Researchers developed multifunctional metal–organic framework nanoparticles that degrade HK-2, suppress glycolysis, and induce cuproptosis. CHNDs showed stronger anticancer activity than either the HK-2 degrader or the copper nanoplatform alone, disrupting protein homeostasis and cancer energy metabolism.
Researchers at Nagoya University identified the neural circuit responsible for timing torpor in mammals, which reduces body temperature and metabolism. The discovery provides new insights into how animals regulate energy use.
A recent study published in Eye Discovery identified a coordinated failure of tissue regeneration and vascular control in corneal alkali burns. The research found that limbal stem cells, transient amplifying cells, and macrophages form an amplified VEGF communication network, leading to excessive vascular growth and vision loss.
UJI researchers recognized for their work in social psychology and psychosocial prevention, with focus on occupational health psychology and development of diagnostic tools. Researchers from various departments rank among the top 300 women scientists in Spain.
Researchers identified two weather patterns associated with an increased risk of headaches in the Northeast US. The study found that approaching cold fronts and high-pressure systems, such as the Bermuda High, can trigger new-onset headaches in people with episodic migraines.
Researchers found that reef manta rays stay within 10km of their tagging site during monsoons, expanding their vertical use of the water column rather than traveling long distances. This suggests they can change behaviors to adapt to ocean conditions and protect themselves from threats like overfishing.
Researchers have developed a novel nano-space confinement strategy for hard carbon anodes, overcoming limitations in sodium-storage mechanisms. The optimized material delivers high reversible capacity and maintains rate capability, making it suitable for next-generation sodium-ion batteries.
Researchers at the University of Tokyo have discovered a method to quantify CO2 absorbed by cementitious materials and its atmospheric contamination using carbon isotope measurements. This breakthrough aims to improve carbon accounting and reduce greenhouse gas emissions in concrete production.
In a study on Japanese macaques, researchers found that semi-shade is an important thermoregulatory option under hot, dry conditions. The macaques preferred semi-shade over full shade or sun when it was hot and dry, but not humid. This suggests that semi-shade may play a significant role in helping endotherms cope with heat stress.
A study of over 1,000 people vaccinated with TAK-003 in Catalonia found no serious adverse events and provided new evidence on the vaccine's short-term safety in travelers. The findings suggest that the dengue vaccine has a good tolerability profile among travelers from non-endemic regions.
A study found that patients continuing ULT remained flare-free for longer over 24 months, with a cumulative flare incidence of 12.3% compared to 31.8% in the ULT discontinuation attempt group. Effective weight management and exercise are key to managing gout and rheumatoid arthritis.
Despite overall declines in child mortality, progress has stalled, particularly among newborns and children under 5, who face major causes like preterm birth complications and pneumonia. Renewed commitment and investment are crucial to prevent an unfolding tragedy and meet international child survival targets.
A UK study found that parents often rely on manufacturer instructions, social media, and babywearing websites for guidance on using baby carriers safely. The research calls for a UK-wide campaign to direct parents to trusted sources of guidance and specialist advice.
Eight healthcare peers urge MPs to support urgent law reform on assisted dying, citing risks to dying people and public trust. The Bill aligns with best practices from overseas, including assessing capacity, informed consent, and safeguards.
Phosphorus and nitrogen, two elements necessary for life, were found in distinct ratios in asteroidal bodies related to iron meteorites compared to younger asteroids. Researchers recreated the crystallization of iron meteorites in the lab and analyzed their chemical composition, which suggested that these life-essential elements origin...
Tiny warty birch caterpillars can distinguish between the approaching footsteps of deathly ladybeetles and invading caterpillars. When threatened, they make a lot of noise to scare off the attacker, but when faced with an intruding ladybug larva, they become silent before deciding to evacuate or throw themselves off the leaf.
Spatial arthroscopy integrates surgical video feeds with advanced hardware and software systems, enabling a heads-up display that keeps surgeons focused on the field. This technology improves ergonomics and opens doors to future capabilities like voice commands and automated documentation.
Researchers found high levels of antidepressant drugs in four North Carolina rivers, exceeding toxic thresholds for aquatic life. The study highlights the need for effective remediation strategies to mitigate environmental contamination and human health risks.
The FLOW trial shows that semaglutide significantly improved health-related quality of life in adults with type 2 diabetes and chronic kidney disease. Health utility scores and self-rated general health scores improved with semaglutide, but declined with placebo.
A study combining citizen science data with experimental research found that switchgrass adapts its flowering time to optimize survival in different regions. The work highlights the potential of pairing public data sets with controlled experiments to uncover mechanisms of adaptation.
A new study by the American Cancer Society finds that nearly five million Americans live in food deserts, where grocery stores are scarce. The number of food swamps, areas with mostly restaurants and fast-food locations, has increased nationwide.
Researchers at the Institute of Industrial Science, The University of Tokyo, analyzed new dataset to identify temporal variations in locking state of the Nankai Trough. Variability was found particularly in shallowest parts of plate boundary, influencing earthquake strength and size.
The university's patented technology assists surgeons in detecting and visualizing significant arterial bleeding using augmented reality overlays, enabling precise control and quick action. This innovation aims to improve patient outcomes, save lives, and reduce hospital stays, infection rates, and treatment costs.
Researchers from Pennington Biomedical will showcase their latest findings on prevention, care, and cures for diabetes and obesity at the American Diabetes Association's 2026 Scientific Sessions. The sessions will highlight cutting-edge advancements driving progress in diabetes research and management.
A new collection of Frontiers for Young Minds articles reviews breakthrough brain research topics, including artificial intelligence and memory. Young reviewers aged 8-15 collaborated with leading neuroscientists to make complex neuroscience topics accessible to their peers.
A recent clinical trial demonstrated that an all-oral drug combination of decitabine-cedazuridine and venetoclax is effective in treating acute myeloid leukemia (AML) in older patients. The regimen showed strong response rates and survival outcomes, with nearly half of patients achieving complete response.
A pioneering clinical trial demonstrates CAR T cells can safely desensitize highly sensitized patients, making kidney transplantation possible. Two patients with end-stage kidney disease successfully received kidney transplants after years of waiting.
A new iron-modified biochar catalyst activates natural oxygen and iron cycling in farmland soil, breaking down sulfamethoxazole at a 4.2-fold increase under laboratory conditions. The material also achieved strong pollutant removal, with degradation reaching 81.2% under favorable soil moisture conditions.
Long-term biochar study reveals that topsoil benefits from biochar's effect on microbial necromass carbon, with significant increase in fungal necromass carbon. In contrast, subsoil shows reduced microbial necromass carbon due to lower nitrogen availability and increased microbial nutrient mining.
A new study found that rice straw biochar applied at moderate levels improved several colony behaviors linked to soil health in ants. Ants showed stronger habitat preference, built larger nests, and maintained more effective social recognition. However, high doses of biochar were detrimental, causing ant survival to drop sharply.
Researchers examine the process of prioritizing river restoration projects using a mathematical computer program called optimization. The study shows that score and rank systems don't always account for barriers in the full river context, leading to stranded investments.
Scientists at the SETI Institute searched for technological signals from 3I/ATLAS, a natural comet-like object from another star system. Despite extensive scanning, no technosignatures were detected, setting new constraints on the power of any radio transmitter on or near 3I/ATLAS.
A new research initiative aims to harness the potential of astrocytes, a type of brain cell often overlooked in AI development. By studying how astrocytes process information, researchers hope to create next-generation AI systems that learn faster and adapt more reliably.
A new proactive treatment protocol, PACT, combines medication and frequent follow-up to prevent alcohol relapse after liver transplant. Researchers found a 0% heavy alcohol relapse rate among patients who followed the protocol, compared to a historical rate of approximately 25%.
Researchers from Drexel University developed BioCoach, a program using AI and computer vision to analyze video and provide form coaching in real time. The system analyzes visual appearance and motion patterns, as well as 3D skeletal movements and body shape, to deliver detailed biomechanics-based feedback.
A study by the American Academy of Neurology found that people with epilepsy living in rural areas had poorer health outcomes, including higher mortality rates, longer hospital stays, and reduced access to specialized care. The study highlights the need for improved access to epilepsy care in rural areas.
A University of California, Davis study found that adding 'high sugar' warning labels to restaurant menus can significantly reduce added sugar consumption among diners. The study tested two types of labels and found that diners ordered an average of 10 grams less added sugar when the labels were present. This amount is substantial, con...
A new study reveals how Philip Morris Companies Inc. used cigarette research and flavor engineering to design Lunchables, a successful ultra-processed food for children. The company's strategy was based on optimizing 'technical synergies' between tobacco and food divisions.
Researchers at Viva Bem have developed an AI method that identifies states of anxiety with high accuracy using smartwatch data. The technology aims to provide a layer of proactive monitoring for users, alerting them to recurring anxiety episodes and recommending specialist consultation.
Research studies reveal suboptimal adherence to treat-to-target strategies in rheumatoid arthritis, with lower rates among spondyloarthritis patients. Additionally, data from registries show the potential benefits of glucagon-like peptide-1 receptor agonists for weight loss and disease activity management in RMD.
A University of Mississippi-led study reveals counties in the US Deep South with high HIV rates and limited access to prevention tools. Public health leaders can use a prevention gap index to identify areas for targeted intervention and allocate resources effectively.
A team of researchers discovered that coffee molecules, such as melanoidins, significantly reduce the bitterness of caffeine. When combined with chlorogenic acid, these compounds halve the bitter taste of caffeine, suggesting a complex formation prevents interaction with bitter taste receptors.
Researchers at NYU developed a 3-D printed stent, called the Lily stent, which can drain faster and cut costs for treating gastric leaks after weight-loss surgery. The stent's unique shape creates more effective routes for fluid to move around it, improving drainage performance.
Researchers from UNICAMP and USP describe three new species of moths in the Eois genus, named after Orixás from Candomblé and Umbanda traditions. The study improves understanding of Lepidoptera diversity in Brazil and ecological interactions with Piper plants.
Researchers present results from Phase 1 trials of CAR-T cell therapies in patients with refractory rheumatoid arthritis and systemic sclerosis, showing improved disease activity and clinical remission. The findings suggest an immunological 'reset' strategy may offer true curative potential for these severe diseases.
A recent review of decades of air pollution studies found that exposure to PM2.5 may harm heart health even at concentrations below EPA guidelines, affecting cardiovascular disease rates worldwide. Certain populations are particularly vulnerable, and increasing public awareness is key to preventing exposure.
The center is the first in the region to offer TCR-T therapy, an FDA-approved treatment targeting proteins inside cancer cells. Patients with chemotherapy-resistant synovial sarcoma can now access this novel cellular therapy.
A new study found that demand for abortion and miscarriage hotlines increased by double digits before the Dobbs decision, with states later enacting abortion bans seeing a significant surge. The hotline saw a 210% spike in use from June 2022 to June 2023.
A study found an association between genetic variants for high pulse pressure and an increased risk of dementia as a contributing cause of death. Researchers constructed polygenic risk scores to calculate predisposition to disease, and found a 16% increased risk with higher scores.
Researchers at the University of Michigan have discovered a new way to understand neurons and their connectivity by studying fruit flies. This breakthrough simplifies future studies on neurobiology and decision-making in mammals, including humans.
The conference covers topics such as ultra-processed foods, GLP-1s and their impact on health. It also delves into the politics of the new Dietary Guidelines for Americans and the rise of tickborne meat allergy.
Lauren Stern, a clinical associate professor of medicine at Boston University School of Medicine, has been recognized for her significant contributions to medical student education. She directs the Integrated Renal Physiology and Pathophysiology curriculum and serves as a field-specific advisor for fourth-year medical students.
Researchers at VCU have developed a technique to control the spins of electrons in diamond qubits using tiny nanomagnets. This approach could enable scalable quantum computing and lead to significant energy savings.
Researchers found that senescent myoblasts released EVs carrying specific miRNAs that impaired normal muscle cell development and triggered cellular stress responses in healthy muscle cells. The study suggests that extracellular vesicles may play a role in shaping the aging muscle environment.
Researchers at the University of São Paulo have developed nanoparticles that deliver therapeutic RNA molecules directly to skin cells, silencing genes responsible for chronic inflammation. This precision nanomedicine approach holds promise for treating complex diseases like psoriasis and vitiligo.
Researchers at King's College London developed a new algorithm that can automatically explain why some self-driving cars crash. The approach analyzes past events to identify the root cause of failures in complex and rare cases.
Researchers have successfully incorporated sulfur into Fe–N–C catalysts to enhance oxygen reduction reaction kinetics and mitigate 'site blocking' effects. This results in a 3.2-fold increase in turnover frequency compared to traditional FeNC catalysts, leading to improved fuel cell performance.
A Simon Fraser University study found that over 91% of adults with ADHD reported hiding or suppressing their traits to fit in socially. This 'camouflaging' can lead to exhaustion, anxiety, depression, and low self-esteem. Researchers emphasize the need for society to reduce stigma and shift norms towards accepting diverse neurotypes.
This study evaluates ChatGPT-4o's alignment with official grades on Finland's national high-stakes matriculation examination. The results show that GPT-4o's grades closely matched human evaluations, with 75% of scores within ±2 points.
A new study reveals that social networks can correct anchoring bias, a pervasive cognitive error. Participants in network groups showed significant improvement in their estimates after exchanging opinions with peers, while those working alone did not. The key to this effect lies in the confidence participants have in one another.