Articles tagged with Cannabinoids
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An updated Cochrane review of 21 clinical trials involving over 2,100 adults found no high-quality evidence that cannabis-based medicines reduce neuropathic pain more than placebo. Small improvements were reported by patients using products with both THC and CBD, but these changes were not clinically meaningful.
A preclinical study shows that cannabidiol restores emotional behavior, reduces alcohol-related vulnerability, and reverses gut microbiota alterations caused by prenatal alcohol exposure. Female mice particularly benefited from CBD treatment, which normalized their emotional alterations and eliminated vulnerability to alcohol addiction.
The funding will support research at UCLA's David Geffen School of Medicine, College of Letters and Science, and Fielding School of Public Health. The studies aim to inform evidence-based regulation and public health priorities.
A systematic review found that cannabis products with higher THC concentration provide small improvements in pain and function, but at the cost of increased risks of common adverse events. CBD-only formulations showed no benefits. Long-term research is needed to guide patients and policymakers.
A new study used deep learning and large-scale computer simulations to identify structural differences in synthetic cannabinoid molecules that cause them to bind to human brain receptors differently from classical cannabinoids. Researchers found that these substances often trigger the beta arrestin pathway, leading to more severe psych...
A recent study found that dogs given CBD supplements show below-average levels of aggression over time, with the most aggressive changes observed in male dogs. The study, which used data from almost 50,000 dog owners, also found a link between CBD use and health conditions such as dementia and osteoarthritis.
A new study from Texas Biomedical Research Institute found that low-dose THC significantly reduced side effects and inflammation caused by HIV and antiretroviral therapy. The treatment also increased serotonin levels, lowered cholesterol and toxic bile acids, and improved cardiovascular health.
Researchers developed a portable sensor to detect synthetic cannabinoids in e-cigarette liquids and biological fluids, allowing for early intervention and harm reduction. The device shows high selectivity and sensitivity, detecting concentrations as low as 0.2 µM and identifying specific peaks that quantify substances present.
Researchers explored the therapeutic potential of cannabidiol for Alzheimer's disease by assessing its effects on immune responses and neuroinflammation. CBD treatment reduced expression of key regulators for neuroinflammation in Alzheimer's mice, associated with less proinflammatory molecules.
Researchers manipulated the endocannabinoid signaling system in prenatal mice, leading to altered gene expression, neural properties, and social interaction deficits. This work suggests that prenatal manipulation of this system may lead to neuropsychiatric conditions, particularly those involving social deficits.
Polyphenols are multifunctional agents with anti-inflammatory, antioxidant, microbiota-modulating, and neuroprotective properties. The Polyphenols Applications 2025 congress explores novel applications of polyphenols in various fields.
A study found a significant increase in adolescent vaping of THC, CBD, and synthetic cannabinoids from 2021 to 2023. The prevalence of THC vaping peaked in 2022, while SCs continued to rise, with females having a higher rate of vaping these substances.
A controlled clinical trial found that two-thirds of participants showed behavioral improvements with CBD treatment, highlighting its potential benefits. However, the study also revealed a significant placebo effect, emphasizing the need for further research to fully understand CBD's therapeutic potential.
Researchers at Macquarie University have discovered that cannabis-derived compounds Cannabidiol (CBD) and Cannabidivarin (CBDV) are effective against a range of fungal pathogens, including Cryptococcus neoformans and dermatophytes. The findings open the door to possible new treatments for these fungal infections.
Researchers at Indiana University discovered a new way acetaminophen targets pain by inhibiting an enzyme that produces endocannabinoids. Reduced levels of these compounds may lead to decreased pain relief, providing a potential target for designing safer pain medications.
A meta-analysis of clinical trials found moderate improvements in social responsiveness and small reductions in disruptive behaviors when cannabidiol (CBD) cannabis extract was used to treat ASD. The therapy also showed a favorable safety profile with no significant increase in adverse events compared to placebo.
A recent study by the University of Arkansas System Division of Agriculture found that consumer understanding of CBD oils has not kept pace with their growth in the market. Consumers were often confused about product names, with full-spectrum CBD containing terpenes and up to 0.3% THC.
The American College of Physicians issues Best Practice Advice for managing chronic noncancer pain with cannabis or cannabinoids. For most patients, common treatments should be recommended first due to limited evidence and known harms associated with cannabis and cannabinoid products.
Scientists at the University of South Australia have developed a phospholipid complex to improve cannabidiol's effectiveness in treating epilepsy, multiple sclerosis, and other neurodegenerative diseases. The new formula increases cannabidiol's solubility by up to six times and improves its absorption in the gastrointestinal tract.
Researchers found that cannabidiol stimulates the biomineralization of teeth even under inflammatory conditions, promoting tissue repair. The substance also inhibited the synthesis of inflammatory mediators in macrophages, suggesting an anti-inflammatory effect.
A NIH-funded research team has engineered a medication that targets the body's cannabinoid receptor type 1 (CB1), which shows promise in treating acute and chronic pain. The new drug, VIP36, is more 'peripherally restricted' compared to previous drugs, reducing unwanted side effects.
Researchers developed a custom-designed compound that mimics natural cannabis molecules to alleviate chronic pain without psychoactive side effects. The modified synthetic cannabinoid compound showed promise as a nonaddictive pain reliever, offering prolonged relief and minimizing tolerance.
Researchers have discovered how a CBD compound can bind to cannabinoid receptors, mitigating the negative effects of THC on pain management while preserving its benefits. The study opens new avenues for harnessing THC's beneficial effects with reduced side effects.
A cross-sectional study found that children exposed to secondhand cannabis smoke at home have significantly higher urinary cannabinoid biomarker levels, indicating increased exposure to toxic and carcinogenic chemicals. Reducing in-home cannabis smoking can substantially reduce child exposure to these harmful substances.
Researchers at University of the Basque Country discover molecule that protects brain and reverses initial cognitive damage caused by dementia; increases activity of cannabinoid and cholinergic systems, improving memory. Further studies needed to identify similar molecules for clinical trials.
A randomized clinical trial found that cannabidiol (CBD) significantly reduced anxiety levels 2-4 hours after ingestion in women with advanced breast cancer. CBD's anxiolytic effect suggests its potential as a treatment for scan-related anxiety.
A new study explores whether CBD can reduce scan-related anxiety in advanced breast cancer patients, finding it was safe but did not significantly change anxiety levels. However, participants who consumed CBD experienced lower anxiety levels after treatment.
Researchers found that increasing levels of the naturally occurring endocannabinoid 2-AG can counteract the rewarding properties of opioids, reducing addiction-like behaviors in mice. The study suggests a potential new therapeutic strategy to alleviate pain while minimizing opioid addiction risk.
Researchers explore potential synergies between chemotherapy, cannabinoids, and intermittent serum starvation in treating colorectal cancer. Combining these therapies could create a strong synergy by depriving cancer cells of glucose, making them more susceptible to treatment.
A WVU research partnership with the DEA aims to improve fast and accurate identification of psychoactive substances like fentanyl. The Expert Algorithm for Substance Identification (EASI) will enable labs using different instruments to share data on chemical profiles, helping to identify drugs like fentanyl.
Research by the University of Sydney has identified CBN as a constituent that improves sleep in rats. The study showed that CBN increased both NREM and REM sleep, leading to increased total sleep time.
The number of seizures in US children due to medication or substance exposure has more than doubled between 2009 and 2023. The main culprits are over-the-counter antihistamines, prescription antidepressants, painkillers, and synthetic cannabinoids.
Researchers will examine cognitive and psychomotor functions to compare effects of CBD on driving performance between men and women. The five-year study aims to provide a comprehensive understanding of the substance's influence.
Researchers found that prenatal exposure to synthetic cannabinoid led to cardiovascular problems in female rats and increased respiratory sensitivity to carbon dioxide in male rats. Sleep quality also deteriorated in both sexes, with males experiencing sleep fragmentation due to frequent wakefulness episodes.
A study published in the journal Insects found that hemp leaf extract containing cannabidiol (CBD) is effective in killing mosquito larvae, including those resistant to typical insecticides. The research suggests CBD's potential as a safe and sustainable alternative for controlling mosquito populations.
A new study by UC Riverside demonstrates that calorie restriction does not significantly reduce voluntary exercise in mice. Researchers found that mice continued to run at similar levels regardless of the amount of food they ate, challenging the long-held belief that dieting drains workout energy. The study's findings have implications...
A new study found that Cannabigerol (CBG) significantly reduced feelings of anxiety at 20, 45 and 60 minutes after ingestion, with stress ratings also decreasing. CBG's effect on memory was unexpectedly positive, enhancing the ability to recall lists of words.
Research on mice exposes to cannabidiol during gestation shows altered behaviors and brain changes, affecting nerve cells involved in processing emotions. The study suggests a public health priority to understand CBD's impact on developing nervous systems.
Researchers found that five cannabis terpenes reduced chronic neuropathic pain levels comparable to morphine. The combination of terpenes and morphine enhanced pain relief without negative side effects. Terpenes offer an alternative to opioids for pain management with a better side effect profile.
A new study found that nearly 3% of healthy adolescents aged 11-15 have used commercial CBD products for medicinal or health-related reasons. The study identified predictors of commercial CBD use, including older age, certain health conditions, and parental attitudes towards cannabis use.
The Society for Academic Emergency Medicine (SAEM) has released a new guideline for managing nonopioid use disorders in emergency departments. The guidelines provide evidence-based recommendations for evaluating and treating conditions such as alcohol withdrawal syndrome, alcohol use disorder, and cannabinoid hyperemesis syndrome. The ...
A recent study found that breastfeeding mothers who use cannabis have detectable amounts of THC in their milk, even after 12 hours of abstinence. The amount of THC detected is low, but its impact on infants is unknown.
Scientists at Salk Institute explore the clinical potential of cannabinol (CBN) in treating traumatic brain injury, Alzheimer's disease, and Parkinson's disease. They identify four CBN analogs with improved neuroprotective ability and drug-like efficacy.
A new study found that non-medical cannabis use is significantly associated with a 96% decrease in odds of subjective cognitive decline. However, medical and dual-use were not significant in reducing the risk of SCD. The study highlights the potential protective effects of cannabis on cognition, but more longitudinal research is needed...
A recent study published in The Journal of Pain has found that CBD products are ineffective in reducing chronic pain and may pose health risks. The research, led by the University of Bath, examined existing studies on CBD and concluded that there is no quality evidence to support its use as a pain reliever.
Researchers found that CBD-dominant products reduced anxiety symptoms and improved mood without the intoxicating effects of THC. The study suggests that CBD may provide a safer alternative for treating anxiety disorders.
A new study published in the Journal of Dairy Science explores the use of spent hemp biomass as a feed ingredient for lactating dairy cows. The research shows that hemp biomass is safe and does not negatively affect milk production or animal health, despite being less palatable due to its characteristic smell. The study suggests potent...
A survey of 2,002 Danish dog owners found that 38% used cannabinoids, primarily CBD, to treat their pets' pain, behavioral issues, and allergies. 77% of these owners reported positive effects on their dogs' mental or physical health.
A recent study published in Sports Medicine found that cannabis users reported increased enjoyment and euphoria during exercise, with CBD seemingly having a greater impact on mood than THC. However, the use of cannabis before exercise was found to have no significant effect on performance.
A new U-M study found that 72% of adults in the US have heard of CBD, while fewer are aware of other hemp-derived cannabinoids like delta-8-THC and CBG. The products' lack of regulation and inadequate safety testing pose health risks to consumers, especially young people.
A new study published in Cannabis and Cannabinoids Research found that 12% of people aged 50-80 have consumed a THC-containing substance in the past year. Those who drink alcohol at risky levels have a higher rate of cannabis use, highlighting the need for education and screening for older adults.
A new study by Cornell University researchers found that higher cannabinoid concentrations in hemp leaves led to proportionately less damage from insect larvae. The study suggests the potential for developing pesticides from cannabinoid extracts, but such uses would be limited to non-edible plants.
A study published in the Journal of Dental Research found that cannabidiol (CBD) reduces dental pain intensity by 70% and improves bite force. While side effects occurred more frequently than placebo, promising results suggest CBD may be an effective alternative to opioid painkillers for managing acute toothache.
A Penn State study found that CBD and CBG promoted fracture healing and reduced pain in mice. The cannabinoids accelerated the process of mineral absorption, leading to higher bone volume fraction and density.
Research suggests delta-8 companies market products to minors with colorful packaging, cheap prices, and easy availability. This lack of age verification and regulation poses risks to minors, who may underestimate the substance's strength and danger. Clinicians and policymakers are advised to take action.
Researchers have identified novel therapeutic targets using single-cell and spatially resolved omics, including cannabidiol for colorectal tumors, Cux1 as a potential target for dry skin diseases, and microglia communication for Alzheimer's disease. These studies offer hope for future treatments.
A new portable device invented by researchers at the University of Bath can detect synthetic cannabinoids like Spice on various materials, including paper and fabric, with high accuracy. The device is expected to be rolled out across the UK within months and may eventually be available globally.
A Northwestern University study found that endogenous cannabinoid molecules released by the brain during stress can calm it down. These molecules activate the same receptors as THC and may provide a natural coping response to stress.
Medical cannabis use in Australian patients with chronic health issues is linked to significant improvements in overall health-related quality of life and fatigue levels. Patients also report clinically meaningful reductions in pain and moderate-severe anxiety and depression.
A study published in Cell Chemical Biology reveals that cannabidiol (CBD) from hemp acts as a molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators. This finding holds promise for developing new therapeutic strategies to treat inflammatory diseases.