A recent study published in the Journal of Clinical Endocrinology & Metabolism found that higher levels of testosterone were associated with reduced loss of lean muscle mass in older men. Higher testosterone levels were also linked to less loss of lower body strength, particularly in those who were losing weight.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found a link between shift work and increased cortisol levels. This association was discovered in individuals working shifts at a young age and may contribute to cardiovascular risk.
A new study published in American Journal of Physiology and Endocrinology Metabolism found that mice born to mothers on a high-fat diet before and during pregnancy have higher fat mass and smaller livers. Switching to low-fat diet reduces risk, according to researchers at Oregon Health & Science University.
A study by UC Davis researchers found biological indicators of toxic fat cells in those with metabolic syndrome, which may lead to diabetes and cardiovascular disease. The discovery supports a new high-risk obesity category for these conditions.
Researchers at the University of Houston discovered the potential for estrogen hormone compounds to prevent colon cancer by activating estrogen receptors. They also identified a key gene involved in breast cancer tumor cell growth, opening new opportunities for targeted therapeutics.
Researchers at York University have identified a protein called nesfatin-1 that stimulates insulin secretion and regulates appetite, leading to potential weight loss and improved blood sugar control. The study found that rats administered with nesfatin-1 ate less, used more stored fat and became more active.
Researchers propose a new field of microbial endocrinology linking probiotics to neurological function. Studies show that neurochemicals produced by gut microbes can influence behavior and immune response. Probiotic intestinal microbiota may deliver beneficial effects through direct uptake from the gut.
A recent study published in the Journal of Clinical Endocrinology & Metabolism found that BMC conducts a high rate of thyroid function testing in pregnant women. The study detected approximately 80 percent of cases of mild hypothyroidism that may have gone undiagnosed without routine testing.
Michael F. Holick, a renowned expert in vitamin D and skin research, has been awarded The Delbert A. Fisher Research Scholar Award from the Endocrine Society. He received this honor for his groundbreaking contributions to understanding the history of endocrinology.
A Mayo Clinic study has found that a mutant gene thought to accelerate tumor growth actually inhibits the spread of malignant cells, showing promise for novel cancer therapies. The PAX8/PPARγ fusion protein functions as a tumor suppressor by upregulating anti-tumor agents.
Researchers at Baylor College of Medicine found that a natural product called DLPC stimulates LRH-1 activity, improving regulation of glucose and fat within the liver. In mice with insulin resistance, DLPC decreased fatty livers and lowered glucose levels, suggesting it may provide a treatment for prediabetes.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that higher metabolic rates are associated with early natural mortality, indicating potential acceleration of aging. Higher energy expenditure was linked to increased risk of organ damage and accumulation of toxic substances.
A recent survey conducted by the American College of Endocrinology found that over half of individuals with type 2 diabetes have experienced low blood sugar, often during daily activities. The study highlights the need for increased education on blood sugar management and symptom recognition to prevent serious consequences.
A recent study found that mice with low ghrelin levels in their mothers experienced impaired uterine development, leading to reduced fertility. Female children of obese women may be more likely to struggle with reproductive issues as adults.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that individuals with fatty liver were significantly more likely to develop type 2 diabetes than those without. Fatty liver was shown to be an independent risk factor for type 2 diabetes, regardless of insulin resistance levels.
A recent study found that maternal fructose consumption during pregnancy results in sex-specific changes in fetal and neonatal endocrinology, with female fetuses showing higher leptin and blood glucose levels. Male offspring also exhibit increased plasma fructose levels and hypoinisulinemia.
Researchers found that people taking bisphosphonates lived longer than those without osteoporosis and even gained an extra five years of life. The study, published in the Journal of Clinical Endocrinology and Metabolism, suggests a possible link between bone health and toxic metal release.
Women with polycystic ovary syndrome (PCOS) have aberrations in their fat tissue that can lead to insulin resistance and increase the risk of developing type 2 diabetes. The study, published in The Journal of Clinical Endocrinology and Metabolism, found that large fat cells and low levels of adiponectin are strongly associated with ins...
Researchers at the NIH have identified a compound that prevents overproduction of thyroid hormone, potentially improving treatment for Graves' disease. The receptor antagonist has not yet been tested in animals or people and still needs to undergo safety testing before potential human trials.
Gökhan S. Hotamisligil, a Harvard expert on inflammation and obesity, received the 2010 Naomi Berrie Award from Columbia University Medical Center. His work focuses on the molecular basis of links between obesity, diabetes, and heart disease.
A new study found that higher baseline leptin and lower ghrelin plasma levels before dieting may predict weight regain in individuals. The research suggests that personalized weight-loss programs targeting appetite hormones could improve long-term success rates.
A new study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that high levels of the stress hormone cortisol are strongly associated with an increased risk of cardiovascular death among both healthy individuals and those with pre-existing cardiovascular disease. The study, which evaluated ov...
The Endocrine Society recommends that every newborn be screened for CAH, and positive results be followed up with confirmatory tests. The guideline also outlines treatment recommendations, including minimizing glucocorticoid dosage and considering patients' quality of life.
A study conducted by University at Buffalo researchers found that resveratrol suppressed the generation of free radicals and reduced inflammation in human blood samples. The compound also showed promise in reducing insulin resistance and related markers, potentially benefiting conditions like type 2 diabetes and heart disease.
A single stimulatory molecule has been found to sustain human insulin-producing cell replication in a mouse model of diabetes, indicating potential treatment options for the condition.
A new study reveals that male sex hormones play a crucial role in regulating female fertility by controlling follicle growth and development. The research suggests that irregular levels of these hormones can lead to infertility, especially in women with polycystic ovarian syndrome.
A new study published in the Journal of Clinical Endocrinology & Metabolism found that long-term elite rhythmic gymnastics significantly improves bone health in adolescent girls. The research measured volumetric bone density and bone geometry, showing increased cortical thickness and bone strength.
A recent study published in the Journal of Clinical Endocrinology Metabolism found that modest weight loss can reverse many of the damaging changes seen in immune cells of obese people. This reversal is achieved through an 80% reduction of pro-inflammatory T-helper cells and reduced activation of other circulating immune cells.
A recent study published in The Journal of Clinical Endocrinology & Metabolism found that women with type 2 diabetes who take thiazolidinediones are at a higher risk for developing bone fractures. Women over 65 years old were shown to be particularly susceptible, with a 50% increased risk after one year of treatment.
A recent study published in Reproductive Biology and Endocrinology found that sperm from men with non-obstructive azoospermia are equally capable of producing embryos through intracytoplasmic sperm injection (ICSI). The study also showed that there were no significant differences in implantation rates or clinical pregnancy rates betwee...
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that eating quickly can lead to overeating by curbing the release of hormones that signal fullness. Researchers discovered that subjects who took their time consuming a meal had higher concentrations of appetite-regulating hormones,...
Sarah DuRant, a Virginia Tech doctoral student, has received two national awards for her research with wood ducks. Her work explores the effects of slight changes in incubation temperature on early growth and stress endocrinology in wood ducklings. This novel approach reveals profound impacts on the health of baby birds after hatching.
Researchers at Stanford University School of Medicine have identified a cellular mechanism that causes lupus-like symptoms in mice. The study found that macrophages play a crucial role in disposing of dying cells, and a specific molecule called PPAR-delta helps regulate this process.
Researchers at UT Southwestern Medical Center have found that the brain plays a vital role in mediating resveratrol's anti-diabetic actions. When injected into the brain, resveratrol alleviated inflammation and activated sirtuin proteins, which may help prevent diet-induced diabetes.
Researchers at Duke University have found a new mechanism of bone formation that works without inducing bone breakdown, suggesting a targeted approach to fighting osteoporosis and other degenerative bone diseases. The discovery involves the G-protein coupled receptor (GPCR) pathway and beta-arrestin molecule.
A new study found that South Asians are more likely to develop insulin resistance and type 2 diabetes due to their body composition, specifically higher total body fat and lower muscle mass. Researchers measured insulin levels in four ethnic groups and discovered a strong association between body fat distribution and diabetes risk.
A new study found that resveratrol improves diabetes by targeting the brain, potentially leading to orally-delivered medications. Activating sirtuins in the brain mediates resveratrol's beneficial effects, which could lead to more effective targeted diabetes treatments.
New research shows that daily fluctuations in glucocorticoids directly synchronize the biological clock and regulate blood sugar levels. This finding may help doctors reduce debilitating side effects of glucocorticoid drugs and aid diabetics in controlling their blood sugar levels.
Recent findings published online first in Cancer Research show that obesity is associated with increased incidence and mortality of leukemia in children. The study reveals that fat cells can block chemotherapy drugs from reaching cancerous cells, leading to reduced treatment effectiveness.
Researchers at UT Southwestern Medical Center used magnetic resonance spectroscopy (MRS) to measure pancreatic fat in humans, finding a significant correlation between fat content and diabetes risk. The study suggests that measuring pancreatic fat could be an effective clinical tool for identifying high-risk individuals.
Researchers have identified SHP-2 as a crucial mediator of insulin-like growth factors' effects on stimulating placental growth. This discovery may lead to new treatments for growth restriction of babies in the womb, improving their health outcomes.
A partnership between MU and state organizations provides medical interpreters to LEP patients, improving communication and reducing costs. The program aims to increase access to quality care and reduce misdiagnoses.
A new study reveals that the absence of angiotensin II receptors in the uteri of pregnant women with preeclampsia contributes to the disease's progression. This finding brings researchers closer to understanding the condition and may lead to new treatments.
A new study published in Annals of Epidemiology found that the waist-to-hip circumference ratio was a better indicator of obesity in high-functioning adults over 70 than BMI. The research also showed a significant link between increased waist size and higher mortality risk in both men and women.
A new study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that adolescent and young children of obese mothers who underwent weight-loss surgery prior to pregnancy have a lower prevalence of obesity and improved cardio-metabolic markers. The research suggests that the intrauterine environment ...
A 12-week moderate aerobic exercise program improved insulin sensitivity in both lean and obese sedentary adolescents, increasing fitness without the need for weight loss. The study suggests an aerobic program like this could be a useful tool in preventing obesity-related illnesses.
A study found that CD14 rs2569190/C-159T gene variants are associated with the formation of portal lymphoid aggregates in chronic hepatitis C patients. These aggregates were also correlated with moderate and severe hepatic inflammation, but not with fibrosis progression.
A new study found that short sleep times may contribute to insulin resistance and reduced glucose tolerance, increasing the long-term risk of diabetes. The research suggests a healthy lifestyle should include adequate sleep, healthy eating habits, and physical activity to prevent diabetes.
Researchers identified a substance in the liver that helps process fat and glucose, which is also a component of the common food additive lecithin. Lecithin products may one day be used to control blood lipids and reduce risk for diabetes, hypertension or cardiovascular disease
Researchers identified a novel strategy to inhibit the hedgehog (Hh) signaling pathway, which is involved in various physiological processes but also stimulates cancer development. By activating the liver X receptor (LXR), they were able to block tumor cell growth and prevent cancer formation in animal studies.
Ben-Gurion University researchers have identified a key signaling pathway in intra-abdominal fat that contributes to obesity-related disorders. The study found that this pathway is activated in response to fat accumulation in the abdomen, correlating with increased cardio-metabolic risk and whole-body insulin resistance.
A team of scientists at Children's Hospital of Pittsburgh UPMC has discovered an enzyme crucial for maintaining a robust immune system into old age. The study found that the novel mouse model has a thymus that remains intact throughout its life.
A new study found that estrogen action through GPR30 promotes breast tumor cell survival, rather than growth, and activates integrin α5β1 to create a provisional extracellular matrix. This suggests that targeting GPR30 may be an important step in controlling ER-positive breast cancer.
An Australian study found that daily sex for seven days reduces sperm DNA damage and improves fertility in men with high DNA fragmentation. Men who ejaculated daily showed a significant decrease in DNA damage and an increase in good-quality sperm.
A new study found that inhaled growth hormone is well-tolerated by children with growth hormone deficiency and can safely deliver the medication to their bloodstream over a one-week period. The inhaler was preferred over traditional injections, which can be painful and difficult to administer.
The glucose challenge test is an accurate, convenient, and inexpensive way to screen the general population for unrecognized diabetes and prediabetes. The study screened 1,573 participants and found that 4.6% had previously unrecognized diabetes and 18.7% had prediabetes.
A new study from Tel Aviv University shows that high glycemic index foods, such as cornflakes and white bread, can cause sudden expansion of artery walls, leading to reduced elasticity and increased heart disease risk. The research provides a new mechanism for understanding how these foods affect the progression of heart disease.
A study presented at ENDO 2009 found that ghrelin infusions increased calorie intake by 51% in older women with frailty, improving growth hormone levels and overall health outcomes. Larger follow-up studies will investigate the therapeutic potential of ghrelin or mimetic agents for this population.
A new study finds that blocking the muscle growth-limiting hormone myostatin can decrease body fat and promote resistance to atherosclerosis in mice. The results show significant reductions in obesity-related biomarkers, including fasting blood sugar, insulin levels, and cholesterol levels.
Researchers found that nicotine promotes insulin resistance, raising blood sugar levels higher than normal. This condition increases the risk of cardiovascular disease in smokers.