Researchers have identified IL1RAP as a key player in the tumor-driven inflammatory network that helps pancreatic cancer resist treatment. Blocking this receptor may help break down tumors and improve response to combination therapy.
A new study by University of Michigan researchers found that smaller tree swallows reproduce less due to declining insect populations. The decline in insects affects the timing of breeding and reproduction, leading to a phenological mismatch, which has significant consequences for bird biology.
Researchers developed engineered CAR-T cells that specifically degrade soluble TNF, preventing and treating all stages of RA in human TNF-transgenic mice. A single infusion provided sustained benefit without redosing or ADA risk, offering a promising alternative to chronic disease management.
Researchers found that the new galaxy has the mass of 100 million suns and no dark matter, suggesting it formed through a violent event without dark matter 'halos'. This discovery provides strong evidence for an extreme process of galaxy formation and offers insight into the nature of dark matter.
A Drosophila study shows that macrophages detect nutritional stress caused by high-sugar diets and send a signal to the endocrine system to delay development. This delay helps buffer the impact of the diet on growth, allowing organisms to reach adulthood in better condition.
Researchers developed biodegradable tissue-carriers from natural biopolymers for effective delivery of anti-aging compounds. These carriers mimic the skin's extracellular matrix, offering controlled release and reducing skin irritants.
Researchers engineered a Bacillus subtilis strain to increase intracellular guanine levels, alleviating feedback inhibition and enhancing the de novo purine biosynthesis pathway. This led to a 15.3% increase in riboflavin production without affecting cell growth or energy charge levels.
Researchers develop cellular model to reproduce NF1-associated tumour progression, identifying new therapeutic opportunities. The combination of olaparib and selumetinib shows promise in reducing tumour growth.
Researchers developed a two-part vaccination method that prevented genital herpes infection in mice, with 80% of treated mice showing no signs of disease. The 'prime and pull' approach uses nanoparticles to stimulate local immunity, establishing strong immune cell and antibody responses against the virus.
BL18U1 supports the determination of numerous high-quality crystal structures, with most structures in the 1.5–2.5 Å range. The beamline has consistently delivered excellent results in lysozyme experiments and demonstrated long-wavelength anomalous diffraction capability.
Transcranial ultrasound stimulation (TUS) has been shown to improve gait and restore communication between cortical brain networks in mice with ischemic stroke. This treatment targets neural mechanisms that may lead to improved motor function, according to the study.
Natural biomass hydrogels can be turned into responsive sensing platforms due to their softness, water-rich structures, tunable networks, and abundant functional groups. By adjusting crosslinking density and network architecture, researchers can tune the sensor's response to various stimuli.
Researchers propose a new strategy combining nobiletin with the HDAC inhibitor SAHA to enhance anti-tumor efficacy in non-small cell lung cancer. The study reveals the critical role of TRKC in NSCLC and demonstrates synergistic inhibition of tumor growth through regulating BH3-only protein expression.
JMIR Publications' journals have achieved strong rankings, with 12 in the first quartile and 6 in the 90th percentile or higher. The journal of Medical Internet Research has an all-time high Journal Impact Factor of 8.2.
Researchers identify cholesterol ester buildup as biomarker predicting progestin therapy response in young women with endometrioid endometrial carcinoma. Combination treatment with progestin and a statin doubles six-month remission rate and helps patients become mothers.
Researchers have developed a polymer-based microring resonator array with over 40 elements, demonstrating broadband acoustic detection and fine spatial resolution. The system achieved strong correspondence with biological structures, including blood vessel regions, in imaging mouse prostate tissue.
Researchers have designed a clay material that can absorb and retain ethylene gas, slowing down the ripening process of fruits and vegetables. This innovation has the potential to reduce food waste and improve fruit flavor by allowing for later harvesting in the ripening process.
The US retains its scientific edge but is losing the race to translate discoveries into cures, warns a new report from Cure Innovation Index. Without immediate renewed investment and policy changes, the US scientific edge will not hold.
Researchers at Georgia Tech found that sulfoxaflor disrupts bee reproduction and gene expression, leading to reduced reproductive output. The study sheds light on the molecular effects of pesticides on bees and highlights a pressing challenge in agriculture.
A newly discovered Australian ballista spider uses a silk-powered snare to target and capture the highly aggressive green tree ant Oecophylla smaragdina, launching its prey into the air with incredible power and speed. The snare is triggered by the prey's reaction and stores elastic energy in the silk to release it rapidly.
Global review of kelp conservation found strongest restoration programs built on unlikely partnerships. Communities have a direct stake in outcome for kelp forests to thrive.
Researchers have found that cats show comparable patterns of brain deterioration as they age, similar to humans. This study, part of the Translating Time project, aims to unlock new insights into human ageing and disease by comparing cat and human brain development.
A new process-based model predicts how biochar affects crop yields, soil carbon, and greenhouse gas emissions. The DLEM-Ag-Biochar model performed well against field observations, capturing patterns in agricultural systems across different environmental and management conditions.
Andrei Khodak, a principal engineering analyst at PPPL, has been awarded the ANS Outstanding Achievement Award for his work on virtual prototyping of liquid-metal plasma-facing components. He has made significant contributions to the design and engineering of major fusion systems, including ITER and DIII-D.
A study found wide variation in contamination by lead and arsenic in soil and ash from California homes burned by the Eaton and Palisades wildfires. Cleanup efforts reduced concentrations of these contaminants, but the study highlights a need for technical review and more effective cleanup methods.
A new research direction proposes building machine-learning systems on top of AI models to detect hidden information and predict behavior. This enables users to supervise the model, control its behavior without understanding the entire mechanism.
A new framework proposes a third way to balance AI innovation and safety: accelerating responsible innovation through technical, organizational, and ethical advancements. The Telus GenAI customer support agent demonstrates how risks can drive further innovation, reducing the need for restrictive safety constraints.
Researchers have developed a new three-dimensional photothermal structure that greatly improves solar evaporation efficiency, achieving a record rate of 38.14 kg m-2 h-1. The material's unique microstructure maximizes sunlight capture and reduces energy consumption by 45.7%.
Researchers introduce a 'failure-mechanism-oriented robustness optimization' framework to address coupled multimode failures and optimize superhydrophobic sensor performance. The framework establishes key quantitative benchmarks for next-generation amphibious flexible sensing, enabling exceptional metrics of up to 10,000 gauge factors ...
A KAIST research team led by Professor Jee-Hwan Ryu has received the IEEE Robotics and Automation Letters (RA-L) Best Paper Award for the second consecutive year. The award-winning paper presents a novel assistive dressing technology that enables garments to autonomously unfold and move along the user's body using soft robotic principles.
Liquid ammonia has high energy density and is compatible with existing infrastructure, making it attractive for decarbonizing marine shipping and heavy-duty transport. However, challenges such as low reactivity and high NOx emissions must be addressed through advanced injection strategies and combustion control.
Researchers at HKUST have discovered that mutations in the RPGR gene can lead to defective cilia structures, resulting in impaired airway clearance and recurrent lung infections. The study provides new insights into the pathogenesis of primary ciliary dyskinesia (PCD) and holds potential for targeted therapeutic interventions.
A review in Engineering highlights advances in sorption-enhanced catalytic hydrogenation of carbon oxides, improving reaction efficiency with selective water vapor removal. Zeolites and fixed-bed reactors are studied for their potential in this technology.
A new study reveals that improving one element of a healthcare system can lead to worse patient outcomes in low- and middle-income countries due to systemic interconnectedness. Enhancing trust in the healthcare system had the greatest impact on clinical outcomes, but increased demand from more patients can quickly overwhelm services.
A research team has successfully designed a novel electrolyte for fluoride shuttle batteries, which boasts high electrochemical stability and reversibility. The KBF4-containing electrolyte effectively regulates the fluorination reaction, enabling reversible electrode reactions.
A new study outlines the technical status and future outlook of ammonia-fired power generation, positioning it as a viable hydrogen energy carrier and low-carbon fuel. The technology has been developed for gas turbines and coal-fired boilers, with significant reductions in emissions and improved performance.
The review provides fundamental insights into combustion kinetics for biomass-derived oxygenated fuels, highlighting distinct reaction patterns across fuel categories. It outlines priority directions to improve predictive kinetic models, such as expanding experimental datasets and adopting advanced computational tools.
The review highlights advancements in intelligent coal-fired power technologies, including ubiquitous sensing systems and advanced control algorithms. Intelligent transformation enables flexible operations and long-term sustainability of coal-fired generating units.
A new study reveals critical limitations in cement carbonation as a climate mitigation strategy, highlighting severe temporal asymmetry and performance uncertainty. The authors call for time-explicit accounting, strict verification, and policy prioritization of established decarbonization levers.
The Bird Sonic system is being used to prevent bird strikes at Narita International Airport and nine other Japanese airports. The system uses high-frequency sound to deter birds from approaching aircraft, reducing the risk of collisions and accidents.
A groundbreaking technology called Time to Move (TTM) offers unprecedented control over object and character movement in AI-generated videos. TTM eliminates the need for complex infrastructure or training on millions of videos, making AI video creation more accessible.
Researchers developed a data-driven method combining GA-BP neural network and chaotic particle swarm optimization to predict and optimize screen-printing parameters for thick-film resistors. The approach achieved an R² of 0.991, recommending optimal settings in 2.38 seconds and reducing resistance deviation within 5%.
Researchers have identified a mechanism to improve energy efficiency by converting wasted heat into electricity using hollow silicon nanotubes. This technology has the potential to replace rare metals with abundant silicon, leading to more efficient thermoelectric devices.
Researchers develop a breakthrough electrolyte system using anion-diluent decoupled solvation chemistry, achieving improved battery life, safety, and voltage tolerance. The new electrolyte design enables compact contact ion pairs, delivering intrinsically higher oxidation stability and faster Li+ desolvation kinetics.
A study published in Psychological Medicine found that a laxative drug, Prucalopride, improved executive function and memory in patients with depression. The research suggests that targeting serotonin receptors may help alleviate cognitive problems associated with depression.
A global study confirms mosquito nets reduce malaria cases by up to 68%, but highlights regional variations and the need for locally adapted control strategies. The researchers warn that relying on ITNs alone may not be enough, especially in areas with established insecticide resistance.
Researchers have found a potential new treatment for DHDDS-related disease by creating mini-brains from patients' cells and testing vitamin B3. The study showed significant improvements in patients' symptoms, including reduced tremors and increased energy levels.
A large-scale study found dozens of genetic mutations linked to cancer type and ancestry, improving survival predictions in breast and glioma cancers. Combining ancestry data with tumour analyses enhances prediction accuracy, particularly for pancreatic cancer patients.
Researchers found a copper-based compound significantly reduces toxic Alzheimer's proteins and improves long-term spatial memory in laboratory experiments. The treatment repairs the brain's waste-clearing pump, allowing it to clear out trapped toxic proteins and reduce amyloid buildup by 42%.
A retrospective cohort study found that menopausal hormone therapy significantly reduces the risk of low bone mineral density by 69% compared to non-users. This suggests that hormone therapy could be an effective way to prevent bone loss and lower fracture risks in women after menopause.
A study presented at ENDO 2026 found semaglutide was associated with a 15% reduction in bone fractures and greater weight loss compared to other anti-obesity medications. The results suggest that semaglutide may have beneficial effects on bone health in people with type 2 diabetes.
A study found that nearly 4 in 10 patients stopped GLP-1 medication within the first year and nearly two-thirds restarted therapy within two years. The researchers also identified sociodemographic, clinical, and provider-level predictors of discontinuation, including Medicaid or Medicare status, Black patients, and side effects.
The first real-world study of fezolinetant found the treatment improved hot flashes, depression, and anxiety in women with menopausal vasomotor symptoms. In a study of 656 women, fezolinetant significantly reduced hot flash symptoms and showed benefits similar to those seen in clinical trials.
Researchers found that certain genetic variants increase the risk of steroid side effects, particularly osteoporosis and stroke. Integrating polygenic risk scores into steroid prescribing can improve risk assessment and identify patients at high risk, allowing for closer monitoring or alternative treatments.
A study presented at the Endocrine Society's annual meeting found that exposure to the plasticizer DEHP in early development can lead to increased anxiety-like behavior in adult male rats. The research suggests that humans exposed to endocrine disruptors before and shortly after birth may experience long-lasting behavioral changes.
A study of 336 mother-infant pairs found that breast milk and infant urine contained over 50 different chemicals, including BPA and phthalates, which can interfere with hormones during baby's development. These chemicals were detected in breast milk and urine up to 6 months after birth.
A nationwide study of over 5.7 million women aged 40 found a link between longer reproductive spans and an increased risk of thyroid cancer. The research also showed that hormone replacement therapy, especially for five years or more, was associated with a higher risk of developing the disease.
The study found a significant increase in type 1 diabetes cases among Hispanic/Latino adolescents in Puerto Rico, from 10.1 per 100,000 in 2009 to 24.1 in 2021, with an average annual increase of 4.1%. This trend has important implications for patient care and public health.
A study published by the Endocrine Society found that testosterone therapy was often prescribed without adequate diagnostic testing, highlighting opportunities for quality-improvement efforts. The research suggests that targeted interventions may be needed to improve guideline-concordant prescribing practices and prevent avoidable risks.
A study found that testosterone alone is not enough to prevent type 2 diabetes in older men; lifestyle interventions are crucial for improving blood sugar control and reducing obesity. Testosterone treatment can improve body composition and sexual desire, but its benefits diminish over time.