Articles tagged with Clinical Studies
The National Comprehensive Cancer Network (NCCN) has awarded four early-career oncologists with $150,000 in funding to tackle pressing challenges in cancer care. The recipients will support studies aiming to improve cancer outcomes through molecular residual disease-guided adjuvant therapy and electronic symptom monitoring.
Researchers propose a general formula modeling bone adaptation as a function of key loading parameters. The formula provides insights into the relationship between mechanical signals and adaptive bone responses, offering guidance for optimizing exercise regimens and designing medical devices to promote bone health.
Researchers developed a blood test that accurately diagnoses Alzheimer's disease and measures its progression. The test correlates with the amount of tau aggregates in the brain, distinguishing between early- and late-stage diseases.
Dr. Christopher Kramer began a one-year term as head of the American College of Cardiology, addressing workforce issues, health equity and AI-driven solutions to improve cardiovascular care. With over 35 years of membership and leadership roles, Kramer brings experience in cardiovascular magnetic resonance imaging.
The study found significant improvements in symptoms for participants with major depressive disorder, generalized anxiety disorder, and eating disorders. Participants reported trusting and communicating with Therabot comparable to working with a therapist.
The American Society for Nutrition will host NUTRITION 2025, bringing together experts to explore topics such as diet, sleep, cardiovascular health, adolescence, and chronic pain. The event features original research studies, scientific symposia, and networking events, offering a platform for the latest nutrition science findings.
A new study by Korea University researchers reveals that switching to besifovir may improve patient kidney and bone health for long-term hepatitis B treatment. The study showed that patients who switched to besifovir had higher estimated glomerular filtration rate indicating improved kidney function and higher hip and spine bone densit...
Hyperuricemia is a metabolic disorder characterized by elevated uric acid levels, linked to cardiovascular diseases, gout, renal dysfunction, and metabolic disorders. Advances in technology and genetic research are transforming management strategies, including personalized treatments and probiotic interventions.
A comprehensive review of studies reveals that over 15% of caregivers of adult cancer patients suffer from post-traumatic stress disorder (PTSD). Caregivers with pre-existing mental health conditions and high caregiver burden are at greater risk. The study highlights the urgent need for proactive screening and support to prevent long-t...
A clinical trial shows that removing amyloid plaques from the brain can delay Alzheimer's symptoms, supporting the amyloid hypothesis. The treatment reduced the risk of developing dementia in people destined to develop early-onset Alzheimer's disease.
Thomas Jefferson University has initiated a phase 1 clinical trial for a Lassa virus (LASV) vaccine, currently enrolling healthy volunteers. The vaccine's safety and immunogenicity will be assessed in both the rabies virus and LASV.
Researchers discovered immature platelet fraction as a clinical predictor for enhanced platelet recovery in patients with dengue fever. IPF% can help monitor platelet recovery and identify thrombocytopenia etiology, but recovery is not solely determined by platelet count.
Eradivir's EV25 is a small molecule immunotherapy biotech company developing treatments for influenza. The Phase 2 challenge study will gather safety and efficacy data from healthy participants infected with influenza.
Children who frequently miss school due to abdominal complaints are more likely to have gut-brain axis disorders like IBS, which can be missed by medical tests. The study found that frequent absences were nearly five times more likely to be caused by functional GI disorders than specific illnesses.
BaCell 3D conference to feature original research in organoids and regenerative medicine, published in Stem Cell Reports. The International Society for Stem Cell Research (ISSCR) partners with Stem Cell Reports to promote discoveries with potential to transform regenerative medicine.
A new study from Denmark reveals that a mother's diet during pregnancy, characterized by a Western dietary pattern high in fat and sugar, may increase the risk of neurodevelopmental disorders such as ADHD and autism. Researchers found that even small dietary adjustments away from this pattern could potentially reduce this risk.
Hepatic biliary adenofibroma (BAF) is a rare, benign tumor with histological characteristics distinct from other biliary tumors. Emerging case reports suggest potential for malignant transformation and overlap with intrahepatic cholangiocarcinoma (iCCA), highlighting diagnostic challenges and need for further research.
This disorder has diverse etiologies, variable presentations, and different therapeutic responses. The proposed diagnostic algorithm can differentiate pediatric MF subtypes to improve patient outcomes.
Colorectal cancer is a leading cause of mortality in China due to late-stage diagnosis. Emerging non-invasive diagnostic tests, innovative imaging techniques, and AI applications enhance CRC detection and diagnosis. However, expanding accessibility and promoting public awareness remain key challenges.
A new study funded by the National Institutes of Health found that cooling treatment for preterm infants does not reduce the risk of disability or death from oxygen loss. The study evaluated 188 preterm infants with hypoxic ischemic encephalopathy and found a higher risk of death and disability in those who received the cooling treatment.
Increased visceral adipose tissue density and decreased skeletal muscle area are predictors of post-esophagectomy pulmonary complications. Decreased skeletal muscle density is associated with poorer overall survival. Routine morphomic analysis can help identify patients at risk and tailor perioperative care.
A panel of experts identified key biomarkers for PND through a comprehensive literature review of 194 clinical studies. The study highlights the potential for these biomarkers to predict and diagnose PND, improving postoperative cognitive health in elderly patients.
A new device has been designed to effectively treat cerebral venous sinus thrombosis (CVST) by navigating complex venous anatomy and removing large thrombi. The device features controllable axial and longitudinal maneuverability, improving clinical outcomes for patients with CVST.
A new study found that artificial sweetener aspartame triggers insulin spikes leading to blood vessel inflammation in mice, which can contribute to atherosclerosis and increased risk of heart attacks and stroke. The researchers identified an immune signal called CX3CL1 that plays a key role in this process.
A new standard dataset defines 16 clinical and patient-reported outcome measures for adults with heart valve disease. The International Consortium for Health Outcomes Measurement (ICHOM) developed the globally inclusive standard dataset.
Osteosarcoma cells often have extra copies of the SETDB1 gene, making the cancer more aggressive and harder to treat. Blocking SETDB1 may help the immune system recognize and attack osteosarcoma cells, offering a promising new way to treat this type of bone cancer.
A systematic review by the American Academy of Neurology found that epidural steroid injections modestly reduce pain and disability for people with certain kinds of chronic back pain, particularly radiculopathy. The treatment may be effective for up to three months, but its long-term effectiveness is unclear.
A large study found that telemedicine and training apps had minimal positive effects on patients with type 2 diabetes and coronary heart disease. The study suggests that direct care from medical professionals remains crucial for improving health outcomes in this population.
A groundbreaking study analyzed data from over 78,000 cancer patients to identify nearly 800 genetic changes impacting survival outcomes. The research also discovered genes significantly associated with survival in various cancers, such as breast, ovarian, skin, and gastrointestinal cancers.
A new drug-free intervention targets the root cause of progressive loss of neural function in SMA by gradually reawakening functionally silent motor neurons. Early results show improved leg muscle strength and walking in adults with SMA, regardless of symptom severity.
A study of US poison center calls reveals a significant rise in caffeine energy product exposures among children and adolescents, with powdered caffeine exposures skyrocketing by 633%. Most exposures were unintentional and occurred in children under 6 years old.
A new clinical study by the BfR found that tattoo ink contains smaller amounts of liquid components than previously thought. The researchers were able to detect metabolites in blood samples shortly after tattooing began and showed that metabolism functions differently when substances are taken up through the skin.
A study by Tokyo Metropolitan University found that nurses have a faster response when presented with words showing high or low risk ailments, but individual directional biases vary. The researchers' findings may inform better ways to present clinical information, potentially leading to improved medical care and lives saved.
A cohort study from JAMA Network Open reveals an association between temperature exposure and increased psychiatric symptoms among adolescents in the Netherlands and Spain. The findings suggest a possible link between climate change and mental health, warranting further research across diverse climates.
Researchers found that patients undergoing mechanical thrombectomies at smaller hospitals did not have less favorable outcomes than those at large healthcare systems. In fact, larger hospitals with higher volumes of procedures saw more adverse outcomes in stroke patients.
A new position paper from the International Osteoporosis Foundation and International Federation of Clinical Chemistry proposes a unified nomenclature for bone status indices to enhance diagnostic consistency and clarity. The guidelines offer a comprehensive framework to unify terminology and improve comparability across studies.
A cohort study found that individuals with higher radon exposure are at a greater risk of developing gestational diabetes during pregnancy. The study suggests a potential link between radon exposure and metabolic health in nulliparous pregnant women.
Climate change is associated with poorer HIV prevention outcomes, including reduced testing and increased risk behaviors, leading to higher new infections and poorer treatment adherence. Researchers identified links between extreme weather events and HIV-related challenges, emphasizing the need for innovative interventions and strategies.
Researchers found that participants who received early therapeutic interventions were significantly less likely to develop clinical depression within the first year. The interventions, which typically lasted six to twelve sessions, reduced symptoms and lowered the risk of depression by 42% in the first six months.
The study demonstrated a median progression-free survival of 18.2 months and a disease control rate of 97.5% among participants with hormone receptor-positive and HER2-positive metastatic breast cancer. The combination treatment was well-tolerated, with no grade 4 adverse events reported.
A scoping review of community health indices has identified a broad range of indicators covering health outcomes and vulnerabilities. These indices offer potential for multi-factorial assessments to inform regional and local policy strategies, aiming to reduce social inequities and improve community health.
A recent study from Trinity researchers uncovers the mechanisms behind COVID-19 disease severity, highlighting the critical role of low-density neutrophils. The findings suggest that lingering immune abnormalities after recovery could contribute to long-term health effects or complications.
A review of 3,000 studies suggests microplastics in the air may cause serious health problems, including colon cancer, poor lung function, and infertility. The tiny plastic particles are believed to contribute to chronic pulmonary inflammation, increasing the risk of lung cancer.
A review of probiotics for restoring antibiotic-disturbed gut microbiota found limited conclusive evidence. While certain probiotics can reduce clinical symptoms like diarrhea and C. difficile colitis, the lack of standardization in measuring microbiota disruption and recovery hinders conclusions.
Researchers developed an ultra-compact transparent ultrasonic transducer for simultaneous high-resolution ultrasound and photoacoustic imaging. This technology improves diagnostic sensitivity by providing detailed information about tissue vasculature, thereby enhancing early cancer detection.
Researchers found β-ionone alleviates ulcerative colitis symptoms by protecting the gut barrier and restoring microbial balance. The study suggests ION's therapeutic potential for UC management, offering an alternative to current drug treatments.
A phase 3 trial shows that autologous stem cell transplants do not improve survival for mantle cell lymphoma patients in complete remission and undetectable minimal residual disease. Patients who remain MRD-positive after induction may benefit from ASCT, but longer follow-up is needed to confirm these findings.
Researchers develop personalized cognitive integrated sensorimotor virtual reality training to improve gait and balance in individuals with traumatic brain injury (TBI). A separate study uses robotic balance training combined with non-invasive brain stimulation to enhance postural control and motor recovery in TBI.
The RATE-XR guideline standardizes reporting for early-phase clinical studies involving extended reality technologies, ensuring transparency, safety, and ethical reporting. Developed through a multidisciplinary team of international experts, the comprehensive framework fosters reproducibility and patient-centeredness.
Researchers developing standardized approach for ACJ reconstruction, evaluating three surgical techniques to restore stability and minimize complications. The study aims to identify most effective technique for long-term shoulder health in young athletes.
Professor Lavretsky's pioneering work integrates conventional psychiatric treatments with mind-body interventions, developing novel therapeutic combinations for treatment-resistant depression and cognitive disorders. Her research has transformed approaches to mental health and aging, emphasizing whole person health and prevention.
This special issue of Calcified Tissue International presents a collection of critical reviews and original research articles on osteogenesis imperfecta (OI), covering essential aspects of the condition, including its nosology, genetics, and clinical presentation. The contributions also discuss treatment strategies for both children an...
A clinical study found increased permeability of the small intestine and inflammation in the gut, linked to higher body weight and insulin resistance. The researchers emphasize the need for further investigations into carrageenan's effects on human health.
The Emory University Hospital team successfully implanted the BrioVAD System, a novel magnetically levitated pump designed for patient ease and long-term health. This marks the first-time use of the device in the US, as part of the INNOVATE clinical trial.
Researchers at UCSF are enrolling patients in a clinical trial to correct the genetic mutation causing sickle cell disease using non-viral CRISPR-Cas9 gene editing. The therapy aims to eliminate the need for a bone marrow transplant and create a new blood system free of the disease.
A global research team has developed an advanced diagnostic kit for detecting the highly pathogenic H5N1 Avian Influenza Virus, allowing for rapid detection of both high and low pathogenic strains. The kit's swift detection enables timely responses to outbreaks, reducing transmission risks and preventing devastating epidemics.
New research shows that routine symptom screening using a validated tool (SSPedi) can reduce symptom burden and support implementing care pathways for improved symptom management. This study found a clinically meaningful decrease in total symptom score, with 12 of 15 symptoms measured showing significant improvement.
The editorial highlights how digital tools improve patient outcomes through better monitoring, individualized care, and seamless communication between patients and healthcare providers. Digital health innovations also address key challenges such as data privacy and accessibility.
A systematic review and meta-analysis found that religiosity, spirituality, and meaning-making have a small but significant protective effect against suicidality. The study suggests that clinicians should personalize and culturally adapt suicide prevention and treatment strategies to effectively address this issue.
The American Heart Association has announced five health technology start-up companies as finalists in its 7th annual Health Tech Competition. The competition aims to drive technological advancements with the potential to transform heart and brain health patient outcomes.