Articles tagged with Clinical Studies
A new study led by Professor Motoko Yanagita has found that advanced tertiary lymphoid tissues in kidney transplant patients are associated with progressive graft dysfunction. The presence of these tissues, which arise in chronic inflammatory conditions, can indicate a higher risk of renal failure within five years.
A new clinical study found that grape consumption increased gut bacterial diversity and reduced cholesterol levels, including total cholesterol by 6.1% and LDL cholesterol by 5.9%. This suggests a potential role for grapes in promoting good gut health and supporting heart health.
A seven-year study by CooperVision indicates that MiSight 1 day contact lenses slow myopia progression without a rebound effect, even after treatment cessation. The lenses demonstrate sustained slowing of myopia progression across different ages and with varying levels of myopia.
Researchers published safety and efficacy data for a novel nusinersen drug delivery method via subcutaneous intrathecal catheter system (SIC) for spinal muscular atrophy (SMA) patients. The study found improvements in arm and hand function, but no significant changes in motor scales or muscle force.
The USPSTF report describes methods used to identify recommendations with sex or gender components and propose an approach to making recommendations respectful of gender diversity. The task force aims to clarify the populations for which these recommendations should apply.
Burt's Bees research finds that natural origin ingredients like bakuchiol, aloe, and rice milk improve skin health for all skin types and tones. The studies also show that these ingredients can restore skin barrier function and lead to positive subject-reported improvements.
A research team from the University of Zurich has identified a common genetic variant in the AQP1 gene that affects treatment efficacy and patient survival on peritoneal dialysis. Patients carrying this variant have a higher risk of death, but researchers found a way to circumvent the problem using colloid osmotic agents.
The National Kidney Foundation has released a research roadmap to accelerate innovations in treatment and increase understanding of kidney disease. The report calls for increased funding in preclinical science, genetics, health equity, and implementation science to tackle the most vexing challenges in kidney disease.
The American Psychiatric Association journals feature research on the mental health of community college students, diabetes, depression, and schizophrenia treatment. The findings extend and validate previous studies relevant to clinical psychiatry.
A recent study published in JNCCN found that four out of five cancer therapies tested in Phase III trials did not achieve clinically-meaningful benefits in prolonging survival. The researchers analyzed 362 industry-sponsored trials and found that 87% were either false-positive or true-negative for meeting overall survival goals.
The National Institute on Aging has expanded its network of cutting-edge Alzheimer's disease and related dementias centers, with two new centers in North Carolina and Texas. The Duke/University of North Carolina ADRC will focus on understanding age-related changes across the lifespan and identifying disparities in dementia among differ...
Researchers from Terasaki Institute for Biomedical Innovation develop methods to enhance mechanical properties of hydrogels, including toughness, stretchiness, and adhesive strength. By introducing dopamine and alkaline conditions, they create gel-like materials with improved biocompatibility and regenerative capabilities.
A pan-Canadian randomized controlled trial is using digital communication to target common reasons for vaccine hesitancy, including age, language, and education level. Family physicians will receive tailored information to share with patients through email and text message, aiming to improve vaccine uptake.
A telephone-delivered nursing care strategy combining heart failure care management with depression treatment improved patients' clinical outcomes. Patients receiving 'blended' collaborative care showed better mental health-related quality of life, including improved mood and reduced limitations in social activities.
Black, Hispanic, Indigenous and Asian Americans remain underrepresented in pancreatic cancer clinical trials, despite federal mandates. The lack of diversity hurts patients and science alike, with racial and ethnic minorities accounting for a disproportionate burden of pancreatic cancer cases.
Researchers found that batters keep their eye on the ball but move their head to direct their gaze. The study suggests that this movement may help reduce visual calculations needed for accurate bat placement. Further investigation is needed to determine if eye-gaze-based training can improve batting performance.
A study confirmed the safety of a novel stem cell therapy for knee pain caused by osteoarthritis. The treatment, which involves transplanting patient's own mesenchymal stem cells into the affected knee, showed no serious side effects over five years.
Eija Kononen is a Professor and Chair of Periodontology at the University of Turku, Finland, known for her pioneering work on oral microbiology and its role in immune response. Her novel salivary diagnostic method, the Cumulative Risk Score, has been used in several studies to diagnose periodontal status.
A non-inferiority study found that biodegradable subacromial balloon spacers produced similar results to partial rotator cuff repairs for patients with massive rotator cuff tears at 24-month follow-up. Early improvements were noted in both groups, particularly the balloon spacer group.
Researchers at Swansea and Cardiff universities have developed the Risk of Suicide Protocol (RoSP), a guide for health professionals to identify individuals at risk of taking their own lives. The protocol assesses 20 key aspects of a person's life, enabling clinicians to formulate problems and develop safety plans to help those in need.
Two new studies provide new insights for treating cardiogenic shock, a rare and life-threatening condition where the heart stops pumping enough blood. The studies confirm the accuracy of the SCAI shock stage classification system and show that early use of mechanical circulatory support improves patient outcomes.
A systematic review and meta-analysis of 52 studies found that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) were associated with reduced mortality and severe adverse events in patients with COVID-19. These findings suggest that these medications may be beneficial for COVID-19 patients.
Women experiencing hot flushes and night sweats, also known as vasomotor symptoms, are 70% more likely to have heart attacks, angina, and strokes. The severity of these symptoms, rather than frequency or duration, is a key factor in increased cardiovascular risk.
A review article by Brazilian researchers highlights the risks of short periods of inactivity on the cardiovascular system and recommends exercising at home during the pandemic. Exercise can help control blood pressure, reduce inflammation, and improve quality of life, even for high-risk groups.
A study published in PLOS ONE found that more than 90% of legal marijuana products offered in medical dispensaries are stronger than recommended for chronic pain relief. This can lead to increased risk of developing cannabis-use disorders and tolerance, according to the study's lead author.
Researchers in Spain found nearly half of patients were misdiagnosed with hypophosphatasia, a rare genetic disorder. Up to 15,000 cases may be currently undetected in the Spanish population.
A new study based on SWAN data shows that frequent and persistent menopausal hot flashes are associated with a higher risk of heart problems. The study found that hot flashes at the beginning of the transition doubled the risk of clinical CVD events, while persistent hot flashes over 20 years increased the risk by 80%.
Asbjørn Jokstad, a Professor at Arctic University of Norway, is recognized for his contributions to prosthodontic and implant research. He received the 2019 Research in Prosthodontics and Implants Award from the International Association for Dental Research for his outstanding research accomplishments.
A recent study found that only fair agreement exists between clinicians' diagnosis of fibromyalgia and the published criteria used by the American College of Rheumatology. Clinicians failed to identify nearly half of patients who met the criteria, highlighting a need for improved diagnostic methods.
About 10% of men and 7% of women reported significant levels of distress and social impairment due to compulsive sexual behavior disorder. A survey study found that 2,325 adults between 18-50 experienced distress and impairment associated with difficulty controlling their sexual feelings, urges, and behaviors.
Research reveals epigenetic changes in IGFBP2 gene influence type 2 diabetes risk. Higher IGFBP2 levels in blood lower diabetes risk.
Researchers found that injecting vasoactive intestinal peptide into the eye of mice significantly improved corneal graft survival. The treatment accelerated endothelial wound closure and protected corneal endothelial cells, leading to clearer grafts. This breakthrough could lead to better outcomes for patients with corneal disease.
Researchers at Boston Medical Center found that warm handoffs have no association with improved attendance at behavioral health intake appointments. The most significant predictor of attendance was time from referral until appointment, contradicting previous theories on the effectiveness of warm handoffs.
Research from the Global Forum on Nicotine highlights reduced cravings for cigarettes after vaping or using iQOS. Smokers who switch to vapour alternatives experience improved health measures, comparable to quitting entirely. Vaping is banned in Thailand, but permitted in the UK.
Two randomized controlled studies show a 65% improvement in treatment group and a 27% improvement in patient-rated measures compared to sham stimulation. The therapy has few side effects, with most participants reporting improvement after receiving treatment.
A clinical study by British American Tobacco found that switching to glo significantly reduces exposure to cigarette smoke toxicants. The results indicate that glo vapour has lower levels of toxicants than cigarette smoke.
Researchers studied 308 older patients who underwent abdominal surgery, finding that both vulnerable and frail patients were at higher risk of readmission or death within 30 days and 6 months. The degree of frailty predicted increasing risk of readmission or death, with frail patients at greatest risk.
A meta-analysis published in Mayo Clinic Proceedings shows that the FeNO test has moderate accuracy for diagnosing asthma, particularly in patients aged 5 and older. The test's sensitivity and specificity vary depending on the cutoff value used.
A RAND Corporation study found that staff at federally qualified health centers, which serve the nation's poorest patients, are experiencing high levels of burnout and job dissatisfaction. The study surveyed clinicians and staff across 296 clinics, finding declines in professional satisfaction, work environment, and practice culture.
Recent studies have built a consensus that ginger has beneficial effects against obesity, diabetes, cardiovascular diseases, and metabolic syndrome. Ginger regulates fat metabolism, suppresses carbohydrate digestion, and modulates insulin secretion to help combat these conditions.
Researchers suggest that Michelangelo's famous chapel contains hidden symbols associated with female reproductive organs, such as the uterus and fallopian tubes. The study, published in Clinical Anatomy, provides a previously unavailable interpretation of one of Michelangelo's major works.
A systematic review of seven studies found that low vitamin D levels are associated with an increased risk of bladder cancer. Vitamin D deficiency may be a key factor in preventing the cells within the bladder from stimulating an adequate immune response to abnormal cells, suggesting a potential mechanism for cancer prevention.
A recent study found that exposure to selective serotonin reuptake inhibitors (SSRIs) during pregnancy is associated with an increased risk of speech and language disorders in children. The study analyzed data from Finland and found that children whose mothers purchased SSRIs at least twice during pregnancy had a higher risk of speech/...
Researchers developed a non-invasive MRI-based method to quantify dermal fat, total WAT volume and BAT activation in mice and humans. Studies showed that dWAT thickness was highly variable between subjects and increased in genetically obese mice and those fed high-fat diets.
A new study has found that intensive care units provide adequate communication and family support for families of chronically ill patients, rendering palliative care unnecessary. The study revealed no difference in patient outcomes when families received additional support from palliative care specialists versus standard ICU care.
A Danish population study found patients with rosacea had a higher risk of new-onset Parkinson's disease compared to the general population. The study also suggests that tetracycline use may reduce PD risk, but further studies are needed for confirmation.
A meta-analysis of 19 studies found that blacks employ pain-coping strategies more frequently than whites, with blacks using praying and catastrophizing as common techniques. This study highlights the need for culturally sensitive medical care and could inform chronic pain care.
A phase 2 clinical study shows finafloxacin was more effective than ciprofloxacin in treating complicated urinary tract infections and acute pyelonephritis. Finafloxacin demonstrated rapid antimicrobial activity against resistant pathogens, including ESBL-producing bacteria.
The Perioperative Surgical Home model significantly improves patient outcomes and reduces healthcare costs through coordinated care. Studies found PSH models reduced cancellations, complications, readmissions, and hospital stays.
A study found that decreased Aß42 and increased phosphorylated tau181 levels in spinal fluid are linked to reduced default mode network integrity. This association suggests that these biomarkers could be used to detect Alzheimer's disease pathology before symptoms appear.
A recent study by Mayo Clinic researchers found that scheduled imaging studies are ineffective in detecting the relapse of diffuse large B-cell lymphoma. Only a handful of patients without symptoms were identified through scans, highlighting the need for individualized care approaches.
Researchers at Mayo Clinic discovered the first dystonia gene linked to an African-American family, paving the way for improved diagnosis and treatment. The study identified a genetic abnormality that led to muscle spasms and abnormal posture in affected individuals.
Researchers found that the order of symptoms matters more for clinicians' descriptions of disorders that are different than those that overlap. This contradicts the assumption that order doesn't matter in psychiatric diagnoses. The study's findings have implications for bringing classification and clinical practice closer together.
Two outstanding studies won top honors at the Canadian Stroke Congress, one discovering brain recovery abilities after stroke and another developing a diagnostic tool predicting clinical outcomes. The studies aim to improve treatment decisions and patient care.
A meta-analysis of 24 studies found that 12% of heart patients develop clinically significant PTSD symptoms, doubling their risk for future cardiac events and death. The study suggests that underdiagnosis may be even more pronounced in cardiac practices than in other types of medical practices.
Three noteworthy studies were presented, including a study on KRAS in non-small cell lung cancer patients and another on dacomitinib's favorable clinical benefits. Additionally, researchers validated the role of tumor lymphocytic infiltration as a favorable prognostic factor for resectable non-small cell lung cancer.
A Mayo Clinic study found that it takes an average of 275 procedures to reach minimal cognitive and motor competency in gastroenterology fellows performing colonoscopies. The research team used a validated testing method to assess the performance of 41 fellows who performed over 6,600 colonoscopies.
New studies from researchers at the University of Cincinnati show that certain measurement tools for assessing non-clinical work intensity can also be used to determine physician work intensity in clinical settings. This could lead to improved health care delivery, increased efficiency, and higher quality of care.
A recent commentary in the Canadian Medical Association Journal highlights inappropriate uses of frozen plasma, with 45% to 48% of audited transfusions found to be misuse. Experts recommend introducing measures to promote alternative use and screen orders against guidelines to improve practice.
Clinical studies show B&L's Lo-Torque design delivers better rotational recovery, resulting in more consistent vision. The design demonstrated statistically significantly better results compared to Acuvue's accelerated stabilization design.