in newborns on ECMO, with a 14% decrease in survival chances for every transfusion. The study suggests that reducing transfusion volumes may improve outcomes.
A large clinical trial involving over 5,000 patients found that commonly used saline solution is as effective at keeping people alive and their organs functioning as more expensive balanced solutions. The study's results provide greater certainty about the safety and benefits of saline solution for treatment.
Researchers from Kumamoto University have discovered that cysteinylated albumin can be used as an early diagnostic marker for diabetic kidney disease. The study found that serum oxidized albumin reflects renal pathology earlier than urinary albumin and predicts disease progression.
A large-scale trial found that daily albumin infusions provide no significant health benefit to patients hospitalised with advanced liver disease, over and above 'standard care'. The study showed no reduction in infection, kidney dysfunction, or death among patients receiving targeted albumin treatment.
Researchers at Flinders University have discovered a new role for fibrinogen in reducing inflammation and protecting against disease. Fibrinogen's ability to neutralize harmful chemicals like hypochlorite could lead to new biomarkers and therapies for kidney, heart, and other diseases.
Researchers developed a method to detect pancreatic cancer by analyzing changes in albumin's structure and function. The approach showed promise in distinguishing between benign and malignant tumours, but further testing is needed.
A new study reveals that serum albumin binds with dexamethasone, a corticosteroid used to treat severe COVID-19, but low albumin levels or diabetes can interfere with this binding, reducing the drug's effectiveness. The researchers suggest doctors may need to adjust dosing for certain patient groups.
Researchers found that serum albumin and geriatric nutritional risk index (GNRI) are independent prognostic factors for cancer-specific survival in patients with esophageal squamous cell carcinoma. Low GNRI levels were significantly associated with worse survival outcomes, particularly in early-stage disease.
Researchers from Kazan Federal University developed a program to predict DSC curves from known binding constants and concentrations. This approach allows for the accurate measurement of high and weak binding constants, as well as stoichiometry of complexes, using albumin as a model protein.
A new study suggests that plasma exchange can rejuvenate tissues and reverse signs of aging in mice by diluting old blood plasma. The technique shows promise for improving health in older people and treating age-associated diseases. Researchers are now finalizing clinical trials to explore its potential in humans.
Researchers have discovered that drugs targeting brain inflammation can reverse cognitive decline in aged mice by reducing the 'fog' of inflammatory load. This breakthrough offers a potential new treatment for dementia and age-related diseases, with two biomarkers identified to flag people with blood-brain barrier problems.
Researchers develop new diagnostic techniques to detect a leaking blood-brain barrier and a new anti-inflammatory drug that slows or reverses age-related cognitive decline. The studies show promise for diagnosing and treating brain diseases, including Alzheimer's disease and dementia.
A new study found that less than 20% of Canadian patients with chronic kidney disease received a critical urine test within six months of diagnosis, highlighting a significant gap in care. The test is crucial for assessing the severity of kidney disease and guiding treatment.
Researchers discovered that albumin and ions in host cell vesicles trigger enterovirus genome release. The findings may provide new insights into understanding the fundamental aspects of enterovirus life cycle and developing targeted therapies.
Scientists developed permanent dermal sensors that can be applied as artistic tattoos to detect changes in blood pH and metabolite levels. The sensors, based on colorimetric chemical reactions, were tested on pig skin patches, showing accurate detection of biomarkers.
A new study found that saline fluids commonly used to treat critically ill children with sepsis may trigger acid blood and lead to organ failure. The research team recommends using alternative buffered solutions that contain less chloride to prevent these adverse effects.
A new compound based on Iridium, a rare metal, can penetrate into cancerous cells and deliver iridium, killing them when exposed to light. The discovery could lead to effective treatment against resistant cancers with reduced side effects.
Elderly patients with gastric cancer undergoing elective laparoscopic gastrectomy are at high risk of postoperative pulmonary complications (PPCs). This study found that preoperative serum albumin levels were strongly associated with PPCs, suggesting that monitoring albumin can help identify patients at risk. The study's findings suppo...
Researchers developed a method to conjugate the cancer therapeutic floxuridine with natural serum albumin, allowing it to target and accumulate in cancer cells. The lipid-conjugated compound halted tumor growth, while the free drug was ineffective.
Scientists at Martin-Luther-Universität Halle-Wittenberg create albumin-based gels, which could be used to produce drug-delivery implants. The gels' structure and properties were altered by modifying solution pH and temperature conditions.
Researchers used condensed matter physics to characterize proteins as amorphous semiconductors. They found the Universal Dielectric Response (UDR) applies to three organic materials, including Shewanella oneidensis MR-1 bacterium.
Researchers at Vanderbilt University developed a novel gene therapy delivery system that uses a human protein called albumin to target cancer cells. The approach overcomes common barriers to successful gene therapy, including drug resistance and toxicity.
Scientists at EPFL have developed a new ligand that can extend the half-life of peptide drugs from minutes to several days. The ligand, which is easy to synthesize and has high affinity for human albumin, can be appended to peptides using standard synthesizing techniques.
The ANSWER study shows that long-term administration of human albumin improves survival rate in patients with decompensated cirrhosis. Treatment also enhances ascites management, quality of life, and reduces severe complications and hospitalization.
A study found that type 1 diabetes patients with elevated albumin in their urine had triple the risk of life-threatening kidney and cardiac disease compared to those with normal levels. Copeptin levels were significantly higher in these patients, suggesting a new potential target for therapies.
Scientists have discovered a complex interaction between zinc and serum albumin, revealing multiple binding sites that facilitate the transport of zinc throughout the body. This finding provides new insights into how the body maintains delicate balances necessary for good health, known as homeostasis.
Researchers discovered that albumin and globulin proteins improve the tribology of artificial joint implants, suggesting a potential solution to reduce wear and tear. The findings have implications for extending the lifespan of prosthetic joints and improving patient quality of life.
Rice scientists observed that blood serum proteins irreversibly attach, unfold, and bring gold nanoparticles together in low concentrations. This counterintuitive behavior has significant implications for diseases caused by aggregation, such as Alzheimer's, and nanoparticle toxicity issues.
Cornell researchers modified stevia's component rebudioside A to dissipate its bitter components, reducing its aftertaste. The study's findings could encourage the beverage industry to adopt more stevia in their products.
A small audit of clinical practice found that doctors often misdiagnose zinc deficiency and are unaware of the impact of excess zinc on the body. High doses of zinc supplements can disrupt copper uptake, leading to anaemia and neurological symptoms.
Researchers have discovered bioplastics with significant antibacterial properties that could reduce hospital-acquired infections and food contamination. Albumin-based bioplastics demonstrated complete inhibition of bacterial growth, making them a potential solution for wound healing dressings and drug delivery.
Researchers found that serum albumin and creatinine levels are related to ALS survival in both sexes. Lower albumin and creatinine levels are related to worse clinical function at diagnosis.
Researchers have found that fructosamine and glycated albumin are strongly associated with retinopathy and kidney disease in patients with diabetes. These tests could potentially replace the standard Hemoglobin A1c test, which is not valid for some patients.
Patients undergoing radical cystectomy for bladder cancer are at higher risk of complications if they have low albumin levels before surgery. A study found that patients with low preoperative albumin levels had twice the risk of experiencing postoperative complications within 30 days after the operation.
A new study by the University of North Carolina School of Medicine has identified low preoperative albumin levels as an independent risk factor for surgical-related health problems after radical cystectomy. Patients with a low albumin level before surgery are 2.1 times more likely to experience complications within 30 days.
The portable device, developed by UCLA researchers, can determine levels of albumin in urine and transmit results within seconds, reducing the need for frequent office visits. The device weighs around one-third of a pound and is compatible with smartphones.
A large national study found that higher levels of urinary albumin-to-creatinine ratio were associated with greater risk of incident but not recurrent coronary heart disease in black individuals compared to white individuals. The study also confirmed that urinary albumin excretion is an important biomarker for CHD risk.
A study found that even in the normal range, urinary protein excretion increases diabetics' heart risks. Patients may benefit from cardioprotective medications to mitigate this risk.