Losartan reduces extracellular matrix content and solid stress in ovarian tumors, increasing blood supply and drug delivery. The addition of losartan to chemotherapy agents could improve outcomes for patients with ovarian cancer.
A new study describes a novel approach to suppressing chemotherapy-induced tumor growth and recurrence in ovarian cancer. Researchers developed an anti-inflammatory drug called PTUPB that blocks the release of tumor-promoting chemicals by macrophages.
Researchers discovered that ovarian cancer cells colonize the omentum after being caught in DNA 'webs' extruded by immune cells. Inhibiting NET formation reduces metastasis in mice, suggesting a new approach to limit ovarian cancer spread. This study provides insights into improving ovarian cancer treatment.
A new blood test has been developed to detect early stage ovarian cancer using a bacterial toxin, with the test detecting significant levels of cancer glycan in over 90% of women with stage 1 ovarian cancer. The test also showed 100% accuracy for later stages of the disease and has potential for simple liquid biopsy monitoring.
A new photoacoustic imaging technique may help diagnose ovarian cancer at an early stage, improving survival rates. The technology uses transvaginal ultrasound and co-registered photoacoustic tomography to reveal information about tumor angiogenesis and blood oxygen saturation.
A new study of over 72,000 women found that simple ovarian cysts are normal and extremely common, with no association to a higher risk of ovarian cancer. Simple cysts should be considered normal findings in women of any age and can be safely ignored unless symptomatic.
Researchers at the University of Arizona are working on a disposable falloposcope to detect early-stage ovarian cancer. The device aims to reduce unnecessary procedures and improve patient outcomes by providing accurate screenings for high-risk women.
A University of Guelph study has found that opening up the blood vessels to an ovarian tumour can potentially improve the effectiveness of treatment. By creating a healthy blood supply, the tumour becomes more accessible to treatment, increasing success rates.
A phase 3 SOLO-1 trial found that olaparib maintenance therapy significantly improved progression-free survival (PFS) in newly diagnosed patients with advanced ovarian cancer and a BRCA1 or 2 mutation. The median PFS for those who received olaparib was approximately three years longer than the placebo group.
Researchers found that cancer cells from the fallopian tube affect ovary's chemical signaling, leading to increased norepinephrine levels, which drive cancer cell migration. This study highlights the importance of understanding chemistry in ovarian cancer development and treatment protocols.
Researchers discovered that mutations in the ARID1A gene lead to a molecular switch in the SWI/SNF protein complex, causing an increase in BCL2 expression and promoting tumor cell survival. Inhibiting BCL2 using a small molecule inhibitor kills ovarian cancer cells resistant to EZH2 inhibition.
A recent study published in JAMA Oncology found that low-dose aspirin (100mg or less) reduces the risk of ovarian cancer by 23% compared to non-users. Long-term heavy use of non-aspirin NSAIDs may increase this risk.
A new study found that daily low-dose aspirin use reduces the risk of ovarian cancer by 23 percent. In contrast, heavy use of non-aspirin NSAIDs increases the risk. The research analyzed data from over 200,000 women and confirms earlier findings about aspirin's role in reducing certain types of cancers.
A new study found that exercise minimizes changes in muscle mass, bone density, and belly fat when estrogen levels drop, but does not protect against metabolic changes. Researchers discovered that while exercise reduces the risk of osteoporosis, it does not affect resting metabolic rate or energy balance in women with menopause.
Researchers identified subtle epigenetic differences that explain why some ovarian cancer patients respond to PARPi drugs, while others do not. The study adds to a vital checklist for matching patients with the right therapy for their cancer.
A large study published by The BMJ found that newer combined oral contraceptives are associated with a reduced risk of ovarian cancer in young women. The positive effect strengthens with longer periods of use and persists for several years after stopping, providing reassurance for women.
Research teams identified CT45 as an independent prognostic factor for patients with high-grade serous ovarian cancer. High levels of CT45 were associated with extended disease-free survival, with patients living up to 7.5 years longer than those without sufficient CT45.
Researchers found that rapidly spreading ovarian cancer cells recruit CAFs to accelerate cancer proliferation and spread by enhancing energy sources. Blocking glycogen mobilization could be a therapeutic strategy for reducing tumor dissemination.
Researchers at UVA are developing a new antibody-based approach that combines targeting two receptors on ovarian cancer cells to increase its effectiveness. The approach has shown promising results in lab tests, with antibodies being more than 100 times more effective than existing therapies.
A recent study found that only 8% of disabled or older women who qualified for Medicare received BRCA1 and BRCA2 testing between 2000 and 2014. Women with these mutations are at higher risk for developing second breast cancer and ovarian cancer, making timely testing crucial for informed decision-making.
Researchers found that normal fallopian tubes can contain pre-cancerous cells that escape and later progress to cancer in the pelvic or abdominal cavity. This 'precursor escape' concept may help explain why some women present with advanced ovarian cancer beyond the fallopian tubes.
Researchers at Johns Hopkins and Insilico Medicine discovered novel epigenetically silenced genes in ovarian cancer, including methylation of the GULP1 gene. GULP1 expression is associated with late-stage disease and poor overall survival, suggesting its potential as a biomarker.
Researchers have discovered that women with low-grade serous ovarian cancer and a BRAF gene mutation experience excellent responses to BRAF inhibitor treatments. This finding is encouraging for patients who may not respond to conventional chemotherapy.
A large population study from Denmark found no causal association between assisted reproduction treatment and increased risk of ovarian cancer. Female infertility, rather than ovarian stimulation, was associated with an increased risk of ovarian cancer.
Scientists successfully isolate and grow human follicles to 'biofunctionality' on a bioengineered ovarian scaffold made of decellularized tissue. The breakthrough uses early-stage follicles from patients with frozen ovarian tissue for fertility preservation.
Researchers discovered that the tumor suppressor protein ARID1A controls global transcription in ovarian epithelial cells, regulating a large set of genes. Its loss causes dysregulation of important cell functions, including DNA repair and cell proliferation.
A new $2.2 million federal grant will fund research into genetic factors regulating ovarian reserve, which can impact fertility and reproductive lifespan. The study aims to identify gene variants contributing to ovarian reserve, offering new diagnosis and treatment avenues for fertility problems.
Researchers found a link between calcitriol and reduced ovarian cancer progression by blocking smad signaling in tumor cells and supportive fibroblasts. The study opens a new potential avenue for treating ovarian cancer, with calcitriol already FDA-approved for other uses.
Researchers have successfully replicated ovarian tumors inside chicken eggs, paving the way for patient-centred cancer treatment. The 'chicken egg tumour model' allows for rapid testing of anti-cancer drugs tailored to each patient's needs.
A new clinical trial analysis found that combining an aromatase inhibitor with ovarian function suppression yields a 10-15% improvement in freedom from distant recurrence for high-risk younger breast cancer patients. Women at low risk saw minimal benefit, while those at intermediate risk gained a 4-5% advantage.
The American Cancer Society report highlights a decline in ovarian cancer incidence and mortality rates in the US, with significant reductions seen among white populations. The strongest risk factor for ovarian cancer is a family history of breast or ovarian cancer, with BRCA1 and BRCA2 mutations accounting for nearly 40% of cases.
A cancer patient with advanced ovarian cancer responded well to treatment with hydroxychloroquine and quinacrine, initially prescribed for an autoimmune disease. The case report suggests that repurposing antimalarial drugs may improve cancer outcomes.
A phase II clinical trial suggests patients with aggressive pancreatic cancer who harbor BRCA mutations may benefit from rucaparib, a PARP inhibitor approved for ovarian cancer. The study found 32% of patients experienced a clinical benefit, including four patients with responses and two with stable disease.
Researchers have identified a key protein, MIP-1β, that enables ovarian cancer cells to spread through the peritoneal cavity by making mesothelial cells sticky. This discovery could lead to new therapies targeting this protein and its related adhesion protein P-selectin.
The study shows that ST1-ADC selectively inhibits tumor cell proliferation and induces tumor cell death in both in vitro and in vivo ovarian cancer models. The data provide promising results for the development of new therapeutic options to treat ovarian cancer.
PARP-1 levels are linked to targeted therapy resistance in ovarian cancer. Researchers have developed a method to image and measure PARP-1 using PET scans, which may predict efficacy and resistance to PARP inhibitors.
Researchers found that hemp extract slowed cell migration and reduced inflammation in ovarian cancer cells, suggesting a possible biological mechanism behind its anti-cancer effects. The study's results are comparable to or even better than current ovarian cancer drug Cisplatin, with potential for fewer side effects.
Researchers found tumors with PTEN loss are less likely to generate an immune response, suggesting PTEN levels can predict treatment outcome. The study's findings may improve personalized medicine for BRCA-deficient ovarian cancer patients.
Ludwig scientists present new data on cancers including colorectal, brain, breast, and ovarian cancer, as well as innovative clinical trials and novel approaches to cancer immunotherapy. The research focuses on mobilizing immunity against ovarian cancer and personalizing cancer treatment strategies.
The Rivkin Center awarded $1.185 million to ovarian cancer researchers worldwide, focusing on prevention and early detection, DNA repair, and novel therapies. This funding aims to improve early detection and discover new treatments for the deadly gynecological cancer.
Researchers developed a novel personalized vaccine made from tumor tissue and immune cells, inducing potent immune responses in patients with recurrent ovarian cancer. The vaccine showed promise in extending overall survival and improving progression-free survival.
A new personalized vaccine has shown promise in boosting immune responses and increasing survival rates in patients with advanced ovarian cancer. The vaccine combines different immunotherapies to better tackle the disease, which is often diagnosed at later stages and lacks curative treatment options.
The Translational Genomics Research Institute (TGen) will receive $450,000 to fund a clinical trial for a newly developed ovarian cancer drug treatment, thanks to Colleen's Dream Foundation. The foundation has funded TGen in the past and has awarded over $1.2 million in grants to 27 institutions.
Researchers at Baylor College of Medicine have identified a key regulator of a cellular pathway that selectively targets mutant p53-R175H proteins, which promote ovarian cancer growth. The study suggests designing drugs directed at this regulator might lead to better ways to control cancer growth.
Researchers at The Wistar Institute have found that HDAC inhibitors can suppress proliferation and induce programmed cell death in ovarian cancer cells with ARID1A gene mutations. This new treatment approach has therapeutic potential, slowing tumor growth and improving survival rates in mouse models.
A new study from Virginia Tech found that fluid shear stress causes cancerous cells to become more aggressive and benign cells to exhibit traits of cancer. This discovery could lead to the development of a predictor for ovarian cancer, enabling earlier diagnosis and potentially saving thousands of lives.
Researchers developed a new screening test for endometrial and ovarian cancers using cervical fluid samples from routine Pap tests. The test, called PapSEEK, detected cancer cells in 81% of endometrial and 33% of ovarian cancers, with improved sensitivity when using different sampling methods.
A new mutation on the X-chromosome has been identified as a potential contributor to earlier onset ovarian cancer in women. The study also found an association between this mutation and higher rates of prostate cancer in fathers and sons.
The US Preventive Services Task Force recommends against screening for ovarian cancer in women without symptoms and at low risk. The task force found that the harms of screening, including unnecessary surgery, outweigh its benefits.
Researchers at Mayo Clinic developed a new test that can establish which inherited BRCA2 gene mutations increase the risk of breast or ovarian cancer. The study identified 54 pathogenic mutations and expanded the list of neutral mutations, providing better decision-making options for patients with genetic testing results.
A study found that screening the general population for cancer genes is cost-effective, preventing more breast and ovarian cancers. This approach could lead to thousands fewer cases of these cancers, particularly among women over 30.
Researchers found that population testing for multiple cancer genes is the most cost-effective strategy, preventing many more ovarian and breast cancers than current screening methods. This approach could save thousands of lives by reducing risk factors through enhanced screening, medical prevention, or risk-reducing surgery.
Researchers found that normal tissue BRCA1 methylation is associated with an increased risk of high-grade ovarian cancer, which may occur as a prenatal event. The study analyzed white blood cells from patients and healthy controls and discovered that elevated BRCA1 methylation was confined to those diagnosed with high-grade serous tumors.
Researchers have discovered a key cellular receptor involved in ovarian cancer metastasis, CXCR4, which can be targeted with inhibitors to reduce tumor cell dissemination. High expression of CXCR4 is associated with aggressive variants of the disease.
Researchers found a novel combination of PARP and BET inhibitors to be effective in treating ovarian cancers without BRCA1 and BRCA2 gene mutations. The combination resulted in enhanced sensitivity of cells to cell death, offering potential applications in broadening treatment options for various malignancies.
Belgian researchers have created a new artificial ovary prototype that resembles human ovarian tissue in terms of architecture and rigidity. The fibrin-based design could be used for ovary transplant, providing alternatives for women with infertility or cancer patients unable to conceive after treatment.
Large racial disparities were found in the survival of patients with ovarian, colon, and breast cancers in the United States. Black women had consistently worse survival compared to white women, despite similar stage distributions. The five-year net survival for black women was lower than for white women in all three types of cancer.
A new treatment approach for ovarian cancer has shown promising results in a mouse model. Combining drugs that reactivate dormant genes with those that activate the immune system led to greater tumor reduction and longer survival rates compared to single-drug treatments.
Researchers identified several lncRNAs linked to ovarian cancer, including DNM30S, which correlates with worse survival rates. Targeting these lncRNAs may represent a viable treatment strategy for ovarian cancer.
A study in Malaysia assesses the effectiveness of mainstreaming genetic counselling for ovarian cancer patients. Preliminary results show that most patients are satisfied with their experience, regardless of whether they receive counselling by a trained clinician or a genetic counsellor.