Articles tagged with Research Impact
Researchers have discovered two novel drugs that can block the growth and shrink the size of schwannoma tumors, a type of nerve sheath tumor found in the nervous system. The treatment works by inhibiting the Hippo signaling pathway, which is dysregulated in multiple types of cancer.
Scientists review natural structures with exceptional properties, such as wood, bones, spider webs, and sea sponges. These hierarchical structures can be used to design innovative materials for vibration damping and acoustic wave control.
The ASU-led SW-IFL aims to understand complex relationships between extreme heat, atmospheric pollutants, and limited water supply on vulnerable urban subpopulations. The integrated field laboratory will combine high-resolution data, advanced computer modeling, and community engagement to create regionally specific predictive tools.
Researchers at the University of Missouri have successfully used click chemistry to deliver radiopharmaceuticals specifically to tumors in large dogs with bone cancer, increasing effectiveness and minimizing circulation. This breakthrough could pave the way for click chemistry-based treatments for humans with cancer in the future.
A recent study published in Oncotarget reveals that Nectin-4 is widely expressed in head and neck squamous cell carcinoma (HNSCC), with significant correlations to clinico-pathological parameters. Non-smokers and p16-positive HNSCC showed higher expression of Nectin-4, leading to better survival rates for positive tumors.
A new study shows that a simple nutrition care program can improve nutritional status, physical functionality, cognitive function, and psychological well-being in older adults. The program reduced hospitalizations by 40% and associated costs.
Researchers developed high-capacity free-space optical links using unipolar quantum optoelectronic devices, achieving unprecedented data rates of up to 30 Gbit/s at 31-meter distances. The system's performance is resistant to weather conditions and showcases potential for fast, long-range optical links.
A new book by Aston University financial regulation expert Dr Daniel Cash proposes a temporary change to the way credit ratings are decided to help poorer countries avoid downgraded ratings and borrow money for vital improvements like healthcare and infrastructure.
The SwRI experiment helped predict the effects of NASA's DART impact on asteroid Dimorphos. The study assessed ejecta momentum enhancement created by the space probe's collision, measuring a 3.4-fold increase in momentum transfer.
Dr. Ralph L. Sacco, a top stroke neurologist, has advanced understanding of cardiovascular and cerebrovascular diseases through his research on race-related stroke risk. He is recognized for his work in creating targeted stroke prevention programs.
A recent study presented at the American Heart Association's Resuscitation Science Symposium 2022 found that ICU evaluations prior to cardiac arrest improved survival rates by 15% among Black adults. This study analyzed data from over 28,000 adults who experienced cardiac arrest between 2000 and 2021.
Survival rates for in-hospital pediatric cardiac arrest events have increased significantly between 2000 and 2021. Children with a history of cardiovascular disease showed slower improvement in survival rates compared to those without a history of CVD.
Researchers from Singapore University of Technology and Design show that restoring natural water availability to the Mekong's floodplains is possible through coordination among hydropower producers. By altering dam release decisions and production plans, key components of hydrological variability can be restored, leading to improved ec...
Twenty early-career researchers from Canada will receive funding for their innovative projects on brain disorders, including epilepsy, depression, and multiple sclerosis. The grants aim to reduce the social and economic burden of these conditions through prevention, early diagnosis, and treatment.
Researchers analyzed data from bike share stations in NYC, Chicago, and Philadelphia to understand disparities in bike share use. Key findings include concerns about traffic safety and personal safety among lower-income and people of color residents.
The American Heart Association honored Drs. Harriette Van Spall and Erica Gunderson with the 2022 Dr. Nanette K. Wenger Research Goes Red Award for their groundbreaking study on sex-specific clinical outcomes of heart failure patients. The research found that women experienced improved outcomes after receiving transitional care service...
Dr. Bibbins-Domingo's research focuses on racial disparities in cardiovascular disease prevention, incidence, and outcomes. She explores long-term effects of early and poorly treated high blood pressure and develops strategies to prevent and manage CVD.
The Beckman Institute has established a new national collaborative Biomedical Technology Research Resource to develop label-free optical imaging technologies. The center aims to create optical and computational imaging technologies that can serve as a resource for clinicians and researchers.
A study of 31,000 medical school graduates found significant disparities in publication rates among women, Black, and Hispanic students compared to men and white students. These inequities suggest that issues with the physician-scientist workforce began early in training, affecting career success.
The University of Missouri has earned an $8 million grant from the National Institutes of Health to expand its National Swine Resource and Research Center. The center will support research using genetically modified pigs to study human diseases, with a focus on therapies that can be translated from pig models to humans.
Researchers from Northumbria University and Brunel University London have developed innovative strategies for emergency planning, including a toolkit for personal debriefing. Their work has helped organizations and councils improve their resilience and community engagement, moving away from traditional top-down approaches.
The US Harmful Algal Bloom Control Technology Incubator aims to advance innovative ways to control blooms impacting marine ecosystems and regional economies. The partnership between UMCES and Mote Marine Laboratory & Aquarium will offer funding and guidance for innovative control technology projects.
A University of Cincinnati study explores how anti-immigration policies affect Latinx mental health, finding increased depression, anxiety, and behavioral difficulties among affected communities. The research also identifies coping mechanisms that help individuals overcome these challenges.
A new study by Johns Hopkins Medicine reveals that stress influences appetite in both obese and lean adults, with differences in brain responses to food. The research found that obese individuals show increased activation of the orbitofrontal cortex after stress, while lean adults exhibit lower activation of cognitive control regions.
A new study by University of Essex researcher Constantina Maltezou-Papastylianou found that older adults are less accurate than younger adults in detecting emotions from speech. This decline is associated with natural changes in the brain as we age, affecting understanding and interpretation of emotional cues.
Research into Myanmar amber fossils is hindered by the country's ongoing political, legal, and economic crises. The strict restrictions on research access have led to international researchers acquiring the valuable amber for study.
A study published at the European Emergency Medicine Congress found that a digital technology platform called HealthCall can reduce emergency department attendances for residents in care homes. The system provides staff with easy access to clinical advice and has been shown to result in a 10% reduction in expected monthly attendances.
A novel genetic analysis by University of Ottawa researchers reveals that climate change could lead to an increased risk of viral spillover in the High Arctic. This increased risk may result in new viruses infecting previously uninfected hosts, potentially leading to emerging pandemics.
Researchers have discovered a family of selfish genes, wtf, that have survived for over 100 million years in yeast, contradicting established beliefs on their longevity. These 'killer meiotic drivers' transmit themselves to half of offspring and destroy reproductive cells without being suppressed by natural selection.
The UK Synchrotron facility, Diamond, has contributed £2.6 billion to the UK science and economy through its delivery of 12,000 published journal papers. This impact is demonstrated by the significant benefits achieved in various scientific disciplines, addressing global challenges such as disease, clean energy, and food security.
Researchers at LSU Health New Orleans have identified a new drug target for triple-negative breast cancer, which lacks estrogen and progesterone receptors. The novel small molecule inhibitor NSC33353 works synergistically with doxorubicin to suppress the growth of TNBC cells.
A landmark study published in The Lancet found that chlorhexidine gluconate and povidone-iodine aqueous solutions are equally effective in preventing surgical site infections in patients with open fractures. This finding has significant implications for healthcare practitioners and may reduce costs associated with accessing these antis...
A recent study published in Engineering Construction & Architectural Management identified the main obstacles preventing digital transformation in the engineering and construction industry. The three main problems are a lack of laws and regulations, a lack of support and leadership, and a lack of resources and professionals.
Research by the University of Exeter found high levels of antibiotic ciprofloxacin in UK wastewater, posing a significant risk to human health. The study suggests that antibiotic pollution from human waste can increase resistance to antibiotics, even in countries with well-established sanitation infrastructures.
A new report finds that men and women in the UK have higher probabilities of dying than predicted, with a marked difference in gender. The slowdown since 2010 has raised questions about the viability of pensions schemes and inequalities within the UK.
Mathematicians at Aston University are developing computational modelling techniques to examine biological drag reduction methods, such as fish slime secreted by predator-avoiding fish. This project aims to reduce skin-friction drag and increase the performance range of electric vehicles, contributing to a reduction in CO2 emissions.
WayPath Pharma has been awarded a $225,000 Phase I Small Business Technology Transfer (STTR) award to develop new metabolic drugs targeting tumor stem cells and crossing the blood-brain barrier. The funding aims to advance treatment options for glioblastoma, a highly aggressive brain cancer with limited treatment options.
A new study found that scientists tend to be most innovative and creative early in their careers, with a significant decline in impact over the course of their careers. The study analyzed 5.6 million biomedical science articles and found that the work of less-innovative researchers tends to drop out as they get older.
The Northern New Jersey Traumatic Brain Injury System will provide ongoing care and research, aiming to improve learning and memory impairment in TBI patients. The system's site-specific study will examine the impact of aerobic exercise training on managing new learning and memory impairment.
Researchers at CNIC have identified metoprolol as a neuroprotective agent after a stroke, greatly reducing cerebral inflammation and neuronal death. The study's findings suggest that metoprolol may also offer benefits in treating severe Covid-19.
Researchers aim to create a unified database network for battery data, facilitating AI analysis and predictions. The Battery Data Genome will collect data across the entire battery lifecycle, from discovery to deployment, with uniform standards for metadata.
The Earth System Grid Federation is upgrading its climate projection data system to improve access and curation, with the goal of enabling scientists to make the best guess about the future trajectory of our climate. The new system will provide faster download speeds and enable previously infeasible data analyses.
Research has found that former Scottish international rugby union players are at a significantly increased risk of developing neurodegenerative diseases, including dementia and motor neurone disease. The study's findings suggest that strategies to reduce head impact and traumatic brain injury in all sports are necessary.
Researchers from the University of Cincinnati found that low levels of soluble amyloid-beta protein in the brain, rather than its buildup into plaques, are associated with cognitive decline and Alzheimer's disease. Patients with high levels of soluble amyloid-beta showed improved cognitive outcomes, contradicting previous theories.
A study of 15 transgender women found they exceeded the cardiopulmonary capacity and muscle strength of their cisgender peers even after years of hormone therapy. However, their performance was lower than that of cisgender men. The findings could inform policy on transgender women's sports participation.
A new study analyzes the benefits and harms of prior authorization policies in Medicare Advantage, highlighting their impact on patients and clinicians. The researchers propose several measures to improve the use of PA in Medicare, including electronic-based processes and enhanced transparency.
The Keck School of Medicine of USC's Stevens INI has received a $149 million grant to study Alzheimer’s disease among diverse communities. The HABS-HD study aims to develop biomarkers that determine risk for developing the disease, addressing health disparities among Hispanic and African American populations.
Researchers found population declines were much larger than previously thought, with Tonga's main island experiencing a decline of 70-86% after European contact. The study used aerial laser scanning data and archaeological records to estimate the pre-contact population size, which was significantly higher than previous estimates.
A new European study confirms that banning menthol cigarettes leads to increased smoking cessation rates, with 26.1% of menthol smokers quitting compared to 14.1% of non-menthol smokers. The study also finds that a proposed US ban on menthol cigarettes could lead to over 1.3 million quitters.
Stronger hurricanes are more likely to reach Europe, with those encountering strong jet stream winds often reintensifying and moving further east. This study investigates the link between hurricane strength and European impact.
A new field study reveals a previously unobserved fluid dynamic process that affects the ocean's deep-sea mining operations. Researchers equipped a pre-prototype collector vehicle with instruments to monitor its sediment plume disturbances, finding that the plumes remained relatively low and spread under their own weight.
A team of international scientists found that many densely populated coastal cities worldwide are at risk from sea level rise due to land subsidence. The study used satellite images to estimate the rate of land sinking in 48 cities, with median speeds ranging from 16.2mm/year to 43mm/year.
A new study found that disclosure of advertising spending significantly lowers investor and analyst uncertainty, enhancing firms' valuation. The study analyzed 2,285 publicly listed firms over 25 years and found a moderate negative effect on idiosyncratic risk.
A recent academic study found that Facebook's introduction at American colleges was associated with a significant worsening in mental health symptoms, particularly depression and anxiety. The study used a novel research method to establish causality between social media use and poor mental health.
The University of Missouri has received a $25 million grant from the USDA to help farmers adapt to climate change through climate-smart practices. The five-year project aims to improve crop and livestock resilience on up to 500,000 acres of Missouri farmland.
Researchers at the University of Rochester Medical Center found that children who experience a mild traumatic brain injury are more likely to develop emotional and behavioral problems. The study, which analyzed data from thousands of children, revealed a 15-percent increased risk of these problems in kids with a mild TBI.
The University of Ottawa-led team aims to bridge the gap between heart and brain health by developing new diagnostic tools and treatments. They will focus on improving patient outcomes for disorders linked to both organs.
A study published in Injury Prevention found that adolescents who experienced a concussion in the past 12 months were 25% more likely to be in poor academic standing. This association was stronger with a history of repeated concussions, and varied by race/ethnicity.
A study by researchers at MSU, Northwestern, Notre Dame and NYU found that gender-balanced teams produced significantly more novel and impactful scientific work compared to unbalanced teams. Teams with an equal number of men and women had the highest likelihood of novel and impactful results.
A small qualitative study found that emergency departments often fail to provide dignified and respectful care to frail older patients, leading to long waits and poor communication. The researchers recommend making healthcare settings more 'frailty friendly' by prioritizing patient comfort and involvement.