A new biomarker, phosphorylated protein kinase LRRK2, has been found in patient urine samples and correlates with the presence and severity of Parkinson's disease. Elevated levels of this biomarker predict the risk for onset of Parkinson's disease and may be a promising guide for future clinical treatments.
Researchers at Johns Hopkins Medicine discovered that blocking the enzyme c-Abl prevents Parkinson's disease symptoms in specially bred mice. The study also found that a chemical tag on the protein α-synuclein may signal the disorder's presence and progression. The findings suggest both a promising target for drug research and a potent...
Researchers at the Babraham Institute have developed a technique to replicate early changes in Alzheimer's disease in a lab-dish model. This breakthrough allows for the study of the disease's progression and potential treatments without animal testing.
A systematic review of 45 studies found that higher whole grain consumption was associated with reduced risks of coronary heart disease, cardiovascular disease, and mortality from various causes. The researchers recommend increasing whole grain intake to reduce chronic disease risk.
By transplanting healthy human glia cells into mice with Huntington's disease, researchers were able to reduce symptoms and slow disease progression. The transplanted cells restored normal neuronal activity and rescued nerve cells at risk of death.
Researchers discovered a novel gene, TMEM230, associated with Parkinson's disease that affects neurotransmitter trafficking between neurons. This new link may lead to novel treatments and better understanding of neurodegenerative diseases.
Researchers found that human activities drive disease distributions at local scales for diseases like West Nile virus and Lyme disease, while climate change impacts regional scales. The study highlights the importance of considering multiple spatial scales to understand human ecological impacts on biodiversity and disease emergence.
A study found that gut bacterial metabolites can accumulate in patients with chronic kidney disease, leading to an increased risk of cardiovascular disease and premature death. The accumulation of phenylacetylglutamine was particularly associated with poor health outcomes.
A recent study found that genetic modifications, such as differential gene expression and alternative splicing, contribute to the development of Parkinson's disease. The research identifies specific genes implicated in the disease, suggesting new avenues for diagnosis and treatment.
A retrospective analysis suggests that regular laxative use can stabilize Parkinson's disease rigidity, pointing to potential modifications in underlying disease processes. Further research is planned to confirm the mechanisms involved.
Researchers at Cincinnati Children's Hospital Medical Center have identified elevated levels of eosinophil progenitor cells in the blood of pediatric patients with active EoE disease. This finding suggests a potential non-invasive biomarker for monitoring disease activity and reducing discomfort, costs, and side effects for patients.
A new study suggests that statins, commonly used to lower cholesterol, can reduce the burden of infection in Lyme disease reservoir hosts, potentially leading to a decrease in human cases. Researchers hope to modify statins to primarily affect the survival of Lyme disease bacteria.
A new study published in Clinical Gastroenterology and Hepatology found that celiac disease is most common among Americans from the Punjab region of India. The study analyzed over 400,000 intestinal biopsies and identified significant differences in celiac disease rates across various ethnic groups.
Non-inflammatory destructive periodontal disease (NIDPD) is a severe destructive periodontal disease marked by generalized gingival recession and periodontal pocket development. The disease's etiology is linked to endogenous opportunistic bacteria, anatomical factors, occlusion pattern, emotional stress, and mouth breathing condition.
Researchers found a common variant in a non-coding RNA that may contribute to intestinal inflammation in people with celiac disease. The study suggests factors outside of protein-coding genes play a role in the development of celiac disease.
Researchers have identified the genetic mutation causing PAAND, a rare inflammatory disease, and found that repurposed anti-arthritis drug anakinra can effectively treat the condition. The treatment was tested on a volunteer from an English family with striking results.
A new US report assesses the massive burden of chronic kidney disease on Medicare, revealing staggering statistics and expensive treatment options. The report aims to inform national healthcare policy and improve care for patients with kidney disease.
A new study has found a strong link between gum disease and increased rates of cognitive decline in people with early stages of Alzheimer's Disease. Periodontitis at baseline was associated with a six-fold increase in the rate of cognitive decline over a six-month follow-up period.
Researchers have identified an effective and safe treatment for Huntington's disease, using IONIS-HTTRx to inhibit huntingtin protein production. The drug has shown promising results in mice and monkeys, with motor skill improvements and reduced cortical huntingtin levels.
Patients with chronic kidney disease and periodontitis have a significantly higher all-cause mortality rate compared to those with chronic kidney disease alone. The study analyzed data from 13,734 participants and found an increased risk of death at 10 years for individuals with both conditions.
Two new studies by Cornell University researchers link warming ocean temperatures to increased disease outbreaks in marine organisms, including lobsters and sea stars. The findings highlight the need for advanced warning systems to prevent disease outbreaks and protect economically important species.
A randomized controlled study published in Annals of Internal Medicine found that providing information about coronary artery disease risk to patients undergoing genetic testing for Alzheimer's disease improved health behaviors and reduced distress. The study suggests that the disclosure of secondary findings from genomic testing can h...
UC Davis researchers discovered an enzyme, LesA, that plays a key role in the bacterial infection of grapevines with Pierce's disease. The enzyme triggers the process causing leaf damage, unrelated to previously thought mechanisms. This finding opens new avenues for understanding and combating the disease.
Scientists successfully analyzed proteins in Lewy bodies of Parkinson's disease patients, revealing β sheet structures and lipid-rich cores that may lead to understanding disease formation. This breakthrough could aid development of epoch-making treatment for the progressive neurodegenerative disorder.
Researchers found an association between weight loss and rapid disease progression in Parkinson's patients. Those who lost weight showed a greater increase in symptoms, while those who gained weight had the smallest annual increase.
Researchers have identified a modifier gene for copper toxicosis in Labradors, which could lead to early detection and treatment of Wilson disease. Mutations in ATP7A protect against hepatic copper accumulation, suggesting antagonistic roles with ATP7B.
The Biogerontology Research Foundation proposes classifying aging as a disease to tackle chronic conditions and attract resources to aging research. The proposed classification system would provide a framework for treating aging as a unique, multisystemic disease, alleviating financial, social, and moral burdens.
Researchers found that people with Alzheimer's who had more physical signs of the disease were also more likely to have psychosis. However, when they looked at those whose autopsies confirmed Alzheimer's, psychosis did not correlate with physical evidence of the disease. Instead, it was linked to vascular risk factors and cerebral inju...
A study found that postmenopausal women with periodontal disease were more likely to develop breast cancer than those without the condition. The risk was particularly high among women who had quit smoking recently, suggesting a potential link between bacterial exposure and breast cancer risk.
A study published in JAMA found that hematopoietic stem cell transplantation does not provide significant improvement for adults with difficult-to-treat Crohn's disease. The treatment was associated with increased toxicity, but no difference in sustained remission rates compared to conventional therapy.
Chagas disease is a life-threatening illness caused by the protozoan Trypanosoma cruzi. In Spain, Latin American migrants are at high risk due to mother-to-child transmission, with an estimated 50,000-70,000 people infected. Screening is crucial to detect heart abnormalities early and prevent sudden cardiac death.
Researchers have identified a simple, non-invasive test to identify patients at risk of chronic kidney disease progression by measuring epidermal growth factor levels in urine. Decreased epidermal growth factor protein is an early sign of diminishing kidney function and pinpoints the at-risk patient population.
A new study found that obese children and those with Non-Alcoholic Fatty Liver Disease (NAFLD) are not meeting the UK's vitamin and mineral guidelines. They are also significantly off meeting the recommended physical activity levels, with excess weight unlikely to be the only factor in NAFLD development.
A consensus report by Mayo Clinic researchers provides a standardized approach to diagnosing glomerulonephritis based on the underlying cause of the disease. This new method aims to improve personalized diagnosis and targeted treatment for patients with kidney disease.
UF Health researchers have discovered four novel proteins that contribute to Huntington's disease by accumulating in the brain and killing neurons. The proteins, known as RAN proteins, are made without a signal in the genetic code and build up as aggregated clusters that lead to cell death.
A study published in Clinical Gastroenterology and Hepatology found that feeding at-risk infants gluten until two years of age increases the risk of developing celiac disease. The research suggests that early gluten intake plays a role in disease course, particularly in children with genetic risk factors for celiac disease.
Researchers have developed a gene therapy approach that delays symptoms and extends lifespan in dogs with a comparable disease to Batten disease. The treatment involves delivering a working version of a gene to produce a key enzyme, resulting in striking clinical improvements and slowed disease progression.
A survey found that only 27% of women can name a woman with heart disease, highlighting the disconnect between widespread cardiovascular disease and personal perceptions. Women are more likely to be concerned about heart health when they know another woman who has experienced it.
Deaths from cardiovascular disease among people with rheumatoid arthritis are declining, according to a new study. Researchers found that efforts to prevent and diagnose heart problems may be paying off for patients with the chronic condition.
The article reviews lessons learned from Alzheimer's disease research to advance the development of screening and diagnostic algorithms for Parkinson's disease. It explores MCI-AD research, clinical trials incorporating biomarkers and genetics, and emerging therapeutic strategies targeting specific biological mechanisms.
Researchers at Columbia University Irving Medical Center analyzed data from 8,846 individuals over 50 years old with celiac disease, finding no increased risk of dementia before or after diagnosis. However, a small increase in vascular dementia was observed in patients with celiac disease.
A blood test that detects Alzheimer's disease presence has shown promise in early detection, allowing patients to make beneficial lifestyle changes to slow or halt disease progression. This discovery provides hope for those affected by the disease, enabling them to take proactive steps before symptoms emerge.
A new study suggests that in-hospital nocturnal dialysis may be beneficial for patients' hearts as well as their kidneys. The procedure was found to reduce left ventricular mass by a significant margin after one year, which is associated with a lower risk of cardiovascular diseases such as heart failure, heart attack, and stroke.
A UTHealth researcher has received a $544,329 CDC grant to develop region-specific educational materials and implement outreach on Chagas disease in South Texas. Approximately 20-30% of infected persons will enter the chronic phase, which can manifest as heart disease or gastrointestinal issues.
Researchers have found that two bile acids, ursodeoxycholic acid and tauroursodeoxycholic acid, can slow the progression of prion disease when given early in the disease process. These compounds bind to proteins causing disease and prevent them from spreading.
A new study has found that children with coeliac disease react to the same key toxic proteins in gluten as adults, suggesting a potential breakthrough in treatments. The research supports the use of existing treatments and diagnostic tests for adults with coeliac disease for children.
Researchers have discovered accumulations of fat droplets in the brains of patients with Alzheimer's disease and found that these abnormal fat deposits could be a trigger for the disease. The study suggests that treating fatty acid production may help prevent or delay the progression of Alzheimer's disease.
A new study by University of California, San Diego researchers has identified a pivotal player in diabetic kidney disease and a potential biomarker for diagnosing and monitoring chronic kidney disease. The study uses metabolomics analysis to clarify a central mechanism of action involving the NADPH oxidase proteins NOX1 and NOX4.
A study published by the American Academy of Neurology found that Alzheimer's disease causes different changes in the brain, or pathologies, in African-Americans compared to white Americans of European descent. African-Americans were more likely to have mixed pathologies and blood vessel disease in their brains.
Certain ECG measures can identify individuals with chronic kidney disease at high risk of dying from heart disease. A panel of 5 common ECG parameters was found to enhance prediction of cardiovascular death in this population, suggesting potential novel interventions to prevent cardiovascular complications.
Researchers analyzed large genome-wide association studies of migraine and heart disease to find no shared gene variants between the two conditions. Instead, genetic variations that protected against heart disease were found in people with migraine without aura.
Scientists develop synthetic prions to study prion disease, demonstrating similarity with natural disease-causing prions. The researchers also explore the transmission capabilities of human prion mutations in mice, revealing the importance of expressing mutant human PrP for infection.
Researchers found that patients who had undergone vagotomy were protected against developing Parkinson's disease, with a risk halved after 20 years. The study suggests that Parkinson's disease begins in the gut and spreads via the vagus nerve to the brain.
Researchers at the University of Veterinary Medicine in Vienna have discovered a new case of koi sleepy disease in Austria, which is believed to originate from Asia. The virus causes symptoms such as sunken eyes and swollen gills in infected fish.
A study found that RA patients with moderate disease activity are at risk of needing joint surgery, challenging existing treatment guidelines. The findings suggest updating disease activity cut-off points to allow moderate-disease-activity patients to receive biologics.
A specialized PET tracer has been developed to visualize the function of nerve cells that lead to neuronal loss and cognitive decline in neurodegenerative diseases. The tracer binds to a transporter of the neurotransmitter acetylcholine, allowing for the quantification of cholinergic neuron loss and its effects on cognition.
According to research published in the Heart journal, cancer has overtaken cardiovascular disease as the primary cause of death in men, but not among women. Cardiovascular disease remains the leading cause of death among women.
A large study found that people with depression were 3.2 times more likely to develop Parkinson's disease within a year after diagnosis. The link between depression and Parkinson's disease remained even when adjusting for other conditions related to depression.
A large study found that people with depression are more likely to develop Parkinson's disease, with a threefold increased risk within the first year. The link between depression and Parkinson's disease holds true even after adjusting for other related conditions.
A nationwide sample of patients in Sweden with biopsy-certified celiac disease were examined to identify the risk of developing neuropathy. The study found a significant association between celiac disease and an increased risk of neuropathy, with absolute risks of 64 per 100,000 person-years for those with celiac disease.