Research on health and aging in later life. Covers attention and cognition, longevity, organ aging, and age-related disease.
A recent Mayo Clinic study found that prescription opioid use is associated with declines in cognitive performance, particularly in memory and attention. Older adults who received at least one opioid prescription over 7.5 years had a 20% higher chance of developing mild cognitive impairment.
A recent study published in NeuroImage found that older adults with improved cognitive performance during dual-task walking had flexible neural resource allocation. This discovery suggests a potential method for tracking brain health and identifying individuals at risk of aging-related cognitive decline.
Researchers from NUS Medicine discovered that specific CPS structures and sugar combinations help Streptococcus pneumoniae colonize the human respiratory tract. The study sheds light on the importance of CPS structure in bacterial survival, which will inform future vaccine development.
Denmark has seen a significant surge in strep A infections, particularly among the elderly, since late 2022. The new M1 subvariant is responsible for 30% of cases and may be contributing to the outbreak's severity.
A new study finds that communities with high proportions of elderly residents and those living in mobile homes or group homes are at greater risk of groundwater contamination from fracking. Higher-income households were more likely to have access to mitigation strategies, while lower-income households faced greater risks.
Researchers found that higher selenium levels were associated with lower blood pressure and HDL concentration in middle-aged women. The study suggests that selenium may moderate the effect of genetic variants on MetS components, such as waist circumference.
Researchers identified potential novel receptors for SARS-CoV-2 that utilize multiple receptors to facilitate its life cycle. The study reveals a strong correlation between tissue age-dependency and SARS-CoV-2 infection-induced receptor expression, with older adults being more susceptible to severe outcomes.
A study of over 43,000 adults found that parathyroidectomy has no estimated effect on long-term kidney function in older adults. However, early treatment may preserve kidney function in patients younger than 60 years old.
A new study found that the Medicaid 'cliff' - an abrupt end to supplemental insurance above federal poverty threshold - disproportionately affects Black and Hispanic older adults. This results in reduced healthcare use, including fewer doctor visits and prescribed medications, exacerbating existing health disparities.
A new UC Davis study found that high blood pressure in young adulthood is associated with lower regional brain volumes and worse white matter integrity, both factors linked to dementia. The research also showed sex differences in the negative brain changes, with men exhibiting stronger effects than women.
A recent Baycrest study found that older adults are less able to distinguish between computer-generated and human speech compared to younger counterparts. This diminished ability could be related to older adults' reduced capacity to recognize emotions in speech, highlighting the need for AI-related training programs.
Researchers found that using monoclonal antibodies within two days of a COVID-19 diagnosis reduced the risk of hospitalization or death by 39% compared to those who did not receive treatment. This finding suggests that early treatment with monoclonal antibodies significantly reduced the severity of COVID-19.
Scientists at SENS Research Foundation have discovered a new class of broad-spectrum senolytic drugs that target the key vulnerability in destructive aging cells. These drugs are effective against both primary and secondary senescent cells, making them a promising approach for treating age-related diseases.
A study explores how people remain productive and find meaning in later life, revealing key lessons from experts like John Cook, Judy Woodruff, and Chris Labenz. The research highlights the importance of following one's passion and not retreating to a conventional retirement lifestyle.
A UCF research team, in partnership with the City of Orlando, aims to prevent falls among older adults through a low-cost, portable technology-based intervention. The project seeks to address public health disparities and support the development of affordable housing options.
Overdose mortality among people aged 65 and older has quadrupled, driven by illicit drugs like fentanyl, heroin, and synthetic opioids. Researchers call for updated Medicare coverage and harm reduction supplies to curb the trend.
Researchers examine how chronological and biological age impact vaccine effectiveness, finding that both factors influence immune system capacity to mount responses. The study highlights the need for further research into 'immune aging' risk and departures from healthy aging.
A recent study published in JAMA Network Open found that food insecurity is associated with a decline in executive function among older adults. The research used data from 3,037 community-dwelling Medicare beneficiaries and suggests that interventions to increase healthy food access may be crucial in mitigating cognitive decline.
A new study found a protein that regulates macrophage function, clearing residues from regenerating muscle and recovering regenerative capacity in aged mice. The discovery holds promise for regenerative medicine and aging, potentially improving the success of current stem-cell based therapies.
The new system, built by researchers at the University of Waterloo, uses low-power radar technology to track activities and alert medical experts to potential health issues. It can detect decline in mobility, increased likelihood of falls, and onset of medical conditions without the need for wearable devices.
A new study warns of a rise in potentially fatal infections caused by bacteria found along parts of the US coast, driven by global warming. The number of Vibrio vulnificus infections has increased from 10 to 80 per year over 30 years, with cases now found further north than ever before.
Researchers discovered that mechanical loading can exacerbate inflammation in aged muscles, hindering healing. However, combining mechanotherapy with anti-inflammatory treatment significantly improves healing in aged muscles.
Researchers found that older adults with depression exhibit accelerated biological aging, poor physical and brain health, and worse cardiovascular health. This association suggests opportunities for preventive strategies to reduce disability associated with major depression in older adults.
Developing postoperative delirium is associated with a 40% faster rate of cognitive decline compared to those who do not develop delirium. The study, which followed 560 older adults for up to six years, found that delirium influences every time point and is linked to sharper drops in cognition and faster declines over time.
A new study found that dual-task walking performance starts to decline by the age of 55, indicating accelerated brain aging. Researchers assessed a cohort of 640 participants and observed non-linear associations between age and dual-task performance.
Researchers have successfully used AAV1.NT-3 gene therapy to improve muscle physiology and prevent age-related sarcopenia in mice. The treatment resulted in restored muscle mass, strength, and neural connections, offering a potential new option for managing this debilitating condition.
Researchers at NTU Singapore have found a way to spur brain immune cells to clear toxic waste linked to Alzheimer’s disease by targeting their metabolism. The study reveals a ‘metabolic switch’ in the brain’s immune cells that can be manipulated to improve their function.
A systematic review of 33 randomized controlled trials found that yoga improved gait speed and lower extremity strength in inactive older people. However, it did not offer a benefit for frailty markers compared to exercise or tai chi.
A new poll shows a decline in loneliness and isolation among older adults, but one-third still experience these feelings, especially those with poor health or disabilities. The study highlights the importance of social interaction for overall mental and physical health, and the need for a concerted effort to address these issues.
A growing connection between diabetes, oral health, and dementia highlights the importance of dental care and diabetes management as we age. Older adults with both poor oral health and diabetes experience accelerated cognitive decline, emphasizing the need for regular dental visits and adherence to diabetes treatment.
Recent studies have identified key psychological processes, such as repetitive negative thinking and self-reflection, that may impact cognitive aging and dementia prevention. Researchers propose incorporating psychological elements to reduce dementia risk through cognitive-behavioral interventions.
A new study reveals that northern and southern resident orcas differ in their hunting behaviors, with males catching more salmon per hour than females. Southern resident males outperform females by 152%, highlighting a distinct pattern of foraging that may contribute to the population decline.
A Cochrane review found that eliminating hazards around the home, such as clutter and poor lighting, can reduce the risk of falls for older people by around a quarter. Decluttering and reducing hazards had the most benefit for those at high risk of falls.
A study by the University of Missouri found that older adults who completed an eight-week resistance training program maintained long-term exercise habits and increased their physical energy despite COVID-19 restrictions. The Stay Strong, Stay Healthy program improved participants' sleep, balance, flexibility, and self-confidence in da...
Researchers found that suppressing AMPKα1 but not AMPKα2 isoforms improved aging-related impairments in mice. The study revealed novel insights into the roles of AMPK signaling pathway in cognitive aging.
A recent study of 24,000 participants aged 45 or older found a significant independent association between perceived stress and both prevalent and incident cognitive impairment. The study's findings highlight the need for regular screening and targeted interventions to address stress in older adults.
A University of Chicago study found that older adults living near fracking sites in Pennsylvania had higher rates of cardiovascular disease hospitalizations compared to those in nearby New York state. The study linked exposure to air and water pollution from fracking activity to increased health outcomes.
A Canadian study found that those infected with COVID-19 in the first wave in 2020 were 40% less likely to get infected during the first six months of Omicron activity. Older adults, particularly those aged 65 and above, were significantly less likely to be infected than younger adults.
A new multicenter study led by Washington University School of Medicine in St. Louis found that adding the drug aripiprazole (Abilify) to an antidepressant improves treatment outcomes for older adults with clinical depression that has not responded to standard treatments. The study, published in The New England Journal of Medicine, sho...
A new study found that walking an additional 500 steps per day was associated with a 14% lower risk of heart disease, stroke or heart failure. This benefit is significant for older adults, as most studies have focused on early-to-midlife adults.
Researchers at Chalmers University of Technology developed a method to predict fall accidents and cognitive illnesses like Alzheimer's disease using radar sensors that track walking patterns. The technology can help healthcare staff make more reliable risk assessments and tailor interventions for improved patient outcomes.
Researchers explore cellular senescence's complex relationship with growth stimulation and cell cycle arrest, revealing potential anti-aging drug targets. Understanding these mechanisms is crucial for developing new treatments for age-related diseases.
A Florida Atlantic University study reveals that while private automobiles remain dominant, the share of car trips has decreased since its peak in 2001. In contrast, transit, non-motorized, and taxicab trips have increased. Lower-income groups rely heavily on public transportation due to limited mobility options.
A new screening tool developed by Cleveland Clinic researchers can effectively detect mild cognitive impairment, early Alzheimer's disease, and other related dementias in older adults. The tool has been shown to identify 90% of patients with mild cognitive impairment, offering a potential solution for early detection and prevention.
Researchers discovered that telomere shortening is associated with early subjective depressive symptoms and cognitive complaints among healthy elderly individuals. The study also found a link between telomere shortening and increased interleukin-6 levels.
A new study called IGROOVE will investigate the effects of various dance styles, frequency, and social interaction on fitness, memory, and brain health in older adults. The research aims to answer fundamental questions about the optimal dosage of dance for cognitive benefits.
A study finds that aggressive end-of-life care remains common among older adults with metastatic cancer, particularly in nursing home residents. Multilevel interventions targeting hospital admissions and in-hospital death are crucial to reducing its prevalence.
A study of 4,000 middle-age workers reveals a link between sustained low hourly wages and elevated all-cause mortality risk. The findings suggest that improving the financial standing of low-wage workers through policies like minimum wage laws could lead to better mortality outcomes.
A recent study published in the Journal of the American Heart Association found that irregular sleeping habits may increase the risk of developing atherosclerosis among adults older than 45. Maintaining regular sleep schedules can help reduce cardiovascular risk for aging adults and improve overall health.
A University of Gothenburg study found that wheelchair users had significantly lower rates of fractures compared to ambulatory older adults. The study, which included 55,442 wheelchair users in Sweden, showed that wheelchair use was associated with a reduced risk of fractures, particularly osteoporotic and hip fractures.
Researchers from the University of Colorado found that Paxlovid significantly reduced rates of hospitalization and death among non-hospitalized patients infected with recent Omicron subvariants. The study used real-world data from 28,000 patients and suggested a benefit for Paxlovid in preventing severe disease.
A recent study published in JAMA Network Open found a significant association between long-term exposure to air pollution and an increased risk of late-life depression diagnosis in older adults. The research analyzed data from 8.9 million Medicare enrollees, highlighting the potential health impacts of air pollution on mental health.
Research finds that older workers who are motivated to grow and develop at work, as well as those in organizations that encourage learning, are more likely to stay. An age-inclusive environment also aids in retention by mitigating age stereotypes and removing barriers for training participation.
A new analysis of 7,068 elderly Americans found that only 41% of cognitive decline can be statistically accounted for by dementia. Personal education, race, household wealth and income were the biggest contributors to population-level variation, but all factors accounted for only 5.6% of age-related change.
A national study found that common risk factors for cognitive decline, such as socioeconomic status and education, explained a modest 38% of the variation in mental abilities among older Americans. Health behaviors like exercise had a small effect on functioning, with only 5.6% explaining the rate of cognitive decline.
A recent study found that nearly half of older adults receive no dental care and half lack dental insurance. After becoming eligible for Medicare, the percentage of people receiving restorative dental care decreased by 8.7%, while complete edentulism increased by almost 5 percentage points among those aged 65 and above.
A recent study published in BMJ Open Sport & Exercise Medicine suggests that golf may be just as healthy or even healthier than Nordic walking for older adults. The research compared the acute effects of three aerobic exercises: an 18-hole round of golf, 6km of Nordic walking, and a 6km walk. The results showed that all three types of ...
A study published in BMJ Open Diabetes Research & Care found that married individuals tend to have lower average glycemic levels compared to those without a partner. The researchers also discovered that marital transitions, such as divorce, can significantly impact blood glucose levels and the risk of pre-diabetes.
The study found that CoronaVac and Pfizer-BioNTech vaccines remained effective against severe SARS-CoV-2 Omicron outcomes, but older individuals' protection waned after six months. A booster dose is recommended for older patients to restore immunity.
Adults living in neighborhoods with dense fast food and unhealthy food environments, known as