An international team of researchers found that destructive quantum interference suppresses transition between superdeformed and spherical ground states in calcium-40 nuclei. This work may help explain nucleosynthesis processes and the remarkable stability of magic nuclei.
The study found that mice lacking both Runx1 and Runx2 in CAR cells showed a significant reduction of HSPCs and immune cells, along with an increase in fibrosis. The researchers suggest that Runx1 and Runx2 may be potential targets for the diagnosis and treatment of myelofibrosis.
Researchers found that infants can punish antisocial behavior exhibited by a third party, indicating an intrinsic motivation for morality. The study's findings suggest that humans may have acquired behavioral tendencies toward moral behavior during evolution.
Scientists at Osaka University have invented a flexible sheet sensor that can detect changes in water temperature and presence of contaminants without disrupting the flow. The technology uses an embedded carbon nanotube film as a photodetector layer, enabling continuous monitoring and non-disruptive sampling.
A study by Osaka University found that fat accumulation in liver tumors can predict patient response to immunotherapy. The researchers identified a unique tumor immune microenvironment, known as steatotic HCC, which is associated with high infiltration of immune cells but exhaustion of nearby T cells.
A study published in Age and Ageing found that modifying lifestyle behaviors can have a marked effect on lifespan, particularly among older adults and those with chronic conditions. Adopting five or more healthy habits increased life expectancy by up to 6 years for healthy 40-year-olds.
Researchers from Osaka University have discovered that mesenchymal stem cells can prevent the onset of type 1 diabetes associated with immune checkpoint cancer therapy. MSCs secrete factors that protect pancreatic cells against immune attack, suggesting a new approach to preventing this debilitating side effect.
Researchers at Osaka University used silicon nanoparticles to visualize the coalescence of quantized vortices in superfluid helium. This technique enables better understanding of quantum fluids and materials, including superconductors. The study also opens up new possibilities for optical research on other quantum properties.
Scientists at Osaka University created 3D human stem cell-derived lacrimal gland organoids that mimic the human tear duct. The organoids exhibited organization and branching patterns characteristic of the human lacrimal gland, demonstrating potential as a platform for regenerative therapies for dry eye syndrome.
Researchers from Osaka University have developed an engineered ACE2 decoy that effectively reduces the rate and severity of infection with the Omicron variant under laboratory conditions. The decoy mimics the SARS-CoV-2 receptor, preventing the virus from binding to cells and entering them.
Osaka University researchers have created a nanocellulose paper semiconductor with 3D network structures that can be tuned for use in various sustainable electronic devices. The treatment process allows for heat-induced conductivity without damaging the nanostructure, enabling flexible macro-scale structures and detailed designs.
Researchers from Osaka University proposed a comprehensive ethical framework and practical guidance for communicating with research participants through the Internet. The framework addresses issues such as participant recruitment, informed consent, and data protection, aiming to improve future practice in medical research.
A study by Osaka University researchers reveals patients waited years for diagnosis of rare diseases like hereditary angioedema. Long diagnostic delays can be fatal, and raising awareness is key to improving treatment.
A team of researchers from Osaka University and Kyoto University developed a stem cell-based biomaterial, hiPS-Cart, to treat IVD degeneration and prevent further deterioration. The biomaterial was able to survive and maintain its functionality in lab rats with NP removal, reversing IVF and vertebral bone degeneration.
Researchers from Osaka University engineered microorganisms to use light as an external energy source, accelerating biomanufacturing of target compounds without disrupting the host microorganism's natural metabolism. This approach has the potential to increase efficiency and reduce carbon emissions in bioprocesses.
Researchers at Osaka University and National Research Council Canada create a gallium arsenide quantum dot that can trap individual electrons. The development could help advance the field of quantum networks by efficiently converting photons into electron spins.
A team of researchers from Osaka University successfully established a mouse model that can reproduce the severe and persistent cough of pertussis. They found that pertussis toxin, Vag8, and lipooligosaccharide are key bacterial factors involved in inducing coughing, which ultimately leads to bradykinin and TRPV1 signaling.
Scientists at Osaka University developed a new numerical technique to visualize heat flux at the atomic scale for the first time. The team found that sub-atomic stresses in solid and liquid structures determine the direction of heat flux, enabling more efficient nanoscale manufacturing.
Researchers from Osaka University discovered a group of brain cells in the claustrum that control stress-induced anxiety behaviors. Activating these cells led to anxious behavior, while deactivating them increased resilience against chronic stress.
Scientists have developed a new technology to decode brain activity and infer the meaning of a person's mental picture. The study used electrocorticogram to detect patterns in brain activity while patients imagined different images, revealing distinct representations for each concept. This breakthrough could lead to the development of ...
A study published in Frontiers in Microbiology has found that machine learning analysis of microscopy images can be used to identify bacteria resistant to antibiotics. Researchers discovered that shape changes in bacterial cells can predict drug resistance, suggesting a new approach for detecting and predicting drug resistance.
A study by Osaka University investigated the relationship between autophagy and metabolism during fasting. Autophagy was found to play a key role in promoting fat loss during fasting, particularly through the upregulation of adipogenic genes. The findings may have important implications for understanding metabolism during aging.
Treatment with an antibody to repulsive guidance molecule-a (RGMa) prevents disease-associated signaling processes and reduces symptoms of neuromyelitis optica in rats. This discovery suggests that anti-RGMa antibodies may represent an effective therapeutic strategy for NMO-associated neuropathic pain and motor deficits.
Researchers from Osaka University discovered that MondoA protein delays cellular senescence by activating autophagy, promoting longevity. Activation of MondoA also maintains mitochondrial stability, preventing senescence in tissues like the kidney.
Researchers from Osaka University report a new technique for tracking the synthesis of core–shell bimetallic nanoparticles in real time, allowing for fine-tuning of nanomaterial preparation. The technique uses a piezoelectric resonator to monitor particle shape changes and track interdiffusion of metals.
A zirconium oxide-supported platinum-molybdenum catalyst enables the selective conversion of esters into valuable unsymmetrical ethers under mild conditions. This process offers a sustainable solution for producing these compounds from renewable biomass-derived materials, reducing waste and energy consumption.
Researchers at Osaka University used advanced microscopy to visualize extracellular vesicles secreted by osteoblasts, identifying a subset that limits bone formation and stimulates osteoclast differentiation. This finding could lead to new treatments for bone diseases.
Researchers at Osaka University identified a new monoclonal antibody target, R8H283, which selectively binds to cancer-specific conformational epitopes on the ubiquitous CD98 heavy chain protein in multiple myeloma cells. This selective binding allows for anti-MM effects without damaging normal host cells.
Researchers at Osaka University have successfully accelerated energetic ions using graphene targets irradiated with ultra-intense lasers, overcoming previous limitations. The findings demonstrate the robustness of graphene in this application and pave the way for compact and efficient plasma-based accelerators.
A team of researchers at Osaka University created a thermocouple made of gold and platinum nanowires to measure the temperature directly next to a nanopore. They found that thermal energy was dissipated in proportion to the momentum of the ionic flow, in line with Ohm's law predictions.
Scientists at Osaka University demonstrated the ability to generate gigagauss magnetic fields via gyro motion of relativistic electrons, with polarity reverse occurring instantly. The study, published in Scientific Reports, reveals a new mechanism for magnetic field growth and amplification.
Researchers from Osaka University created patient-derived heart cells that exhibit reduced contractility and impaired desmosome assembly when carrying a mutation associated with arrhythmogenic cardiomyopathy. Replacing the mutated gene restored normal function, suggesting a potential treatment approach for this disease.
Scientists at Osaka University have successfully manipulated nanoparticles suspended in superfluid helium using optical tweezers, opening the way for new cryogenic applications and potential visualization or control of vortices. The research may help better understand interactions between quantum fluids and classical nanomaterials.
Researchers at Osaka University have made a breakthrough in understanding the molecular mechanisms behind Intrahepatic cholangiocarcinoma (ICC), a deadly form of liver cancer. By identifying TRAF3 and NIK as key players, they have uncovered potential therapeutic targets for novel ICC treatment.
A recent study published in Science Translational Medicine identified a novel causative gene, BAG5, for dilated cardiomyopathy, a leading cause of heart failure. The researchers found that mutations in this gene can lead to cardiomyopathy and found a potential treatment alternative using adeno-associated viruses (AAV) gene therapy.
Osaka University researchers have developed a highly active and durable metal-phosphide catalyst for the deoxygenation of sulfoxides. The catalyst shows wide substrate applicability and can deoxygenate structurally complex drug intermediates in high yields.
A team of researchers from Osaka University has developed a simple system based on electrochemical reactions that can perform complex calculations. The system uses polyoxometalate molecules and deionized water to process information and solve nonlinear problems.
A study published in Leukemia found that cord blood transplantation (CBT) was more effective than matched related donor transplantation (MRDT) for patients with refractory and relapsed acute myeloid leukemia (R/R AML). The study compared the survival rates of 1,738 CBT-treated patients with those of 713 MRDT-treated patients, revealing...
A study published in Annals of the Rheumatic Diseases found that crAss-like phages, a component of the gut virome, are less abundant in individuals with autoimmune diseases. This discovery may lead to the development of targeted therapies to manage autoimmune conditions.
A team built a virtual reality system to study the search behavior of male silkmoths, revealing that accurate information from multiple modalities increases success rate. The system also showed a modulation of behavior based on environmental complexity.
A research team at Osaka University successfully generated megatesla magnetic fields through three-dimensional particle simulations on laser-matter interaction. The strength of MT magnetic fields is significantly stronger than geomagnetism, enabling laboratory experiments that were previously thought impossible.
A comprehensive genomic analysis reveals the genetic basis of neuroendocrine carcinoma of the gastrointestinal system, a rare cancer that is highly resistant to treatment. The study identifies key biological processes underlying the development of the disease, including structural variants, methylation events, and gene fusions.
A new method measures glomerular filtration rate using D-serine clearance, showing strong correlation with GFR and lower bias than creatinine clearance. This could improve clinical practice and reduce dialysis patients.
Researchers from Osaka University have successfully grown high-quality magnetite thin films on a hexagonal boron nitride substrate without compromising the film's properties. This breakthrough enables the development of flexible spintronics devices with preserved electronic and magnetic properties.
A Japanese study found that a robot's physical texture, such as softness or elasticity, affects perceptions of its personality. The researchers used six humanoid robots with varying arm textures and asked participants to touch and evaluate them.
A study published in eLife reveals that a small signalling protein called ARL4C is overexpressed in pancreatic cancer patients, facilitating their aggressive behavior. By inhibiting ARL4C, researchers have shown promise in reducing the spread of pancreatic cancer cells, opening up new therapeutic avenues.
A team at Osaka University has initiated the world's first in-human investigator-initiated clinical trial of sodium astatine ([ <sup> 211 </sup> At]NaAt) injection for refractory differentiated thyroid cancer patients. The phase I trial evaluates safety, pharmacokinetics, and efficacy of astatine for use in alpha therapy.
Researchers from Osaka University found that over half of intensive care workers experienced moral distress during the pandemic due to limited communication with patients and families. Virtual communication and psychological support were identified as potential solutions to prevent burnout and ensure proper medical care.
Osaka University researchers developed an ultra-thin film of magnetite with superior crystallinity and conductive properties, overcoming challenges in spintronics technology. The discovery enables the film to undergo a temperature-dependent resistivity change, crucial for implementation in quantum computing technologies.
Osaka University researchers have successfully synthesized a stable, crystalline nanographene with predicted magnetic properties, opening the door to revolutionary advances in electronics and magnets. The breakthrough uses a simplified model system called triangulene, which has long been elusive due to polymerization issues.