Researchers have identified IL1RAP as a key player in the tumor-driven inflammatory network that helps pancreatic cancer resist treatment. Blocking this receptor may help break down tumors and improve response to combination therapy.
A new study by University of Michigan researchers found that smaller tree swallows reproduce less due to declining insect populations. The decline in insects affects the timing of breeding and reproduction, leading to a phenological mismatch, which has significant consequences for bird biology.
Researchers developed engineered CAR-T cells that specifically degrade soluble TNF, preventing and treating all stages of RA in human TNF-transgenic mice. A single infusion provided sustained benefit without redosing or ADA risk, offering a promising alternative to chronic disease management.
Researchers found that the new galaxy has the mass of 100 million suns and no dark matter, suggesting it formed through a violent event without dark matter 'halos'. This discovery provides strong evidence for an extreme process of galaxy formation and offers insight into the nature of dark matter.
A Drosophila study shows that macrophages detect nutritional stress caused by high-sugar diets and send a signal to the endocrine system to delay development. This delay helps buffer the impact of the diet on growth, allowing organisms to reach adulthood in better condition.
Researchers developed biodegradable tissue-carriers from natural biopolymers for effective delivery of anti-aging compounds. These carriers mimic the skin's extracellular matrix, offering controlled release and reducing skin irritants.
Researchers engineered a Bacillus subtilis strain to increase intracellular guanine levels, alleviating feedback inhibition and enhancing the de novo purine biosynthesis pathway. This led to a 15.3% increase in riboflavin production without affecting cell growth or energy charge levels.
Researchers develop cellular model to reproduce NF1-associated tumour progression, identifying new therapeutic opportunities. The combination of olaparib and selumetinib shows promise in reducing tumour growth.
Researchers developed a two-part vaccination method that prevented genital herpes infection in mice, with 80% of treated mice showing no signs of disease. The 'prime and pull' approach uses nanoparticles to stimulate local immunity, establishing strong immune cell and antibody responses against the virus.
BL18U1 supports the determination of numerous high-quality crystal structures, with most structures in the 1.5–2.5 Å range. The beamline has consistently delivered excellent results in lysozyme experiments and demonstrated long-wavelength anomalous diffraction capability.
Transcranial ultrasound stimulation (TUS) has been shown to improve gait and restore communication between cortical brain networks in mice with ischemic stroke. This treatment targets neural mechanisms that may lead to improved motor function, according to the study.
Natural biomass hydrogels can be turned into responsive sensing platforms due to their softness, water-rich structures, tunable networks, and abundant functional groups. By adjusting crosslinking density and network architecture, researchers can tune the sensor's response to various stimuli.
Researchers propose a new strategy combining nobiletin with the HDAC inhibitor SAHA to enhance anti-tumor efficacy in non-small cell lung cancer. The study reveals the critical role of TRKC in NSCLC and demonstrates synergistic inhibition of tumor growth through regulating BH3-only protein expression.
JMIR Publications' journals have achieved strong rankings, with 12 in the first quartile and 6 in the 90th percentile or higher. The journal of Medical Internet Research has an all-time high Journal Impact Factor of 8.2.
Researchers identify cholesterol ester buildup as biomarker predicting progestin therapy response in young women with endometrioid endometrial carcinoma. Combination treatment with progestin and a statin doubles six-month remission rate and helps patients become mothers.
Researchers have developed a polymer-based microring resonator array with over 40 elements, demonstrating broadband acoustic detection and fine spatial resolution. The system achieved strong correspondence with biological structures, including blood vessel regions, in imaging mouse prostate tissue.
Researchers have designed a clay material that can absorb and retain ethylene gas, slowing down the ripening process of fruits and vegetables. This innovation has the potential to reduce food waste and improve fruit flavor by allowing for later harvesting in the ripening process.
The US retains its scientific edge but is losing the race to translate discoveries into cures, warns a new report from Cure Innovation Index. Without immediate renewed investment and policy changes, the US scientific edge will not hold.
Researchers at Georgia Tech found that sulfoxaflor disrupts bee reproduction and gene expression, leading to reduced reproductive output. The study sheds light on the molecular effects of pesticides on bees and highlights a pressing challenge in agriculture.
A newly discovered Australian ballista spider uses a silk-powered snare to target and capture the highly aggressive green tree ant Oecophylla smaragdina, launching its prey into the air with incredible power and speed. The snare is triggered by the prey's reaction and stores elastic energy in the silk to release it rapidly.
Global review of kelp conservation found strongest restoration programs built on unlikely partnerships. Communities have a direct stake in outcome for kelp forests to thrive.
Researchers have found that cats show comparable patterns of brain deterioration as they age, similar to humans. This study, part of the Translating Time project, aims to unlock new insights into human ageing and disease by comparing cat and human brain development.
A new process-based model predicts how biochar affects crop yields, soil carbon, and greenhouse gas emissions. The DLEM-Ag-Biochar model performed well against field observations, capturing patterns in agricultural systems across different environmental and management conditions.
Andrei Khodak, a principal engineering analyst at PPPL, has been awarded the ANS Outstanding Achievement Award for his work on virtual prototyping of liquid-metal plasma-facing components. He has made significant contributions to the design and engineering of major fusion systems, including ITER and DIII-D.
A study found wide variation in contamination by lead and arsenic in soil and ash from California homes burned by the Eaton and Palisades wildfires. Cleanup efforts reduced concentrations of these contaminants, but the study highlights a need for technical review and more effective cleanup methods.
A new research direction proposes building machine-learning systems on top of AI models to detect hidden information and predict behavior. This enables users to supervise the model, control its behavior without understanding the entire mechanism.
A new framework proposes a third way to balance AI innovation and safety: accelerating responsible innovation through technical, organizational, and ethical advancements. The Telus GenAI customer support agent demonstrates how risks can drive further innovation, reducing the need for restrictive safety constraints.
Researchers have developed a new three-dimensional photothermal structure that greatly improves solar evaporation efficiency, achieving a record rate of 38.14 kg m-2 h-1. The material's unique microstructure maximizes sunlight capture and reduces energy consumption by 45.7%.
Researchers introduce a 'failure-mechanism-oriented robustness optimization' framework to address coupled multimode failures and optimize superhydrophobic sensor performance. The framework establishes key quantitative benchmarks for next-generation amphibious flexible sensing, enabling exceptional metrics of up to 10,000 gauge factors ...
A KAIST research team led by Professor Jee-Hwan Ryu has received the IEEE Robotics and Automation Letters (RA-L) Best Paper Award for the second consecutive year. The award-winning paper presents a novel assistive dressing technology that enables garments to autonomously unfold and move along the user's body using soft robotic principles.
Liquid ammonia has high energy density and is compatible with existing infrastructure, making it attractive for decarbonizing marine shipping and heavy-duty transport. However, challenges such as low reactivity and high NOx emissions must be addressed through advanced injection strategies and combustion control.
Researchers at HKUST have discovered that mutations in the RPGR gene can lead to defective cilia structures, resulting in impaired airway clearance and recurrent lung infections. The study provides new insights into the pathogenesis of primary ciliary dyskinesia (PCD) and holds potential for targeted therapeutic interventions.
A review in Engineering highlights advances in sorption-enhanced catalytic hydrogenation of carbon oxides, improving reaction efficiency with selective water vapor removal. Zeolites and fixed-bed reactors are studied for their potential in this technology.
A new study reveals that improving one element of a healthcare system can lead to worse patient outcomes in low- and middle-income countries due to systemic interconnectedness. Enhancing trust in the healthcare system had the greatest impact on clinical outcomes, but increased demand from more patients can quickly overwhelm services.
A research team has successfully designed a novel electrolyte for fluoride shuttle batteries, which boasts high electrochemical stability and reversibility. The KBF4-containing electrolyte effectively regulates the fluorination reaction, enabling reversible electrode reactions.
A new study outlines the technical status and future outlook of ammonia-fired power generation, positioning it as a viable hydrogen energy carrier and low-carbon fuel. The technology has been developed for gas turbines and coal-fired boilers, with significant reductions in emissions and improved performance.
The review provides fundamental insights into combustion kinetics for biomass-derived oxygenated fuels, highlighting distinct reaction patterns across fuel categories. It outlines priority directions to improve predictive kinetic models, such as expanding experimental datasets and adopting advanced computational tools.
The review highlights advancements in intelligent coal-fired power technologies, including ubiquitous sensing systems and advanced control algorithms. Intelligent transformation enables flexible operations and long-term sustainability of coal-fired generating units.
A new study reveals critical limitations in cement carbonation as a climate mitigation strategy, highlighting severe temporal asymmetry and performance uncertainty. The authors call for time-explicit accounting, strict verification, and policy prioritization of established decarbonization levers.
The Bird Sonic system is being used to prevent bird strikes at Narita International Airport and nine other Japanese airports. The system uses high-frequency sound to deter birds from approaching aircraft, reducing the risk of collisions and accidents.
A groundbreaking technology called Time to Move (TTM) offers unprecedented control over object and character movement in AI-generated videos. TTM eliminates the need for complex infrastructure or training on millions of videos, making AI video creation more accessible.
Researchers developed a data-driven method combining GA-BP neural network and chaotic particle swarm optimization to predict and optimize screen-printing parameters for thick-film resistors. The approach achieved an R² of 0.991, recommending optimal settings in 2.38 seconds and reducing resistance deviation within 5%.
Researchers have identified a mechanism to improve energy efficiency by converting wasted heat into electricity using hollow silicon nanotubes. This technology has the potential to replace rare metals with abundant silicon, leading to more efficient thermoelectric devices.
Researchers develop a breakthrough electrolyte system using anion-diluent decoupled solvation chemistry, achieving improved battery life, safety, and voltage tolerance. The new electrolyte design enables compact contact ion pairs, delivering intrinsically higher oxidation stability and faster Li+ desolvation kinetics.
The Virtual World of Stonehenge offers an immersive digital tour of the original exhibition, allowing users to explore thousands of years of history. The experience includes interactive content, animation, soundscapes, and rarely seen prehistoric objects, making it a unique way to understand the world of Stonehenge.
A new study by NYU Langone Health researchers found that nearly half of Americans with kidney failure who are referred for transplantation never begin the process required to be considered for a new organ. The study analyzed data from over 720,000 patients and found that those who were unmarried, had severe obesity, or lived in rural a...
A survey of healthcare professionals revealed limited cardio-oncology training during undergraduate and postgraduate education, with only 10% reporting exposure to the subject during medical school. The study highlights the need for standardised educational programmes to address cardiovascular side effects of cancer therapies.
Researchers have identified 18 distinct cell type clusters in the inflorescence meristem that generate a plant's above-ground organs. The study provides new insights into how stem cells make the transition from an undifferentiated state to specialized cell types.
Researchers at the University of Technology Sydney have discovered a new method for controlling tiny quantum emitters in hexagonal boron nitride by twisting its layered structure. This breakthrough brings them closer to practical applications in quantum computing, secure communication and ultra-sensitive sensing.
A meta-analysis of studies found that guideline-recommended heart failure therapies protect heart function in patients treated for cancer. RAAS inhibitors and beta-blockers improved left ventricular ejection fraction, while mineralocorticoid antagonists showed encouraging protective effects.
Researchers at UCL and Great Ormond Street Hospital have successfully treated a deadly childhood liver disease using mice with a healthy version of the VPS33B gene. The treatment, which specifically targeted liver cells, showed no harm and improved liver function in mice.
A USC-led team has developed a way to grow and genetically engineer progenitor cells that give rise to macrophages, a type of immune cell promising for cancer immunotherapies. The team successfully expanded these cells in the laboratory and engineered them to target specific cancer markers.
A psychologist warns of the profound psychological implications of gifting or taking a DNA test, including identity disruption, acceptance challenges, and data security worries. The decision requires careful consideration to ensure recipients can cope with unexpected outcomes.
Research in zebrafish shows that altered presence of neural microexons leads to hyperarousal, insomnia, and stress-like behavior. The study suggests that this mechanism could be conserved in humans and may contribute to symptoms of disorders like autism and schizophrenia.
Researchers tracked Arabian Sea humpback whales' movements, revealing the first direct evidence of a whale crossing the Arabian Sea. The study found that these whales have adapted to their habitat in a unique way, deviating from traditional migration patterns.
Optical approaches offer unique advantages for chiral analysis, including non-contact operation and ease of integration. Recent advances in optical sorting and detection of chiral particles have improved sensitivity, selectivity, and practicality through engineered light fields and AI-assisted strategies.
Researchers have developed a non-invasive method to determine chicken egg sex, assess quality, and detect fertilization using light-based optical spectroscopy. The technique could curb the practice of killing billions of male chicks at birth, reducing animal suffering and promoting more sustainable farming practices.
A new review highlights how animals exchange information through movements, visual displays, calls, and other cues to coordinate interactions and align interests across species. This cooperation enables individuals to access shared resources and exchange services, such as protection from predators.
A team of MIT researchers has developed a machine-learning approach that captures the diversity of atomic environments in chemically disordered materials. This allows for more accurate predictions of material properties and opens up possibilities for creating new sustainable steels and materials for aerospace, energy, and computing.
Computational studies reveal that the tetrahedral order of water molecules collapses at the contact line during complete wetting, leading to a change in line tension. This discovery provides a new design principle for controlling interfacial mechanics and wetting in inorganic and biological systems.