Articles tagged with Clinical Studies
A recent MRI study by the CNIC has established reference values for anatomical and functional parameters in adolescents' hearts, providing a crucial resource for clinical practice. The study involved 123 adolescents and aimed to fill the knowledge gap on 'normal' cardiac parameter values in this age group.
The BIAL Award in Biomedicine is a prestigious international award that recognises outstanding biomedical research. The €300,000 prize is given to researchers whose work has shown exceptional quality and scientific relevance, published within the last ten years.
Recent findings in spina bifida (SB) care highlight comorbidities such as autism and scoliosis, as well as the impact of COVID-19 on healthcare use. Telecommunication platforms like Zoom have evolved into clinical tools for SB care.
Researchers found that doxycycline postexposure prophylaxis did not prevent chlamydia or gonorrhea among cisgender women in a clinical trial. The lack of efficacy was attributed to differences in anatomy and antibiotic resistance.
A recent clinical study reveals a correlation between low intracranial pressure and impaired patient visibility, especially in the nasal zone. Higher translaminar pressure difference is estimated as a risk factor for normal tension glaucoma development.
Researchers have developed a tool to predict females' heart response to medications using male data, aiming to prevent deaths from drug-induced complications. The tool uses regression-based models to analyze differences in heart physiology between males and females.
Ultrafast MRI provides beneficial information for predicting DCIS upgrade to invasive cancer, including time to enhancement and lesion size. A study found that UF-MRI can accurately predict lesions diagnosed as DCIS at percutaneous biopsy that will be upgraded to invasive cancer at surgery.
A team of biostatisticians created a framework to evaluate the congruence and discordance of laboratory animals with specific human diseases. The tool removes bias from scientific interpretation of animal data for human conditions, revealing that some models mimic biological mechanisms well while others poorly.
French researchers found that human and organizational factors negatively impact clinical decision support system use, whereas technological factors have a neutral effect. Despite benefits, PCPs report decreased efficiency due to increased workload, highlighting the need for developers to address these issues.
A new study found that the antibody-drug conjugate STRO-001 showed nanomolar cytotoxicity in 88% of cancer cell lines tested, with potent efficacy against proliferating B cells. The research supports ongoing clinical studies for patients with B-cell non-Hodgkin lymphoma.
Researchers at Texas A&M University are testing Raman spectroscopy as a diagnostic tool for Lyme disease, which shows promise in accurately identifying infected individuals. The new test could improve Lyme disease diagnosis and treatment outcomes for both humans and animals.
A new AI tool developed by Brigham and Women's Hospital improves the accuracy of time-critical pathology diagnostics during surgery. The tool, which leverages deep-learning technology, translates frozen tissue samples into high-quality images, increasing diagnostic accuracy and reducing the need for lengthy laboratory tests.
A review of 75 publications found significant knowledge gaps on health inequities affecting the LGBTQ+ community and minority groups, including American Indian and Alaska Native individuals. The study emphasizes the importance of investigating barriers to clinical studies and medical trainee recruitment in under-resourced areas.
Researchers have developed a new X-ray technology that visualizes lung tissue microstructure, providing additional information for accurate diagnosis. Dark-field X-ray images can differentiate between diseased and healthy lung tissue, potentially replacing computed tomography (CT) for repeated examinations.
The study aims to assess the effectiveness of recombinant Factor VIIa (rFVIIa) in decreasing bleeding in the brain of patients with intracerebral hemorrhage (ICH). ICH is a deadly stroke type with no effective treatment, and this trial seeks to improve outcomes.
Research conducted at Linköping University found that screening for atrial fibrillation in older people could increase the chance of preventing stroke while saving money for healthcare systems. The study, based on data from the STROKESTOP clinical trial, suggests that screening can be a cost-effective intervention.
A survey study of 151,000 students found that e-cigarette users were more likely to initiate tobacco use within minutes of waking. This increase in intensity and addiction is a concern, emphasizing the need for clinicians to address youth nicotine addiction during clinical encounters.
Researchers at Kyoto University have developed a prodrug form of curcumin called TBP1901, which has shown anti-tumor effects without causing harm. The study found that TBP1901's conversion to active curcumin is dependent on the enzyme GUSB, suggesting its potential therapeutic targets.
The University of Minnesota is leading a comprehensive global clinical study to reveal the functional effects of vagus nerve stimulation (VNS) across the human body. The $21M REVEAL project aims to assess autonomic, cardiovascular, metabolic, immune, and gastrointestinal function in response to VNS parameters.
The NCI-MATCH precision medicine cancer trial found a promising signal for the AKT inhibitor ipatasertib, meeting its primary endpoint with a 22% response rate in patients with rare AKT1 E17K tumor gene mutations. The study demonstrated clinically significant activity in patients, warranting additional studies.
A study of obese women on the 'warrior diet' found no significant change in sex-binding globulin hormone levels but a moderate drop in dehydroepiandrosterone (DHEA) levels, linked to reduced breast cancer risk. Women also experienced weight loss and improved insulin resistance.
Researchers analyzed 408 patients receiving immune checkpoint inhibitor therapy and found no increased risk of side effects from receiving both immunotherapy and the vaccine. The study supports NCCN's recommendations for COVID-19 vaccination in people with cancer, citing strong protection against severe COVID-19 for all variants.
A new Danish-led study has demonstrated a way to strengthen the body's own ability to fight HIV, even when standard treatment is paused. The study found that monoclonal antibodies and Romidepsin can help the immune system recognize and kill infected cells.
Research institutes from Finland, Germany, Norway, Spain, and Sweden have launched the Federated European Genome-phenome Archive (Federated EGA) to improve data sharing across national borders. The new platform enables secure access to sensitive human data for research while respecting national data protection regulations.
A phase 3 study shows that tumour-infiltrating lymphocytes (TIL) therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma. The treatment reduces disease progression or death by 50% in patients treated with TILs.
A study published in JAMA Internal Medicine found that COVID-19-associated hospitalizations among unvaccinated adults were significantly higher than those with booster doses. The study suggests continued vaccination efforts for eligible persons to mitigate hospitalization rates.
A new study has successfully predicted ovarian cancer in patients with a pelvic mass using a simple blood test. The liquid biopsy technology captures circulating tumor cells, allowing for genetic analysis in just a couple of hours, which can help diagnose the disease earlier.
The 20th edition of the Prémio BIAL de Medicina Clínica seeks innovative clinical research with high quality and relevance. The €100,000 award will recognize the best work on clinical practice.
The CHEETAH Center is a leading institution for HIV research, publishing over 300 papers on the virus's inner workings and potential treatments. Researchers are focusing on understanding HIV's life cycle, identifying key components essential for viral infection and replication.
A study of 17,000 US primary care patients with COPD found 49.9% experiencing multiple exacerbation episodes despite treatment. Patients reported high symptoms and breathlessness, highlighting the need for non-pharmacologic treatments and improved physician education.
The International Vaccine Institute (IVI) has launched a two-week training course for biologics development and manufacturing, targeting low- and middle-income countries. The program aims to enhance local production of vaccines and biologics in LMICs to address vaccine inequity and global pandemic preparedness.
Researchers have developed an app to help doctors identify patients with chronic lymphocytic leukemia (CLL) at risk of developing infections, allowing for earlier treatment. The app uses blood test results and genetic data to predict patient risk, improving treatment outcomes and reducing pressure on the healthcare system.
The Global Organization for EPA and DHA Omega-3s (GOED) has introduced an interactive tool to catalog all human studies on EPA and DHA omega-3s. The Clinical Study Database (CSD) provides a comprehensive searchable database with over 45,000 studies, allowing users to filter by outcome, population demographics, study size or dosage.
A recent study of 7,073 adults found that those with glaucoma had higher cognitive function scores but steeper declines over 18 years. The association was small and unlikely to be clinically meaningful.
Researchers analyzed data from over 1.3 million patients and found females experience ear, nose, and throat issues, mood disorders, and fatigue, while males are more likely to suffer from renal disorders. Sex-disaggregated research is crucial for effective therapies and public health interventions.
The integrated tool allows tracking of clinical trial enrollment and cost effectiveness, enabling study teams to ensure trials are the best fit for the enterprise. It also enables standardization of data collection and reporting, giving the institution a competitive edge.
A novel AI-empowered robotic device successfully assisted in percutaneous nephrolithotomy—surgery for removing large kidney stones. The trial showed improved precision and reduced complications, with a significant reduction in needle punctures and puncture duration.
A small study found that an experimental hydrogel injection into spinal discs significantly reduced chronic low back pain and improved physical function. The gel, known as Hydrafil, is easy to administer with no open surgery required, offering a promising treatment for degenerative disc disease.
A review of scientific evidence concludes that diet has little impact on the progression of osteoarthritis and rheumatoid arthritis. While a healthy diet brings other health benefits, the impact on these diseases is small and not clinically meaningful.
A new study found that hormone replacement therapy within six months of COVID-19 diagnosis was associated with a 78% reduction in all-cause mortality in women. This suggests estrogen may offer protective effects against COVID-19 severity, explaining the lower hospitalization and death rates among women compared to men.
A recent study found that 70% of adults with stage 3 or 4 cancer were at risk of drug-drug interactions, highlighting the importance of deprescribing medications to avoid harm. The study's results emphasize the need for education and problem-solving to address polypharmacy in older adults with cancer.
Researchers discovered a link between traumatic brain injuries and changes in the gut microbiome, suggesting a potential diagnostic tool for concussions. The study found two bacterial species that dropped significantly after concussions, indicating a correlation with traumatic brain injury-linked proteins in the blood.
A new article explores how plant-based diets can support immunity and decrease the risk of severe COVID-19 infection. Studies have shown that plant-based foods rich in nitrates and antioxidants can improve heart health and respiratory immunity.
A study found that pediatric transplant patients attend on average less than one appointment per year after transferring to adult care, resulting in longer hospital stays and poorer health outcomes. Maintaining regular appointments is crucial for continued transplant success, according to the researchers.
A multi-pillar approach to nutrition can help increase lifespan by promoting optimal carbohydrate intake from non-refined sources, low but sufficient protein from plant-based sources, and enough plant-based fats. The 'longevity diet' may also involve intermittent fasting and a 5-day cycle of a fasting or fasting-mimicking diet every 3-...
The latest neurophotonic tools and techniques are reviewed in a new status report, covering advances from molecular nanoprobes to cortical column imaging. The report provides an overview of current state and future directions for brain science research.
Researchers at Tokyo University of Science discovered that disulfiram inhibits FROUNT protein and chemokine signaling pathways, reducing anxiety levels in mice. The study suggests a potential breakthrough anti-anxiety medication with safe and effective treatment for elderly patients suffering from anxiety and insomnia.
Researchers have identified a biomarker that indicates high risk of impending stroke post-subarachnoid hemorrhage, enabling early treatment initiation in comatose patients. Electrodiagnostic monitoring detects 'spreading depolarizations' caused by toxic by-products of blood breakdown, allowing clinicians to intervene before it's too late.
Researchers from Goethe University and University of Kent found aprotinin effective against SARS-CoV-2 variants, including Delta and Omicron, by preventing virus entry into host cells. A recent phase III clinical study demonstrated the treatment reduced hospital stays by five days.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
Researchers analyzed 3D facial size and shape to quantify sex differences, providing data-driven anatomic guidance for gender-affirming facial surgery. The study shows significant differences in male and female craniofacial features, particularly in brow, jaw, nose, and cheek regions.
Research suggests that physically active individuals experience a milder form of COVID-19, with a reduced risk of hospitalization and death. Studies have found that physical activity can prolong vaccine effectiveness and boost the immune response, offering promising avenues for future research.
Dr. Kushani Jayasinghe, a nephrologist and trainee in clinical genetics, received the 2022 Richard King Award for her article on genomic testing in patients with suspected monogenic kidney disease. The award recognizes high-quality research published in Genetics in Medicine by trainees.
The conference will cover topics such as musculoskeletal biomechanics and assistive technology, featuring keynote speakers on the latest developments in the field. The event provides a forum for information dissemination and discussion on research and case studies.
The National Comprehensive Cancer Network has published new consensus recommendations to improve the safety and efficiency of research studies involving investigational drugs. The recommendations focus on seven areas, including pharmacy workflows and collaboration with sponsors.
A study by Nagoya City University researchers found that patients with persistent postural-perceptual dizziness (PPPD) often exhibit exacerbating factors shortly after onset, worsening symptoms. These factors include upright posture, movement, and visual stimulation.
In young adults, women are at a higher risk of ischemic strokes, with a 44% greater incidence compared to men. Researchers highlight the need for further research into the causes and non-traditional risk factors that contribute to this disparity.
The WV Clinical and Translational Science Institute is leading a national study on post-acute sequelae of COVID-19 (PASC) among adults. The study, funded by the National Institutes of Health, aims to better understand the long-term effects of COVID-19 and develop effective treatments for this disabling complication.
The German Research Foundation has approved a new Collaborative Research Center (CRC) focused on developing sustainable iron alternatives to replace toxic or rare elements. The CRC will investigate iron's potential as a building block for the future, aiming to enhance its properties and make it more affordable and resource-efficient.
Researchers have developed an assay that uses specific immune-biomarkers to monitor patient survival chances and effectiveness of ovarian cancer treatments. The 'sFIS' assay will enable targeted therapy for each patient, improving treatment outcomes.