A study published in PNAS successfully eliminated pancreatic tumours in mice completely and durably, with no significant side effects. The treatment, combining three molecular targets, induced robust regression of experimental PDACs without causing tumor resistance.
Researchers studied a 78-qubit superconducting quantum processor subjected to random multipolar driving. The system exhibited a long-lived prethermal regime before rapid heating, with the plateau's lifetime depending on driving frequency. Entanglement spread across the system, violating classical simulation methods.
Randy Davis, MBA, has been named President of Vanderbilt Clarksville Hospital, a 270-bed facility joining Vanderbilt Health's network. He aims to improve operating performance and add programs and services to enhance the region's healthcare.
Researchers at Duke University have created a programmable Lego-like material that can change its stiffness and damping in response to temperature changes. The material, made from gallium and iron, can be programmed to mimic various commercially available soft materials.
A UC Irvine-led study suggests that high estrogen levels in the brain may increase women's risk of stress-related memory issues, such as post-traumatic stress disorder and dementia. Women are more likely to develop PTSD and face higher dementia risk due to hormonal fluctuations during stressful events.
A new axis-based data model resolves long-standing issues in Earth data grids, enabling more accurate, flexible, and interoperable data across science, policy, and industry. The framework clarifies grid structure, coordinate handling, and value interpretation, allowing for efficient querying of massive multidimensional datasets.
Researchers investigate real-world blockchain security incidents to extract representative attack patterns and categorize them into six classes based on standard blockchain architecture layers. The study also evaluates current detection and defense strategies, highlighting their strengths and limitations.
A new study using Victorian recordings from Lancaster University's archive found strong links between industrial growth and accent evolution in northern England. The Barrow-in-Furness accent developed due to intense population change and mixing, leading to distinct social histories and settlement patterns.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center developed a new zinc oxide formulation that significantly reduces the white, chalky cast associated with traditional mineral sunscreens. The tetrapod-shaped particles provide strong protection against UV radiation while staying evenly distributed in the sunscreen.
Research found that widespread contaminants like mercury and certain PFAS compounds affect the function of mitochondria in wild seabirds, potentially undermining fitness. The study measured pollutant levels and mitochondrial function in Scopoli's shearwaters and connected diet to exposure through stable isotopes.
George Coukos directs the Ludwig Laboratory for Cell Therapy at Weill Cornell Medicine's Sandra and Edward Meyer Cancer Center. The lab focuses on developing personalized cellular immunotherapies to optimize cancer treatment strategies.
MIT engineers have designed a 3D-printed floor truss system made from recycled plastic, which exceeds building standards set by the US Department of Housing and Urban Development. The printed flooring can hold over 4,000 pounds and weighs about 13 pounds per truss, making it a lighter alternative to traditional wood-based trusses.
A University of Calgary-led international research team has identified the runt-related transcription factor 1 (RUNX1) as a genetic factor influencing opioid responses. People carrying the RUNX1 variant require higher doses for pain relief and experience more intense withdrawal symptoms.
A nationwide study found that trazodone reduces the risk of death and rehospitalization among older adults with delirium. Trazodone may offer a safer alternative to antipsychotic drugs, particularly when medication use cannot be avoided.
A clinical prediction model called the Goliat score can estimate the risk of acute complications in patients with minor and moderate traumatic brain injuries. The model, developed by researchers at UOC and IRBLleida, uses easily accessible variables to predict neurological or cardiorespiratory complications and mortality within 48 hours.
Researchers at Monash University have discovered a way to permanently switch off cancer-causing genes, potentially leading to shorter treatment periods and reduced side effects. The breakthrough uses epigenetic therapy, targeting specific proteins that keep cancer-promoting genes switched on.
Researchers found that warmer waters and commercial fishing lead to smaller meals for predators, resulting in reduced energy intake. This can weaken predators and make marine ecosystems more fragile. The study suggests managing climate change and fisheries together is essential to protect marine food webs.
Researchers found OXCT1 to be a key regulator of colorectal cancer liver metastasis, with low expression linked to increased metastasis. OXCT1 suppression promotes oncogenic signaling through the CDK8/beta-catenin complex, highlighting its potential as a novel therapeutic target and prognostic biomarker.
Researchers found molecules such as syringic acid that protect neurons from aging, while others like resveratrol promote neurodegeneration. An AI-powered approach identified potential therapeutic substances to preserve brain function and prevent neurodegenerative diseases.
A study by the University of Córdoba reveals that olive pomace oil extraction is the most sustainable alternative for managing olive oil industry byproducts. The methodology considers economic, environmental, and social indicators, concluding that this option is economically attractive while also offering significant environmental bene...
The ESMT Berlin DEEP Institute and Creative Destruction Lab will be launched in Doha to support technology transfer and innovation. The initiative aims to connect the innovation ecosystems of Germany and Qatar, fostering entrepreneurial growth and driving economic growth.
NTU Singapore has unveiled its first locally designed and built full-sized eVTOL aircraft technology demonstrator, combining aerodynamic efficiency with hovering capability. The aircraft was developed over three years by researchers and engineers, powered by NTU-designed electric motors and featuring eight lift rotors.
A new study found that social media influencers are promoting unproven claims about low testosterone in young men, framing common experiences as hormonal deficiencies. The content is linked to the manosphere, encouraging hyper-masculine ideals and positioning testosterone as a way for men to reclaim power and status.
Researchers developed AAVLINK, harnessing Cre/lox-mediated intermolecular DNA recombination to enable in vivo reassembly of large genes. The method achieves high-efficiency full-length gene reconstitution and significantly improves therapeutic outcomes in animal models.
The study validates the use of SOFA-2 in sepsis care and research, demonstrating its ability to identify clinically meaningful organ dysfunction. The findings suggest that incorporating immune markers may not improve predictive performance, highlighting the biological complexity of sepsis.
The partnership aims to support conservation genetics efforts globally by sequencing up to 4,000 unique animal samples across 1,300 species. The project will provide valuable genomic insights to inform conservation management decisions and promote ecological resilience.
A cohort study found a disproportionate increase in postpartum depression among women and adolescents in low-socioeconomic status communities following state abortion bans. The legislation disproportionately affects vulnerable populations, highlighting the need for targeted mental health support and policy interventions.
The study found that 2024-2025 COVID-19 vaccines offer protection against COVID-19 hospitalization and severe in-hospital outcomes. Monitoring vaccine effectiveness remains crucial to guide vaccine composition and recommendations.
Researchers from the US and UK have created a method to predict September Arctic sea ice extent with high accuracy, improving monitoring of sea ice health and its impact on global climate. The model captures effects from subseasonal to seasonal timescales and outperforms other models.
The integration of Prophy with ARPHA's editorial platform enables data-driven reviewer recommendations based on researcher expertise and publication history. This supports a more sustainable and balanced approach to peer review, reducing delays and fatigue.
Research reveals that probiotics can enhance root development and nitrogen uptake in plants, improving growth without excess fertilizer use. The Sphingopyxis genus supports plant function, offering a potential solution to reduce environmental impact of agriculture.
Dr. John C. Carey, a globally respected clinical geneticist and educator, will receive the 2026 David L. Rimoin Lifetime Achievement Award for his career-defining contributions to medical genetics. He has authored over 400 peer-reviewed articles and co-authored widely used textbooks.
Researchers evaluated the hearing sensitivity of Kemp's ridley sea turtles, finding they are most sensitive to low-frequency sounds produced by ships and machinery. This understanding will inform efforts to monitor and mitigate noise impacts on these endangered species.
A recent study found that respiratory syncytial virus (RSV) hospitalizations are associated with a higher risk of cardiorespiratory events, with some conditions experiencing elevated risks up to 180 days after admission. The findings highlight the importance of increasing RSV immunization in adults to mitigate this risk.
A new study published in the Strategic Management Journal challenges long-standing assumptions about managerial specialization by examining when organizations perform better with shared purpose. The findings reveal that a common purpose advantage emerges when managers share practices and operate in stable or moderately turbulent enviro...
A long-term study with over 700 participants shows that focusing on the strength of people with depression increases their self-confidence and enables them to better achieve personal goals. Reflecting on their strengths also leads to improved progress towards set goals.
Researchers found that early pregnancy reduces the buildup of abnormal cells in breast tissue, which can lead to breast cancer. Pregnancy prevents these 'confused' cells from accumulating and triggers a 'cellular reset button,' maintaining tissue lineage integrity.
Researchers have catalogued 2554 non-native plant species that may pose a threat to Arctic biodiversity. The study used data from over 51 million occurrences of these species to create a map highlighting hotspot areas in the region.
Dr. Barron Bichon has been promoted to vice president of SwRI's Mechanical Engineering Division, overseeing a team of over 400 staff members. He will lead the division in advancing additive manufacturing and composite material bonding for defense and aerospace applications.
Researchers found that tick infection prevalence in Ohio has increased to 47.6%, comparable to endemic US regions like Connecticut. The study suggests that Ohio's forested areas have the same risk of Lyme disease as Connecticut.
A team from Donghua University has developed a new molecular design that improves the performance of photothermally healable elastomers. The resulting material, PIB5Cu, achieves all-round upgrades in toughness, tensile strength, photothermal conversion efficiency and healing efficiency.
A new study offers hope that kidney transplant patients may one day have a more effective treatment regimen. The Phase 2 pilot study showed improved kidney functioning in all patients who completed the study, with no patients experiencing rejection due to antibodies produced by the immune system.
The Korea University Medical Scientist Training Program marks a significant milestone in nurturing future physician-scientist leaders. The program's comprehensive system bridges basic science and clinical practice, expanding global research collaboration networks.
A new survey by the Crohn's & Colitis Foundation found that 93% of people with inflammatory bowel disease (IBD) or at risk for it would be interested in a test to predict their risk of developing IBD. Lifestyle interventions, such as diet and exercise, were preferred over pharmaceutical approaches.
A new FAU study uncovers the impact of acidic water on shell-building marine organisms, highlighting the need for strategies to mitigate coastal acidification. The research found that nutrient pollution, freshwater input, and other environmental factors contribute to reduced aragonite saturation.
Two Egyptian priests, Nes-Min and Nes-Hor, were scanned using CT technology to reveal details about their lifespans, health, and life experiences. The scans showed healed injuries, dental issues, and modern-day ailments, providing new insights into ancient lives.
The lack of data on safety and dosage limits life-saving antibiotics from children in Australia, New Zealand, and the Pacific Islands. Only six out of 12 recommended antibiotics are licensed for children under 12, with standard doses often too low.
Insilico Medicine received a USD 5 million milestone payment from Menarini Group after completing first-in-human dosing in a Phase 1 study of MEN2501, a small molecule inhibitor targeting cancers with chromosome instability. This achievement follows the completion of a successful Phase 1 clinical trial.
A study by Mass General Brigham found that individuals with traumatic brain injury and their caregivers consider recovery of basic communication an 'acceptable' outcome, challenging traditional assumptions about what constitutes a 'favorable' recovery. The study highlights the need for person-centered approaches to TBI outcome research.
Researchers have discovered a new thermoelectric material, MoSi2, that can convert waste heat into electricity with high efficiency. The material's unique electronic structure and axis-dependent conduction polarity enable it to generate transverse thermopower, paving the way for efficient waste heat recovery systems.
A study found that a 2013 policy restricting maternal migration in Sri Lanka led to fewer hospital admissions, fewer illness-related inpatient stays, and improved educational outcomes for children. This suggests investments in human capital with lasting positive impacts on future outcomes.
Researchers at Chiba University developed oxygen-functionalized graphene membranes that selectively separate carbon dioxide from methane while maintaining high permeability. The study demonstrates the potential of graphene-based filtration systems for next-generation gas purification, enabling cheaper and cleaner energy production.
A recent poll found that 42% of people over 50 haven't gotten either flu or COVID-19 vaccines in the past six months. The leading reason for not getting vaccinated was a lack of perceived need, despite clear evidence showing vaccination reduces the risk of serious illness and death in older adults.
Researchers identify contextual errors as a major contributor to the gap between medical AI model performance on standardized test cases and real-world clinical applications. To address this, experts suggest incorporating contextual information into datasets, computational benchmarks, and model architecture.
A study mapping the genetic risk of haemochromatosis across the UK and Ireland identifies key regions, including Outer Hebrides, north-west Ireland, and mainland Scotland. Early detection and treatment can prevent liver damage, cancer, and arthritis associated with the condition.
Scientists at The Wistar Institute have developed an innovative HIV vaccine candidate that induces neutralizing antibodies against HIV after a single immunization in nonhuman primates. The approach could significantly shorten and simplify HIV vaccination protocols, making them more accessible worldwide.
Researchers from ASU found that status inequality in influence has been part of human societies since early times, with people gravitating towards skilled and successful individuals. This 'prestige' effect creates a snowball effect where popular leaders emerge quickly, shaping group decisions and driving imbalance.
A randomized controlled trial demonstrates the effectiveness of mylovia, a digital therapy for female sexual dysfunction, showing significant improvements in sexual function and related symptoms. The study suggests that mylovia can provide women with a self-guided intervention to overcome sexual dysfunction and experience deeper pleasure.
Researchers have identified two immense, ultra-hot rock structures at the base of the mantle that affect the Earth's magnetic field. The study suggests strong temperature contrasts in the rocky mantle and stagnation of liquid iron in the core, shedding light on the dynamic evolution of the deep Earth.
Dr. Ronald C. Kessler's decades-long research transformed international understanding of psychiatric disorders and suicide prevention. His work exposes the global scope of mental health challenges and highlights key factors in prevention.