Articles tagged with Cannabinoids
New research suggests that cannabis use can lead to harmful drug-drug interactions by interfering with two families of enzymes that metabolize a wide range of drugs. This could result in unintended side effects such as toxicity or accidental overdose, particularly for older individuals using medications.
Research conducted by Mount Sinai Hospital reveals that cannabis exposure in utero can lead to higher levels of anxiety, aggression, and hyperactivity in children. Placental gene expression also shows lower immune-activating genes, predicting these outcomes.
A study at the University of Turku found that brain function regulating satiety and appetite is altered before obesity develops, with family background risk factors contributing to these changes. The findings suggest the brain and central nervous system are key targets for treating obesity.
A woman with non-small cell lung cancer experienced a 76% tumor reduction after taking CBD oil for 2.5 years, raising hopes for alternative cancer treatments. However, more research is needed to confirm the mechanism of action and potential side effects.
Researchers at the University of Sydney have discovered three rare cannabinoids that reduce seizures in a mouse model of Dravet syndrome. These findings provide new insights into the potential therapeutic effects of cannabis extracts on treating epilepsy.
Researchers from the National University of Singapore have identified three new urinary biomarkers that can detect consumption of ADB-BUTINACA, an emerging synthetic cannabinoid. The discovery will help boost global surveillance of synthetic cannabinoid abuse and aid in tackling the increasing abuse of this substance.
Researchers found that cannabis terpenes mimic the effects of cannabinoids, providing pain relief without increasing negative side effects. The study suggests terpenes may be used to boost the efficacy of THC and reduce psychoactive effects, leading to a potential dose-reduction strategy for pain management.
Researchers at the University of Illinois have discovered modified compounds called epo-NA5HT and epo-NADA that target multiple cannabinoid receptors, interrupting pain and inflammation pathways. These lipid epoxides are much more potent than their precursor molecules and offer a promising alternative to opioid-based painkillers.
A mammography screening strategy based on a baseline breast density measure at age 40 is the most effective and cost-effective way to reduce breast cancer mortality. The study suggests that this approach can lead to a significant reduction in breast cancer mortality, but also increases the number of mammograms performed and false posit...
Scientists at Scripps Research have developed a vaccine that can deactivate the effects of synthetic cannabinoids in rodents, sequestering drug molecules before they interact with the central nervous system. The approach worked in models simulating smoking and vaping, a common method of use for these drugs.
Researchers at Texas Biomed will study the effects of cannabinoids on Human Immunodeficiency Virus (HIV) associated neurocognitive disorder (HAND), with a focus on delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD). The goal is to develop better therapeutic options for HIV patients suffering from HAND.
The Association of Cannabis Specialists (ACS) has named Cannabis and Cannabinoid Research their Official Journal, providing evidence-based education and standards for cannabis medicine. The journal aims to enhance clinical best practices, safeguard patient care, and advance cannabinoid research.
A recent study published in Medical Cannabis and Cannabinoids found that CBD oils are equally or less effective than pure CBD at inhibiting the growth of certain cancer cells. The researchers tested different types of CBD oil against pure CBD on various cancer cell lines, including brain, skin, and colorectal cancers.
Researchers explore the role of cannabinoids in limiting secondary damage of traumatic brain injuries (TBIs), where inflammation can accelerate after initial injury. By inhibiting an enzyme that worsens TBI outcomes, cannabinoids may help restore a healthy balance between pro-inflammatory and anti-inflammatory responses.
A study by Megan Carey and Catarina Albergaria found that altered cannabinoid signalling impairs learning in mice. However, this was not due to direct effects on neural plasticity, but rather the reduced activity levels of the mutant mice. Restoring behavioral state through exercise fully restored learning abilities.
Researchers found a significant association between cannabinoids and negative respiratory health effects in older adults with COPD. The study, published in Thorax, showed that higher doses of cannabinoids were linked to increased hospitalizations and all-cause death among patients with the disease.
A new study reveals that cannabis data is lacking on lesser-known compounds, but machine learning can help fill the knowledge gap. By analyzing a dataset of over 17,600 cultivars, researchers found that only 1.4% of strains had complete data on THC and CBD, highlighting the need for standardization in product labeling.
Research reveals cannabinoids reduce astrocyte glucose metabolism, impairing neuronal function and social interaction behaviors. The study identifies CB1 receptors as key players in this process.
A UBCO study examined pain tolerance among frequent cannabis users and found no association with increased sensitivity to pain. The research suggests that cannabis may be a safer alternative to opioids for managing chronic pain, offering hope for patients seeking relief.
Researchers at the University of South Carolina have found that Δ9-tetrahydrocannabinol (THC) can completely prevent Acute Respiratory Distress Syndrome (ARDS) caused by Staphylococcal enterotoxin. The study suggests a possible treatment for ARDS caused by COVID-19.
Penn State researchers identified 57 medications with a narrow therapeutic index that may be impacted by concomitant cannabinoid use. This list helps medical professionals make safe prescribing choices for patients using prescription or over-the-counter cannabinoids.
Research reveals that cannabis exposure leads to dysfunction of glucose metabolism in astrocytes, compromising neuronal functioning and resulting in reduced social interactions. The study sheds light on the link between cannabis use and sociability, highlighting potential therapeutic solutions.
A new study of regular cannabis users found that high-potency marijuana concentrates spike blood levels of THC more than twice as much as conventional weed, but do not lead to greater impairment. Despite this, the study raises concerns about the potential long-term health risks of concentrated cannabis use.
A recent study led by Washington State University's Carrie Cuttler found that cannabis reduces the severity of post-traumatic distress disorder (PTSD) symptoms by about 62% for intrusions, 51% for flashbacks, and 67% for irritability. However, the symptom reductions were not permanent.
Fatah Kashanchi and Lance Liotta investigate cannabidiol's impact on reducing HIV-1 transcription and extracellular vesicle release, which may lead to decreased virus production and neuroinflammation. The study aims to define the mechanisms behind cannabinoid-mediated EV production reduction.
Dr. Staci Gruber will use the grant to investigate differences between whole-plant, full-spectrum and single extracted compounds in cannabis products. Her research aims to clarify the potential for synergistic effects of full-spectrum products versus single extracted compounds.
Research focuses on simultaneous cannabis and alcohol use's impact on fetal brain development, nerve growth, and blood vessels. The study aims to understand the combined effects of SAC on developing offspring.
A rodent study found that prior cannabinoid exposure enhances adolescent rats' response to cocaine's stimulatory effects. The researchers observed increased histone acetylation and reduced levels of the enzyme histone deacetylase 6 in the prefrontal cortex.
The need for correct CBD labeling is a growing concern due to its increasing use in food and supplements. Accurate labeling helps protect consumers from false or unsubstantiated claims, ensuring they receive evidence-based treatments.
A systematic review and meta-analysis found that cannabinoid treatment reduced subjective pain scores compared to placebo in patients with acute pain. Intramuscular cannabinoids were more effective than oral cannabinoids in reducing pain relative to placebo.
Cannabinoids can interact with various drugs, increasing the risk of adverse effects. Regular marijuana use may also affect the clearance of other medications. Understanding these interactions is crucial for patients and physicians.
Researchers at McMaster University have discovered a non-psychoactive cannabinoid called CBG that shows promising antibacterial activity against drug-resistant MRSA. The study found that CBG prevents the ability of bacteria to form biofilms and destroys preformed biofilms, targeting the cell membrane of the bacteria.
Researchers analyzed 38 liquid samples from first cases of EVALI in New York State and found vitamin E acetate as a major diluent in 64% of samples. No unknown compound linked to EVALI was found in nicotine-containing liquids.
A recent study published in the Journal of the American College of Cardiology found that approximately 2 million adults in the US who have cardiovascular disease currently use or have used marijuana. The review also reveals that cannabinoids can interact with drugs used to treat heart disease, increasing the risk of adverse effects.
Researchers at the University of Alberta found that blocking natural cannabinoid receptors in zebrafish has detrimental effects on development, including reduced muscle innervation and locomotor activity. These findings suggest long-term negative consequences for fish even as adults.
A new study reveals that stalked glandular trichomes in cannabis flowers are the richest source of THC- and CBD-forming metabolites and fragrance-giving terpenes. The findings provide insight into how these trichomes make and store valuable products.
A meta-analysis of 83 studies found inadequate evidence for the effectiveness of medicinal cannabinoids in relieving depression, anxiety disorders, ADHD, Tourette syndrome, post-traumatic stress disorder, or psychosis. Despite some low-quality evidence suggesting pharmaceutical THC may improve anxiety symptoms, the overall risks and ne...
A study found that older adults with chronic obstructive pulmonary disease (COPD) are twice as likely to use prescription synthetic oral cannabinoids compared to those without COPD. This raises concerns about the potential dangers associated with this medication class, particularly in subgroups at heightened risk for adverse events.
The Society of Cannabis Clinicians has named Cannabis and Cannabinoid Research its official journal, expanding its mission to advance the understanding of medical cannabis. The partnership aims to promote rigorous clinical research on cannabis and disseminate new discoveries to practicing physicians and the scientific community.
A systematic review suggests that cannabinoids in cannabis may help reduce nightmares and improve sleep for people with PTSD. However, more research is needed to confirm the effectiveness of these treatments and ensure their safety.
A UC Riverside-led study reveals that overactive endocannabinoid signaling in the gut blocks satiation signals, leading to overeating and obesity. Researchers hope to develop drugs targeting these receptors to address obesity.
Researchers suggest that cannabinoids may relieve symptoms of OCD and related disorders through targeting the endocannabinoid system. Animal study data and preliminary human clinical trial results support continued pharmaceutical development.
Researchers at Washington State University have developed a new method to analyze the genetic characteristics of cannabis strains, providing a powerful tool for addressing industry claims and concerns. The analysis reveals distinct gene networks orchestrating each strain's production of cannabinoids and terpenes.
A clinical review provides interim advice on prescribing cannabis-based products and cannabinoids for certain conditions. The guidance highlights the importance of educating patients and clinicians about different products and their effects, particularly the difference between THC and CBD.
A new study found that inhaled doses as little as 2 mg of the synthetic cannabinoid JWH-018 can significantly impair cognitive function. The study also revealed that mixtures of synthetic cannabinoids can lead to serious adverse effects.
Scientists at UC Berkeley engineered yeast to produce pure cannabinoids, including THC and CBD, at a lower cost than extraction from marijuana plants. This breakthrough could enable easier medical research on the complex chemicals in cannabis.
A new study found that smoked cannabis as an adjunctive therapy can be both effective and cost-effective in treating chronic peripheral neuropathy. The research simulated its use in one million patients and compared it to usual care, finding that cannabis was a viable alternative.
A survey of dermatology providers found that they are interested in learning about and recommending cannabinoids as treatments for conditions like psoriasis and atopic dermatitis. Despite their enthusiasm, many expressed concerns about societal stigmas surrounding cannabis use, highlighting the need for further education and research.
Cannabidiol (CBD) has demonstrated significant antiepileptic efficacy, resulting in a 38-41% reduction in seizure frequency compared to placebo. CBD is well-tolerated but may cause side effects such as sedation and decreased appetite.
A new review of animal studies reveals that sex differences in response to cannabis are not just socio-cultural, but biological too. Estradiol affects control of movement, social behavior and filtering of sensory input via modulation of the endocannabinoid system.
Researchers found perrottetinene, a natural compound in liverwort moss, to be more effective than THC in treating inflammation and pain. The study suggests perrottetinene could have potential therapeutic applications, but further research is needed.
A systematic review and meta-analysis of 17 clinical trials found that medical marijuana reduced subjective patient assessments of spasticity, pain, and bladder dysfunction in patients with multiple sclerosis. However, the therapy may carry a higher risk of adverse events compared to placebo.
A UBC study discovered that many cannabis strains have virtually identical levels of THC and CBD, contradicting their unique street names. The research also found new, previously unknown cannabinoids in low quantities that could be related to pharmacological effects and serve as a source of new medicines.
A Syracuse University study found that cannabinoid drugs make pain feel less unpleasant and more tolerable, without reducing its intensity. The review of over 1,800 experimental studies suggests an affective component to their analgesic properties.
A national approach is needed for trialing cannabinoids in children due to the lack of high-quality evidence and unregulated use of products. Collaboration among academics, industry, and provincial governments is required to conduct multiple-site clinical trials with long-term follow-up.
A study found that frequent tobacco smokers had a nearly 20% decrease in CB1 receptors across the brain, similar to previous findings in cannabis and alcohol abuse. This reduction may be associated with addiction and could have negative effects on normal brain functions like memory and stress coping.
A recent study published in the Journal of Neurochemistry reveals that long-term use of cannabis or cannabis-based drugs impairs memory in mice, with significant effects on brain function and communication between learning and memory regions. The research highlights the potential negative side effects of long-term cannabinoid exposure.
A review of cannabinoids suggests they can stop cancer cells from dividing and invading normal tissue. Cannabinoids may also enhance the immune response against tumor growth and spread, providing potential new treatment options for cancer patients.
Researchers at University of British Columbia developed a new hydrogel-based eye drop that effectively treats glaucoma by quickly absorbing and reaching the back of the eye. The treatment, which contains cannabigerolic acid, was tested on donated pig corneas and showed promising results.
A new medical guideline from the University of Alberta suggests that the benefits of medical cannabis for pain treatment may be outweighed by its harms. The guideline recommends considering medical cannabinoids only in specific cases with adequate evidence and after standard therapies have been tried.