Researchers found that lithocholic acid, a secondary bile acid, can alleviate fatty liver in mice and non-human primates when administered at CR-mimetic doses. The study identified two safe regimens, 0.25 mg/kg and 0.5 mg/kg twice daily, without detectable toxicity.
Using artificial cells, researchers uncovered fundamental physical principles governing cell shape changes and front-rear polarity. They discovered that local interactions within the actin cytoskeleton can generate large-scale shape changes and front-rear polarity without relying on biochemical signaling.
Researchers redesign atomic interface to balance competing requirements, enabling aggressive dielectric scaling and preserving electrical performance in atomically thin transistors. This breakthrough advances wafer-scale manufacturing and paves the way for faster, smaller, and more energy-efficient devices.
Researchers at Shandong University developed a stepwise growth strategy to fabricate high-quality monolayer graphene on silicon carbide. By decoupling buffer layer formation from subsequent graphene growth, they stabilize the SiC surface, eliminate giant step bunching, and achieve uniform graphene growth. The approach enables wafer-sca...
A rare case of uterine carcinosarcoma was reported, characterized by a dual molecular signature that may refine prognosis and guide treatment decisions. The patient's tumor displayed a high-grade endometrioid homologous uterine carcinosarcoma with TP53 and MSH6 genetic alterations.
UT MD Anderson has been ranked No. 1 in the nation for cancer care by U.S. News & World Report for 12 consecutive years, with top rankings in two adult specialties and six common procedures and conditions earning High Performing ratings.
A new study from UT Health San Antonio found that any degree of physical activity can slow cognitive decline in Hispanics. The research, which included 402 participants, also showed that controlling blood sugar levels and cardiovascular health are associated with a slower rate of cognitive decline.
A collaborative study between Insilico Medicine and top research institutions uses AI to identify therapeutic targets for IP-SNSCC, a rare and aggressive subset of head and neck cancers. The study provides the first comprehensive molecular atlas of this disease, enabling future translational research.
A new study reveals soaring infant formula milk prices are causing financial strain, anxiety, guilt, and isolation among UK parents. The research found nearly every parent surveyed reported damage to their mental health, with some feeling regret over having a baby due to the high cost of formula.
Researchers from Adelaide University study how fungal diseases spread across crops by analyzing the location where infection begins — a leaf's waxy surface. They found that mimicking this coating can help understand how it functions and its recognition signals can be turned off, potentially leading to practical crop protection strategies.
A new study published in JAMA Pediatrics found no association between male circumcision and an increased risk of autism. The analysis of nearly 3,000 boys followed from birth into childhood showed that circumcised boys did not have a higher risk of autism compared to uncircumcised boys.
After COVID-19 pandemic restrictions relaxed, Kawasaki disease incidence rebounded in Japan, with distinct age-dependent patterns. Nonpharmaceutical interventions may have contributed to the observed greater rebound in older children, while infants showed minimal changes, suggesting different exposure pathways.
Exposure to pesticides increases the risk of amyotrophic lateral sclerosis (ALS) by 60-70%. Men exposed to herbicides and insecticides are twice as likely to develop the condition as unexposed men.
Scientists developed a scalable solution for robust optical frequency transfer in noisy field environments using digital phase recording and multifunctional relay stations. The system achieved stable operation and fractional frequency instability of 2.9 x 10^-21 at 1 Hz over 2067 km fiber network.
For 15 years, Ochsner Health hospitals have ranked as the best in Louisiana for overall care, with numerous specialties and procedures recognized as High Performing by U.S. News & World Report. The hospital's obstetrics and gynecology service lines, including lung surgery, are among the top-ranked in the nation.
Researchers at SKKU develop a highly efficient catalyst that converts carbon dioxide into industrially valuable 2-propanol, achieving world-record efficiency under ambient conditions. The breakthrough technology uses bifurcated reaction pathways to guide carbon atoms and produce 2-propanol with high selectivity and yield.
Researchers at Weill Cornell Medicine discovered that a protein called BRG1 helps protect cells from ferroptosis, an iron-dependent form of cell death triggered by BTK inhibitors. This finding reveals a potential new therapeutic vulnerability to overcome drug resistance and extend treatment benefits for patients with B-cell cancers.
Researchers mapped kiwifruit genome's chromatin architecture, epigenomic signals, and gene expression to understand how genes shape fruit development. The 3D genome atlas resolves layers of genome organization, including compartments, domains, and loops that influence gene activity.
A study of bull shark behavior found that individuals are slightly more likely to associate and socialise with relatives than unrelated sharks. This 'kinfluence' effect may contribute to both proximity-based associations and directed social interactions, particularly among male sharks.
Researchers at Kyoto University use public Starlink satellite data to estimate thermospheric density around 1,200 satellites. The resulting two-dimensional snapshot provides the first tomographic analysis of its kind, demonstrating high consistency with European Space Agency observations.
A $3.2 million NIH grant will support a five-year study investigating the role of thymulin, a hormone produced by the thymus, in age-related inflammation and cancer. The research aims to explore whether thymulin can improve cancer immunotherapy outcomes, particularly in older individuals.
Researchers identified a fungal cell wall assembly protein as a weak point in plant defense against powdery mildew. Silencing this protein reduced disease severity by up to 75% in controlled experiments.
A study published in Judgement and Decision Making found that participants gave highest ratings to stories generated by AI when attributed to humans. This bias towards narratives written by real people may be due to the assumption of uniquely human qualities required for creative writing, leading people to underestimate AI's capabilities.
A study published in Molecular Psychiatry found that about 65% of patients who developed psychosis after age 40 showed abnormal tau buildup, compared to 15% of healthy older controls. The findings suggest diverse tau-related brain changes may be involved in late-onset psychosis.
A study of nearly 61,000 women in Denmark found that childhood obesity and overweight trajectories were associated with a lower likelihood of giving birth in adulthood. Women with higher BMI trajectories during childhood had a greater risk of childlessness, particularly at older ages.
A team of researchers at UMass Amherst has developed an AI model, DiffuDose, that generates a patient's radiation dose map with gold-standard accuracy in under 23 seconds. This technology has the potential to unlock the full potential of radiopharmaceutical therapy for prostate cancer treatment.
The American Chemical Society has unveiled its new brand, strengthening how it delivers its mission and empowering a global community. The evolved brand brings together scholarly publishing, educational opportunities, and events into a unified identity, making it easier for people to discover ACS resources.
A three-year field experiment found that warming accelerates nitrogen cycling while promoting retention in protected soil pools. This changes where nitrogen goes and how securely it is stored, potentially helping develop climate-resilient nitrogen management strategies for rice production.
Researchers developed a self-powered blue-light photodetector that operates at zero bias, enabling low-power underwater imaging and optical sensing. The device features an asymmetric electrode design and achieves high responsivity and quantum efficiency, making it suitable for real-world tasks.
A cohort study analyzing factors associated with abandoned buprenorphine prescriptions found that US adults are increasingly dropping their medication for opioid use disorder. The study, published in JAMA Network Open, examines the decline of prescribed buprenorphine from 2020 to 2024.
A cross-disciplinary team developed a near-infrared fluorescent dye, SID-788, with excellent biocompatibility and superior ureter imaging performance. The dye enables clear ureter visualisation for at least four to five hours in porcine models using clinical NIR laparoscopes and robotic surgical systems.
The Center for Large Aperture Secure Sensing, Imaging and Communications aims to develop advanced antenna technologies for future wireless systems. Led by Edward Knightly, the research team will investigate how extremely large-scale antenna arrays can expand wireless system capabilities in challenging environments.
A new method creates 3D models of underground plant–fungal networks, revealing fine structures and spatial connections. The technique enables researchers to study climate-resilient plants and understand how plants and fungi interact in the soil.
A recent study found that bypass surgery was more cost-effective than endovascular procedures for treating chronic limb-threatening ischemia, although uncertainty remains. The findings highlight the need for further research to identify subgroups where each approach may be more cost-effective.
The study presents a novel 3D brain tissue model that accurately replicates the complex interactions in human brain tissue with Alzheimer's disease. The model uses human stem cells to form neurons, astrocytes, and microglial cells, which exhibit key functions similar to those in a real human brain.
A team from Tsinghua University developed the 'calculus of intelligence' framework to break down complex problems in agentic AI. This framework provides a mathematical approach to decomposing tasks into smaller, manageable subtasks that can be solved independently and then combined for a coherent whole.
A research team from HKU School of Computing and Data Science has developed ClairS, a novel deep-learning algorithm that improves the detection of cancer mutations. Tested on breast, lung, and melanoma cell-line datasets, ClairS demonstrates exceptional accuracy across various cancer types and sequencing conditions.
Researchers from Stanford University found that using AI companions can exacerbate feelings of loneliness and isolation in vulnerable individuals. Participants who engaged with chatbots for emotional support reported lower well-being despite initial perceptions of improvement.
A new immunotherapy for Alzheimer's disease has shown promising results in a Phase 1 clinical trial. The treatment aims to reverse immune aging and reduce biomarkers of neuronal damage, supporting further clinical development of this innovative strategy.
Professor Hengshuang Zhao has established a general framework for Physical Intelligence, spanning perception to understanding and virtual environments to physical reality. His work cites over 20,000 times and propels AI from perceiving to transforming the world.
A study of 1,160 patients with dilated cardiomyopathy found that left ventricular hypertrabeculation is not associated with increased risk of heart failure, arrhythmias, or embolic events. The presence of hypertrabeculation does not modify clinical risk in any genetic subgroup.
An analysis of over 4 million letters reveals that most are less readable than recommended for patients, highlighting a gap between policy recommendations and real-world practice. The study suggests that clinician letters must balance medical record requirements with patient communication, emphasizing the need for targeted intervention...
Karlsruher Institut für Technologie (KIT) has been selected as a research hub for fusion technology, focusing on the development of the fuel cycle and new materials. The institution will pool its expertise with industry partners to master technological challenges associated with fusion energy.
Researchers developed a toolkit to tap into the influence of people we trust, such as celebrities and neighbours, to encourage sustainable behaviour. The four-dimensional framework analysis highlights key messengers, audiences, modes of influence and behavioural domains.
Researchers discovered how breast tumors recruit immune cells to attract nerves that support tumor growth and treatment resistance. Blocking nerve growth may boost the immune response to fight cancer.
Professor Jun Yang, HKU engineer, wins State Natural Science Award for his groundbreaking research on soil anisotropy and its impact on geotechnical engineering. His work provides a comprehensive theoretical framework and advanced constitutive models that accurately predict soil strength and deformation.
A new study found that four in ten children who attend Child and Adolescent Mental Health Services (CAMHS) in Scotland go on to access adult mental health services. Eight percent of these children accounted for 46% of all adult psychiatric inpatient bed days and 41% of all NHS adult mental health outpatient appointments by the age of 32.
Dr. Aaron Schimmer takes the helm at Ontario Institute for Cancer Research (OICR) with a wealth of scientific expertise, aiming to accelerate cancer research in Ontario. With his appointment, OICR is poised to deliver life-changing solutions to the biggest challenges in cancer.
The robot combines two biomimetic strategies to achieve exceptional speed, load capacity, and maneuverability. It maintains high speed under heavy loads and has impressive energy efficiency.
Keren Zhou and Binqian Yin are working on a project to address fundamental computational challenges in ragged tensor operators for AI computation. They aim to develop innovative auto-tuning modules and compiler tools to optimize deep learning workloads on graphics processing units.
The University of Illinois Chicago's UI Health ophthalmology program has earned a top national ranking and another regional ranking in U.S. News & World Report's 2026-27 Best Hospitals rankings. The hospital's cancer care also received top recognition, with the ophthalmology department being ranked No. 16 in the nation.
Researchers have developed a new membrane technology that efficiently separates water from isopropanol, a widely used solvent in pharmaceuticals and electronics. The new membrane reduces energy consumption and improves purity levels, making it an attractive solution for a more climate-friendly chemical industry.
A study published in the Journal of Cachexia, Sarcopenia and Muscle reveals that deleting transforming growth factor-beta 1 (TGF-β1) from macrophages enhances muscle regeneration and mitochondrial function. The research found that this approach protected against obesity-related muscle wasting and improved exercise performance.
PaveX will develop an AI-sensor-based system to collect street-level data and produce practical road condition ratings, helping agencies plan repairs sooner and more efficiently. The project aims to improve distress detection reliability and reduce route planning overhead.
Massimiliano Albanese and Songqing Chen will host a two-day conference to strengthen secure and viable open-source ecosystems amidst the rise of artificial intelligence. The event aims to identify shared priorities and practical opportunities for improving long-term stewardship.
A new study reports that loading biochar with oxygen nanobubbles can help overcome the problem of rapid oxygen depletion in flooded rice soils, creating a more oxidizing environment around rice roots. This leads to reduced cadmium accumulation in rice plants and improved plant growth.
A study of 5,500 individuals aged 50+ found that both conditions alone increase the risk of death, but together it more than doubles. Abdominal obesity and vitamin D deficiency create a vicious cycle, exacerbating chronic inflammation and impairing bodily functions.
Tianjun Sun's research develops better ways to measure human behavior and abilities, ensuring AI systems are accurate, fair, and trustworthy. Her work combines psychological measurement with AI, aiming to ground AI assessments in scientific standards.
Reducing artificial light at night (ALAN) in cities has been found to have ecological effects, including advances in plant growth cycles. Cities with mitigation policies show earlier leaf emergence and less delayed fall color, suggesting a positive impact on ecosystems.
Researchers from Heidelberg University and international partners used (U-Th)/He dating to establish consistent age models for several maars in the West Eifel. The analysis reveals that many volcanic eruptions occurred in short pulses, with three episodes occurring approximately 75,000, 48,000, and 25,000 years ago.