Articles tagged with Clinical Studies
A new study highlights major hurdles for multinational clinical trials in Europe, including differences in timelines and processing times between countries. Researchers found that the UK made significant gains in efficiency during the pandemic, while non-UK countries lagged behind.
Researchers at Mass General Brigham found a novel strategy to help patients control their disease, increasing eligibility for stem cell transplants. The combination of duvelisib and romidepsin was effective, tolerable, and safe for patients with relapsed/refractory peripheral and cutaneous T-cell lymphomas.
The American Thoracic Society has launched an initiative to provide paid time-off for employees participating in clinical trials. This effort aims to reduce barriers to participation, particularly among underserved communities, and promote diversity in medical research.
The US Department of Energy's Isotope Program will supply a U.S. company with accelerator-produced actinium-225 for the first FDA-approved targeted cancer therapy clinical trial. This milestone marks a new pipeline for this lifesaving isotope, addressing its limited production due to complex manufacturing.
A landmark national study in China identifies the most effective treatment strategies for unruptured brain aneurysms, analyzing over 874,000 clinical entries and 42,000 radiological scans. The trial aims to guide patient-specific treatment strategies and inform healthcare planning in China's aging population.
A common medication used for autoimmune diseases has been found to be effective in treating giant cell arteritis, with nearly half of patients achieving sustained remission. The treatment reduces dependence on glucocorticoids, a common but side-effect-ridden option.
A phase 3 trial demonstrated the efficacy of selumetinib in reducing tumor size and alleviating pain in adults with neurofibromatosis type 1. The treatment was found to be effective in patients who received it from day one, as well as those who started it later, with significant reductions in tumor size and pain reported.
A study of 95 patients found that wrapping autologous tissue materials around anastomoses after airway reconstruction significantly reduced short-term postoperative complications. This technique may offer a positive effect on the prognosis of patients undergoing complex tracheobronchial resection and reconstruction.
A retrospective study found ESL to be a safe and viable alternative to pneumonectomy for selected patients with centrally located NSCLC. ESL offered better event-free survival compared to pneumonectomy.
Researchers at the University of Missouri have developed a new imaging probe that can help surgeons accurately identify and remove aggressive brain tumors during operations. The tool, known as FA-ICG, uses near-infrared light to highlight tumor cells from within.
The BathMat clinical trial evaluates an innovative inflatable pillow designed to make moving intensive care unit patients safer, faster, and less labour-intensive for NHS staff. The trials aim to reduce staff time required for repositioning proned patients and improve patient healthcare outcomes.
A new study from the University of Colorado Anschutz Medical Campus shows that primary care clinics can effectively introduce continuous glucose monitors (CGMs) into their practices. The study found that both self-guided and virtual CGM initiation services were successful, regardless of clinic size or diabetes expertise.
The small intestine's epithelial cells and immune cells work together to maintain gut integrity and regulate immune responses. Dysfunction in these cellular networks is linked to systemic diseases such as obesity, insulin resistance, and autoimmune conditions.
The CONFIDENCE trial demonstrates that combination therapy with finerenone and empagliflozin leads to significantly greater reductions in albuminuria than either agent alone. The study shows a 52% median reduction in urinary albumin-to-creatinine ratio, achieving the ADA-recommended target for 70% of patients.
Researchers have discovered that nicotinamide riboside supplementation significantly improves NAD+ levels, reducing arterial stiffness, skin ulcer area, and kidney dysfunction. This breakthrough offers new hope for patients with Werner syndrome who lack effective treatment options.
A large study has found that cholesterol-lowering drugs do not have an antidepressive effect, contradicting previous small studies. The research, published in JAMA Psychiatry, involved 161 patients with depression and obesity, who received either statins or a placebo for 12 weeks.
The annual Alzheimer's disease drug development pipeline report, led by Dr. Jeffrey Cummings, highlights an increase in active clinical trials and promising drugs, offering reason for optimism. The report assesses 138 drugs currently being studied and notes the growing importance of biomarkers in clinical trials.
The American Association for Anatomy has awarded over $238,000 to nearly 200 individuals through various awards and scholarship programs. The organization recognizes outstanding achievements in research, education, and professional development, supporting career advancement and further education opportunities.
The CompassHER2 trial found that neoadjuvant THP led to a pathologic complete response (pCR) rate of 64% in patients with early-stage HER2-positive, ER-negative breast cancer. Lower ER expression levels resulted in higher pCR rates among ER-positive tumors.
DB-1310, a HER3-targeted antibody-drug conjugate, has shown real potential as a new treatment option for patients with advanced solid tumors that have progressed after standard therapies. In an international clinical trial, DB-1310 demonstrated significant tumor shrinkage and delayed cancer growth in 44% of EGFR-mutant NSCLC patients.
The Experimental Drug Development Centre's EBC-129, an antibody-drug conjugate targeting pancreatic cancer, has received FDA fast track designation. The treatment is undergoing Phase 1 clinical trials and aims to provide new treatment options for patients with solid tumours.
The research aims to improve the survivability of wounded soldiers, enhance combat safety, and accelerate postoperative recovery in a multicenter pivotal clinical study. OYE's technology has shown promise in reducing mortality rates, lowering healthcare costs, and improving surgical workflow efficiency.
A new smartphone app, ECHAS, can help people determine if they are suffering from a heart attack or stroke and need medical attention. The app, developed by experts at UVA Health and other leading institutions, proved effective in identifying patients with cardiac and neurological emergencies.
Tracy Crane has been appointed as the new Chair of the NRG CPC Committee, focusing on improving adherence to healthy lifestyle behaviors, while Mylin Torres joins as Vice-Chair, leading research on breast cancer and radiation-induced side effects. Both experts bring extensive experience in clinical trials and mentorship.
Yōni.Fit demonstrated significant reduction in 12-hour pad weights spanning seven days compared to the control device, highlighting its superior performance. The study showed mild to moderate adverse events, but no serious ones.
Researchers found that tirzepatide increases energy expenditure directly after treatment, while semaglutide reduces it. Both drugs aid weight loss by decreasing food intake and enhancing fat oxidation.
A cross-sectional study analyzing over 18,000 clinical notes found notable disparities in stigmatizing and positive language documentation across racial and ethnic groups. The study highlights the need for improved documentation practices to reduce stigmatizing language use.
Researchers found that current drinkers who consumed 14 or more drinks per week had a 25% higher risk of colorectal cancer compared to those who drank less than one drink per week. The study also presented data on a novel immunotherapy treatment for acute myeloid leukemia, showing greater success and fewer side effects.
The inaugural Joint Congress brings together paediatric and adult endocrine specialists to learn from each other, collaborate, and celebrate endocrinology. Over 7,500 delegates from 100 countries attend the event to experience the latest research and developments.
A 10-year study confirms a one-week course of post-surgery radiotherapy is just as safe and effective as the traditional three-week regimen for early-stage breast cancer patients. This shorter schedule provides similar cancer control without additional long-term side effects.
Kristin Higgins has been appointed Chair of the NRG Lung Cancer Committee, succeeding Dr. Jeff Bradley, while Karthik Sundaram joins as Chair of the NRG Imaging Committee, succeeding Dr. Daniel Pryma. These appointments aim to advance research and clinical trials in these areas.
A phase III clinical trial has shown that a two-and-a-half week course of precision radiotherapy is equally successful in beating prostate cancer as the standard eight-week approach. After 10 years, both options produced similar disease control rates and survival rates.
The conference brings together leading experts to examine cardiovascular disease trends and share insights on prevention and management. ACC Asia 2025 will also recognize over 30 individuals who have earned the Fellow of the ACC designation.
New technology can enhance screenings when it is tailored to individual patient needs, improving early detection and management of disease. Digital tools work best in conjunction with clinicians, addressing barriers like care coordination to ensure better outcomes.
A new review advocates for building confidence in AI applications by implementing robust data governance frameworks, enhancing transparency, and involving stakeholders. The authors emphasize the importance of addressing ethical implications and ensuring equitable access to AI-driven innovations in clinical oncology.
Researchers developed a new method to determine optimal threshold time for restricted mean survival time analysis, improving statistical power in clinical and epidemiological studies. The method outperformed traditional statistical analysis methods in real-world scenarios, revealing clear differences between treatment groups.
Researchers have discovered genetic properties in prostate cancer that can be targeted to improve patient outcomes, particularly for Chinese men. The findings highlight the potential of precision medicine and more effective treatments.
The study found that serum-derived hsa_circ_101555 showed excellent diagnostic accuracy in differentiating HCC patients from healthy controls. It also demonstrated a prognostic role in predicting tumor progression and response to therapy, with significant correlations with markers of liver inflammation and tumor features.
SKINdeep, a new international journal on translational dermatology and clinical studies, is now available online. The journal features original articles, reviews, and perspectives on skin diseases and their therapeutic relevance.
New research suggests that patients' muscle quality before hip replacement surgery may predict their risk of poor recovery. Patients with poor muscle quality were more likely to perform poorly on movement tasks after surgery, compared to those with good muscle quality.
A new study provides a method to estimate sample size required for microbiome studies based on effect sizes and analysis methods. For strong associations, around 500 participants were needed to achieve 80% statistical power, while weaker associations may require thousands of samples.
The updated CONSORT 2025 statement provides a minimum set of essential items for reporting randomised trials, aiming to enhance the reliability and validity of trial findings. The guidelines include new checklist items and revisions to existing ones, focusing on open science principles.
A newly-published Cochrane review found significant gaps in clinical rating scales used to assess pain in newborn babies. The review of 79 studies involving over 7,000 infants across 26 countries revealed that none of the available scales are backed by high-quality evidence.
A two-week in-patient study found that eating during the day but not at night reduced cardiovascular risk factors in healthy young participants after simulated night work. This finding supports adjusting food timing to mitigate health risks associated with shift work.
A new case report presents a highly unusual combination of two benign ovarian tumors: serous cystadenofibroma and collision lesions. Accurate preoperative diagnosis is critical for effective treatment planning, and this case emphasizes the need for personalized evaluation of each ovarian mass.
The National Comprehensive Cancer Network (NCCN) has awarded four early-career oncologists with $150,000 in funding to tackle pressing challenges in cancer care. The recipients will support studies aiming to improve cancer outcomes through molecular residual disease-guided adjuvant therapy and electronic symptom monitoring.
Dr. Christopher Kramer began a one-year term as head of the American College of Cardiology, addressing workforce issues, health equity and AI-driven solutions to improve cardiovascular care. With over 35 years of membership and leadership roles, Kramer brings experience in cardiovascular magnetic resonance imaging.
Researchers propose a general formula modeling bone adaptation as a function of key loading parameters. The formula provides insights into the relationship between mechanical signals and adaptive bone responses, offering guidance for optimizing exercise regimens and designing medical devices to promote bone health.
Researchers developed a blood test that accurately diagnoses Alzheimer's disease and measures its progression. The test correlates with the amount of tau aggregates in the brain, distinguishing between early- and late-stage diseases.
The study found significant improvements in symptoms for participants with major depressive disorder, generalized anxiety disorder, and eating disorders. Participants reported trusting and communicating with Therabot comparable to working with a therapist.
The American Society for Nutrition will host NUTRITION 2025, bringing together experts to explore topics such as diet, sleep, cardiovascular health, adolescence, and chronic pain. The event features original research studies, scientific symposia, and networking events, offering a platform for the latest nutrition science findings.
A new study by Korea University researchers reveals that switching to besifovir may improve patient kidney and bone health for long-term hepatitis B treatment. The study showed that patients who switched to besifovir had higher estimated glomerular filtration rate indicating improved kidney function and higher hip and spine bone densit...
A comprehensive review of studies reveals that over 15% of caregivers of adult cancer patients suffer from post-traumatic stress disorder (PTSD). Caregivers with pre-existing mental health conditions and high caregiver burden are at greater risk. The study highlights the urgent need for proactive screening and support to prevent long-t...
A clinical trial shows that removing amyloid plaques from the brain can delay Alzheimer's symptoms, supporting the amyloid hypothesis. The treatment reduced the risk of developing dementia in people destined to develop early-onset Alzheimer's disease.
Hyperuricemia is a metabolic disorder characterized by elevated uric acid levels, linked to cardiovascular diseases, gout, renal dysfunction, and metabolic disorders. Advances in technology and genetic research are transforming management strategies, including personalized treatments and probiotic interventions.
Researchers discovered immature platelet fraction as a clinical predictor for enhanced platelet recovery in patients with dengue fever. IPF% can help monitor platelet recovery and identify thrombocytopenia etiology, but recovery is not solely determined by platelet count.
Thomas Jefferson University has initiated a phase 1 clinical trial for a Lassa virus (LASV) vaccine, currently enrolling healthy volunteers. The vaccine's safety and immunogenicity will be assessed in both the rabies virus and LASV.
Eradivir's EV25 is a small molecule immunotherapy biotech company developing treatments for influenza. The Phase 2 challenge study will gather safety and efficacy data from healthy participants infected with influenza.
Children who frequently miss school due to abdominal complaints are more likely to have gut-brain axis disorders like IBS, which can be missed by medical tests. The study found that frequent absences were nearly five times more likely to be caused by functional GI disorders than specific illnesses.
A new study from Denmark reveals that a mother's diet during pregnancy, characterized by a Western dietary pattern high in fat and sugar, may increase the risk of neurodevelopmental disorders such as ADHD and autism. Researchers found that even small dietary adjustments away from this pattern could potentially reduce this risk.