Articles tagged with Clinical Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent study found that only fair agreement exists between clinicians' diagnosis of fibromyalgia and the published criteria used by the American College of Rheumatology. Clinicians failed to identify nearly half of patients who met the criteria, highlighting a need for improved diagnostic methods.
About 10% of men and 7% of women reported significant levels of distress and social impairment due to compulsive sexual behavior disorder. A survey study found that 2,325 adults between 18-50 experienced distress and impairment associated with difficulty controlling their sexual feelings, urges, and behaviors.
Research reveals epigenetic changes in IGFBP2 gene influence type 2 diabetes risk. Higher IGFBP2 levels in blood lower diabetes risk.
Researchers found that injecting vasoactive intestinal peptide into the eye of mice significantly improved corneal graft survival. The treatment accelerated endothelial wound closure and protected corneal endothelial cells, leading to clearer grafts. This breakthrough could lead to better outcomes for patients with corneal disease.
Researchers at Boston Medical Center found that warm handoffs have no association with improved attendance at behavioral health intake appointments. The most significant predictor of attendance was time from referral until appointment, contradicting previous theories on the effectiveness of warm handoffs.
Research from the Global Forum on Nicotine highlights reduced cravings for cigarettes after vaping or using iQOS. Smokers who switch to vapour alternatives experience improved health measures, comparable to quitting entirely. Vaping is banned in Thailand, but permitted in the UK.
Two randomized controlled studies show a 65% improvement in treatment group and a 27% improvement in patient-rated measures compared to sham stimulation. The therapy has few side effects, with most participants reporting improvement after receiving treatment.
A clinical study by British American Tobacco found that switching to glo significantly reduces exposure to cigarette smoke toxicants. The results indicate that glo vapour has lower levels of toxicants than cigarette smoke.
Researchers studied 308 older patients who underwent abdominal surgery, finding that both vulnerable and frail patients were at higher risk of readmission or death within 30 days and 6 months. The degree of frailty predicted increasing risk of readmission or death, with frail patients at greatest risk.
A meta-analysis published in Mayo Clinic Proceedings shows that the FeNO test has moderate accuracy for diagnosing asthma, particularly in patients aged 5 and older. The test's sensitivity and specificity vary depending on the cutoff value used.
A RAND Corporation study found that staff at federally qualified health centers, which serve the nation's poorest patients, are experiencing high levels of burnout and job dissatisfaction. The study surveyed clinicians and staff across 296 clinics, finding declines in professional satisfaction, work environment, and practice culture.
Recent studies have built a consensus that ginger has beneficial effects against obesity, diabetes, cardiovascular diseases, and metabolic syndrome. Ginger regulates fat metabolism, suppresses carbohydrate digestion, and modulates insulin secretion to help combat these conditions.
Researchers suggest that Michelangelo's famous chapel contains hidden symbols associated with female reproductive organs, such as the uterus and fallopian tubes. The study, published in Clinical Anatomy, provides a previously unavailable interpretation of one of Michelangelo's major works.
A systematic review of seven studies found that low vitamin D levels are associated with an increased risk of bladder cancer. Vitamin D deficiency may be a key factor in preventing the cells within the bladder from stimulating an adequate immune response to abnormal cells, suggesting a potential mechanism for cancer prevention.
A recent study found that exposure to selective serotonin reuptake inhibitors (SSRIs) during pregnancy is associated with an increased risk of speech and language disorders in children. The study analyzed data from Finland and found that children whose mothers purchased SSRIs at least twice during pregnancy had a higher risk of speech/...
Researchers developed a non-invasive MRI-based method to quantify dermal fat, total WAT volume and BAT activation in mice and humans. Studies showed that dWAT thickness was highly variable between subjects and increased in genetically obese mice and those fed high-fat diets.
A new study has found that intensive care units provide adequate communication and family support for families of chronically ill patients, rendering palliative care unnecessary. The study revealed no difference in patient outcomes when families received additional support from palliative care specialists versus standard ICU care.
A Danish population study found patients with rosacea had a higher risk of new-onset Parkinson's disease compared to the general population. The study also suggests that tetracycline use may reduce PD risk, but further studies are needed for confirmation.
A meta-analysis of 19 studies found that blacks employ pain-coping strategies more frequently than whites, with blacks using praying and catastrophizing as common techniques. This study highlights the need for culturally sensitive medical care and could inform chronic pain care.
A phase 2 clinical study shows finafloxacin was more effective than ciprofloxacin in treating complicated urinary tract infections and acute pyelonephritis. Finafloxacin demonstrated rapid antimicrobial activity against resistant pathogens, including ESBL-producing bacteria.
The Perioperative Surgical Home model significantly improves patient outcomes and reduces healthcare costs through coordinated care. Studies found PSH models reduced cancellations, complications, readmissions, and hospital stays.
A study found that decreased Aß42 and increased phosphorylated tau181 levels in spinal fluid are linked to reduced default mode network integrity. This association suggests that these biomarkers could be used to detect Alzheimer's disease pathology before symptoms appear.
A recent study by Mayo Clinic researchers found that scheduled imaging studies are ineffective in detecting the relapse of diffuse large B-cell lymphoma. Only a handful of patients without symptoms were identified through scans, highlighting the need for individualized care approaches.
Researchers at Mayo Clinic discovered the first dystonia gene linked to an African-American family, paving the way for improved diagnosis and treatment. The study identified a genetic abnormality that led to muscle spasms and abnormal posture in affected individuals.
Researchers found that the order of symptoms matters more for clinicians' descriptions of disorders that are different than those that overlap. This contradicts the assumption that order doesn't matter in psychiatric diagnoses. The study's findings have implications for bringing classification and clinical practice closer together.
Two outstanding studies won top honors at the Canadian Stroke Congress, one discovering brain recovery abilities after stroke and another developing a diagnostic tool predicting clinical outcomes. The studies aim to improve treatment decisions and patient care.
A meta-analysis of 24 studies found that 12% of heart patients develop clinically significant PTSD symptoms, doubling their risk for future cardiac events and death. The study suggests that underdiagnosis may be even more pronounced in cardiac practices than in other types of medical practices.
Three noteworthy studies were presented, including a study on KRAS in non-small cell lung cancer patients and another on dacomitinib's favorable clinical benefits. Additionally, researchers validated the role of tumor lymphocytic infiltration as a favorable prognostic factor for resectable non-small cell lung cancer.
A Mayo Clinic study found that it takes an average of 275 procedures to reach minimal cognitive and motor competency in gastroenterology fellows performing colonoscopies. The research team used a validated testing method to assess the performance of 41 fellows who performed over 6,600 colonoscopies.
New studies from researchers at the University of Cincinnati show that certain measurement tools for assessing non-clinical work intensity can also be used to determine physician work intensity in clinical settings. This could lead to improved health care delivery, increased efficiency, and higher quality of care.
A recent commentary in the Canadian Medical Association Journal highlights inappropriate uses of frozen plasma, with 45% to 48% of audited transfusions found to be misuse. Experts recommend introducing measures to promote alternative use and screen orders against guidelines to improve practice.
Clinical studies show B&L's Lo-Torque design delivers better rotational recovery, resulting in more consistent vision. The design demonstrated statistically significantly better results compared to Acuvue's accelerated stabilization design.
A study by Brown University researchers found that ER physicians do not follow established clinical guidelines for diagnosing suspected pulmonary emboli. According to the study, many patients receive CT scans despite having low clinical suspicion of PE, resulting in unnecessary radiation exposure.
A study of 2,050 people aged 70-89 found that 15% had mild cognitive impairment, with men being one-and-a-half times more likely to experience it. The study's findings suggest a delayed progression to dementia in men and potentially faster development in women.
A study published in the Journal of Periodontology found a correlation between periodontal disease and an increased risk of coronary heart disease. Regular brushing and flossing can help lower this risk, according to experts from the American Academy of Periodontology.
Associate Professor Mazza aims to work with GPs to increase folate supplementation, which can prevent 70% of NTD cases. The project will also develop patient-focused education material to address the gap between evidence and practice.
A Mayo Clinic review found that gene expression profiling has limitations in predicting lung cancer prognosis, with conventional methods remaining more accurate. Despite promising results, the technology's accuracy varies greatly among studies, and its clinical relevance is unclear.
A large international study provides strong evidence that common genetic variants in the alpha-synuclein gene contribute to Parkinson's disease worldwide. Variability in this gene is associated with a 1.5 times greater risk for the disease, highlighting potential therapies to reduce alpha-synuclein protein production.
The study presents a comprehensive overview of oral health research worldwide, highlighting the high risk of dental caries in rural children and adolescents. It emphasizes the importance of preventive efforts, education, and public awareness to improve oral health outcomes.
Researchers at Mayo Clinic have found a significant association between acid reflux and esophageal cancer, with patients who experience acid reflux having a 30- to 125-fold increased risk of developing esophageal cancer. The study also discovered susceptibility genes in familial Barrett's esophagus and esophageal cancer.
Community surveys overestimate depression due to flawed methodologies that fail to account for normal life stress reactions. Experts call for contextual criteria to accurately diagnose mental disorders.
A study by D.N. Tatakis and colleagues found that individuals with lip piercings had significantly more gum recession compared to those without piercings, with an average depth of double the control group. Increased time of wear was also linked to a higher prevalence of gum recession in pierced individuals.
The Research in Prosthodontics and Implants Award honors Dr. Naert's contributions to prosthodontics through his extensive clinical studies and biomechanical analysis. His work has significantly impacted the practice of implant dentistry.
Researchers recruiting patients from high-risk clinics for cancer intervention studies risk introducing bias, as controls are more likely to receive interventions than some case patients. This can lead to a false impression of intervention efficacy or underestimate its harm.
A study suggests that regular doses of cranberry juice or tablets can reduce the risk of female urinary tract infections (UTIs) by up to 50% in sexually active adult women. Cranberry juice's effectiveness in treating existing UTI cases is still unknown, but it offers a potential natural alternative to antibiotics.
A national survey of 321 dentists found that most never screened for domestic violence, despite visible signs. Education on intervention increased likelihood of screening and responding appropriately. The study recommends standardized training and the AVDR model for dentists to recognize and respond to signs of abuse.
Researchers found that mouse allergen is a significant contributor to childhood asthma in urban areas, with 18% of children allergic to mice experiencing more severe asthma. Doctors recommend testing for mouse allergy and recommending aggressive extermination of mice.
Two studies found that women with the four risk factors had five times the risk of death as men, and children with metabolic syndrome risk factors were more likely to be obese. Researchers emphasize the need to prevent obesity in young people to reverse alarming trends in heart disease.
A meta-analysis of 42 studies found that regular church attendance and public religious involvement are associated with a 29% higher survival rate. Private religious involvement also shows some benefits, but the effects appear to be partially due to social support and health behaviors.
Two Hopkins studies confirm prenatal exposure to normal male hormones dictates male gender identity in genetically male children born with cloacal exstrophy. Most reassigned as females later reassign themselves back to males, exhibiting strong male behaviors and attitudes.
The American Psychoanalytic Association's 89th Annual meeting will address a wide range of clinical and societal issues. A public forum on addressing violent youth will be held on May 12, moderated by John Callaway and featuring experts from the University of Pennsylvania and Yale Child Study Center.
A study published in Urology suggests that patients treated with radiation therapy for prostate cancer have a high chance of being disease-free after four years, with minimal risk of recurrence. Patients with favorable prognoses also show a lower risk of treatment failure sooner than those with less favorable prognoses.
Research suggests that violent video games can increase aggressive thoughts, feelings, and behavior in individuals, particularly young men who are habitually aggressive. The interactive nature of these games may be more harmful than exposure to violent television and movies, as they require players to identify with the aggressor.
A 12-week study found that carotenes and vitamin E supplements reduced sunburn intensity in fair-skinned individuals. The duration of supplementation was more effective than dosage in protecting against sunburn damage.
A study of middle-aged women found that high consumption of zinc, magnesium, potassium, fiber, and vitamin C was linked to higher bone mineral density and reduced evidence of bone loss. Moderate alcohol intake also appeared to have a positive effect on bone health.
Two studies published in December 1999 found that green tea consumption can trigger biochemical mechanisms affecting human health. The studies suggest that increasing green tea intake can increase energy utilization, thermogenesis, and fat oxidation, while also protecting cells from oxidative damage.
A recent Mayo Clinic study found that traumatic brain injuries increase the risk of Alzheimer's Disease, with a median observed time from injury to onset of 10 years. The study suggests that traumatic brain injury interacts with other factors to hasten the onset of Alzheimer's in susceptible individuals.
Researchers found that microbial pathogens induce atheroma plaque formation in mice lacking anti-inflammatory cytokine IL-10. The study suggests that exposure to air-borne pathogens multiplies plaque formation by a factor of 10 in IL-10-deficient mice, making the plaque more likely to rupture.
A recent study published in the American Journal of Clinical Nutrition found that prolonged mental stress increases the levels of atherogenic lipoproteins and decreases the rate at which fats are cleared from the blood after a meal. This can lead to higher lipid levels and increased risk of cardiovascular disease.
Researchers advocate for standardized examination techniques to improve physicians' precision and accuracy in screening for breast cancer. The study found that spending adequate time on the clinical breast examination (CBE) and using proper techniques can increase early detection of lumps in the breast.