A new study led by CAMH shows that a combination of therapies can slow cognitive decline in older adults with conditions increasing the risk of dementia. Participants receiving Cognitive Remediation plus transcranial direct current stimulation experienced slower cognitive decline compared to those receiving a control intervention.
SourceCentre for Addiction and Mental Health·JournalJAMA Psychiatry·TypeRandomized controlled/clinical trial·DateOct 30, 2024
Two UCF cancer researchers, Alicja Copik and Debbie Altomare, have received $100,000 grants from the Florida Breast Cancer Foundation to develop new treatments for breast cancer. They focus on enhancing natural killer cells to fight cancer and harnessing the body's immune system to create new therapies.
Researchers explore immune activation and tumor-promoting transcription factor FOXM1's role in CDK4/6-MEK resistance. They suggest targeting the oncogenic network of CDK4/6, MEK, PD-L1, and FOXM1 as future treatment options for MPNST patients.
SourceImpact Journals LLC·JournalOncotarget·TypeSystematic review·DateOct 1, 2024
Researchers developed a mathematical model predicting enhanced survival outcomes for NSCLC patients with novel treatment combinations. The model neutralizes the negative effects of miR-155, boosting standard-of-care treatments like cisplatin and immune checkpoint inhibitors.
SourceHouston Methodist·JournalMolecular Cancer·TypeComputational simulation/modeling·DateSep 27, 2024
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
The integration of artificial intelligence in intratumoral immunotherapy can refine diagnoses, guide interventions, predict treatment responses, and adapt therapeutic strategies. This enables the enhancement of patient outcomes, including improved survival rates and quality of life.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateSep 19, 2024
Recent years have seen therapeutic advances in kidney cancer due to deeper understanding of the disease's biology, with improved treatments and early detection contributing to decreased deaths. Cigarette smoking and being overweight remain major risk factors for kidney cancer.
SourceUniversity of North Carolina Health Care·JournalJAMA·TypeMeta-analysis·DateAug 28, 2024
The study compared FDG-PET/CT and CT for evaluating treatment response in unresectable malignant pleural mesothelioma patients. The results showed that both imaging modalities provided accurate findings for tumor response evaluation, with high concordance between the two methods.
SourceImpact Journals LLC·JournalOncotarget·TypeImaging analysis·DateJul 15, 2024
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A special issue of WORK Journal explores the importance of designing healthy workplaces that address musculoskeletal conditions, burnout, and chronic pain. The issue highlights the need for an interdisciplinary approach integrating medical, psychological, and occupational therapies to prevent work-related illness and injury.
SourceIOS Press·JournalWork·TypeObservational study·DateJul 10, 2024
Researchers uncover the importance of kainate receptors in enabling synaptic plasticity and transmission in the cerebellum. The study's findings have significant implications for understanding neurological disorders and developing new treatments.
SourceUniversidad Miguel Hernandez de Elche·JournalCell Reports·TypeExperimental study·DateJul 10, 2024
Researchers at the University of Zurich have discovered a factor secreted by tumor cells that impeds the effectiveness of therapies. The POSTN gene plays an important role in resistant tumors and triggers resistance through its interaction with immune cells, particularly macrophages.
SourceUniversity of Zurich·JournalCell Reports Medicine·TypeExperimental study·DateJun 27, 2024
A novel combination of oncolytic virus and immune checkpoint inhibitor has shown remarkable efficacy in treating non-muscle invasive bladder cancer, with a complete response rate of 57.1% at 12 months. The therapy demonstrated durable responses, with a median duration of response not yet reached after a median follow-up of 26.5 months.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalNature Medicine·TypeRandomized controlled/clinical trial·DateJun 6, 2024
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
A new study demonstrates personalized phage therapy's effectiveness in treating antibiotic-resistant infections in animals, with a case of a cat healing from a persistent wound. The treatment combines a specific anti-Pseudomonas aeruginosa phage with ceftazidime, achieving full healing after 14 weeks.
SourceThe Hebrew University of Jerusalem·JournalVeterinary Quarterly·TypeCase study·DateMay 27, 2024
Researchers at Baylor College of Medicine identified PKMYT1, a protein kinase associated with resistance to endocrine therapy and CDK4/6 inhibitors in ER+ breast cancers. The study found that combining a PKMYT1 inhibitor with chemotherapy drug gemcitabine selectively reduced the viability of resistant cancer cells.
SourceBaylor College of Medicine·JournalMolecular Cancer Therapeutics·TypeExperimental study·DateMay 24, 2024
Researchers from Penn Medicine's Abramson Cancer Center and Perelman School of Medicine will present results from clinical trials for esophageal cancer, CAR T cell therapy, and ovarian cancer. The meeting will feature more than 200 sessions on AI in cancer care.
SourceUniversity of Pennsylvania School of Medicine·DateMay 23, 2024
A retrospective cohort study found that PERT significantly reduced the incidence of acute pancreatitis episodes among children with recurrent or chronic pancreatitis. The study also identified genetic markers, such as SPINK1 mutation, that influence treatment outcomes and suggest a tailored approach to patient care.
SourceOchsner Health System·JournalThe American Journal of Gastroenterology·DateMar 27, 2024
Researchers unveil innovative strategies to overcome metabolic constraints in CAR-T cell therapy, aiming to boost its efficacy in treating solid tumors. Metabolic interventions targeting immunosuppressive metabolites, metabolite uptake, and mitochondrial metabolism are proposed to enhance anti-tumor activity.
SourceCactus Communications·JournalChinese Medical Journal·TypeSystematic review·DateMar 26, 2024
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers have discovered a new immunotherapy approach to overcome resistant leukemia by targeting the mutated TP53 gene. Combining pharmacological therapies with genetically engineered CAR T-cells increases effectiveness against cancer cells, offering promising strategies for patients with resistant disease.
SourceUniversity of Zurich·JournalEMBO Molecular Medicine·TypeExperimental study·DateMar 21, 2024
Researchers propose combining osimertinib with gefitinib to increase progression-free survival rates in EGFR-mutant lung cancer patients. A comprehensive PC approach could dramatically boost PFS for 80% of patients, eliminating harm and improving treatment outcomes.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMar 19, 2024
A new DNA origami platform, DoriVac, enables precise spacing of adjuvant molecules and a variety of antigens to enhance anti-tumor responses. The vaccine demonstrated enhanced efficacy in controlling tumor growth and prolonging survival in mice, synergizing with immune checkpoint inhibitors.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalNature Nanotechnology·TypeExperimental study·DateMar 15, 2024
Researchers at Johns Hopkins Medicine have developed a novel approach to target group 3 medulloblastoma tumors in mice, reducing tumor growth by 40-50% and extending survival by up to 84 days. The therapy uses antisense oligonucleotides to block lnc-HLX-2-7 from binding to the HLX promoter region.
SourceJohns Hopkins Medicine·JournalCell Reports·DateMar 13, 2024
A groundbreaking study found that combining partial normoxic recovery with senolytic Navitoclax significantly reduced sleepiness and improved cognitive function in mice with OSA. This suggests targeting accelerated senescence may be a promising avenue for improving treatment outcomes.
SourceMarshall University Joan C. Edwards School of Medicine·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateJan 3, 2024
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A Phase III trial demonstrates significantly improved progression-free survival and remission rates for patients with relapsed/refractory mantle cell lymphoma treated with the oral combination of ibrutinib and venetoclax. The treatment achieved an overall remission rate of 82% and a median PFS of 31.9 months.
SourceUniversity of Texas M. D. Anderson Cancer Center·DateDec 12, 2023
Two studies led by UCLA researchers reveal how cancer cells use energy to survive and grow, shedding light on why some prostate cancers become resistant to hormone therapy. The findings highlight the importance of considering cell metabolism in developing new cancer treatments, particularly those targeting the androgen receptor.
SourceUniversity of California - Los Angeles Health Sciences·JournalNature Cell Biology·DateDec 4, 2023
A Phase II clinical trial has shown a clear clinical benefit of combining Dabrafenib and Trametinib in treating BRAF mutated low-grade paediatric gliomas. The combination therapy improved overall response rate by over four-fold and increased median progression-free survival.
SourceUniversity College London·JournalNew England Journal of Medicine·DateNov 21, 2023
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers found that changing treatment can lead to significant improvement in mobility and quality of life for patients with advanced Parkinson's disease. A nationwide registry is planned to develop scientifically sound guidelines for combination therapies.
SourceTechnical University of Munich (TUM)·JournalNeurology·TypeData/statistical analysis·DateNov 6, 2023
Researchers developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to treat rheumatoid arthritis. This approach provides both immediate pain relief through ROS scavenging and long-term immune tolerance by delivering immunomodulatory cytokines.
SourceInstitute for Basic Science·JournalNature Nanotechnology·TypeExperimental study·DateOct 26, 2023
Dana-Farber Cancer Institute presents several studies on novel treatments, combination therapies, and personalized medicine for lung, kidney, and neuroendocrine tumors. The studies include pivotal trials on adagrasib with pembrolizumab for non-small cell lung cancer and belzutifan versus everolimus for clear cell renal cell carcinoma.
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers found that patients' immune systems play a vital role in determining the duration of remission from multiple myeloma. Sustained minimal residual disease (MRD) negativity is associated with prolonged survival, with patients achieving MRD negativity for at least two years remaining free from multiple myeloma 10 years later.
SourceUniversity of Miami Miller School of Medicine·JournalNature Communications·DateSep 6, 2023
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
SourceXi'an Jiaotong-Liverpool University·JournalCancer Gene Therapy·TypeExperimental study·DateSep 6, 2023
A new gene-editing technique combines peptide nucleic acids and prokaryotic Argonautes to introduce targeted breaks in the genome. The approach, called PNP editing, offers advantages over CRISPR-based methods, including improved specificity and targeting.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalNucleic Acids Research·DateAug 24, 2023
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers have found that a prostate cancer drug called proxalutamide can block SARS-CoV-2 viral entry and reduce inflammation. The compound works by binding to androgen receptors, inhibiting levels of TMPRSS2 and ACE2, and blocking infection.
SourceMichigan Medicine - University of Michigan·JournalProceedings of the National Academy of Sciences·DateAug 18, 2023
Researchers have identified a family of broadly neutralizing antibodies targeting the HIV-1 envelope protein, which may contribute to long-term remission from infection. These antibodies were found to induce the elimination of infected cells and impose a selective pressure on the virus, paving the way for new therapeutic approaches.
SourceInstitut Pasteur·JournalCell Host & Microbe·DateAug 8, 2023
A new study led by Sandra Casimiro and Luís Costa found a promising molecular target, the RANK signaling pathway, that could be used in combination with standard care to avoid resistance to treatment in metastatic breast cancer. High levels of RANK in cancer cells are associated with resistance to treatment with CDK4/6 inhibitors.
SourceInstituto de Medicina Molecular·JournalCell Reports Medicine·TypeExperimental study·DateJul 13, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A new study found that cetuximab plus radiotherapy is an active treatment option for locally advanced cutaneous squamous cell skin cancer, with an objective response rate of 83.2%. The treatment was well-tolerated, with most patients experiencing mild acneiform skin rash or fatigue.
SourceImpact Journals LLC·JournalOncotarget·TypeCase study·DateJul 12, 2023
Researchers discovered that Nerofe and Doxorubicin can downregulate KRAS signaling, leading to enhanced apoptosis in colorectal cancer cells. The combination also activates the immune system against tumor cells, increasing immunostimulatory cytokines and recruiting NK cells and M1 macrophages.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJul 5, 2023
A large Danish study found that use of menopausal hormone therapy is associated with an increased rate of dementia and Alzheimer's disease. The study revealed a significant increase in dementia risk among women who received treatment at the age of 55 years or younger, even for short-term users.
SourceBMJ Group·JournalThe BMJ·TypeObservational study·DateJun 28, 2023
A research team from HKUMed has developed a new platform to rapidly engineer and select the best precise genome editors for therapeutic applications. The platform allows for parallel testing of hundreds of base editor variants, enabling the selection of the most suitable ones with maximal efficiency and minimal undesired edits.
SourceThe University of Hong Kong·JournalCell Systems·TypeExperimental study·DateJun 28, 2023
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers at MD Anderson Cancer Center have identified disparities in end-of-life immunotherapy treatment, highlighting the need for further examination to ensure quality care. A new study also reveals a novel target to improve immunotherapy responses in KRAS-mutant lung cancer and strategies to manage immune-related toxicities.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalJournal of Clinical Oncology·DateJun 27, 2023
Scientists found that CXCL13-mediated recruitment of B cells helps predict response to immunotherapy treatment. This cooperation between T cells and B cells is associated with improved survival in patients treated with immunotherapy.
SourceUniversity of California - Los Angeles Health Sciences·JournalFrontiers in Immunology·DateJun 26, 2023
Cancer cells can hide and escape therapies leading to recurrence. Researchers identify three possible mechanisms: cancer stem cells, polyploidy, and senescence. Combination treatments involving chemoradiation-induced transitory senescence and senolytic therapies may be effective in preventing repopulation.
SourceImpact Journals LLC·JournalOncoscience·TypeCommentary/editorial·DateJun 23, 2023
Researchers at University Hospital Bonn have developed a new approach to predict therapy response in patients with metastatic renal cell carcinoma by incorporating two simple blood parameters, CRP and albumin. This method improves the prediction of treatment response, especially in patients with disease control in the first follow-up.
SourceUniversitatsklinikum Bonn·JournalJAMA Oncology·DateJun 22, 2023
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
A new study found that combining conventional speech therapy with singing can improve voice problems in individuals with Parkinson's disease. The tele-rehabilitation program showed significant improvements in voice intensity and Voice Handicap Index scores, suggesting a more effective treatment approach.
SourceWiley·JournalInternational Journal of Language & Communication Disorders·DateJun 7, 2023
A study found that adding ribociclib to hormone therapy significantly improves invasive disease-free survival rates in patients with stage 2 or 3 HR positive/HER2 negative breast cancer. The combination therapy reduced the risk of cancer recurrence by 25%, with a three-year invasive disease-free survival rate of 90.4%.
SourceUniversity of California - Los Angeles Health Sciences·DateJun 2, 2023
Researchers successfully demonstrate AAV vector efficacy in aged animal models, showing robust hearing rescue in mice with a mutation equivalent to a defective human gene. The study suggests that virally mediated gene therapy could potentially treat genetic hearing loss, especially for patients diagnosed at advanced age.
SourceMass Eye and Ear·JournalMolecular Therapy·TypeComputational simulation/modeling·DateMay 26, 2023
Scientists at Temple University have developed a novel gene-editing strategy that disrupts the ability of HIV-1 virus to enter host cells by targeting a rare genetic disorder. This approach may offer another target for developing next-generation CRISPR technology for HIV elimination, while avoiding adverse effects on cell mortality.
SourceTemple University Health System·JournalMolecular Therapy — Nucleic Acids·DateMay 19, 2023
Researchers investigated the roles of STAT3α and STAT3β in aggressive breast cancer and found that differential silencing of these isoforms leads to changes in STAT3 activation. This study emphasizes the importance of distinguishing between STAT3 isoforms for accurate cancer diagnosis and therapy.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateApr 26, 2023
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A recent study found that immunotherapy alone resulted in a 89% favorable treatment response rate for patients with desmoplastic melanoma. This suggests that combination therapies may not be necessary for these patients, reducing the risk of toxicity.
SourceOhio State University Wexner Medical Center·DateApr 16, 2023
Researchers at St. Jude Children's Research Hospital developed a novel combination therapy approach that uses both BET and GSK3 inhibitors against KMT2A mutated leukemia, overcoming drug resistance without increasing toxicity. The approach was confirmed in cell lines and xenograft mouse models, and holds promise for further development.
SourceSt. Jude Children's Research Hospital·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateApr 10, 2023
A phase 2 study found a 92% disease control rate with the combination of belzutifan and cabozantinib in pre-treated advanced kidney cancer patients. The treatment has a manageable safety profile, providing a potential alternative for patients experiencing disease progression on immunotherapy.
SourceDana-Farber Cancer Institute·JournalThe Lancet Oncology·DateMar 31, 2023
The magrolimab plus azacitidine regimen resulted in a complete response rate of 33% and partial response rate of 75%. Patients with TP53 mutations showed improved overall survival rates compared to previous studies.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalJournal of Clinical Oncology·TypeRandomized controlled/clinical trial·DateMar 9, 2023
A study found that the Omicron variant can dodge immune responses with just one or two dramatic mutations, while combinations of many mutations enable it to escape specific antibodies. The research suggests trade-offs between escaping immunity and maintaining infective capacity.
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers discovered that combining ferroptosis induction with immune checkpoint inhibition reduces liver tumour growth and metastases, offering a promising new approach for treating liver cancer
SourceGoethe University Frankfurt·JournalGut·TypeExperimental study·DateFeb 17, 2023
Researchers at Helmholtz-Zentrum Dresden-Rossendorf developed a new strategy to increase target molecules for radionuclide therapy in pheochromocytoma tumors, delaying tumor growth. The combination of valproic acid and decitabine prior to therapy doubled the radiation dose absorbed by the tumor.
SourceHelmholtz-Zentrum Dresden-Rossendorf·JournalTheranostics·TypeExperimental study·DateFeb 9, 2023
The work group reframed what is clinically meaningful to slow Alzheimer's disease progression, including the need for combination therapies and realistic expectations of benefits and risks. Slowing brain deterioration by four to six months in early stages may preserve function, leading to meaningful outcomes for patients and families.
SourceMayo Clinic·JournalAlzheimer s & Dementia·DateFeb 7, 2023
The American College of Physicians recommends using cognitive behavioral therapy (CBT) or second-generation antidepressants as initial treatment for adults with moderate to severe major depressive disorder. The guideline also suggests considering combination therapy and discussing patient preferences when selecting a treatment.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeMeta-analysis·DateJan 23, 2023
Researchers found that regorafenib, a dual PDGFR α/β inhibitor, modifies the cancer microenvironment and enhances the efficacy of anti-PD-1 immunotherapy in advanced gastric cancers. This combination therapy boosts tumor infiltrating immune cells and reduces tumor fibroblasts.
SourceKumamoto University·JournalCancer Research·TypeExperimental study·DateJan 19, 2023
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers found that combination therapy of buprenorphine and naloxone was as safe as buprenorphine alone during pregnancy, with similar outcomes in maternal health and newborn health. Larger studies are needed to confirm these findings.
SourceWiley·JournalActa Obstetricia Et Gynecologica Scandinavica·DateJan 11, 2023
Medical University of South Carolina researchers develop a novel LSD1 inhibitor that shows early promise at fighting neuroblastoma when paired with bortezomib. The combination boosts anti-tumor response and is a viable strategy for targeting high-risk MYCN-amplified neuroblastoma.
SourceMedical University of South Carolina·JournalEuropean Journal of Medicinal Chemistry·TypeExperimental study·DateDec 13, 2022
Rice University researchers are developing implants that can produce and deliver monoclonal anti-HIV antibody therapeutics for at least a year. The project aims to reduce the cost and improve the logistics of HIV treatment, making it more accessible and beneficial for patients worldwide.
Researchers at Karolinska Institutet found that internet-delivered anonymous cognitive behavioural therapy (CBT) significantly reduced the viewing of child sexual abuse material. The study, published in Internet Interventions, shows promise for a feasible and effective treatment approach.
SourceKarolinska Institutet·JournalInternet Interventions·TypeRandomized controlled/clinical trial·DateNov 30, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.