Ruben van Boxtel's research focuses on understanding the origins of late treatment effects in children with blood cancer, exploring the role of stem cells. His work aims to find solutions to prevent these effects and predict their likelihood.
Scientists at Heidelberg University have identified a second stem cell population in the mouse brain, which is primarily involved in producing new neurons in the olfactory bulb. This discovery refutes the single stem cell type theory and suggests that both apical and basal stem cells are responsible for adult neurogenesis.
Researchers discovered that macrophages eliminate stressed stem cells with high levels of reactive oxygen species, while healthy cells are amplified. The study found that a specific marker, calreticulin, acts as an 'eat me' signal for stressed cells.
Researchers at UNSW Sydney have made significant discoveries about embryonic blood stem cell creation that could one day eliminate the need for blood stem cell donors. Two studies have emerged from UNSW researchers in this area that shine new light on how precursors to blood stem cells occur in animals and humans, and how they may be i...
A study published in Cell Stem Cell found that mitochondrial dynamics regulate the dormant state of adult muscle stem cells, which are essential for tissue stability. The researchers discovered that the protein OPA1 regulates this process and its depletion leads to severe muscle stem cell defects.
A recent study published by the German Cancer Research Center found that inflammation in early life leads to a permanent decline in functional blood stem cells, suppressing their ability to regenerate. Mice exposed to inflammatory challenges developed clinically relevant features of aging, including anemia and decreased number of cells...
A recent study published in Science reveals that hyaluronic acid plays a key role in controlling muscle repair. The natural compound awakens stem cells to start the repair process after a 40-hour cleanup job by immune cells is complete.
Researchers have developed a unique 3D printed system to harvest mesenchymal stem cells from bioreactors, which can be used for various treatments. The system combines microfluidics and 3D printing to process adult stem cells, potentially making stem cell therapies more widely available.
Researchers have discovered an alternative route that pluripotent and endoderm extra-embryonic stem cells can use to form intestinal organs in the lab. This finding could lead to improved cell development and potentially treat diseases, but further function testing is needed.
A receptor protein called insulin receptor is pivotal for brain stem cell longevity, according to a Rutgers study. The researchers also found that the same protein plays a crucial role in sustaining brain cancer cells.
A recent study published in Stem Cell Reports found that sleep deprivation negatively affects corneal stem cells, leading to increased rates of cell multiplication and reduced tear film antioxidants. This can result in serious effects on corneal health, such as thinning and ruffling of the cornea.
Scientists have identified a retinoic acid-dependent hemogenic endothelial progenitor from human pluripotent stem cells, enabling the development of transcriptionally similar cells in tissue culture. This breakthrough method brings researchers closer to developing blood-forming stem cells for transfusions and cancer treatments.
Scientists at Johns Hopkins Medicine have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice. The self-renewing stem cells were created by reprogramming laboratory-grown human skin cells, which then differentiated into specific cell types using a nutrient-rich broth.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
The article highlights the need for a more diverse approach to stem cell policy, including consideration of Muslim contexts and perspectives. Researchers argue that this could lead to a more nuanced understanding of bioethics and potentially expand the use of embryonic stem cells in research.
A new study from North Carolina State University found that feeling inclusive in the classroom is key to promoting STEM education and student engagement. Students who felt their classrooms were inclusive were more likely to feel like they belonged and engage with their STEM classes.
Scientists at University of Helsinki found that older mitochondria determine cell fate, controlling daughter cell differentiation and self-renewal. Studying cellular respiration, researchers identified key metabolic changes influencing stem cell identity.
Researchers discovered a protein, syndecan-2, that helps identify and deploy blood stem cells for treatments. Transplanting only cells expressing syndecan-2 could make blood stem cell transplants more efficient and less toxic.
Researchers at University of Helsinki have developed a faster and more reliable method for converting adult skin cells into pluripotent stem cells, known as induced pluripotent stem cells (iPS). The new technique uses CRISPRa gene-editing and produces high-quality iPS cells with improved accuracy and reliability.
The reNEW Center aims to harness therapeutic potential in stem cell medicine for incurable diseases, with a focus on translation and collaboration. Scientists will work together to develop new treatments and therapies.
A PSU study reveals that parents' STEM backgrounds significantly impact their children's likelihood of majoring and persisting in STEM fields. Researchers identify STEM-specific cultural capital as a key factor, highlighting the importance of parental involvement in fostering STEM values and habits.
A recent study analyzed 59 US stem cell clinics and found that most rely on weakly scientifically credible marketing tactics, including technical descriptions of stem cells and patient testimonials. Only a minority invokes stronger forms of evidence, such as registered clinical trials or scientific peer-reviewed articles.
Researchers have developed a new method of stem cell transplantation that does not require chemotherapy or radiation. The approach uses immunotherapeutic drugs to eliminate cancer cells and prevent immune rejection. This technique has the potential to be curative for blood cancers and treat other diseases like sickle cell anemia.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
A study published in the Journal of Cell Biology found that skin stem cell motility is crucial for wound healing and skin regeneration. The researchers discovered that a specific molecule, EGFR, drives skin stem cell movement and coordinates the production of collagen COL17A1.
Russian STEM specialists do not receive higher wages than their non-STEM counterparts, regardless of education level or job type. The study examines the supply and demand of STEM professionals in Russia, finding that the gap between skilled workers does not exist.
Aging stem cells in bone marrow lose function due to epigenetic changes that affect bone production. Researchers reverse these changes by adding acetate, rejuvenating the epigenome and improving stem cell activity. This finding holds promise for treating diseases like osteoporosis.
Researchers found no significant DNA changes in stem cells after transplant, but an anti-virus drug called ganciclovir may contribute to cancer development. Further research is needed to investigate this further.
Researchers at Kyoto University have made a groundbreaking discovery by creating functional sperm cells from mouse pluripotent stem cells. The breakthrough has significant implications for male fertility and reproduction, providing a new model for generating male germ cells in a test tube.
Using human stem cells and small molecules, researchers successfully differentiated them into insulin-producing pancreatic beta cells. This breakthrough could lead to a personalized treatment option for type 1 diabetes, reducing costs and increasing accessibility for those affected.
Researchers from Tokyo Medical and Dental University have developed an AI system called DeepACT that quickly identifies healthy stem cells with the same accuracy as humans. This technology speeds up the process of evaluating stem cell quality, which is crucial for skin grafts and other applications.
Researchers at the University of Basel have discovered two new types of glial cells in the brain that may play a crucial role in brain plasticity and repair. These cells can potentially be used to treat neurodegenerative diseases such as multiple sclerosis.
A Singapore study explores how female students fare in STEM careers, revealing only half of graduates stay in the field. The research aims to stem the 'leaky pipeline' by investigating early exposure to female role models and group work dynamics.
Researchers at NIH have devised a four-part small-molecule cocktail, CEPT, that protects induced pluripotent stem cells from stress and maintains normal stem cell structure and function. The cocktail enhances the potential therapeutic uses of stem cells in treating diseases like diabetes, Parkinson's disease, and spinal cord injury.
Researchers are developing new conditioning therapies with fewer side effects, targeting specific proteins on hematopoietic stem cells to make room for healthy ones. This could lead to more patients being able to safely undergo stem cell treatments, reducing complications and improving outcomes.
Researchers develop a 3D biomaterial scaffold that slowly releases stem cells, reducing dosages and improving therapeutic effects in mice with osteoarthritis. The cryogel 'sponge' ensures implanted stem cells stay in the knee joint area longer, allowing for more effective treatment.
The International Society for Stem Cell Research (ISSCR) has launched a new podcast called The Stem Cell Report with Martin Pera, which delves into the inspiration and stories behind stem cell research. The podcast features interviews with leading researchers and experts in the field.
A new study published in Cell Stem Cell reveals that neural stem cells in the nervous system age rapidly, leading to a decrease in their ability to divide and replicate. The researchers found that certain genes, including Abl1, play a key role in this process, which may contribute to cognitive decline and dementia.
Scientists at Institut Pasteur have successfully visualized neural stem cell activation in adult zebrafish brains, demonstrating coordinated events in time and space. This breakthrough may improve understanding of regulation processes during brain tumor formation.
Researchers have identified a pair of microRNAs that help maintain breast cancer stem cells and drive tumor growth. Targeting these microRNAs may improve the prognosis of patients with aggressive forms of breast cancer by making cancer stem cells more susceptible to chemotherapy.
Harvard researchers identify how chronic stress impairs hair follicle stem cells, leading to delayed regeneration and hair loss. The study found that the stress hormone corticosterone delays stem cell activation, while Gas6 pathway activation promotes hair growth.
Researchers at Hokkaido University developed a hydrogel that rapidly reprograms differentiated cancer cells into cancer stem cells within 24 hours. The study has significant implications for developing targeted anti-cancer therapies and personalized medicines by targeting cancer stem cells, which are resistant to current treatments.
The research team identified vinculin as critical for maintaining the quiescent properties of hair follicle stem cells. Vinculin's loss leads to weak cell-cell junctions and dysregulated YAP1 pathway, causing increased cell proliferation and loss of quiescence.
Researchers successfully transformed oral epithelial cell rests of Malassez into progenitor stem-like cells, which were then directly differentiated into endothelial, mesenchymal stem, and osteogenic cells. This breakthrough could lead to the development of new periodontal regenerative therapies.
A UCLA-led research team identified a chemical cocktail that enables large numbers of muscle stem cells to be produced within 10 days. The approach shows promise for improving muscle regeneration and could lead to the development of stem cell-based therapies for muscle loss or damage due to injury, age, or disease.
Researchers found that impaired microRNAs, particularly miR-30c, are responsible for the ineffective function of stem cells in diabetic hearts. Increasing miR-30c levels in the heart improves stem cell survival and growth, offering a novel therapy for treating type-2 diabetic heart disease
Researchers successfully grow mouse stem cells into sperm in the body of rats, paving the way for efficient reproduction and future applications.
Researchers have identified a new signaling pathway, LIGHT/LTbR, that is specific to leukemic stem cells and can be targeted to eliminate them. Blocking this pathway has been shown to increase the survival of animals with leukemia.
Researchers at USC are developing a virtual mentor platform, CareerFair.ai, using AI to amplify the effects of STEM mentors. The platform aims to improve retention and diversity in STEM fields by providing students with personalized conversations with real-life professionals.
Researchers at North Carolina State University found that treating mesenchymal stem cells with TGF-β2 reduces the immune response in recipients. This could lead to simplified treatment options for ligament and tendon injuries in horses, as well as potential human therapies.
In mice, blood vessel cells produce factor that stimulates blood stem cells, maintaining their self-renewal capacity. However, production of this factor ceases with aging, leading to loss of self-renewal ability and weakening of the immune system.
Researchers have discovered that two anti-viral enzymes, APOBEC3C and ADAR1, fuel the transition from pre-cancer stem cells to leukemia stem cells. Inhibiting these enzymes with existing medications may help prevent cancer, including leukemia.
Researchers at Inselspital and the University of Bern discovered that metoclopramide inhibits the proliferation of leukemia stem cells, a key target in CML treatment. The study identifies CD93 as a specific regulator responsible for leukemia stem cell growth, paving the way for potential new therapies.
Researchers at the University of New South Wales have created adaptive stem cells, called induced multipotent stem cells (iMS), from human fat. These cells can reprogram to act as stem cells and adapt to their surroundings, repairing a range of damaged tissues in mice.
A mathematical model developed by researchers predicts that autologous gene-edited stem cell transplants could achieve viral control after antiretroviral therapy withdrawal. The conditions required for this include a sufficient dose of edited stem cells and allowing them to repopulate the blood before ART is stopped.
Researchers have discovered that brain stem cells in the hippocampus of mice can divide repeatedly over several months, leading to new insights into the formation of nerve cells. This finding has significant implications for future therapeutic approaches to conditions such as depression and Alzheimer's disease.
New research from the University of Exeter's Living Systems Institute has found that human embryonic stem cells do not acquire cancer-causing mutations when grown in their most primitive state. The study provides a significant breakthrough in understanding the genetic stability of human pluripotent stem cells.
Researchers identified two cell signals that can guide stem cells to repair eye damage, increasing their survival and function after transplantation. The study's findings offer a promising approach to restoring eyesight by modifying stem cells with enhanced chemokine receptors.
Researchers used genome-wide profiling to study the epigenetic landscape of human stem cells, revealing important information about gene regulation. They found differences in chromatin structures between long-term and short-term stem cells, which could improve understanding of cancer cell behavior and stem cell therapy.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue, improving treatment efficacy for neurological disorders. The discovery could expand the use of stem cell therapies to new conditions such as heart disease or arthritis.