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Small-volume hypertonic saline plus furosemide linked to lower inflammatory and remodeling markers in acute heart failure

Treatment with i.v. furosemide plus HSS significantly decreased serum levels of inflammatory biomarkers IL-6, sST2, hsTnT, galectin-3, and NT-proBNP. The study found that this combination therapy modulated some miRNA expression and was associated with reduced miR181b expression compared to furosemide alone.

SourceImpact Journals LLC·JournalAging-US·TypeNews article·DateApr 7, 2026

JMIR Publications examines AI-driven discovery bottleneck: scientific evidence trapped in a predigital system

The article highlights the urgent need to modernize scientific record with AI-powered discoveries trapped in a predigital system. Top-tier research universities face $10-15 million annual subscription expenditures, while author-facing processing charges range from $5,000 to over $11,000 per article.

SourceJMIR Publications·JournalJournal of Medical Internet Research·TypeCommentary/editorial·DateApr 7, 2026

COCOON trial shows proactive skin care can halve dermatologic toxicity in EGFR-mutant NSCLC

The COCOON trial found that a structured dermatologic prophylaxis regimen reduced moderate-to-severe dermatologic adverse events by half, with fewer grade ≥3 events and treatment discontinuations. This approach could improve tolerability and maintain dose intensity for EGFR-mutant non-small cell lung cancer patients.

SourceImpact Journals LLC·JournalOncoscience·TypeCommentary/editorial·DateApr 3, 2026

JMIR Publications and the University of Nevada, Las Vegas announce flat-fee unlimited open access publishing partnership

JMIR Publications and the University of Nevada, Las Vegas announce a new Flat-Fee Unlimited Open Access Publishing Agreement. The agreement eliminates financial obstacles for researchers, reducing administrative workload for library staff and ensuring research findings are available via immediate open access in JMIR's high-impact journ...

Exergames could improve mood in older adults

A systematic review of experimental studies found exergames to be associated with better mood outcomes, including reductions in tension and depressive symptoms. The evidence base remains small and heterogeneous, but the study calls for longer-term interventions and larger samples to determine the durability of benefits.

SourceImpact Journals LLC·JournalAging-US·TypeSystematic review·DateMar 25, 2026

Tumor-informed liquid biopsy suggests structural-variant ddPCR can monitor high-grade serous ovarian cancer

A novel method for monitoring on-treatment disease burden in high-grade serous ovarian cancer uses tumor-informed breakpoints-spanning ddPCR, detecting superior sensitivity and specificity compared to real-time PCR. The approach may enable sensitive and specific detection of minimal residual disease and early relapse detection.

SourceImpact Journals LLC·JournalOncoscience·TypeNews article·DateMar 19, 2026

Scholars propose transparency, credit and accountability as key principles in scientific authorship guidelines

A working group of scholars and experts proposes three principles - transparency, credit, and accountability - to form the foundation for responsible authorship. The principles aim to address issues of gift, ghost, and coercive authorship and promote a culture of transparency and accountability in scientific research.

SourcePLOS·JournalProceedings of the National Academy of Sciences·DateMar 11, 2026

P38 MAPK linked to epigenetic activation of fibrotic genes in senescent lung fibroblasts

A new study reveals that p38 MAPK plays a key role in epigenetic regulation of fibrotic genes in lung fibroblasts, particularly in senescent cells. Pharmacological inhibition of p38 MAPK significantly reduced α-SMA and Col3A1 expression, suggesting a potential therapeutic target for treating age-related fibrotic diseases like IPF.

SourceImpact Journals LLC·JournalAging-US·TypeNews article·DateMar 10, 2026

Rare pancreatic tumor case suggests distinctive calcification patterns in solid pseudopapillary neoplasms

A new case report describes a large, calcified solid pseudopapillary neoplasm of the pancreatic head, emphasizing the importance of multidisciplinary evaluation and long-term follow-up for monitoring recurrence. The case underscores the diagnostic value of integrating imaging, histopathology, and immunohistochemistry.

SourceImpact Journals LLC·JournalOncoscience·TypeCase study·DateMar 6, 2026

Next-generation metabolic theory suggests glycolytic ATP decline may limit lifespan

A new metabolic theory proposes that a decline in glycolytic ATP production is the fundamental mechanism limiting lifespan. Species with an optimal rate of decline survived, suggesting that maintaining a stable glycolytic flux may support repair processes and tissue regeneration. The authors propose testing this hypothesis through expe...

SourceImpact Journals LLC·JournalAging-US·TypeNews article·DateMar 3, 2026

Study identifies aging-associated mitochondrial circular RNAs

A study profiles mitochondrial circular RNAs in Peripheral Blood Mononuclear Cells from young and old human cohorts, revealing that circMT-RNR2 levels are depleted in older cohorts and are involved in promoting the TCA cycle. Loss of GRSF1 reduces circMT-RNR2 levels, decreasing mitochondrial TCA intermediates and accelerating cellular ...

SourceImpact Journals LLC·JournalAging-US·TypeNews article·DateFeb 24, 2026

Early recognition and surgical management key in necrotizing fasciitis of the head and neck

Early recognition and surgical management are crucial in treating necrotizing fasciitis of the head and neck, a rare but life-threatening soft tissue infection. The authors emphasize the urgent need for coordinated care, including immediate surgery, broad-spectrum antibiotics, and airway protection to reduce mortality rates.

SourceImpact Journals LLC·JournalOncoscience·TypeNews article·DateJan 29, 2026