Researchers analyzed carotid plaque samples from 75 Chinese and 111 US patients, revealing distinct differences in plaque morphology, size, and composition. The study highlights the importance of understanding population-specific variations to develop personalized treatment approaches for cerebrovascular events.
A randomized clinical trial has shown that rituximab is effective in preventing relapses and reducing the need for corticosteroids in adults with relapsing nephrotic syndrome. The study involved 66 adult patients treated with either rituximab or a placebo, with impressive results at the 49-week follow-up.
Researchers can utilize a combination of automated and manual actions to quickly identify suspicious behavior and prevent fraudulent actors from enrolling in online studies. A comprehensive checklist of indicators helps researchers spot potential fraud, such as similar patterns in email addresses or predictable responses.
The Louisiana ECHO program, which focuses on pre-, peri- and postnatal outcomes, obesity, and other areas, will continue its efforts to expand access to clinical trials for Louisiana children. The grant renewal supports the collaboration between researchers from Pennington Biomedical and Ochsner Health System, as well as two free-stand...
Researchers at Aalto University have developed a promising new treatment approach for dry age-related macular degeneration (AMD), which can potentially stop the disease's progression. The novel method uses heat and near-infrared light to trigger healing responses at a cellular level, strengthening protective mechanisms of affected cells.
New tools, such as CheatBlocker and QuotaConfig, help address challenges of data integrity in decentralized clinical trials. CheatBlocker detects fraud, while QuotaConfig ensures sample representativeness. These innovations aim to increase the reliability and security of remote clinical trials.
A novel risk model has been developed to predict postoperative infections in transplant recipients, incorporating lifestyle and psychological variables. The model identified several novel risk factors, including regular tea consumption and higher guilt scores.
The Mays Cancer Center stands among the nation's leading institutions recognized for excellence in cancer care and research. It is one of only four NCI-designated Cancer Centers in Texas, offering specialized programs and delivering comprehensive, multidisciplinary care supported by clinical research.
Researchers at FAU Engineering have developed foot-mounted wearable sensors and a 3D depth camera that accurately measure how people walk, even in busy clinical environments. The study findings reveal that these technologies match the accuracy of traditional tools but are more scalable, remote, and cost-effective.
The termination of thousands of federal grants has raised ethical concerns about clinical trial closures, particularly among children and adolescents. Researchers argue that sudden stops can break trust and harm participants, violating long-standing principles.
A new clinical trial by ECOG-ACRIN Cancer Research Group found pembrolizumab reduced cancer recurrence risk to 73% in patients receiving the treatment after surgery. Patients also showed a 42% lower risk of developing distant metastases.
Scientists analyzed thousands of proteins in blood samples to understand when multiple sclerosis attacks the myelin sheath and nerve fibers. Researchers identified a protein called IL-3, which plays a key role in this early phase of damage.
Researchers found a targeted immunotherapy regimen yielded promising survival outcomes for patients with B-cell ALL, outperforming historical results. The treatment was well-tolerated, with more than half completing the full course of therapy, and responded similarly in patients with complex medical histories.
Scientists found a promising candidate, pleiotrophin, which is essential for brain development and function; restoring it may improve brain circuits in individuals with Down syndrome and other neurological diseases. The study's findings suggest using modified viruses to deliver the protein directly into cells could lead to new treatments.
Researchers developed TAMENDOX to supplement (Z)-endoxifen in patients with CYP2D6 enzyme deficiency, improving drug concentration and effectiveness. The new therapy was well-tolerated, showing promise as an alternative to aromatase inhibitors for premenopausal women.
A cross-sectional study reveals that medical students with disabilities experience both general and race-based discrimination, as well as gender-based discrimination. The findings highlight the need to address these intersecting forms of discrimination in medical education.
A new study found that entering menopause at an earlier age is associated with a higher risk of dementia. On the other hand, post-menopause hormone replacement therapy appears to lower the risk of dementia. The research involved over 1,300 women from the Framingham Heart Study and analyzed various factors related to brain aging.
A recent study published in Leukemia found that age-based classifications in acute myeloid leukemia (AML) treatment may be outdated. The research analyzed data from 2,823 adult AML patients, revealing nuanced age-related trends in genetic mutations and survival outcomes.
Boston Children's Hospital has received a $35 million donation from Hansjoerg Wyss to further its translational neuroscience research, focusing on rare brain disorders and intellectual disability. The gift will support clinical trials, fellowships, and pilot studies, aiming to develop new therapies for vulnerable children.
A new study found that slow-tempo music did not reduce delirium or anxiety in critically ill older adults, but a trend showed fewer days with delirium among those who received more doses of music. Researchers suggest personalized approaches and targeted populations for future studies.
The new centre supports multiple clinical trials in parallel, enabling comprehensive evaluations of organ health across physiological systems. It also provides hands-on training opportunities for healthcare professionals, bridging the gap between theoretical knowledge and practical application.
The ASPIRE trial is a Phase III clinical study investigating whether adding chemotherapy to standard treatments can extend survival in men with advanced prostate cancer. The trial aims to determine the effectiveness of combining docetaxel with hormone therapy and apalutamide.
A topical formulation has been shown to reduce the incidence of hand-foot neuropathy in cancer patients undergoing chemotherapy, improving quality of life. The cream, developed at UMH, acts directly on neurosensory pain receptors, reducing hypersensitivity and tolerance to chemotherapy.
Colin Hill joins C-Path's Board of Directors with experience in AI, drug development, and translational acceleration. He aims to bring precision medicine focus to advance treatments worldwide.
A groundbreaking study enrolls 465 AYA cancer patients to test if chatbot technology and digital education tools increase uptake of genetic counseling and improve patient outcomes. The trial aims to address longstanding gaps in genetic services for AYAs aged 18-39, who often receive care with limited access to genetic specialists.
A clinical study reveals that masturbation can alleviate menopause symptoms such as fatigue and night sweats. The study, conducted by the Kinsey Institute, found that participants who engaged in self-pleasure reported significant improvements in their overall wellbeing.
A randomized clinical trial found that parents who received remote motivational counseling and mobile-based support improved their use of appropriate child car seats. The intervention included tailored web content, periodic text messages, and personalized feedback.
Insilico Medicine's founder Alex Zhavoronkov, PhD, is named among 100 global leaders driving the future of artificial intelligence. The company has developed breakthrough solutions for novel target discovery and drug development using generative AI.
The University of Arizona and University of New Mexico received a $43.6 million NIH grant to support translational science and training for early-career researchers. The partnership aims to translate research discoveries into improved patient care, with a focus on substance use disorders and rural health initiatives.
Researchers are testing whether low-concentrate atropine drops can delay the onset of myopia in children. The study aims to reduce the risk of sight-threatening complications later in life by decreasing how nearsighted someone becomes.
A new study shows that remote perioperative monitoring significantly improves recovery for cancer surgery patients, with a 6% greater functional recovery rate by day 14 after surgery. The study also found fewer major complications and improved symptom management.
The American Society for Radiation Oncology, American Society of Clinical Oncology, and Society of Surgical Oncology jointly published a guideline outlining when post-mastectomy radiation therapy (PMRT) is appropriate based on new evidence. PMRT reduces cancer recurrence risk in patients with node-positive disease or high-risk features.
PCORI announces funding for 9 new patient-centered comparative clinical effectiveness research studies addressing various health concerns, including sleep health and chronic low back pain. The studies aim to provide evidence-based information for informed healthcare decisions.
A clinical trial found that patients with mesothelioma who received combination immunotherapy drugs before surgery had successful surgeries and improved early outcomes. The study showed that tracking tumor DNA in the blood could help predict treatment benefit.
A clinical study suggests that immunotherapy can be effective in treating mesothelioma, a rare cancer affecting the lining of the lungs. The trial found improvements in time to tumor growth and overall length of survival for patients with operable diffuse pleural mesothelioma.
A clinical trial led by Professor Robert Bals found that azelastine nasal spray significantly reduced the risk of SARS-CoV-2 infection by 66%. The treatment group showed fewer symptomatic infections and lower respiratory rates compared to the placebo group.
A new class of targeted therapy showed promise in treating head and neck squamous cell carcinoma (HNSCC) in pet cats, with 35% of patients experiencing controlled disease. The drug, which targets the transcription factor STAT3, also raised levels of PD-1, a protein associated with an immune response to cancer.
A synthetic molecule called Pep19 has been shown to reduce visceral fat and improve sleep quality in overweight adults, with no side effects observed. The study involved 24 volunteers who took either a placebo or Pep19 in capsules, and found a 17% reduction in visceral fat and improved sleep quality in those who received the molecule.
Researchers at Kennedy Krieger Institute have developed biomarkers to help identify children with Sturge-Weber syndrome at risk of developing the condition. These tools can monitor disease progression and guide individualized treatment plans, potentially changing a child's development trajectory.
A cohort study found a higher prevalence of eating disorders among adolescents from lower socioeconomic backgrounds. The study suggests that reducing population-level socioeconomic inequalities may aid in preventing eating disorders.
Researchers identified a distinctive CT imaging pattern called PRACE that predicts severe postpartum hemorrhage cases requiring emergency procedures. The finding was strongly associated with the need for uterine artery embolization and improved maternal outcomes.
A recent study by researchers at the University of Missouri has made a groundbreaking discovery using patient's own cartilage cells to aid in healing after hip surgery. The research team successfully cultured and expanded cartilage cells, or chondrocytes, in the lab, paving the way for future clinical applications.
Insilico Medicine has completed IND-enabling studies for ISM8969, an orally available NLRP3 inhibitor targeting inflammation and neurodegenerative disorders. The drug candidate demonstrated favorable PD/PK profiles and dose-dependent efficacy in motor functions in animal models.
A Duke-NUS platform has been awarded US$1.5 million to develop new antifibrotic therapies for lung and kidney diseases, conditions with no effective treatment. The project aims to deliver first-in-class antifibrotic therapies using a cutting-edge computational biology approach.
The BREATHE-3 clinical trial evaluates a novel bronchoscopic device to open airways and release trapped air in patients with severe emphysema. The study will assess the safety and efficacy of the Apreo BREATHE Airway Scaffold, an implantable device granted FDA Breakthrough Device Designation.
Researchers have found a way to rearrange atoms in a new generation of malaria drugs to make them more soluble, maintaining their effectiveness against drug-resistant parasites. This breakthrough could lead to an effective successor to artemisinin-based combination therapy.
Researchers at La Jolla Institute for Immunology examine how genetics, sex hormones, and environmental factors shape the immune system. Women have a stronger immune response due to their XX chromosomes and estrogen, but also face an increased risk of autoimmune diseases.
Genethon is launching a Phase 3 clinical trial in Europe for its low-dose microdystrophin gene therapy GNT0004, targeting boys aged 6 to 10 with retained walking ability. The trial aims to demonstrate efficacy and tolerance of the treatment.
The study analyzed 90 reviews covering over 1,200 studies to identify barriers and facilitators of clinical integration. Family physicians' characteristics, knowledge, and experience were found to be significant factors in successful integration.
A new study published in JAMA Network Open found no statistical relationship between pathologic complete response (pCR) and overall survival in rectal cancer patients. This challenges the FDA's use of pCR as a surrogate endpoint for drug approval, which may lead to treatments being fast-tracked without evidence of improved long-term su...
A 0.1% pterostilbene skincare emulsion demonstrated remarkable improvements in skin elasticity, firmness, and reduced wrinkles over 28 days in a double-blind, split-face design study with 31 participants. The emulsion also increased epidermis layer thickness, enhanced collagen and elastic fibers, and minimized pores.
A study published in Pediatrics reveals a sharp surge in nicotine pouch ingestions among young children, with a 763% increase in rate of reported cases between 2020 and 2023. The ingestion rates for other nicotine products declined during the same period.
A study of 62,839 people diagnosed with non-metastatic prostate cancer in Sweden found that those treated according to NCCN Guidelines were likely to survive their cancer for their remaining life-expectancy. Those with low- and intermediate-risk cancer were six times more likely to die of other causes than prostate cancer.
Researchers at Sutter Health tested the performance of the American Heart Association's PREVENT equations in diverse Asian and Hispanic subgroups, showing accurate prediction of cardiovascular disease, atherosclerotic CVD, and heart failure events. The study findings aim to improve cardiovascular healthcare for all populations.
A new study highlights major hurdles for multinational clinical trials in Europe, including differences in timelines and processing times between countries. Researchers found that the UK made significant gains in efficiency during the pandemic, while non-UK countries lagged behind.
The American Thoracic Society has launched an initiative to provide paid time-off for employees participating in clinical trials. This effort aims to reduce barriers to participation, particularly among underserved communities, and promote diversity in medical research.
Researchers at Mass General Brigham found a novel strategy to help patients control their disease, increasing eligibility for stem cell transplants. The combination of duvelisib and romidepsin was effective, tolerable, and safe for patients with relapsed/refractory peripheral and cutaneous T-cell lymphomas.
A landmark national study in China identifies the most effective treatment strategies for unruptured brain aneurysms, analyzing over 874,000 clinical entries and 42,000 radiological scans. The trial aims to guide patient-specific treatment strategies and inform healthcare planning in China's aging population.
The US Department of Energy's Isotope Program will supply a U.S. company with accelerator-produced actinium-225 for the first FDA-approved targeted cancer therapy clinical trial. This milestone marks a new pipeline for this lifesaving isotope, addressing its limited production due to complex manufacturing.
A study of 95 patients found that wrapping autologous tissue materials around anastomoses after airway reconstruction significantly reduced short-term postoperative complications. This technique may offer a positive effect on the prognosis of patients undergoing complex tracheobronchial resection and reconstruction.