Articles tagged with Cannabinoids
A Northwestern University study found that endogenous cannabinoid molecules released by the brain during stress can calm it down. These molecules activate the same receptors as THC and may provide a natural coping response to stress.
Medical cannabis use in Australian patients with chronic health issues is linked to significant improvements in overall health-related quality of life and fatigue levels. Patients also report clinically meaningful reductions in pain and moderate-severe anxiety and depression.
A study published in Cell Chemical Biology reveals that cannabidiol (CBD) from hemp acts as a molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators. This finding holds promise for developing new therapeutic strategies to treat inflammatory diseases.
A recent analysis of published studies reveals a lack of evidence to determine the dosing, safety, and efficacy of medical marijuana or cannabis-containing products for managing symptoms experienced by children with cancer. The study found that cannabinoids performed better in managing nausea and vomiting, but data are lacking on their...
A study of 28,000 middle and high school students found high vaping cannabidiol (CBD) prevalence, particularly among e-cigarette users and Hispanic youth. Evidence-based interventions are needed to reduce health risks associated with vaping CBD among developing youths.
A new study by UCLA chemists reveals that many HHC products contain less of the biologically active isomer, which can lead to inconsistent effects. The researchers have developed a method for synthesizing the more active isomer, reducing variability in products.
A CU Anschutz study found that oral consumption of high doses of CBD during pregnancy impaired problem-solving skills in female mice. Fetal exposure to CBD also reduced the excitability of the pre-frontal cortex, a key area for learning.
A University at Buffalo-led study found that THC-O-acetate produces moderate relaxation, euphoria, and pain relief, but no psychedelic effects similar to LSD or psilocybin mushrooms. The study suggests that people may overreport their experiences due to social media hype and online claims.
Researchers at Linköping University have created a rapid method for measuring the effect of new psychoactive substances, enabling faster narcotics classification. The method was tested on 17 suspected cannabinoid drugs and classified 14 as narcotics.
Brazilian researchers found that corticosteroids increase endocannabinoid production and decrease platelet-activating factor levels in COVID-19 patients. This discovery points to potential new treatments for severe inflammatory and neurological diseases.
A new edible CBD coating has been developed to increase the shelf life of strawberries by reducing microbial growth. The coating, made with encapsulated CBD nanoparticles, was found to preserve berries for up to 15 days while maintaining their color and antioxidant activity.
A Brazilian study found that prenatal exposure to cannabinoids increases the risk of sudden infant death syndrome, breathing difficulties, and impaired control of breathing. The study suggests that consumption of cannabis or derivatives during pregnancy can have severe effects on the fetus's neural and physiological functions.
A new study on nematode worms reveals that they react to cannabinoids in the same way as humans, increasing hunger for favorite foods and decreasing hunger for non-favored foods. The discovery emphasizes the commonality of cannabinoid effects across species.
A study by University of Oregon researchers found that worms become even more attracted to high-quality food when exposed to anandamide, a molecule in marijuana. This phenomenon is similar to human 'hedonic feeding' behavior, where people crave certain foods after consuming cannabis.
Research finds that endocannabinoids protect against addiction in individuals exposed to childhood maltreatment. The 'resilient' group showed increased function of the endocannabinoid system and different brain activity compared to other groups.
Researchers have identified marijuana-derived compounds that can reverse fentanyl overdoses by reducing its binding to opioid receptors and boosting naloxone's effects. These compounds, derived from cannabidiol (CBD), demonstrate a synergistic effect when combined with naloxone.
A randomized trial found that CBD oil did not reduce pain scores after surgical treatment and stent placement for patients with urinary stones. The study involved 90 patients who received either CBD oil or a placebo, with no significant difference in pain reduction or opioid use between the two groups.
A West Virginia University study found that patients treated for motor vehicle collision injuries during the COVID-19 pandemic used more drugs, including cannabinoids, opioids, and stimulants. The study suggests public health interventions may be needed to curb this behavior in rural areas.
Researchers at Washington State University found that CBD inhibits a key enzyme for nicotine metabolism, slowing down its effects and allowing smokers to wait before feeling the urge to smoke. The study suggests that CBD could be a useful tool in reducing harm from smoking and quitting nicotine addiction.
A study reveals how CBD reduces seizures in pediatric epilepsy by blocking signals carried by lysophosphatidylinositol (LPI), a molecule that can amplify nerve signals and promote seizures. The research provides new insights into the mechanisms behind seizures and suggests potential targets for future drugs.
A study by Johns Hopkins Medicine found that high doses of CBD may increase the adverse effects of THC in edible cannabis products. The study showed that CBD inhibits the metabolism of THC, resulting in stronger and longer drug effects.
A new study by UCL and King's College London researchers found that vaporized cannabis has the same short-term effects on adolescents (16-17 years old) as on adults (26-29 years old), regardless of CBD levels. The study also showed that CBD does not reduce the psychoactive effects of THC in cannabis.
A new study explores the relationship between fatty acid amide hydrolase (FAAH) levels and heavy drinking patterns in young adults. Lower FAAH activity was associated with more severe drinking, increased cravings, and reduced sensitivity to alcohol's negative effects.
Researchers at EMBL Grenoble have discovered that THC inhibits the human enzyme autotaxin, which is involved in cancer, inflammation, and pulmonary fibrosis. This finding provides new molecular insights into the therapeutic effects of medical cannabis.
A team of scientists has identified three new biomarkers for detecting the consumption of emerging synthetic cannabinoids like OXIZID. These biomarkers will facilitate work by drug enforcement agencies worldwide in monitoring OXIZID abuse, enabling more accurate identification of abusers and potentially preventing overdoses.
A new national study found pregnant women in legalized US states are far more likely to use cannabis, with a 4.6 times higher rate compared to CBD-only states. The study emphasizes the need for prenatal and primary care providers to screen and counsel patients regarding cannabis use in pregnancy.
A recent study found that cannabis studies are often reported in positive terms in the media regardless of their results. The analysis of 20 studies involving 1,500 individuals showed a moderate to large placebo response, where pain was rated as being significantly less intense after treatment with placebo.
Researchers discovered a new signalling pathway using enzyme FAAH to dilate bronchial tubes, which may lead to new treatment options for lung diseases. Asthma patients have lower levels of anandamide and other endocannabinoids in their bronchial system.
Researchers found that exposure to e-cigarettes, marijuana, and tobacco led to increased scarring, decreased blood vessels, and changes in heart nerves, all contributing to an increased risk of arrhythmias. These substances can cause similar harm to the heart as traditional cigarettes.
New research from King's College London found increasing CBD content in cannabis does not significantly change the effects of THC on cognitive performance or psychotic symptoms. The study suggests that choosing cannabis with higher CBD:THC ratios may be safer due to lower THC levels, but CBD has no impact on intoxication quality.
Researchers have created a CBD-based bioplastic material that could be used in medical implants, food wrappers, and other applications due to its antioxidant properties. The material has a broad melting temperature range and stretchability, making it suitable for industrial use.
A recent Oregon State University study found that spent hemp biomass is a safe and nutritious alternative feed for lambs, with nutritional quality comparable to alfalfa. The findings provide evidence for the use of hemp byproducts as an animal feedstuff, potentially offering economic benefits for hemp farmers and livestock producers.
Lenabasum has been shown to improve skin symptoms in patients with amyopathic dermatomyositis, demonstrating significant reductions in inflammation and disease severity. The study's findings suggest that lenabasum is a well-tolerated treatment option for refractory skin disease.
The conference highlights recent discoveries on polyphenol applications in microbiota, adipose tissue, nervous system, senolytic activity, ageing, and endothelial function. Over 131 communications will be presented during three days.
A new study analyzed point-of-sale data from nearly 17,000 patients in New York's medical cannabis program to understand patient preferences for products and dosing. The researchers found considerable variability in product choice and dosing levels across different conditions, highlighting the need for clear clinical guidelines.
The workshop will discuss recent advances, perspectives, and applications of medical cannabis and cannabinoids. Researchers will explore their chemistry, pharmacology, analysis, influence on mitochondria, and potential use as anticancer agents.
A study by Washington State University found a 37% drop in poisoning reports for illicit synthetic cannabinoids in states with legal recreational or
Cannabis cells use a 'supercell' biofactory to create an efficient pipeline from raw materials to end products. The study reveals subcellular 'shipping routes' for THC and CBD production, enabling new paradigm for cannabinoid synthesis.
The Polyphenols Applications 2022 World Congress will focus on the latest findings and emerging trends in polyphenol research, covering various topics such as microbiota, adipose tissue, nervous system, senolytic activity, ageing, endothelial function, radioprotection, atherosclerosis, and more. Over 300 international participants will...
A new PSU study found that vaping cannabinoid acetates leads to the formation of ketene, a toxic gas known to cause vaping-induced lung injury. The study suggests that prolonged exposure to ketene could be particularly hazardous, as it is virtually untraceable in the human body.
The 15th World Congress on Polyphenols Applications will be held in Valencia, Spain from September 28-30, featuring over 100 communications and discussions on polyphenol applications and innovations. The congress aims to explore the role of polyphenols in food and their impact on human health.
Scientists have made a breakthrough in understanding cannabis biology by using firefly genes to study trichome development and cannabinoid synthesis. By cloning promoters and expressing firefly luciferase, researchers can evaluate signals that orchestrate cannabinoid production and trichome development.
Researchers have developed innovative tests for multiple chemicals using plant-based molecules that can detect synthetic cannabinoids and banned pesticides. The system uses a simple and inexpensive approach to quickly signal the presence of nearly 20 different chemicals.
A review of 25 trials found that synthetic cannabis products with high THC-to-CBD ratios improved chronic pain, but were associated with higher risks of adverse events. In contrast, products with comparable THC-to-CBD ratios showed few benefits in overall functioning.
The Polyphenols Applications World Congress 2022 will host a cannabis symposium in Valencia, Spain, discussing recent advances on polyphenols, their applications, and innovations. The symposium aims to evaluate the constituents of cannabis and medical cannabis, mainly cannabinoids and flavonoids.
Patients who use cannabis require higher levels of sedation during gastric endoscopies than non-users, according to research. Cannabis use is associated with increased odds of requiring higher total sedation during gastroscopy but not colonoscopy.
Patients who use cannabis require more drugs than non-users during gastric endoscopies, according to a study. Researchers found that cannabis use was associated with increased odds of requiring higher sedation levels during gastroscopy but not colonoscopy.
A new study found that an orally absorbed tablet containing cannabidiol (CBD) effectively reduced post-operative pain after shoulder surgery without side effects. The study showed significant pain relief and higher patient satisfaction compared to placebo, highlighting the potential of CBD as a safe and effective pain management tool.
A research team at Leibniz-HKI has developed a new method to produce complex natural products, including the precursor to THC, in amoebae. By leveraging the natural properties of the amoeba, they were able to produce a functional inter-kingdom hybrid enzyme that produces olivetolic acid without additives.
A new synthetic substance, PECS-101, has been shown to prevent neuropathic pain caused by chemotherapy while improving cancer treatment outcomes. The study, conducted in mice, found that PECS-101 had no adverse effects and did not cause dependence.
A new study found that female adults who heavily used cannabis had a lower incidence of diabetes compared to those who did not use cannabis. In contrast, light cannabis use among females and male adults with any level or no cannabis use showed no association with diabetes diagnosis.
A University of Oklahoma chemist is engineering a sustainable method for producing valuable compounds found in nature, such as cannabinoids and squalenes, using enzymes and E. coli. This approach avoids the environmental and economic challenges associated with traditional plant-based methods.
A large-scale survey of over 500 delta-8-THC users found they experience fewer negative side effects and use it in safer modalities compared to delta-9. The study's findings have significant implications for lawmakers, public health officials, and consumers as more states legalize cannabis while prohibiting delta-8.
Researchers at Oregon State University identified two cannabinoid acids, CBGA and CBDA, that can block the SARS-CoV-2 spike protein, preventing virus entry into human cells. These compounds have a good safety profile in humans and may be effective against variant strains.
A case series of 10 children with severe epilepsy found that whole plant medicinal cannabis reduced monthly seizure frequency by an average of 86%. The study suggests that whole plant products may be more effective than CBD products in treating childhood-onset severe treatment-resistant epilepsy.
New research suggests that cannabis use can lead to harmful drug-drug interactions by interfering with two families of enzymes that metabolize a wide range of drugs. This could result in unintended side effects such as toxicity or accidental overdose, particularly for older individuals using medications.
Research conducted by Mount Sinai Hospital reveals that cannabis exposure in utero can lead to higher levels of anxiety, aggression, and hyperactivity in children. Placental gene expression also shows lower immune-activating genes, predicting these outcomes.
A study at the University of Turku found that brain function regulating satiety and appetite is altered before obesity develops, with family background risk factors contributing to these changes. The findings suggest the brain and central nervous system are key targets for treating obesity.
A woman with non-small cell lung cancer experienced a 76% tumor reduction after taking CBD oil for 2.5 years, raising hopes for alternative cancer treatments. However, more research is needed to confirm the mechanism of action and potential side effects.
Researchers at the University of Sydney have discovered three rare cannabinoids that reduce seizures in a mouse model of Dravet syndrome. These findings provide new insights into the potential therapeutic effects of cannabis extracts on treating epilepsy.