Articles tagged with Digital Publishing
A new genetic mutation, RUFY1-RET fusion, was discovered in a patient with stage IV CD-74-ROS1 fusion NSCLC who developed resistance to lorlatinib. The finding highlights the importance of ongoing genetic testing to guide therapy decisions.
A large study found pregnant women with cervical cancer face higher health risks during pregnancy and childbirth, including premature birth and cesarean sections. However, the babies' health is largely unaffected, with no significant differences in birth defects or stillbirths.
A study found clear differences in brain health between Hispanic and non-Hispanic White older adults, with Hispanic participants scoring lower on tests of memory, attention, and problem-solving despite similar mental health. Researchers emphasize the importance of considering social, economic, and cultural factors when developing progr...
Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
Dr. Gunther Eysenbach is stepping down as CEO of JMIR Publications to focus on innovation in academic publishing and AI-driven solutions. Sean Jeong takes over with a proven track record in digital transformation, agile delivery, and program execution.
A new algorithm proposes measuring quadriceps muscle mass for more accurate sarcopenia diagnosis, potentially leading to earlier detection and better treatment options. Ultrasound imaging is recommended as a cost-effective and practical solution for diagnosing sarcopenia in clinical settings.
A recent study evaluating NewsGuard's media reliability rating service found no evidence of bias against conservative news outlets. The analysis of over 11,000 sources in nine countries revealed stable trustworthiness scores since 2022, with the US receiving lower ratings due to hyper-partisan sources lacking editorial practices.
Researchers found a genetic change, pR552*, that could give the RB1 gene a new function leading to cancer growth. This challenges the common belief that both copies of the RB1 gene must be damaged for cancer to develop.
Aging cats with chronic kidney disease (CKD) have lower levels of key kidney transporter genes, leading to impaired waste removal. Monitoring these transporters and toxin buildup may help detect CKD early and improve treatment options.
Researchers tracked cfDNA levels before, during, and after colorectal cancer surgery, revealing significant increases associated with age, comorbidities, and surgical manipulation. The study suggests that cfDNA could serve as a non-invasive biomarker to monitor patient outcomes and evaluate surgical effectiveness.
Researchers discovered that removing arginase-II gene can slow down muscle aging in mice, leading to improved muscle health and reduced inflammation. This finding suggests targeting the Arg-II gene could help maintain muscle strength and mobility in older adults.
The new eReader combines full range of features, including personalization, powerful search and offline access, to provide a seamless experience. Developed in conjunction with Taylor & Francis' accessibility team, it meets European Accessibility Act requirements and supports ePub3 format.
A new study published in Oncotarget discovered an anti-correlation between PD-1 and KLRG1 expression in human tumor infiltrating CD8 T cells. This finding suggests the potential for combination therapy to enhance cancer treatment by targeting both markers simultaneously, which could lead to more significant and long-lasting benefits.
The Global Conference on Gerophysics aims to bridge statistical mechanics, complex systems theory, and dynamical modeling with biological mechanisms of aging. The conference will bring together leading scientists to promote healthy longevity and reshape our understanding of the aging process.
A study found that a simple blood test could predict breast cancer risk in older women by measuring biological aging via DNA methylation changes. Lifestyle factors, such as obesity and hormone replacement therapy, also influenced epigenetic aging and breast cancer risk.
A new study published in Aging found that pioglitazone reduced the frequency of skin ulcers in Werner syndrome patients. The research suggests that pioglitazone's anti-inflammatory properties may help wounds heal faster and prevent ulcers from forming.
A meta-analysis found a dose-dependent relationship between alcohol consumption and the risks of cirrhosis and HCC in HBV patients, with daily alcohol consumption exceeding 12g increasing risk by 6.2% and 11.5% respectively.
Raym Crow, a leading expert in mission-driven open publishing, has won the APE Award for Innovation in Scholarly Communication. The award recognizes his significant impact on sustainable and equitable open publishing models.
Dr. Blagosklonny's work introduced a new theory and promoted the use of rapamycin to slow aging and extend healthy life by targeting the mTOR pathway, leading to improved immune responses, heart protection, and potential cancer prevention.
A new study using a novel mouse strain expressing Halo-tagged SOCS1 reveals that the inhibitor needs to exceed a threshold level to suppress GM-CSF and IFN-gamma signaling. The findings emphasize SOCS1's crucial function in modulating cytokine signaling.
Researchers identified early cellular changes associated with Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy (MDPL) syndrome, a rare genetic aging disorder. MDPL syndrome is characterized by premature aging of mesenchymal stem cells, which can form tissues like bone and fat.
The book highlights innovative strategies for addressing Latino cancer disparities, including risk assessment, prevention, screening, detection, diagnosis, treatment, survivorship, and policy. It also shares model programs and resources to shape future efforts to address cancer among Latinos and all people.
GetFTR has integrated Taylor & Francis eBooks platform, enabling researchers to access books with real-time entitlement checks. The integration directs eBook requests to the eBooks platform and journal article requests to Taylor & Francis Online.
The University of Texas at Arlington's Amphibian and Reptile Diversity Research Center (ARDRC) has expanded its library with a donation of over 10,000 rare items, including books, scientific journals, and reports. This addition will provide scientists worldwide with access to a wealth of literature on reptiles and amphibians.
A large international study of GLP1-RA users and dipeptidyl peptidase-4 inhibitors (DPP-4i) found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer. The study, published in the Thyroid journal, analyzed data from 92,497 GLP1-RA users and 2,484,408 DPP-4i users.
Researchers found that brown adipose tissue enhances exercise endurance and supports healthy aging by improving blood circulation and reducing cellular stress. The study suggests that treatments mimicking BAT's benefits could lead to innovative therapies for improved energy levels and heart health.
A systematic literature search identified high-priority clinical actions for post-acute care, including early education, risk assessment, and mental health screening. Implementing these actions can improve the quality of care for non-hospitalized TBI patients.
The accumulation of nuclear lipid droplets (nLDs) is linked to metabolic conditions such as fatty liver disease, obesity-related disorders, and premature aging. Lifestyle interventions like caloric restriction can reduce nLD buildup, suggesting a potential therapeutic target for slowing cellular aging.
Researchers developed a gene therapy approach to treat chronic hypereosinophilia by delivering an anti-human eosinophil antibody via AAV-based gene therapy. The therapy successfully suppressed blood eosinophil levels in mice, showing promise as a potential treatment for the condition.
A research team at Pohang University of Science & Technology developed a technology that visualizes the deformation of 'serpentine' structures in real-time through color changes. This innovation eliminates the need for complex nanofabrication processes, providing actionable design guidelines for optimizing these structures.
A scoping review of community health indices has identified a broad range of indicators covering health outcomes and vulnerabilities. These indices offer potential for multi-factorial assessments to inform regional and local policy strategies, aiming to reduce social inequities and improve community health.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
A study published in Journal of Medical Internet Research found that open-world video games provide cognitive escapism, reducing stress levels and improving mental health. Popular titles like The Legend of Zelda: Breath of the Wild offer a sense of freedom and autonomy.
The innovative vision of Genomic Press is shaped by the story of Flicts, a tale about a color that found its true home on the moon. The publisher supports research that transcends traditional academic boundaries, providing a home for ideas that could reshape our understanding of science.
Researchers compared urine NAA levels in patients with mild and typical Canavan disease, finding lower levels in those with the milder form. This discovery has potential for a rapid and cost-effective way to screen for CD incidence and severity.
JMIR Aging has achieved top ranking, with a Journal Impact Factor of 5.0, making it the #1 ranked journal in the 'Gerontology' category. The inclusion in SCIE and SSCI underscores its exceptional quality and impact.
Researchers have developed a new generation of cell-penetrating antibodies that can target cancer cells and deliver therapeutic molecules directly into tumor cells. The 3E10 antibody shows great promise for treating cancers with defective DNA repair pathways.
Researchers found significantly higher levels of p16INK4a in young people with sickle cell disease, indicating accelerated cellular aging. This discovery may lead to new treatments targeting cell aging and improved quality of life for SCD patients.
A study found that ADAMTS13 regulates VWF expression and reduces hepatic platelet accumulation in PA-ILI patients and mice. Systemic administration of recombinant ADAMTS13 decreased platelet accumulation and mitigated liver necrosis.
Four ORNL researchers were recognized as Highly Cited Researchers for their impact factor using data from the Web of Science. They exemplify excellence in science and collaboration, advancing their respective fields.
A CU Anschutz study found that using a decision aid led to less personal uncertainty and distress among older adults, but not reduced depression. The online tool helped participants feel more confident in their decisions.
A new study found that gene therapy delandistrogene moxeparvovec significantly extended the median survival of Duchenne muscular dystrophy (DMD) rats to >25 months. Additionally, the treatment elicited statistically significant improvements in cardiac parameters and mobility.
A study published in PLOS Global Public Health found that individuals with high credulity are more susceptible to fake news and vaccine hesitancy. Mistrust was also linked to conspiracy thinking and difficulty distinguishing between real and fake news, particularly in those exposed to childhood adversity.
Researchers have found that B7-H4 helps ACC tumors evade the immune system, leading to poor survival outcomes. A new drug targeting B7-H4 showed promising results in shrinking tumors in aggressive cases.
Bentham Science journals Central Nervous System Agents in Medicinal Chemistry and CNS & Neurological Disorders – Drug Targets accepted for PsycInfo database indexing, enhancing global visibility of research. PsycInfo provides extensive coverage of behavioral and social sciences, making this move a significant step forward.
Mesenchymal stem cells (MSCs) show promise in delivering treatments directly to cancer cells and boosting the immune system's fight against cancer. However, ongoing research highlights challenges related to MSC behavior, including variability in their effects and potential to create conditions that support tumor growth.
A large-scale clinical trial involving over 9,000 patients reveals that text message reminders failed to improve medication refill adherence over a year. The study included diverse representation from subgroups, including females, Hispanic ethnicity, and Spanish-speaking patients.
A new review reveals how sleep disturbances exacerbate dementia symptoms, impacting overall health and caregiver well-being. The study emphasizes the need for holistic approaches to address coexisting conditions like cardiovascular disease and diabetes.
This editorial introduces persistence landscapes as a mathematical method to identify and correct biases in medical imaging. Persistence landscapes offer a way to reduce random noise while preserving important details, making it easier for clinicians to focus on meaningful image parts.
A recent study found that combining informative and persuasive cues, especially monetary incentives, boosts opt-ins. However, purely informative messages don't necessarily increase opt-ins. Firms with significant offline presence tend to use more persuasive strategies.
Researchers used machine-vision technology to compare targeted sprays with traditional broadcast applications, saving an average of 28.4-62.4% on postemergence herbicides. This study demonstrates potential for lower herbicide costs and improved environmental stewardship in soybean farming.
This systematic review analyzes 33 biological clocks used for aging and mortality quantification, categorizing them into epigenetic and phenotypic clocks. Epigenetic clocks demonstrate precision in estimating chronological age through DNA methylation, while phenotypic clocks predict mortality using easily measurable clinical variables.
Researchers introduce persistence barcodes, a tool that reduces diagnostic bias and uncovers subtle details in medical images. The method preserves key structural details, enabling clearer insights into the data.
A new review highlights the differences in brain aging and Alzheimer's disease between humans and non-human primates, revealing that primate brains are more resistant to aging-related damage. The study suggests that tau tangles play a critical role in Alzheimer's progression, challenging the amyloid cascade hypothesis.
Researchers developed a novel lentivirus-based gene therapy strategy in CD34+ hematopoietic progenitor cells, which showed therapeutic levels of expression of the anti-sickling beta globin protein. Cyclosporin improved transduction efficiency and preserved cell viability.
A new approach using topological data analysis (TDA) enhances the reliability and reduces bias in AI systems used for medical diagnosis in radiology. TDA captures intricate features and provides a holistic view of medical images, leading to more accurate diagnoses and equitable patient care.
The International Mycological Association has partnered with Pensoft to transition its flagship journal, IMA Fungus, to the ARPHA publishing platform. The new collaboration aims to improve and streamline the publication process, providing faster review cycles and more efficient communication.
Greg Liu has developed a revolutionary way to convert certain plastics into soaps, detergents, lubricants, and other products through thermolysis. The process breaks down polypropylene and polyethylene molecules into chemical compounds, leaving minimal residual solids and usable oil.
A randomized trial found reconditioned pacemakers comparable to new devices in terms of safety and effectiveness up to 90 days after implantation. However, longer-term follow-up is necessary to confirm the safety and efficacy of reconditioned devices.
A clinical trial found that combining two commonly recommended medications into a single pill lowered blood pressure and was safe among Indian adults. The study's results have significant meaning for South Asian adults, including those living in the US.