Researchers discovered a Bt protein that kills pests via two different pathways, making it harder for resistance to evolve. This
Researchers created an anchoring-borrowing strategy to form artful single-atom catalysts, overcoming traditional oxidative addition steps in cross-coupling reactions. The new catalysts achieve high yields, excellent stability, and set a benchmark for turnover numbers.
A Baylor University/Dell Medical School study reveals that digital technologies are associated with reduced cognitive decline and a lower risk of dementia for older adults. Digital technology use correlates with better cognitive aging outcomes, promoting behaviors that preserve cognition.
This study revisits the India-Asia collision by integrating geological, geophysical, and geochemical data. It challenges the ongoing collision assumption and instead suggests that the plateau uplift was governed by post-collisional mantle dynamics in the Late Cenozoic.
A study led by University of Bristol found that COVID-19 pandemic reduced elective surgery in children with CHD, but did not increase post-operative complications or death. The research suggests prioritizing urgent and emergency procedures may be appropriate during healthcare disruptions.
A Rutgers Health study surveyed 27 research assistants working on a multistate firearm violence project, finding that 26% lacked emotional support outside their teams. Research assistants used short breaks (89%) and informal peer interactions (41%) to cope with the emotionally difficult topics.
Researchers identify CLE16 peptide as key molecule promoting symbiotic relationship between plants and beneficial soil fungi. Supplementing with this peptide or its fungal equivalent can enhance nutrient exchange and strengthen these traits in crops.
Archaeologists uncover evidence confirming Les Coves Llongues site was inhabited during Early Neolithic, highlighting the Bergantes River as a key route for early farming communities. The site's strategic location along a natural corridor connects the Iberian Mediterranean to the Ebro Valley.
A new study by Martin-Luther-University Halle-Wittenberg found that brain stimulation can influence decisions, making choices faster with anodal stimulation and slower with cathodal stimulation. The research used transcranial direct current stimulation to activate or inhibit specific brain regions.
Researchers found a radical new way to move heat, faster than ever before, using hexagonal boron nitride to direct heat like a beam of light. This breakthrough could revolutionize cooling in high-performance electronics, allowing faster and more powerful devices without overheating.
The team fabricated a probabilistic bit device based on manganite nanowires, achieving full control of its probabilistic characteristics with nanoampere-level currents. This p-bit exhibited exceptional computational potential in Bayesian inference tasks, outperforming existing similar probabilistic bits.
A new study published in Health Economics reveals that the universal Japanese school lunch program effectively reduces Body Mass Index (BMI), Percent Overweight (POW), and obesity rates, particularly among students from lower socioeconomic backgrounds. The study found significant short-term benefits of such programs in addressing child...
The study found an increase in pancreatic adenocarcinoma among all age groups, while a notable rise was observed in colorectal adenocarcinoma among younger patients. This trend highlights the importance of early detection and evaluation for clinicians when evaluating patients with relevant symptoms.
Researchers at U-M and Stanford aim to create implantable brain computer interfaces to detect and interpret brain signals, enabling stroke victims to communicate more effectively. The devices will use tiny carbon-based electrodes to record signals from the brain's temporal region and transmit them wirelessly.
A comprehensive natural history study of SCN8A-related disorders has been completed, revealing a range of seizure types and neurodevelopmental features. The findings identify potential targets for future clinical trials, including the use of sodium channel blockers to manage epilepsy.
University of California researchers developed a new drug, JRT, with reduced hallucinogenic potential compared to LSD. The compound has shown promise in treating the negative and cognitive symptoms of schizophrenia, including anhedonia and cognitive function.
A new study suggests that CT scans could account for 5% of all cancer cases each year, primarily due to radiation exposure. The largest risk is among infants, followed by children and adolescents. To mitigate this risk, reducing the number of scans and doses per scan can help save lives.
A new study found that individuals with hospital visits due to cannabis use were at a 23% and 72% greater risk of new dementia diagnoses within five years compared to those with ED visits or the general population. The study included 6 million adults aged 45 and older from Ontario, Canada.
A new study provides unprecedented light on the Transpolar Drift's transport system and factors controlling its dynamics. The findings indicate that warmer temperatures could increase the spread of human-made pollutants in the Arctic.
Researchers at TU Graz have developed a new method for detecting nanoplastics in transparent body fluids, including urine, tear fluid, and blood plasma. The method uses optofluidic force induction and Raman spectroscopy to determine the size and chemical composition of particles.
A study by Edith Cowan University found that children born to mothers with gestational diabetes have consistently higher attention-deficient hyperactivity disorder (ADHD) symptoms. Externalising problems, such as hyperactivity and impulsivity, were also more prevalent in these children.
Researchers integrated 2D CuCrP₂S₆ onto silicon microring resonators, achieving compact, efficient non-reciprocal optical response with low insertion loss and high isolation. The device operates directly in the transverse electric mode, eliminating polarization rotators and simplifying integration.
Persistent sleep fragmentation accelerates liver damage and cardiac dysfunction by epigenetically controlling Nox4 expression through Sirt1. Targeting the SIRT1-NOX4 axis offers a promising strategy for mitigating cardio-hepatic damage.
Researchers developed a bispecific killer engager that selectively depletes PD-1 positive lymphocytes, a promising avenue for treating autoimmune diseases. The bike technology enhances NK cell-mediated apoptosis and depletion of activated immune cells, supporting its potential as a safe and potent tool.
Researchers studied dipole eddies in the South China Sea, revealing unique sound-speed structures and acoustic propagation patterns. The team found that warm-core AEs decrease temperature, salinity, and sound speed, while cold-core CEs increase these factors.
A novel channel-wise cumulative spike train image-driven model (cwCST-CNN) is presented for hand gesture recognition, achieving a classification accuracy of 96.92% in recognizing 10 gestures. The method leverages HD-sEMG signals and reconstructs them into two-dimensional images to capture spatial activation patterns.
A newly-published Cochrane review found significant gaps in clinical rating scales used to assess pain in newborn babies. The review of 79 studies involving over 7,000 infants across 26 countries revealed that none of the available scales are backed by high-quality evidence.
This study establishes highly accurate cell viability prediction models with an area under the receiver operating characteristic curve (AUROC) of 0.90 and 0.84, respectively. The models show good performance across diverse cell lines and enable accurate high-safety substance screening via cytotoxicity prediction.
A synthetic peptide derived from neurotoxin GsMTx4 has been found to alleviate mechanical hyperalgesia and neuropathic pain through the TRPV4 channel. The peptide's analgesic effects are comparable to those of morphine, but without any side effects.
Researchers evaluated different types of Glasgow Outcome Scale Extended (GOSE) scores among US trauma center patients. They found that GOSE-All scores capture the combined effect of brain and extracranial injuries, while GOSE-TBI scores exclude extracranial injury effects.
A retrospective cohort study found that azvudine treatment was not inferior to Paxlovid in terms of all-cause death, composite disease progression, and adverse events in elderly hospitalized COVID-19 patients. The study also suggested a greater benefit of azvudine over Paxlovid for patients with primary malignant tumors.
A pioneering study demonstrated that an AI-powered lung ultrasound surpasses human experts by 9% in diagnosing pulmonary tuberculosis. The technology leverages deep learning algorithms to interpret lung ultrasound images in real-time, making it more accessible for TB triage, especially for minimally trained healthcare workers.
Researchers developed a lipid-based pharmaceutical that disrupts calcium homeostasis and glycometabolism, leading to increased cancer immunogenic death. This approach combines ion interference therapy with starvation therapy to create an effective anti-tumor immune environment.
This study demonstrates how Parabacteroides distasonis increases β-hydroxybutyric acid (BHB) production, which drives STAT3 signals to promote liver regeneration. Treatment with live P. distasonis significantly promotes hepatocyte proliferation and liver regeneration after partial hepatectomy.
A new method using UV light and machine learning can detect microbial contamination in cell cultures, providing a quicker yes/no assessment within 30 minutes. This technology aims to reduce the time spent on sterility tests, making it crucial for life-saving treatments.
A new breath test has been developed to diagnose and monitor bacterial infections. The test is non-invasive and can detect various types of bacteria, making it a promising tool for early detection and treatment.
Researchers have developed a pioneering method that combines atomic force microscopy with artificial intelligence to detect changes in cancer cells at a small scale. This enables more accurate and reliable diagnoses, potentially leading to earlier detection and better treatment outcomes.
Acta Pharmaceutica Sinica B publishes original research articles and reviews on pharmaceutical sciences, including a retrospective cohort study on elderly COVID-19 patients and the use of machine learning to predict cytotoxicity, as well as studies on liver regeneration and cancer immunotherapy.
Research found a significant increase in the prevalence of overweight and obesity among English adolescents, from 22% to 33% between 2008-2010 and 2021-2023. Adolescents living with these conditions are at higher risk for developing comorbidities, including mental health issues, physical problems, and cardiometabolic diseases.
A landmark study found that over 3 million children worldwide lost their lives in 2022 due to antimicrobial resistance (AMR)-related infections. The study data also revealed a sharp rise in the use of Watch and Reserve antibiotics, posing serious long-term risks.
Researchers found that Schistosoma haematobium parasitic infection triggers cancer-related gene activity in cervical lining, with treatment causing further changes. This study sheds light on how the parasite may contribute to cervical cancer risk at a molecular level.
The conference will bring together experts from around the globe to share latest research findings and drive innovation in interdisciplinary fields. Accepted papers will be published in the Journal of Physics: Conference Series and a partner journal with an impact factor of 10.5.
A new method for detecting cancer from blood samples has been developed, enabling the detection of extremely low concentrations of circulating tumor DNA. The technique, which combines whole-genome sequencing with error-correcting methods, shows high sensitivity and accuracy in identifying cancer mutations.
A study reveals the critical role of α-synuclein's fuzzy coat in its pathological transmission, with implications for disease progression and potential therapeutic targets. The researchers identified two structural variants of α-synuclein fibrils, which differ in their dynamic nature and ability to seed new aggregates.
A collaborative research team has developed a novel mixed reality (MR) technology that uses real-world doors as natural transition points. The system allows users to select a door within their MR interface and seamlessly transition into a virtual space, creating an unprecedented sense of immersion.
A Northwestern University-led team directly observes a catalytic event in real time, discovering short-lived intermediate molecules and a previously hidden reaction pathway. This breakthrough enables scientists to understand how catalysts work, potentially leading to more efficient and sustainable chemical processes.
Researchers from Tsinghua University sent 2D materials and field-effect transistors into orbit aboard China's reusable recoverable satellite, Shijian-19. The materials maintained their structural integrity, exhibiting stable switching characteristics after a 14-day space flight.
A team of physicists at the University of Pennsylvania has discovered that pouring water from a height creates a stronger mixing effect, increasing extraction efficiency in pour-over coffee. By optimizing flow rates and pour heights, they found that more coffee grounds can be used without diminishing overall quality.
Kyushu University's Direct Air Capture and Utilization device captures CO2 from air, allowing it to be reused in daily life. The technology enables small-scale, decentralized carbon capture, making it suitable for densely populated cities like Japan.
Harvard physicists develop an optical vortex beam that twists and changes shape, resembling spiral shapes found in nature. The 'optical rotatum' has potential applications in controlling small particles and micro-manipulation, and its creation is made possible with a single liquid crystal display.
The study highlights the need for better identification of autism in mothers and their children, as well as increased awareness of sensory reactivity and anxiety. Researchers emphasize the importance of personalized care and collaboration with diverse groups to break down barriers surrounding motherhood and diversity.
A study by Kyoto University researchers found that captive otters in Japan are coming from Thailand, highlighting the country's role in illegal trade. The discovery sheds light on the risks posed by otter demand and aims to protect vulnerable species.
A new study found that tirzepatide can produce sustained weight loss of up to 31% in adults with overweight or obesity without diabetes, regardless of age or BMI. The study also identified patterns of weight loss trajectories and found that females and those without obesity-related complications may be more responsive to the medication.
A new analysis of the SURMOUNT-1 trial found that around two-thirds of participants regained only 5% or less of their lowest weight over three years. The study suggests that most patients receiving tirzepatide had a relatively stable weight journey, with limited weight regain after reaching their nadir weight.
Researchers from the University of the Basque Country's MikroIker group explored microorganism diversity in Añana Salt Valley springs using molecular techniques. They found that archaea predominate in salty waters and bacteria in brackish waters, with similar microbiological profiles between similarly salinated waters.
Physicists have shown that particles produced in 'jets' retain information about their origins in subatomic particle smashups. The study establishes a direct connection between the 'entanglement entropy' at the earliest stage of jet formation and the particles that emerge as a jet evolves.
The deep sea accounts for 90% of ocean volume and hosts diverse ecosystems. However, human activities like mining and climate change threaten these areas. Scientists emphasize the need for major investment in deep-sea research to address knowledge gaps and inform sustainable management strategies.
A pioneering study has identified interleukin-6 (IL-6) as a powerful diagnostic biomarker for the early detection of sepsis in high-risk patient groups. IL-6 outperformed traditional biomarkers in distinguishing bacterial from non-bacterial infections and stratifying sepsis severity.
Insilico Medicine is a pioneer in generative AI-driven healthcare, showcasing its Pharma.AI platform and pipeline portfolio featuring IND clearance molecules. The company will share insights at Abu Dhabi Global Health Week panel discussions, focusing on longevity and precision health.
Scientists have discovered antiferromagnetism in a real icosahedral quasicrystal, exhibiting long-range magnetic order. The discovery opens new avenues for developing novel antiferromagnetic QCs by controlling the electron-per-atom ratio.