Articles tagged with Clinical Studies
A team of scientists used functional near-infrared spectroscopy (fNIRS) to measure brain activity in two key visual regions, the lateral occipital complex (LOC) and fusiform face area (FFA). The study found that fNIRS successfully measured LOC activity but had limitations in detecting FFA activity due to its depth. This research has th...
The £30M ADVANCE study aims to accelerate the development of new therapies for people with liver cirrhosis by identifying translational biomarkers. Researchers will enroll 200 patients with cirrhosis and use advanced techniques to analyze gene expression, blood tests, and MRI scans.
A large clinical study led by Linköping University found no difference in the risk of severe complications between breast milk-based and cow's milk-based enrichment for extremely preterm infants. The study included 228 infants and found that both groups had a similar incidence of necrotising enterocolitis, sepsis, and death.
Researchers revisited melatonin's effects on cancer in mice, finding that nighttime administration inhibits chemically induced mammary tumor development. The study highlights the importance of timing in using this freely available compound for cancer prevention and treatment.
Researchers explore the properties of cytostatic persisters in cancer treatment, highlighting their therapeutic potential and challenges. The study suggests that targeting these persisters before resistance emerges can reduce cancer recurrence.
Two Melbourne-made COVID-19 vaccines demonstrated strong boosting capabilities against SARS-CoV-2 variants in a Phase 1 clinical trial. The vaccines focus the immune response on the receptor binding domain, potentially providing a more efficient approach to boost immunity.
A phase 1 clinical trial demonstrates the efficacy of third-generation anti-CD19 CAR T-cells in treating relapsed or refractory B-cell non-Hodgkin lymphomas without causing neurotoxicity. The study also shows a robust response rate of 52% and improved safety profile compared to previous CAR T-cell therapies.
A systematic review has identified 29 primary risk factors associated with long-term arm morbidities following breast cancer treatments. The main risk factors include removal of lymph nodes, high body mass index, mastectomy, radiation therapy, chemotherapy, infection, and trauma to the affected arm.
Researchers validate a new Japanese version of the implementation leadership scale to promote evidence-based practice in Japan. The scale measures strategic leadership demonstrated by nurse managers and staff nurses in implementing evidence-based practices.
Researchers found that BCMA-positive extracellular vesicles (EVs) in plasma levels correlated with myeloma patient responses to belantamab-mafodotin therapy. High EV levels preceded FLC progression and were associated with mafodotin-induced eryptosis.
A novel mental health risk screen for hospitalized patients accurately predicts mental health outcomes, with 10 items correctly identifying 75% of those who later developed mental health issues. A tailored recovery program can also be effective in reducing mental health problems after trauma, increasing health equity among historically...
Researchers found that 1,5-AF activated AMPK, leading to upregulation of the PGC-1α/BDNF pathway and alleviating aging-related decline in motor cognitive function. The study suggests that 1,5-AF can induce endogenous neurovascular protection, potentially preventing aging-associated brain diseases.
Researchers discuss CRISPR's limitations in generating accurate cancer models, including variable mutations and indels. Despite these challenges, the technology holds promise for cancer research due to its potential for natural selection and Darwinian evolution.
Researchers developed a new diagnostic tool to identify and treat Hikikomori, a condition characterized by prolonged physical isolation or social withdrawal. The Hikikomori Diagnostic Evaluation (HiDE) assesses the severity of social withdrawal, providing a practical guide for clinicians.
A systematic review and meta-analysis of 16 studies involving 875 patients with knee osteoarthritis found significant reductions in patient-reported pain from the third month onwards. Stem cell treatment was most effective when using patient's own fat-derived stem cells, leading to better pain alleviation and recovery of joint function.
Researchers have developed a method to camouflage stem cell-derived transplants, avoiding immune rejection and tumor formation. Genetically engineered liver cells can persist in the body despite lack of immune matching, offering a potential solution to organ donor shortage.
A recent study analyzed asthma mortality rates in China and the US from 1990 to 2019, revealing substantial differences in mortality rates and risk factors. The study found that smoking was a leading risk factor for asthma mortality in China, while high body mass index (BMI) was a larger public health challenge in the US.
A novel robotic system developed by USC researchers can help clinicians accurately assess a patient's rehabilitation progress. The method generates an 'arm nonuse' metric using machine learning and a socially assistive robot to track how much a patient is using their weaker arm spontaneously.
Bio-TCV, a typhoid conjugate vaccine developed by IVI and Bio Farma, has been licensed in Indonesia following marketing approval from BPOM. The vaccine is expected to provide protection against typhoid fever as early as 9 months of age.
A new study by Anglia Ruskin University and University of Oxford highlights the lack of clinical research on severe sight impairment (SSI) among working-age individuals in the UK. The study finds that inherited retinal disorders, such as IRDs, are under-researched despite being a leading cause of SSI certifications in this population.
A new study by RCSI University of Medicine and Health Sciences found that boosting levels of a deficient protein improves survival rates for people with severe alpha-1 antitrypsin deficiency. The research, which tracked health data from over 600 patients, showed a clear survival benefit from augmentation therapy.
A new therapeutic option has been found for patients with a treatment-resistant tumor mutation called KRAS G12C. The sotorasib and panitumumab combination demonstrated superior progression-free survival rates compared to standard of care.
A phase 3 clinical trial found belzutifan significantly reduces the risk of progression in patients with metastatic clear cell renal cell carcinoma who had previously treated with immune checkpoint inhibitors and anti-angiogenic therapies. The drug demonstrated improved progression-free survival, higher overall response rates, and redu...
Researchers identify mechanism by which specific protein condensates transition from liquid to solid states, enabling stability and transmission of mechanical forces. MEC-2 proteins' biological function switches with rigidity maturation, facilitating mechanosensation.
A Phase IIIb study published in the New England Journal of Medicine found that esketamine nasal spray achieved higher remission rates (27.1%) compared to quetiapine extended-release (17.6%) in patients with treatment-resistant depression, indicating its potential as a targeted therapy for this population.
A new study reveals that esketamine nasal spray is effective in treating treatment-resistant depression, with 27.1% of patients achieving remission after 8 weeks compared to 17.6% on quetiapine XR. Long-term data shows sustained remission rates at 21.7% for esketamine NS and 14.1% for quetiapine XR.
A new editorial paper highlights the importance of including older patients in lung cancer clinical trials, where they are often undertreated due to age-related factors. The paper emphasizes the need for increased collaboration among stakeholders to enhance enrollment and retention of older cancer patients.
A study showed that yoga therapy can improve heart failure patients' endurance, strength, balance, symptom stability, and overall quality of life. Additionally, echocardiographic parameters revealed improved left ventricular systolic function in the yoga group compared to the non-interventional group.
A meta-analysis of 34,000 older adults found that antihypertensive treatment decreased dementia risk compared to untreated hypertension. Individuals with treated hypertension had no increased risk of dementia.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
A new study using eye-tracking technology found that it can accurately predict autism diagnoses, comparable to expert clinical diagnosis. The research suggests potential for earlier diagnosis and assessment of autism in routine practice.
New research led by Nansi Boghossian found that sickle cell disease contributes to racial disparities in severe maternal morbidity, with Black individuals at least 1.5 times more likely to experience complications. The study suggests preconception care and management are critical for improving pregnancy outcomes for patients with sickl...
A case series reveals that young brain donors with a history of repetitive head impacts exhibit severe symptoms, which may be caused by multiple factors. Further research is needed to clarify the association between exposure to head impacts and clinical symptoms in young athletes.
A team of New Jersey researchers reviewed the evidence on robotic exoskeleton devices for individuals with acquired brain injury, laying out a systematic framework for future research. The review highlights the need for comprehensive approaches to evaluate these devices and their role in improving mobility in individuals with acquired ...
Researchers examine translational studies on peripheral surrogates of tumor burden, including circulating tumor DNA, miRNA, and HPV-specific antibodies, to inform chemotherapy and immunotherapy strategies. These biomarkers show promise as prognostic and predictive markers of response to treatment.
A new study by MU researcher Roy Thompson found that immigrant nurses in long-term care facilities often have more 'human capital' than their American-born counterparts, including language skills and additional certifications. This diversity can improve patient health outcomes and create a more equitable workforce.
The Phase 2a trial of OVX836 showed a notable signal of protection against influenza symptoms with an 84% level of protection compared to placebo. The vaccine candidate elicited significant humoral and cellular immune responses, highlighting its potential as a universal influenza vaccine.
A study of 800 Dutch children found that modified treatment protocols increased the five-year survival rate for all children with acute lymphatic leukemia to 94%. The modifications resulted in a three times lower risk of disease recurrence, especially in children with an aggressive form of leukemia.
A large-scale study found that exercise programs for dialysis patients lead to significant improvements in physical fitness, quality of life, and reduced hospital stays. Personalized exercise plans showed low costs per training unit, making them a viable option for standard healthcare coverage.
Researchers developed MemTrax, a continuous recognition test for advanced cognitive impairment screening. The test quickly and accurately quantifies memory processing, storage, and retrieval, providing precise assessments of severity and rate of change over time.
A new study reveals that preoperative hydroxyprogesterone administration can improve disease-free and overall survival in patients with node-positive breast cancer by modulating cellular stress response and negative regulation of inflammation. Non-coding RNAs, such as DSCAM-AS1, play a regulatory role in this process.
A new study by George Washington University researchers reveals that Mexican Americans and other Latinos face significant barriers to occupations in the healthcare field that require an advanced degree. The study found that despite being the largest Latino subpopulation, Mexican Americans represent one-quarter or less of the professions.
A study published in Brain and Behavior found that humor therapy reduced symptoms of depression and anxiety in participants from various countries. The analysis included 2,964 participants and nine different countries, suggesting that humor therapy may be a feasible complementary alternative for clinicians, nurses, and patients.
A systematic review and meta-analysis found that wearable activity trackers improve patient activity, reduce sedentary behavior, and enhance physical function, supporting faster recovery in hospitalized adults. The study examined 15 studies with a combined total of 1911 patients and found significant improvements in clinical outcomes.
The use of psychedelics in mental health treatment is gaining traction, but concerns about patient safety and regulation need to be addressed. Psychedelic-assisted therapy shows promise in treating conditions like depression and PTSD, but more research is needed on dosages, settings, and guidelines.
A study analyzed emoji and emoticon use in secure clinical texting systems, finding they primarily convey new and interactionally significant information. The results suggest that emoji use may not undermine professionalism as much as initially thought.
A study of 48,320 Japanese patients with type 2 diabetes found that 10.5% achieved remission per 1,000 person-years, with factors such as HbA1c levels, BMI reduction, and sex significantly associated with remission. Those who relapsed had longer durations of diabetes, lower BMI at baseline, and lower BMI reduction over time.
Researchers have developed a simple blood test that can diagnose De Vivo disease, a rare and disabling neurological disorder. The test, called METAglut1, has a high sensitivity and specificity, allowing for accurate diagnosis in a short amount of time.
Decentralized trials aim to improve access to clinical research, but disparities in technology access and potential barriers to trust remain unknown. Rigorous randomized controlled trials are needed to evaluate the impact of decentralized trials on trial enrollment and pipeline aspects.
ComboMATCH initiates patient enrollment to test new cancer drug combinations guided by tumor biology, exploring precision medicine and targeting proteins that control cancer growth. The project aims to identify beneficial therapies for patients with rare malignancies and/or rare molecular abnormalities.
Researchers identified novel genetic associations between AD and modifiable risk factors, including high HDL cholesterol concentrations and systolic blood pressure. These findings may inspire new drug targets and improved prevention strategies for AD.
Online radiologists choose studies based on financial attractiveness, leading to delays in high-priority cases. This study found that expedited priority class contained the highest percentage of delayed studies.
A large-scale study of patient experiences with telemedicine and in-person visits found that telemedicine consistently outperformed in-person visits in terms of access to care and provider engagement. The study analyzed survey responses from over 39,000 patients across more than 50,000 visits.
The study shows that zolbetuximab delays tumor progression and improves overall survival by 25% compared to chemotherapy alone. Patients with CLDN18.2-positive tumors responded well to the treatment, indicating a new clinically relevant biomarker for gastric cancer.
Quitting smoking early after a lung cancer diagnosis was associated with lower mortality rates. Detailed smoking history collection can improve lung cancer prognosis and treatment selection. The study's findings suggest that smoking cessation timing may impact overall survival, particularly at different clinical stages.
A retrospective study found that elevated CA 19-9 and CEA levels were associated with worsened outcomes in duodenal adenocarcinoma patients. The study, which included 68 patients, suggests that these tumor markers may show promise as prognostic tools for this rare malignancy.
The CHEST journal April issue features cutting-edge research on asthma, chronic obstructive pulmonary disease (COPD), and sarcoidosis. Key findings include the potential of efzofitimod as a treatment for managing sarcoidosis. The journal also showcases innovative approaches to clinical practice and education in chest medicine.
A new study published in Metabolism reveals that the hormone neurotensin is released in greater amounts by people who successfully maintain weight loss after a low-calorie diet. This suggests that neurotensin may play a key role in regulating appetite and weight management.
Recent studies have highlighted the importance of tumor microenvironment in developing and controlling triple negative breast cancer progression. Researchers suggest that technological advancements like genomics and epigenomics hold promise for overcoming TNBC's current limitations.
Researchers propose a new method of clustering colorectal cancer patients using differential presence of exons (DPE) sequencing, which can provide valuable information on CRC progression and response to therapy. This analysis may also reduce costs and time required for staging CRC patients.