A new editorial proposes a transformative shift in healthcare focus from reactive disease management to proactive healthspan extension. The approach targets the root causes of age-related diseases through aging biology, aiming to prevent diseases before they emerge.
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Researchers found that aging increases the brain's vulnerability to low oxygen levels, disrupting the blood-brain barrier and leading to inflammation and cognitive decline. The study identified specific oxygen levels that trigger BBB disruption, with older mice showing increased sensitivity even at mild hypoxic levels.
Researchers discovered that blocking PRDX1 protein can make ovarian cancer cells more responsive to DNA-damaging platinum therapies. The study suggests targeting PRDX1 could be a viable strategy to improve chemotherapy efficacy.
A study investigated immune-related adverse events (irAEs) in Latin American patients with advanced liver cancer treated with atezolizumab and bevacizumab. Most irAEs were mild or moderate and resolved within a month, without impacting overall survival.
A new research paper published in Aging-US identified unintentional weight loss as the strongest predictor of fall risk among Taiwanese elderly. The study found that analyzing each frailty feature individually provided more accurate predictions of fall risk than using a broad frailty label.
UNAM and Taylor & Francis announce a three-year agreement to publish research articles in over 2,400 journals. This move aims to boost the global reach and impact of UNAM's research.
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A 25-year review highlights the stomach cancer-fighting potential of Brazilian plant species, which contain bioactive compounds with potential anticancer properties. The studies suggest that regular consumption of fruits and vegetables rich in polyphenols and flavonoids may help lower the risk of stomach cancer.
Researchers review clinical and scientific advances combining radiation therapy with immunotherapy to strengthen the immune response and improve disease control. The approach may offer new treatment options for patients facing hard-to-treat forms of bladder cancer.
The University of Hong Kong has joined Bentham Science to publish research as Open Access under CC-BY 4.0 license at reduced APCs in Bentham Science journals. This partnership supports high-quality research and expands global access to scholarly knowledge.
Researchers found that consuming foods high in methyl adaptogens, such as green tea and berries, can reduce markers of epigenetic aging. The study, which involved middle-aged men, suggests that targeted food choices may help slow the aging process.
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Tianjin University has joined the Bentham Science Institutional Membership Program to publish research as Open Access under CC-BY 4.0 license at discounted rates. This partnership aims to foster high-quality research and expand global access to scholarly knowledge.
A new DNA-based blood test using PhasED-Seq technology detects minimal residual disease (MRD) in B-cell malignancies, offering a powerful tool for early detection and monitoring treatment response. The assay demonstrates exceptional performance and high accuracy in detecting cancer cells in the bloodstream.
Shandong University has joined the Bentham Science Institutional Membership Program, enabling researchers to publish under Open Access at concessionary rates. The program promotes open research and collaboration with institutions worldwide in science, medicine, and technology.
New indicators have been introduced to Taylor & Francis journal articles to inform readers when cited research has been retracted or updated. These updates ensure researchers are fully informed about the status of the research and can make informed decisions.
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The University of Science and Technology of China has joined Bentham Science's institutional membership program, enabling researchers to publish Open Access articles at concessionary rates. This partnership promotes open research and fosters scientific advancements in science, medicine, and technology.
Nankai University has joined the Bentham Science Institutional Membership Program to publish its research as open access under CC-BY 4.0 license in various Bentham Science journals. The partnership aims to foster high-quality research and expand global access to scholarly knowledge.
A nationwide cohort study found that immune checkpoint inhibitors significantly increase the risk of myocarditis in NSCLC patients, with a 7.4-fold increase in risk compared to non-users. Cardiac monitoring for at least six months following ICI initiation is recommended.
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The 'How Equitable Is It?' tool, now updated with community feedback, evaluates scholarly communication models based on seven core assessment criteria. The new version offers clearer guidance and definitions for assessing equity in publishing arrangements.
A systematic review and meta-analysis found that individuals with blood type A have a significantly higher risk of developing breast cancer compared to those with blood type O. The research, which pooled data from over 13,000 breast cancer patients and 717,000 controls, suggests an 18% increased risk associated with blood type A.
A new study found that patients using factor Xa inhibitors experienced significantly fewer cardiovascular problems than those on other anticoagulants. Researchers followed over 1,000 patients aged 80 and above for up to five years, revealing lower rates of heart failure, artery disease, and cardiovascular death.
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A new study published in Aging (Aging-US) Volume 17, Issue 4 has found that the drug buthionine sulfoximine (BSO) produces similar reductions in fat mass and weight gain as the sulfur amino acid-restricted diet. BSO may offer a practical alternative to difficult-to-maintain diets for treating obesity.
Researchers discovered that METTL3, an oncogene, regulates the expression of SMAD4 via miR-146a-5p in OSCC. This pathway can potentially have therapeutic implications for treating oral squamous cell carcinoma.
The Scientific Annals of the Danube Delta Institute (SADDI) joins Pensoft's portfolio as an open-access, peer-reviewed journal. SADDI publishes research in ecology, biodiversity, environmental protection, and sustainable development related to the Danube Delta and similar wetland ecosystems.
The PEARL trial found that low-dose rapamycin improved lean muscle mass and reduced pain in women, while also showing improvements in emotional well-being. The study suggests rapamycin may offer measurable benefits for physical function and overall well-being in older adults.
The partnership will expand open access scholarship through Direct to Open, featuring multiple package options combining content from both presses. Duke University Press brings its humanities and social sciences catalog to the program.
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Researchers found that fisetin reduces calcium buildup and protects blood vessels from hardening in vascular smooth muscle cells. Fisetin's anti-calcification activity depends on the phosphatase DUSP1, which inhibits p38 MAPK.
Impact Journals will exhibit its publications, including Aging-US, Oncotarget, and Genes & Cancer, at the SSP 47th Annual Meeting. The event aims to reimagine the future of scholarly publishing and aligns with Impact Journals' mission to foster open and impactful scientific communication.
Aging-US invites submissions for a Special Collection on cellular senescence, focusing on its mechanisms, physiological and pathological functions, and clinical applications. The collection honors Dr. Judith Campisi's groundbreaking work on senescence in aging, cancer, and tissue homeostasis.
Researchers have discovered that inhibiting the metalloprotease ADAM19 can reduce gut inflammation and cell aging markers across species. The study found that blocking ADAM19 reduced gut damage and inflammation in fruit flies, mice, and human cells, offering a promising path for creating treatments to maintain healthy tissues.
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A study found that journalism engagement training reduced the prevalence of 'horse race' stories and boosted more substantive, community-oriented content. The training program, Democracy SOS, worked with journalists and news outlets across the country to promote solutions-focused coverage and increase transparency.
Two Taylor & Francis journals will be converted to open access for 2025, thanks to funding from collective OA agreements and read access. The Collective Pathway to Open Publishing model combines multiple funding sources to support the conversion of HSS journals.
A new study reveals that China's sell-by-plan mandate, aimed at preventing insider trading, has failed to stop executives from profiting from private information. Executives have found a way to plan their sales far in advance, allowing them to cash out before bad news breaks, undermining market fairness and eroding investor trust.
The RFS Awards in Science 2024 recognize outstanding peer-reviewed research by women and underrepresented minorities in STEM. The awards honor the best papers written in 2024, with winners receiving a $1,000 cash prize and free access to their publications for 90 days.
A team of researchers at POSTECH has identified a hidden mechanism in Electrochemical Random-Access Memory (ECRAM) technology, enabling faster and more efficient AI computations. This breakthrough could lead to significant improvements in data processing and reduced energy consumption.
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A study on captive olive baboons found that about a quarter exhibited accelerated aging, while another quarter showed signs of slower aging. The researchers investigated physical indicators such as walking speed and fine motor skills, but found that these changes were more closely related to chronological age than epigenetic age.
A new study by Virginia Tech researchers Jin Xu and Pengfei Ye finds that value-based stock grants can weaken executive motivation and limit corporate growth. The study analyzed thousands of U.S. firms from 2006-22, revealing that companies tying CEO compensation to a fixed dollar amount can unintentionally discourage executives from m...
Participants who took the supplement showed improvements in grip strength, lower body mobility, and reductions in body weight. The supplement appeared to reduce stem cell turnover, regulate immune function, and influence gene activity related to stress response.
Researchers found that most people are open to their friends asking to join plans, but hesitate to self-invite due to concerns about offending others. The study's findings suggest that people tend to underestimate the likelihood of getting invited and overestimate how much others consider them.
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The American Physical Society has received the leading score among publishers participating in SCOAP3 for its investment in open science practices. The Society earned high marks in elements like data availability, article metadata, and persistent identifiers.
The University of Texas at Arlington's 23 patents granted in 2024 helped boost the UT System's position among the nation's top innovators in patent technology. The UT System ranks No. 3 in the National Academy of Inventors' prestigious top 100 ranking.
Researchers at POSTECH developed a nickel-based high-entropy alloy that maintains strength and ductility across a wide temperature range from -196°C to 600°C. This stability is attributed to the presence of nanoscale precipitates, which inhibit deformation and accommodate stress through consistent slip behavior.
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Researchers developed a new method to measure changes in DNA that can help predict a person's age, focusing on how random chemical tags become over time. The study found that methylation entropy predicted age as accurately as traditional methods, with an average error of just five years.
A new study finds that a specific genetic variation in the PTGS2 gene is associated with an increased risk of benign prostate hyperplasia (BPH) in Lebanese men. Men carrying the C version of this gene were more than twice as likely to have BPH compared to those without it.
Researchers found that GSK3β becomes increasingly active in melanoma cells during treatment, helping them survive and adapt despite BRAF inhibitors. Treating resistant cancer cells with a GSK3β inhibitor significantly reduced their growth, suggesting blocking this protein could restore sensitivity to treatment.
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A study found that smaller embryos already hatching are more likely to be chromosomally normal. This insight helps fertility clinics select better embryos during IVF, particularly for women over 35 or those undergoing PGT-A.
The STAR initiative has benefitted over six thousand researchers worldwide by providing access to top-tier articles and enabling them to update references and enrich their findings. This support has helped scholars from under-resourced regions contribute to global knowledge, transforming their careers and advancing academic discourse.
The first phase of Janeway development is complete, enabling a unified publishing platform tailored for science communication and beyond. The system promises to address challenges in open science and AI integration with a modular, expandable architecture.
A new case report presents a highly unusual combination of two benign ovarian tumors: serous cystadenofibroma and collision lesions. Accurate preoperative diagnosis is critical for effective treatment planning, and this case emphasizes the need for personalized evaluation of each ovarian mass.
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Three Taylor & Francis journals will be published open access in 2025 volumes with no cost to authors. Institutional support has reached the required threshold for the Subscribe to Open pilot, enabling OA publishing.
Researchers found that NSD2 helps maintain MM cell identity by reorganizing DNA and influencing gene activity. This discovery could shape future treatment approaches for patients with t(4;14) myeloma.
Researchers discovered senolytics can target Alzheimer's disease-associated brain enzymes AChE and BChE without affecting healthy ones. This selective approach may lead to safer treatments that improve memory and reduce inflammation in older adults.
All articles with at least one author based in Africa can now be submitted to the platform and will no longer require funding from a partnering research funder. This expansion aims to increase publication efficiency and improve the experience of African authors, while promoting the rapid sharing and discovery of high-quality research.
Researchers at Cornell University discovered that the FGR protein can induce cell differentiation in leukemia cells similar to retinoic acid treatment. The presence of FGR alone was enough to make these cells mature, producing well-known markers of maturation and expressing inhibitor of the cell cycle p27.
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The MIT Press has funded the open publication of 320 books through its Direct to Open framework, which shifts from market-based purchase models to collaborative library-supported open access. This approach has shown significant usage and citation increases for Humanities and STEAM books, with a notable impact on global readership.
A new review highlights how breast cancer cells change their communication and growth patterns, helping tumors survive, spread, and resist treatment. The review explores disrupted signaling pathways, including PI3K/Akt/mTOR and RAS/RAF/MEK/ERK, which can promote tumor progression and resistance to treatment.
A new study found that treating aged mice with montelukast improved retinal health by reducing inflammation and boosting proteasome activity. This approach may offer a promising new way to slow age-related vision loss and protect eye health in older adults.
The company will use AI translation tools to publish books in multiple languages, making them accessible to a broader audience. This initiative aims to promote better understanding between cultures and accelerate awareness of knowledge required to meet today's challenges.
Scientists at POSTECH and University of Montpellier successfully synthesized wafer-scale hexagonal boron nitride (hBN) with an AA-stacking configuration using metal-organic chemical vapor deposition (MOCVD). This achievement introduces a novel route for precise stacking control in van der Waals materials.
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This study found that aging impacts the gut microbiome composition and metabolites differently in male and female rats, influenced by biological sex and mitochondrial DNA. The researchers analyzed fecal samples from genetically diverse rats to assess bacterial changes with age, revealing more significant shifts in females.
Breast cancer survivors experience accelerated aging due to detrimental effects of BC and its treatments, particularly systemic therapies. The study highlights the need for ongoing monitoring and potential strategies to slow down aging in cancer survivors.