The new EULAR consensus provides guidance for investigating treatments in people at risk of RA. The guidelines recommend considering subclinical inflammation, clinical arthritis, or progression to RA as study endpoints across trials.
Researchers investigated glass fiber-reinforced epoxy-based flat laminates with pultrusion, a fast and versatile composite manufacturing process. The study found significant promise for structural applications of these 'shape memory' composites in various industries.
Researchers at University of Chicago and Argonne National Laboratory found that primate neurons receive two to five times fewer excitatory and inhibitory synaptic connections than similar mouse neurons. The study suggests that metabolic costs may drive larger neural networks to be sparser, as seen in primates versus mouse neurons.
Researchers developed lab-grown cochlear organoids to screen FDA-approved drugs for hair cell-inducing properties. The study identified Regorafenib as a potent stimulator of hair cell formation, even regenerating lost cells in mouse tissues.
Researchers found that a family of proteins enhances the immune response to HIV, Ebola and Zika by boosting signals sent within immune cells. This discovery has implications for potential broad antiviral therapy.
A new transgenic pig model has been developed to study beta-cell function and insulin turnover, bridging the gap between rodent models and humans. The model enables researchers to distinguish different pools of insulin secretory granules and follow their rates of turnover in vivo.
Researchers at Max-Planck-Gesellschaft engineered synthetic exosomes that regulate cellular signaling during wound closure, leading to faster healing and improved formation of new blood vessels. The study provides a systematic understanding of extracellular vesicle communication and its potential therapeutic application.
A single-center study in Libreville, Gabon, found that COVID-19 severity and death were associated with advanced age and stage of lung damage. The study involved 837 patients with no symptoms in 63% of cases.
The Academy of Breastfeeding Medicine recommends keeping lactating mothers and their infants together, using direct breastfeeding over pump use whenever possible. The new guidelines also emphasize the importance of considering fluid needs, infection control, and creating a policy to support lactating mothers and breastfeeding children.
A study at 19 workplace cafeterias found that reducing portion sizes and replacing high-calorie food with lower-calorie options led to a 4.8% reduction in calories purchased per day. This simple intervention could contribute towards tackling obesity, particularly in deprived areas where access to healthy foods is limited.
Aging stem cells in bone marrow lose function due to epigenetic changes that affect bone production. Researchers reverse these changes by adding acetate, rejuvenating the epigenome and improving stem cell activity. This finding holds promise for treating diseases like osteoporosis.
A geoscientist is using a $640,000 NSF grant to investigate why the Earth retains surface water instead of sequestering it in the mantle. He aims to develop a novel technique that links noble gas concentrations with water in subducted rocks to construct a map of water concentration across pressures and temperatures.
Researchers from Tokyo Medical and Dental University have identified HMGB1 as a central protein mediator in dementia, including frontotemporal lobar degeneration and Alzheimer's disease. Treating mice with an antibody to HMGB1 improved their memory and spatial recall, suggesting potential treatment reversal of brain damage.
Researchers developed a handheld photoacoustic finder to detect cancer metastasis without radiation exposure. The device uses a solid-state dye laser and transparent ultrasound transducer to locate sentinel lymph nodes or melanoma.
Researchers analyzed 1,785 ancient human genomes to determine parental relatedness, revealing that cousin marriages occurred only 3% of the time. The new method allowed for more efficient screening of ancient DNA, also providing insights into population dynamics and demographic impact of agriculture.
Researchers argue that improving policy analysis methods can lead to better decisions, particularly for transformative policies like climate change. A new framework focuses on evaluating risks, opportunities, and resilience, rather than just costs and benefits.
A mathematical model developed at Linköping University predicts that many species in polar regions will become extinct due to global warming, with ecosystems already showing signs of strain. The model simulates the impact of climate change on species interactions and diversity, highlighting the importance of considering ecological proc...
Researchers found that patients with low sTK1 levels live longer and have slower disease progression after anti-estrogen treatment. Patients with high sTK1 levels tend to have shorter progression-free survival times and die sooner.
A new algorithm provides accurate solutions that mimic natural human movement, reducing the risk of injury. The Pro-ISADE approach improves calculation speed while ensuring calculated joint angles are feasible for robotic use in daily activities like drinking water and brushing teeth.
Researchers at Binghamton University found that wood frog eggs laid later in the breeding season are less resilient to road salt pollution. The study highlights the complex effects of climate change on amphibian breeding, which may lead to population declines in vulnerable species.
Researchers at Mayo Clinic's Center for Individualized Medicine found that the gut microbiome is connected to a patient's outcome in rheumatoid arthritis. By analyzing stool samples from 32 patients with rheumatoid arthritis, they identified several traits of the gut microbiome linked to future prognosis.
A study published in PLOS Biology suggests that microparticle concentrations in lakes are higher than previously reported and can be predicted by surrounding land use. The researchers found that areas with more human activity and lower forest cover had higher microparticle concentrations, while lakes with more active microorganisms had...
The Camel Site's life-sized carvings of camels and equids are part of a wider rock art tradition that depicted naturalistic animals. The reliefs were created using stone tools during the Neolithic period, approximately 6th millennium BCE.
A new study by UCLA researchers reveals that respiratory emissions produced during labor and vaginal delivery can increase the risk of respiratory disease transmission. The findings support the recommendation of providing full PPE, including N95 masks, to healthcare workers in labor and delivery units to prevent COVID-19 transmission.
A team of scientists from Incheon National University developed a programmable DNA-based microfluidic chip that can perform complex mathematical calculations, such as Boolean logic operations. The chip uses a motor-operated valve system to execute a series of reactions in rapid and convenient manner.
Physicians prescribed opioids more frequently to their white patients with new-onset low back pain, while prescribing non-steroidal anti-inflammatory drugs (NSAIDs) to patients of color. The study's findings suggest racial bias in pain treatment, with white patients being more likely to develop long-term opioid reliance.
A new study suggests that modern snakes originated from a few species that survived the Cretaceous-Paleogene mass extinction event, which wiped out dinosaurs and other species. Snakes began to diversify into new habitats and exploit new prey, leading to the emergence of diverse lineages such as vipers, cobras, and pythons.
Researchers investigated BCL11A's role in dopamine-producing neurons and found that its absence makes them more susceptible to death. The transcription factor may play a protective role for neurons, which could help prevent Parkinson's disease.
A new, low-cost 3D-printed sensor can accurately detect and measure glyphosate levels in liquids with high sensitivity and specificity. The sensor uses nano-sized tubes and technology similar to glucose tests to detect the herbicide in orange juice and rice beverages.
A recent study found nearly three-quarters of pregnant individuals reported moderate to high levels of distress and one in five experienced depressive symptoms during the COVID-19 pandemic. The top concerns among expectant parents included hospital policies, introducing their baby to loved ones, and conflicting medical information.
The USPSTF advises regular screening for chlamydia and gonorrhea in young women due to their high incidence rates. Screening is also recommended for women at increased risk, with current evidence insufficient to support recommendations for men.
Researchers at IPK Leibniz Institute have discovered a hormonal regulatory module that controls root elongation in response to nitrogen deficiency. The study reveals that brassinosteroids act upstream of auxin, triggering the local biosynthesis of auxin and inducing genes TAA1 and YUCCA8.
A longitudinal study by SMU and the Ministry of Sustainability and Environment aims to quantify and qualify the impact of the Extended Producer Responsibility (EPR) framework. The five-year study will examine the effects on recycling rates, waste reduction, and economic benefits in Singapore.
A team of researchers identified a sequence of hand and footprints on the Tibetan Plateau, dated between 169,000 and 226,000 years ago. The prints are considered a potential example of art, with some researchers speculating that they may have been created by early human ancestors as a form of performance or creative expression.
Researchers at Tel Aviv University have created a system that enables the production of 'good' bacteria capable of eliminating 'bad' bacteria. This breakthrough technology uses a toxin injection system to target specific types and amounts of toxins, offering an alternative to antibiotics.
A new study suggests that peripherally produced amyloid-beta protein from the liver can cause neurodegeneration and brain atrophy in mice. The findings indicate that peripheral A-beta has the ability to cause neurodegeneration and may be a potential contributor to human Alzheimer's disease.
Researchers at Baylor College of Medicine have developed a novel technology that enables scientists to track genetic manipulations in fruit flies more efficiently. The system uses drug-based markers for selection or counter-selection of genes, reducing the need for manual screening and increasing productivity by at least 10 times.
A study on Antarctic jellyfish was conducted using footage from an amateur nature video. The research team identified 12 species, with two likely representing undescribed species. A machine learning training set for video annotation was also developed.
A common glaucoma test can expel tear droplets up to a meter away from the patient, potentially spreading viruses like COVID-19. Researchers recommend improved room ventilation and cleaning protocols to minimize pathogen transmission.
Researchers have observed the forced release of energy from a Mo isomer using an electron capture process, which could lead to the development of ultra-efficient nuclear batteries. The study, conducted at the Argonne National Laboratory, found a surprisingly high probability of occurrence for this process.
A new study found that global light pollution has increased significantly over the past 25 years, with the true increase potentially being much higher. The study, led by the University of Exeter, reveals that the transition to solid-state LED technology has masked the impact of light pollution in many regions.
A new $2.5 million grant will help students see math in their surroundings through guided walks and an app that turns cell phones into math tools. The Mathfinder app will provide feedback on student-created STEM walks, enhancing math education outside of school.
Researchers are developing a new machine learning approach to reduce health disparities caused by biased cancer-related genomic and clinical omics studies. By using transfer learning on large-scale data, the team aims to create an open resource system for unbiased multiethnic machine learning.
Research reveals that stronger lettuce stems are a key part of disease resistance against Sclerotinia spp., the causative agent of lettuce drop. The study found that wild lettuce species exhibit increased stem strength and reduced symptom development, while modern commercial cultivars are susceptible to rapid basal stem rot.
A new study found that Republican control of state legislatures is associated with increased infant mortality rates, especially among Black infants. The research suggests that the party's influence on social determinants of health, such as safety-net programs and minimum wage, contributes to these disparities.
A randomized clinical trial found that yogurt containing Bifidobacterium lactis BB-12 protected against harmful changes in the gut microbiome after antibiotic administration. The study also showed that levels of beneficial short-chain fatty acid acetate returned to baseline within 30 days.
Researchers found that homemade face masks made from cotton towel fabric are most effective in blocking aerosolized viruses. The study suggests that a three-layered mask is recommended for maximum efficacy, and washing has a negligible influence on mask effectiveness.
A small trial found that the low-dose Moderna vaccine generated long-lived T cell immunity comparable to natural infection. The presence of cross-reactive T cells enhanced immune response in younger and older patients alike.
Researchers developed a mathematical model to predict the angle of repose of sand hills, which is influenced by particle size and gravity. The model was validated using simulations and has potential applications in space exploration, additive manufacturing, and planetary science.
A new indigo dyeing technology reduces water usage by up to 90% and eliminates toxic chemicals, securing over 90% color retention with only one coat. The process also streamlines the industry, saving time and energy for workers.
Researchers have developed a new approach to generating terahertz radiation, which can be directly generated on an electronic chip. This breakthrough enables the use of terahertz radiation in various applications, including materials science and communications technology.
Researchers from the University of Cambridge have created a real-time approach to predict drone flight paths and intentions, enabling safer use of drones. The solution uses statistical techniques and radar data to identify potential threats before they enter restricted airspace.
Researchers created indenene, a topological quantum material with a triangular honeycomb structure, which exhibits robust properties and doesn't require ultra-low temperatures to manifest its characteristics. This design improvement enables the growth of perfect films suitable for device nanofabrication.
Researchers analyzed over 2000 SARS-CoV-2 protein structures to identify viral proteins that 'mimic' and 'hijack' human proteins. The study found three coronavirus proteins that 'mimicked' human proteins, allowing the virus to evade the immune system and contribute to variation in COVID-19 outcomes.
Researchers developed a treatment using cowpea mosaic virus nanoparticles that target lung tumors, slowing tumor growth and preventing cancer spread. The treatment showed efficacy against aggressive cancer cell lines and may offer protection to patients at high risk of metastatic disease.
A study by UCSF researchers found that emergency department visits and hospitalizations made by patients with addictions increased by 30% and 57%, respectively, between 2014-2018. The authors highlight the urgent need for hospitals to develop systems of hospital-based interventions to provide addiction treatment.
A new model developed by Ben-Gurion University scientists can help policymakers simulate their choices and find the optimal strategy for combining vaccines and social distancing. The model suggests that vaccinating the elderly and imposing social distancing on adults is generally more effective than other approaches.
Seabirds are dying from starvation after being exposed to cyclones, which disrupt their ability to feed. The study found that birds can't fly in high winds and dive into stormy seas, leaving them without food sources.
A team of Texas A&M University researchers propose capturing CO2 and water from passenger vehicle exhaust for use in urban greenhouses. Preliminary simulations indicate that the system could reduce greenhouse gas emissions and provide a sustainable source of reclaimed resources for food production.
Dr. Cynthia Smith, an associate professor at George Mason University, will receive $23,119 in funding to manage an invasive plant removal project. The project aims to inform public lands and wetland managers on best practices for invasive species removal.