Hao Wu, a Penn Medicine genetics researcher, has received a 2017 NIH New Innovator award to pursue high-risk research on epigenome editing. The grant will fund his study of how the epigenome of heart muscle cells respond and adapt to changing environmental oxygen levels.
A new Yale study finds that Medicare plans place few restrictions on the coverage of prescription opioids, despite federal guidelines recommending such restrictions. The researchers highlighted an untapped opportunity for Medicare formularies to limit opioid prescribing, citing a modest increase in opiate coverage between 2006 and 2015.
M344 altered key gene expression in a cellular model of AD, preventing cognitive decline and improving memory. In mouse models, low-dose administration of M344 prevented cognitive decline and improved learning and memory.
A mouse study shows that cannabidiol treatment effectively reduces the severity and duration of seizures and their frequency. The study also found improvements in social interactions and reduced autism-like symptoms in mice with Dravet syndrome.
A new study by Ohio State University finds that moderately farsighted preschoolers have poorer scores on attention-related tests. The research suggests that uncorrected vision problems in young children can lead to deficits in learning and literacy.
Researchers have identified a gene that may provide potential therapy for cerebral cavernous malformations (CCMs), a condition characterized by enlarged and irregular blood vessels in the central nervous system. The study suggests using angiogenesis inhibitors, such as TSP1, to treat or prevent CCMs.
A new study will investigate the biological mechanisms triggered by exposure to air pollution during pregnancy, leading to lower birth weight in newborns. The research aims to understand how air pollution affects fetal growth and development.
Researchers from SingHealth, Duke-NUS Medical School, and NCCS have sequenced the complete genetic blueprint of durian, a tropical fruit known for its unique smell. The study reveals that durian has approximately 46,000 genes, nearly double those found in humans.
Compounded bioidentical hormone therapies are not FDA-approved, lack quality control, and have the same risks as FDA-approved hormone therapy products. Women often unknowingly choose these over FDA-approved options due to misconceptions about safety and efficacy.
Research at Universitat Autonoma de Barcelona suggests that green gentrification in cities may not equally benefit all residents, particularly socially disadvantaged neighbours. The process of recovering natural spaces tends to displace low-income populations, increasing chronic stress and negatively affecting their mental health.
Researchers have developed a new influenza vaccine that uses a nanoscale, controlled-release capsule to provide quick and long-lasting protection against pandemic A strains. The vaccine is based on the M2 protein, which remains constant across different flu viruses.
A Dartmouth-led study reveals Indigenous nations are adapting to invasive species through public programs, education, and collaborative efforts with non-Indigenous governments. These initiatives not only mitigate the impact of invasive species but also protect cultural identity and traditional economic knowledge.
The devices can be cut to the size needed for specific applications due to their symmetrical fractal wiring patterns. The modular generators could be inkjet printed on flexible substrates like fabric and manufactured using inexpensive roll-to-roll techniques.
NASA's Aqua and Suomi NPP satellites analyzed cloud top temperatures in Hurricane Nate, revealing the strongest storms were near the center of the tropical cyclone. Temperatures as cold as minus 80 degrees Fahrenheit indicate strong thunderstorms capable of heavy rain.
The NASA's Aqua satellite provided valuable temperature data to forecasters, showing the strongest storms were located in Hurricane Nate's eastern side. The storm's cloud top temperatures reached as low as minus 80 degrees Fahrenheit, indicating strong storms capable of heavy rain.
Researchers pack laser-written structures deep into silicon chips, enabling arbitrary 3D fabrication without layers above or below. The method also enables creating functional optical devices and 3D sculpturing of entire wafers.
A study by University of Utah Health found that 7% of US athletes and staff infected with mosquito-borne viruses during the 2016 Rio Olympics were positive for West Nile virus, Dengue fever, and Chikungunya. Most had mild symptoms or no symptoms at all, highlighting the importance of post-travel diagnostics.
Scientists have developed a new class of antifungal drugs called 'orotomides' to treat life-threatening invasive fungal infections. The novel mechanism of action offers hope for patients with leukemia and bone marrow transplantation, who are often affected by these infections.
Tropical Storm Nate is forecasted to produce life-threatening flash floods and mudslides across a wide area of Central America. The storm's center is expected to move across the northwestern Caribbean Sea, reaching the eastern coast of Mexico before moving into the southern Gulf of Mexico.
Scientists at NAIST have discovered a molecular pathway that explains how plant cells cease cell division upon DNA damage. The study found that the transcription factor family MYB3R prevents progression to the M phase of the cell cycle, allowing plants to maintain genome integrity.
The innovative method developed by JGU and Evonik Performance Materials GmbH allows for flexible reaction to available electricity supply, eliminating the need for customized electrolysis apparatuses. This breakthrough in electro-organic synthesis enables sustainable production of fine chemicals with minimal environmental impact.
Androgen receptor targeted imaging is emerging as a potential modality for early, rapid, and efficient diagnosis of prostate cancer. Current medical imaging reviews discuss traditional diagnostic approaches and summarize current imaging approaches using PSMA, BN, and AR targeted imaging.
A recent study found that polyvictimization - exposure to multiple forms of victimization - significantly erodes feelings of school safety, equity, and connection. The study highlights the need for schools to implement comprehensive policies addressing all forms of victimization to create a safe environment.
A study published in Nature Quantum Materials suggests that observing a flow of energy or particles can alter its direction, defying classical thermodynamics. Researchers propose new strategies for designing quantum transport devices with direction control.
A new study by Cleveland Clinic researchers has found a significant link between bacterial imbalances and breast cancer, with healthy breast tissue containing more of the bacterial species Methylobacterium. The study's findings could lead to new perspectives in the battle against breast cancer.
Architectural historians at the University of York have reconstructed the first dedicated House of Commons chamber using 3D visualization technology. The project has brought St Stephen's Chapel back to life, revealing parallels between 16th-century political debate and modern-day discussions.
According to the nTIDE September 2017 jobs report, Americans with disabilities have seen a significant increase in employment-to-population ratio, rising from 28.0% in September 2016 to 30.4% in September 2017. The labor force participation rate also increased for working-age people with disabilities.
Researchers develop magnet-free non-reciprocal components on silicon chips for millimeter-wave frequencies, enabling full-duplex wireless communications, high-speed data transfer for self-driving cars and virtual reality, and transforming 5G networks.
A new telescope attachment using custom beam-shaping diffusers enables highly precise ground-based observations of exoplanets. The technology minimizes distortions caused by the Earth's atmosphere, allowing for stable and smooth images that are essential for maximizing precision in measurements.
Two new studies evaluate the safety and effectiveness of endoscopic submucosal dissection (ESD) and liquid nitrogen spray cryotherapy (LNSCT) in treating Barrett's esophagus. ESD was found to have high en-bloc and curative resection rates, while LNSCT showed long-term efficacy in eliminating dysplasia and intestinal metaplasia.
A study from the University of Pennsylvania reveals how defective viral genomes can help infected cells survive despite an immune system attack. The researchers discovered that signaling proteins encoded by these genomes protect infected cells from apoptosis, enabling them to persist in the face of an antiviral response.
Researchers from the University of Liverpool have made a significant breakthrough in converting carbon dioxide and methane into liquid fuels and chemicals. The new process uses non-thermal plasma synthesis to achieve high selectivity at room temperature, producing valuable chemical feedstocks.
A new study using DNA metabarcoding technology is helping to improve the monitoring of Canada's vital boreal forest. The approach enables quick and accurate detection of aquatic organisms, providing valuable insights into ecosystem health.
Scientists have discovered a new type of rare molecules whose properties can be controlled by changing an external magnetic field. These paramagnetic molecules, part of the porphyrin class, are closely related to photosynthesis and respiration in living organisms.
Researchers have successfully modelled electrons under extreme temperatures and densities, providing new insights into fusion experiments and potentially leading to a clean source of energy. The study solves a decades-old problem in physics by accurately simulating the thermodynamic properties of interacting electrons.
Researchers are developing a 'lab-on-a-chip' platform to study cellular communication in bone remodeling, aiming to improve our understanding of bone health and disease. The platform could also be used to test medications meant to halt bone loss, offering a potential solution for osteoporosis and related conditions.
A large-scale Canadian study found that nearly one percent of the population has elevated antibodies indicating celiac disease. Despite a strong genetic link to Caucasians, South Asian individuals were surprisingly affected by a specific genetic variant, suggesting other factors may play a role in who develops the disease.
Researchers at Woods Hole Oceanographic Institution are developing tools and technology for mass production of seaweed for biofuels and chemicals. A breeding program and monitoring system will be created to improve efficiency and reduce environmental impact.
Jessica Blackburn, a University of Kentucky Markey Cancer Center researcher, has received a $1.5 million NIH New Innovator Award to study leukemia relapse in zebrafish models and patient samples.
A study found that antibiotics prescribed by dentists may contribute to Clostridium difficile infections, a serious and potentially deadly infection. The research highlights the importance of using antibiotics only when needed and notes that many unnecessary prescriptions are likely.
A new study found that sustained cannabis use is associated with an increase in violent behavior in young people after discharge from a psychiatric hospital. Chronic cannabis use also leads to deficits in the prefrontal cortex, a part of the brain that inhibits impulsive behavior.
Researchers identify DLX5 gene as key player in preeclampsia, a complex disease affecting 4% of pregnancies. An in vitro model demonstrates the disorder's dysregulation and opens door to new treatments.
Researchers found a direct connection between deletions in two genes in the 16p11.2 region of human chromosome 16 and certain brain and body traits, including seizures, hyperactivity, and obesity. The study suggests that multiple genes interact to produce various characteristics.
Researchers developed a method to predict parasitism rates using interaction preferences, allowing for efficient prediction without extensive field data. The approach was tested in three countries and found consistent patterns, enabling the design of models that capture systematic shifts in interaction preferences.
New technologies like Scintillometer and Eddy Covariance can estimate water requirements for crops with higher accuracy. A new system called Cosmic-ray Soil Moisture Observation System also determines optimal water application amounts.
A new study found that white-tailed deer prefer native plants to invasive species like garlic mustard and Japanese stiltgrass. This leads to a decrease in native plant diversity and an increase in non-native species, altering forest ecosystems.
The Philadelphia Pediatric Medical Device Consortium has awarded $50,000 in seed grants to Voxello and InfraScan for developing speech-generating systems and handheld scanners for detecting intracranial bleeding in children.
A new study from the University of Edinburgh found that lifestyle factors such as diet and activity levels have a major impact on regional obesity rates in Scotland. By addressing these factors, public health initiatives can help narrow the health divide between regions.
Researchers found that a protein named ZATT can eliminate DPCs with the help of another protein TDP2. Understanding how TDP2 and ZATT work together may improve cancer patient health outcomes. The discovery could lead to development of new drugs targeting these defenses.
Researchers at USC Viterbi School of Engineering have developed a new type of microlaser that uses gold nanoparticles to improve frequency comb technology. This innovation enables the creation of smaller, more efficient systems for applications such as portable chemical spectroscopy and cybersecurity.
PrEP prescriptions increased by 976% in NYC between 2014 and 2016, but men of color, women, and those outside city centers were less likely to receive the HIV prevention medication. Many medical students and healthcare providers remain unaware of PrEP's benefits, highlighting the need for education and outreach programs.
Researchers have developed an asymmetric sound absorber that can absorb sound energy while allowing light and air to pass through. The system uses a two-port design with a waveguide, enabling near-total absorption of sound energy from outside the room.
A recent study in the Journal of Applied Volcanology analyzed volcanic fatalities in unprecedented detail, identifying common causes and victims. The research found that nearly half of all fatal incidents occurred within 10 km of volcanoes, with tourists, media, and emergency response personnel being among the most at-risk groups.
Researchers at UC Berkeley are building a new MRI brain scanner with improved resolution, allowing them to image functional regions in the cortex and connect individual neurons. The new scanner will enable studies of human brain function and circuitry on a finer scale.
NICT achieved a world record for 53.3 Tb/s optical switching capacity in short-reach data-center networks using SDM and a high-speed spatial optical switch system. This breakthrough enables significant network efficiency improvements and reduced end-to-end energy consumption per bit compared to existing technologies.
Researchers in Brazil are testing a technique combining low-intensity electric current with nanoencapsulated chemotherapy to treat skin cancer. The study found that topical application combined with iontophoresis resulted in a significantly greater reduction in tumor size and made the tumor less aggressive.
The study found that neurons on the upper-layer cerebral cortex play a crucial role in gyrus formation, and that Cdk5 is an important gene involved in this process. This breakthrough could lead to a better understanding of brain evolution and development, as well as new treatments for diseases caused by gyrus impairment.
A novel textile material called Surfaceskins has been developed to reduce hospital-acquired infections by disinfecting itself. The device can reduce bacteria levels by more than 90% and is designed to be replaced after seven days or one thousand uses.
A recent study by Tal Danino at the Data Science Institute demonstrates that bacteria in pancreatic tumors degrade a chemotherapy drug, Gemcitabine. The study found that antibiotics were effective in killing these bacteria in over 70% of mice, leading to rapid tumor progression without treatment.
Heavy rainfall is expected to occur over a wide area, including locations well away from the center, along the Pacific coast of Central America. The tropical cyclone is forecast to strengthen as it moves over the Gulf of Mexico, threatening coastal areas from Louisiana through the Florida panhandle.