Researchers at Tel Aviv University discovered that tumor cells 'hijack' an inflammatory pathway in the brain to spread melanoma, and blocking this pathway could prevent brain metastases. The study found that inhibiting the expression of a specific receptor on melanoma cells significantly inhibited the development of brain metastases.
Researchers at the University of Cambridge discovered that increasing brain stiffness as we age causes brain stem cell dysfunction. They developed new materials to study this effect, showing that older stem cells can be rejuvenated into younger, healthier states.
Researchers developed a tissue model that mimics blood-brain barrier disruption in Alzheimer's disease, showing how damaged barriers allow harmful molecules to enter the brain. The model also revealed that restoring the blood-brain barrier with certain drugs can slow down neuron cell death.
Researchers found that restful REM sleep helps brain circuits adapt to stress, while restless REM sleep disrupts this process. This finding has significant implications for treating mental disorders such as PTSD, anxiety, depression, and insomnia.
A study led by Dr. Stephanie Kullmann found that exercise improves brain function in overweight and obese individuals by normalizing brain functions important for metabolism and increasing regional blood flow in areas of the brain dependent on dopamine. Participants also reported improvements in mood and executive function.
Researchers found that brain networks are spatially and functionally fluid, with rapid changes in network activity over time. This challenges the long-held assumption that brain regions contribute to each network in a fixed way.
Researchers created a living blood-brain barrier that functions as in the human body, opening new avenues for studying brain disorders and predicting drug effectiveness. The breakthrough uses induced pluripotent stem cells and Organ-Chips technology.
The University of Texas at Arlington has received a DURIP grant to purchase equipment that can determine the severity of brain injuries, even those that are not immediately apparent. The new equipment will be used to expand associate professor Ashfaq Adnan's research in damage detection for blast-related traumatic brain injuries.
Researchers tracked outcomes from 537 people with brain haemorrhage while taking antiplatelet medicines, finding fewer recurrences compared to those who didn't take these treatments. The study suggests treatments may reduce rather than increase risk of further bleeding in the brain.
Studies found that all brain parts process touch signals, complementing each other for perception. Brain network processing information as a single network with partially different functions from situation to situation.
The study identifies a distinct control architecture in brain networks, characterized by a distributed and overlapping control system that enables robustness against targeted attacks and high efficiency in switching between network states. This finding has broad implications for cognitive neuroscience and clinical applications.
Researchers at Yale University successfully restored circulation and cellular activity in a pig's brain four hours after its death using a specially designed chemical solution. However, the treated brain lacked recognizable global electrical signals associated with normal brain function.
Researchers have discovered a new way to measure brain function in milliseconds using MRE, allowing scientists to visualize responses in the brain as they unfold. This breakthrough could help diagnose and understand neurological diseases like Alzheimer's, dementia, and epilepsy.
A new study published in PLOS ONE found that ICU patients with non-brain-related injuries often experience cognitive deficits, despite lack of brain injury. The study used online tests to detect cognitive impairments in 20 patients and revealed significant cognitive deficits in memory, attention, decision-making, and reasoning.
Researchers at the University of Minnesota have developed a 3D-printed transparent skull implant that allows for real-time brain activity monitoring. The device, called See-Shell, provides unprecedented control and precision in studying brain function, enabling new insights into human brain conditions.
A new study suggests that deep brain stimulation boosts the number and strength of mitochondria in brain cells, which may help reduce Parkinson's symptoms. The treatment, used for late-stage Parkinson's disease, involves surgically implanting thin wires into the brain to deliver small electric pulses.
Researchers analyzed brain connectomes to understand healthy brain development and contribute to disorders like epilepsy. The study identified abnormalities in the salience network of subjects with autism, providing insights into the neural basis of autism.
A new study has created a 3D reconstruction of a marmoset brain and mapped neuronal connectivity across the entire brain with unparalleled detail. The resulting data set may offer insights into human neural connectivity and potentially lead to therapeutic advances for human diseases.
Researchers created a high-resolution map of the brain's immune system, showing that all microglia have the same core signature but adapt differently depending on their function. This discovery is significant for understanding brain diseases like multiple sclerosis and Alzheimer's.
A team of scientists has captured a high-resolution, three-day image of the fly brain using expansion plus lattice light-sheet microscopy. The new imaging technique allows for rapid 3D images of brain tissue with details as small as 60 nanometers across.
A new study using brain vital signs technology detected neurophysiological impairments and cognitive processing deficits in ice hockey players with concussions, even those who were cleared for return-to-play. The study also found significant delays in cognitive processing for players without diagnosed concussions.
A large-scale study published in Neurology found a significant link between excessive body fat around the middle and reduced brain volume, specifically lower gray matter volumes. Researchers measured BMI, waist-to-hip ratio, and overall body fat in 9,652 participants and found those with higher ratios had lower brain volume.
The My Brain Robbie campaign aims to fill an educational gap in dementia prevention by providing public health education for children aged 6-12. The project uses an animated video and free resources to teach eight simple steps to keep brains healthy, connecting with modifiable risk factors for cognitive decline.
The endocast of Australopithecus fossil Little Foot shows a brain with asymmetrical structures similar to modern humans, but also features distinct from us, including an expanded visual cortex and reduced parietal association cortex. This suggests that the brain's complexity evolved over time in response to environmental pressures.
A study published in BRAIN journal used a brain wiring diagram to reconcile inconsistent neuroimaging findings for Alzheimer's disease. The researchers found that all 26 studies reported abnormalities within the same connected brain network, improving reproducibility and understanding of the disease.
Researchers developed high-resolution functional ultrasound imaging to study brain activity in awake and behaving mice. They found that out of 181 consistently identified brain regions, 87 were modulated during the optokinetic reflex, a stabilizing eye movement response.
Researchers have developed a tiny device that electrically stimulates the brain, paving the way for minimally invasive treatments for conditions such as epilepsy and Parkinson's disease. The Stentrode can deliver targeted stimulation without open-brain surgery, opening up new possibilities for treating neurological disorders.
Researchers used genetically modified mice with a highly permeable blood-brain barrier to test whether prions in blood can enter the brain. Their results suggest that passage of prions through the blood-brain barrier may not be relevant to disease development. Instead, prions likely reach the brain by traveling along nerves.
The Blue Brain Cell Atlas provides detailed information on major cell types, numbers, and positions in all 737 brain regions, accelerating progress in brain science. The atlas is freely available online, allowing users to visualize brain regions and download data for new analyses and modeling.
Researchers have used magnetoencephalography to measure magnetite levels in the human brain, which could lead to new studies on its role in neurodegenerative diseases. The study found greater accumulation of magnetite in the brains of older individuals, primarily in the hippocampus.
A UCLA cell study has discovered the impact of head injuries on individual cells and genes, leading to serious brain disorders. The researchers found that hundreds of genes are adversely affected by mild traumatic brain injury, which can later lead to diseases such as Alzheimer's and Parkinson's.
A Columbia-led team has been awarded $16.75 million from the BRAIN Initiative to study the primary visual cortex, a region crucial for making sense of visual information. The five-year project aims to bridge the gap in knowledge between theoretical and experimental neuroscience.
Researchers have successfully detected brain tumor DNA in cerebrospinal fluid (CSF) using a cheap and widely available technique, opening up new possibilities for monitoring and treating brain tumors. The test has the potential to increase detection rates and provide more tailored treatment approaches for patients with brain tumors.
The NIH has increased investment in the BRAIN Initiative to over $400 million, supporting more than 200 new awards for cutting-edge brain research. These projects aim to develop new tools and knowledge to discover answers for neurological and neuropsychiatric disorders.
A study published in Nature Communications reveals the nature of immune cells in the human brain, including their location and function. The research provides valuable insights into the immune system's role in brain disorders such as multiple sclerosis and tumors.
A randomized phase III trial found that avoiding the hippocampal region during whole-brain radiotherapy significantly reduces the risk of cognitive decline. The study results have far-reaching implications for brain tumor treatment, offering a safer alternative to traditional whole-brain radiation therapy.
A new radiation treatment approach, hippocampal-avoidance whole-brain radiotherapy with memantine, demonstrated better preservation of cognitive function compared to traditional whole-brain radiotherapy. The study found similar cancer control and overall survival outcomes for both groups.
Researchers have discovered a potentially new approach to deliver therapeutics more effectively to the brain, harnessing the brain's waste removal system. This method could revolutionize the treatment of diseases such as Alzheimer's, Parkinson's, ALS, and brain cancer.
A new study using computational models shows promise in understanding how brain structure impacts performance on language-related tasks. The research found relationships between brain characteristics and task speed, potentially leading to advancements in treating diseases and enhancing human performance.
A new study by Imperial College London reveals that kisspeptin, the master regulator of reproduction, affects brain activity in healthy volunteers, leading to decreased sexual aversion and increased brain activity associated with sexual arousal. The hormone also boosts networks involved in mood and depression.
Researchers found that brain activity patterns during sleep can reveal which memories are stored and which forgotten. The brain reactivates memory traces during certain sleep phases, especially when gamma band activity from deep processing is reactivated during ripples in the hippocampus, leading to later recall of images.
Researchers discovered how the brain encodes speech production, finding that it controls both goals (speech sounds) and individual movements (lip, tongue, and larynx movements). This breakthrough aims to develop better brain machine interfaces to decode speech for paralyzed individuals.
A UCI research team found that brain endothelial cells can engulf and deposit red blood cells outside of blood vessels without a blood vessel tear. This discovery could lead to new efforts to eliminate brain bleeding and its consequences.
Researchers found that re-engaging the brain immediately after injury can help recover from brain damage or stroke faster. The study suggests that other primitive brain regions may be involved in touch perception and that patients could benefit from earlier reintroduction to activities.
A team of researchers developed a new strategy to overcome the blood-brain barrier's limitations in treating brain cancer. By engineering T cells with a 'homing system' molecule, they enabled these cells to cross the barrier and target tumors effectively.
Researchers discover a new type of human brain cell that has never been seen in mice and other laboratory animals. These 'rosehip neurons' may play a role in fine-level control between regions of the human brain, and their absence in rodents suggests difficulties in modeling human brain diseases.
A Northwestern University study found that noninvasive brain stimulation improved the brain's ability to form new memories, with increased excitability lasting at least 24 hours. The research has implications for treating memory problems due to aging or brain damage.
Researchers at Wyss Institute create brain organ chip model, called BBB-Brain Chip system, to study the effects of drugs like methamphetamine on the brain and its blood vessels. The system, which includes linked chips with microfluidic channels, reacts like human brain tissue and shows how cells interact to regulate function.
The Virtual Brain platform will be integrated into the Human Brain Project, enabling researchers to better understand the brain and develop personalized diagnostic and treatment options. This collaboration aims to accelerate adoption of TVB among European researchers and advance brain health throughout lifetimes.
Researchers aim to safeguard fetal brain health in pregnancies complicated by CHD by identifying vulnerable regions and correlating with infant development. Early findings suggest impaired fetal brain growth and metabolism, highlighting the need for interventions during the prenatal period.
Researchers at the University of Guelph have discovered that leopard geckos can create new brain cells using a specific type of stem cell. This finding has implications for treating brain injuries and diseases, as it suggests that geckos may be able to regenerate parts of their brains.
The Virtual Brain neuroinformatics platform is integrating into the EU's Flagship Human Brain Project to promote efficiency and reproducibility in research. The platform will enable researchers to refine computer models, develop efficient simulation technology, and improve study reproducibility.
Researchers have discovered a possible treatment approach for cerebral small vessel disease (SVD), the most common cause of dementia and stroke in older adults. Studies with rats showed that treating SVD can reverse changes in blood vessels in the brain associated with the condition, as well as prevent damage to brain cells.
Researchers have discovered a new fundamental feature of brain oscillations: they actually move rhythmically across the brain, reflecting patterns of neuronal activity that propagate across the cortex. This movement is important for memory and cognition, and may provide a new type of signal for brain-computer interfaces.
A MSU neuroscientist published research that reveals how the brain maintains attentional focus during eye movements, which could lead to new treatments or therapies for some brain disorders. The study's findings may also contribute to the development of screening technologies and targeted behavioral therapies for conditions like autism.
A new, fully implanted deep brain stimulation device uses real-time brain signals to fine-tune its signaling, reducing side effects and improving symptom control in Parkinson's patients. The adaptive system was shown to be equally effective as traditional stimulation methods in initial short-term studies.
Researchers created personalized brain models using The Virtual Brain platform, accurately predicting the effects of tumors on brain connectivity. This breakthrough opens up new possibilities for integrating neuroimaging data with virtual brain modeling to enhance surgical planning.
A novel computational approach has been developed to calculate optimal personalized brain stimulation treatment for Alzheimer's disease. The new framework incorporates patients' MRI scans and physiological brain signaling measurements to identify specific brain regions that would benefit from stimulation.
A Canadian research team has discovered how brain stem cells collaborate to build brain circuits during development. This understanding may lead to new treatments for neurodevelopmental disorders in children. The study also suggests that manipulating these brain-resident stem cells could promote brain repair.
A CAMH study analyzed over 1,000 brain scans to provide new insights into brain networks in people with autism. The personalized brain mapping approach showed that each person's brain has unique differences in network functioning despite sharing the same diagnosis.