Articles tagged with Vaccination
A new vaccine patch has delivered an effective immune response to Zika virus in mice, providing rapid protection against the disease. The patch, which uses a high-density microarray platform, targets a specific protein crucial to the virus's survival and evokes T-cell responses up to 270% higher than traditional vaccines.
A study will examine the cognitive function of older adults who were exposed to measles during childhood, shedding light on potential long-term benefits of routine childhood vaccinations. The research aims to better understand how childhood experiences shape health and well-being across the life course.
A Canadian study found that infants exposed to biologic agents during pregnancy have normal immune development and can safely receive the rotavirus vaccine. The study, involving 191 infants across six sites in Canada, aimed to change vaccination guidelines to protect more babies from severe illness.
Leading experts recommend five major factors for FDA trustworthiness, including procedural and substantive conditions, to enhance public trust in its decisions. The report aims to rebuild trust in health care and science after controversies around vaccine approvals.
Pfizer's Abrysvo vaccine was approved with conditions, including a warning about preterm birth. Experts debate whether pregnant women should have been informed about the potential risk. Some critics argue that notification would have caused unnecessary anxiety.
Bio-TCV, a typhoid conjugate vaccine developed by IVI and Bio Farma, has been licensed in Indonesia following marketing approval from BPOM. The vaccine is expected to provide protection against typhoid fever as early as 9 months of age.
A new study published in The BMJ found that the live zoster vaccine continues to provide some protection against shingles and its complications ten years after vaccination. The study analyzed data from over 1.5 million adults aged 50 and older, revealing a decline in vaccine effectiveness over time.
The UK has launched four new research hubs to address challenges of vaccine manufacturing and delivery in developing countries. The hubs will use lessons from the global COVID-19 rollout to improve processes, with funding from £33 million UK aid and £1.5 million EPSRC co-funding.
A primary mRNA vaccine series offers significant protection against SARS-CoV-2 infection in Singaporean children aged 1-4. The study found a low incidence of hospitalization and severe illness, but highlights the potential benefits of vaccination in preventing infection and sequelae.
The team created a glycoengineering platform that simplifies the production of customized sugar carbohydrates, known as glycans, which play a crucial role in various therapeutic applications. This innovation enables the engineering of new glycans with unprecedented flexibility, addressing limitations in existing approaches.
A recent study by Finnish Institute for Health and Welfare reveals that the two-dose varicella vaccination programme significantly reduced health centre appointments related to chickenpox among children under 12. The number of cases decreased by more than 95% in 2022 compared to pre-vaccination levels.
Pregnant women are urged to get vaccinated against COVID-19 to protect themselves and their babies. A new study suggests that COVID-19 vaccines and boosters can significantly improve maternal-fetal outcomes.
A study by University of Tsukuba found that elderly patients receiving better services from their primary care providers are more likely to receive the varicella-zoster virus vaccination. The study suggests that providing adequate services needed by patients during primary care may improve shingles vaccine coverage.
A new study published in Virology Journal confirms 25 different types of HPV prevalent in Nigeria, highlighting the need for region-specific vaccines. The discovery underscores the limitations of existing vaccines like Gardasil-9, which only protects against nine cancer-causing types.
A study of over 15,000 individuals with chronic kidney disease found that young age, Black race, and low education and income were linked to lower flu vaccine uptake. The study suggests that targeted vaccination efforts could improve uptake among those with kidney disease.
Researchers at George Washington University found that Facebook's core design features undermine its policies aimed at removing Covid-19 vaccine misinformation. The platform's architecture, designed to build communities around shared interests, can inadvertently facilitate the spread of misinformation.
Researchers found that hepatitis C treatment improved response to hepatitis B vaccine in individuals who previously didn't respond. The study recommends checking for hepatitis B immune protection and offering vaccination after treatment.
A study published in eBioMedicine identified the mechanism behind rapid vaccine waning in patients on TNF-α blockers for autoimmune diseases like Crohn's and rheumatoid arthritis. Regular booster vaccinations are crucial to maintain protection, especially for those receiving immunosuppressive therapy.
A new study found that voluntary collective isolation was unlikely to prevent rapid spread of COVID-19 among the Tsimané, a small-scale Indigenous society in remote Amazonia. The simulation predicted nearly identical rates of infection in real-world data, highlighting the need for targeted interventions and medical resources
Researchers found that sequential vaccinations given in the same arm generated a stronger immune response than those administered in different arms. This is particularly true for cytotoxic CD8+ T cells and antibodies targeting the SARS-CoV-2 virus.
A community-based health program implemented in Madagascar increased vaccination rates in the country's most remote villages. The study found that households with a Catholic or Protestant affiliation were more reluctant to vaccinate their children, highlighting the need to address these barriers in future programs.
QUT researchers have created a booster vaccine using implant technology to protect wild koalas from Chlamydia disease. The new device allows for in-the-field vaccination without recapturing the animals, reducing human interference and increasing vaccination efficiency.
A new study by the Annenberg Public Policy Center found that people are more likely to recommend an RSV vaccine if they understand the rigorous process of the FDA's vaccine approval process. The study showed that 57% of those exposed to a flowchart were very or somewhat likely to recommend the vaccine, compared to 40% in a control group.
A study found COVID-19 vaccination coverage was high among healthcare workers and older adults, but low among non-priority recipients. The main reason for wanting to be vaccinated was to prevent self-infection and protect family members.
Researchers created a flexible and potent 'on-demand' whole tumor cell vaccine (TCV) that responds to near-infrared laser irradiation, boosting the immune response and effectively suppressing tumor growth. The TCV was tested in various murine xenograft models and showed promising therapeutic efficacy.
A survey of over 20,000 respondents in Japan found that 23% of male and 13% of female respondents were willing to receive the smallpox vaccine for Mpox prevention. Higher vaccination rates were observed among homosexual men compared to their heterosexual counterparts.
Scientists at the University of Pittsburgh Center for Vaccine Research have identified a protein responsible for lethal liver disease in mice infected with Rift Valley fever virus. Removing this protein, Lrp1, from the liver prevented viral replication and extended mouse lifespan.
A study found that family medicine physicians have the lowest net returns per dose for HPV vaccines, while pediatricians received higher reimbursement amounts. The researchers also observed a positive association between reimbursement and increased HPV vaccine doses administered, particularly among family physicians.
A study suggests that bare minimum reimbursement rates could be a barrier to HPV vaccination, with non-pediatric specialties receiving lower rates. Family medicine doctors were found to be most sensitive to changes in reimbursement, which may contribute to geographic disparities in vaccination rates.
Two vaccines to protect against RSV are now available for those over age 60, providing high levels of protections against the virus. The vaccines were developed by Glaxo SmithKline and Pfizer and have been approved by the US Food and Drug Administration.
A new combination treatment of GVAX vaccine, nivolumab, and urelemab has shown to increase the amount of cancer-killing immune cells in tumors and appear effective when given two weeks prior to surgery. The study found a median disease-free survival of 33.51 months and a median overall survival of 35.5 months.
A UCLA-led team is tracking mpox outbreaks across the US with a new surveillance project called CRASHED. The research aims to identify cases beyond high-risk groups and determine if mpox remains rare or resurges more broadly.
A University of Queensland developed vaccine will protect farmed saltwater crocodiles from West Nile virus (WNV), providing economic benefits worth $10million per year. The vaccine is the first of its kind to achieve proven safety and efficacy in crocodiles, with a robust immune response induced after two doses.
CHOP researchers have developed stable, universal MHC-I molecules that can be produced rapidly at scale, allowing for the development of effective and universal immunotherapies. These engineered MHC-I molecules promote peptide exchange across multiple HLA allotypes, covering various forms.
A phase 3 trial found that the VLA1553 vaccine candidate produced an immune response in 99% of participants, inducing protection against disease. The study also showed that the vaccine was generally safe and well-tolerated across all age groups, with most adverse events being mild or moderate.
Researchers have made a breakthrough in treating melanoma by adding an mRNA vaccine tailored to individual tumour genetics to common immunotherapy, significantly improving survival and disease recurrence rates. After two years, cancer-free survival increased to 78.6%, and the risk of death or cancer returning was reduced by 44%.
Researchers analyzed hospitalization and fatality rates of SARS-CoV-2 infection in England between May 2020 and March 2022. The study found that the mass vaccination campaign significantly reduced severe effects of the virus, with notable improvements after the emergence of Alpha, Delta, and Omicron variants.
A new study published by LSU Health New Orleans found that a diet high in fruits, dark-green vegetables, and beans can significantly lower the risk of genital high-risk-HPV infection, which is associated with cervical cancer. The research also showed that women who eat healthily tend to practice other healthy behaviors.
A new vaccine against meningococcal disease has shown safety and efficacy in a phase 3 trial, generating higher immune responses than existing vaccines across five strains. The vaccine, NmCV-5, also induces a strong response to the emerging meningococcal X strain, providing potential protection against epidemics.
Researchers from Karolinska Institutet in Sweden report that individuals vaccinated against smallpox decades ago retain cross-reactive immunity to mpox. The study found that previous smallpox vaccination provides about 80% protection against mpox.
Research reveals that age-dependent changes in germinal centres lead to reduced vaccine response in older people. The study demonstrates that reversing these changes can be achieved through interventions.
Dengue infection prevalence in US territories highlights need for improved control measures. Novel vector control methods and vaccine development hold promise for combating the disease.
Trials of Pfizer's maternal RSV vaccine suggest a possible increase in preterm births, prompting experts to call for further analysis and post-approval monitoring. The vaccine aims to protect infants from severe RSV illness, but its safety concerns have raised eyebrows.
The MUSC Hollings community health van has increased access to the human papillomavirus (HPV) vaccine in South Carolina's underserved communities. The vaccine is linked to six different kinds of cancer, including cervical, throat, anal, penile, vaginal and vulvar cancers.
The International Vaccine Institute (IVI) has started clinical development of DuoChol, a new oral cholera vaccine in capsule form. This innovation offers improved thermostability, reducing storage challenges, while making vaccines more accessible to those who need them most.
A systematic review and meta-analysis found that SARS-CoV-2 infection significantly increases the risk of Bell palsy, whereas vaccination poses a lower risk. The Pfizer/BioNTech vaccine did not differ significantly from the Oxford/AstraZeneca vaccine in terms of BP incidence.
Researchers developed bottlebrush-like nanoparticles that deliver immunostimulatory drugs to tumors, provoking an immune response and slowing tumor growth. The approach avoids systemic inflammation, making it a potential solution for boosting immune system responses in cancer patients.
The NIH is conducting a clinical trial to evaluate the JYNNEOS mpox vaccine's safety and immune response in adolescents aged 12-17. The trial, launched at George Washington University, aims to determine if the vaccine can protect teens from this painful and sometimes deadly disease.
Experts recommend managing SARS-CoV-2 like other endemic respiratory viruses using Standard and Transmission-based Precautions. They also suggest reconsidering pandemic-era strategies such as asymptomatic testing and contact tracing in the endemic era.
Researchers from NUS Medicine discovered that specific CPS structures and sugar combinations help Streptococcus pneumoniae colonize the human respiratory tract. The study sheds light on the importance of CPS structure in bacterial survival, which will inform future vaccine development.
A modelling study in Denmark found that universal varicella vaccination significantly reduces chickenpox-related cases and deaths in both children and adults. The study also showed cost-effectiveness of the vaccine, informing policymakers about routine immunization.
Researchers at Rice University have created a new technology called PULSED that can deliver time-released drugs and vaccines for extended periods. The technology uses high-resolution 3D printing and soft lithography to produce microcylinders made of biodegradable polymers, which can be loaded with drugs and release them over time.
An international project aims to discover modifiable cellular and molecular pathways of the developing infant immune system to improve infant vaccine responsiveness and prevent respiratory disease. By analyzing infants' immune systems from birth to five years old, researchers hope to identify biomarkers that predict vaccine responsiven...
Researchers have created two novel adjuvants that significantly enhance the immune response to vaccines. The new adjuvants target toll-like receptors and are designed to be tailored for every individual vaccine, potentially reducing side effects and increasing effectiveness.
Scientists have developed a new vaccine delivery method using powdered vaccines and a system driven by compressed gas, called MOF-Jet. The device can deliver therapeutics against cancer and other diseases in a relatively painless way, eliminating the need for needles and potentially reducing pain.
A global maternal Strep B vaccination program could avert over 200,000 cases and more than 31,000 deaths, as well as reduce disability in children. The study found that a one-dose vaccine program could cost $1.7 billion globally, while saving $385 million in healthcare costs.
A meta-analysis of seven studies found that sleeping less than six hours per night reduces the immune response to vaccination. The deficit was equivalent to two months of antibody waning. This suggests that getting good sleep may also extend the duration of protection provided by vaccines.
A web-based program educating mothers about reliable health information and vaccine-preventable illnesses was effective in persuading vaccine-hesitant mothers to vaccinate themselves and their infants. The study found that 82% of hesitant pregnant women received flu and Tdap vaccines after participating in the online intervention.
A global study aims to better understand the burden of Human papillomavirus (HPV) among girls and women in low- and lower middle-income countries. The study will inform effective strategies to prevent infection and introduce HPV vaccine into national programs, protecting the health of girls and women and reducing rates of cervical cancer.
A recent study found that anxiety about contracting COVID-19 is a significant predictor of vaccine hesitancy. However, proactive coping, a trait involving future planning, also plays a surprising role in vaccine hesitation, amplifying it at both ends of the spectrum.