Research on vaccines and immunization. Covers COVID and flu vaccines, outbreak response, long-lasting antibodies, and vaccination in vulnerable groups.
The RSV protein subunit vaccine showed similar efficacy to clinical trials, with diminished immune response in immunocompromised patients. The vaccine was associated with a small increased risk of Guillain-Barré syndrome, but not immune thrombocytopenic purpura.
The study found that mRNA-1083 induced higher immune responses than standard care influenza and COVID-19 vaccines, with an acceptable tolerability and safety profile. The vaccine met noninferiority criteria for all 4 influenza strains and SARS-CoV-2 across various age groups.
A study of over a million people found that shingles vaccination lowers the risk of cardiovascular events, including stroke and coronary heart disease, by up to 26%. The vaccine's protective effect lasts for up to eight years, with strongest benefits in younger people and men.
Anal cancer is increasing rapidly among older, white and Hispanic women due to HPV vaccination delays. The study found a significant increase in anal cancer rates for these groups, reaching 11.4 cases per 100,000 in 2021.
A cohort study found that vaccination against influenza alone or with COVID-19 was associated with a small but temporary change in menstrual cycle length. This finding may help clinicians confirm the utility of vaccination for patients concerned about menstrual side effects.
The review highlights the limitations of existing dengue vaccines, such as CYD-TDV and TAK-003, and the urgent need for more effective vaccines to protect millions of people. The Butantan-DV vaccine has shown promise with its single-dose regimen, but its efficacy against DENV-3 and DENV-4 is still unclear.
Research reveals inequalities in MMR vaccination that may contribute to measles outbreaks and epidemics. In France, vaccines were dispensed later for children from low-income families, while a UK investigation found that deprived communities and some ethnic groups were more affected by the outbreak and less likely to be vaccinated.
The European Centre for Disease Prevention and Control (ECDC) emphasizes the need for high immunization coverage to protect European populations from diseases like measles and polio. Vaccination remains a crucial tool in public health, with recent data showing a tenfold surge in reported measles cases in the EU/EEA.
A modeling study predicts declining childhood vaccination rates will increase outbreaks of vaccine-preventable infections, leading to their reemergence. Measles is likely to be the first disease to return to endemic levels, even under current vaccination levels.
Researchers found that B cells guide CD8 T cells to mount lasting defenses after vaccination, but their absence weakens immunity. The discovery could lead to new strategies to enhance vaccine effectiveness for those with compromised immune systems.
Researchers investigated the potential link between herpes zoster vaccination and dementia. They found that vaccination may be associated with a lower risk of developing dementia in older adults. The study's findings suggest a possible causal relationship between vaccination and reduced dementia occurrence.
Measles vaccination is deemed essential for preventing serious complications, including hospitalization and death. The risk of complications is particularly high in children under 5 years old and those under 1 year old, highlighting the importance of timely vaccination.
Researchers found that full-genome differences between rotavirus strains influence vaccine effectiveness, highlighting the need for a broader approach to vaccine design. The study's results suggest that vaccines should be designed based on the whole genome of circulating strains, rather than just two surface proteins.
A new study published in Nature found that the shingles vaccine may lower dementia risk by 20%, with researchers analyzing health records of over 280,000 older adults in Wales. The vaccine was shown to reduce the occurrence of shingles by 37% and is considered a promising preventive intervention for dementia.
A cross-sectional study found that hospitalized adults with RSV vaccine eligibility were more likely to receive the vaccine. Sociodemographic differences in vaccine uptake occurred, suggesting appropriate prioritization of populations with increased risk.
Researchers from La Jolla Institute for Immunology and UC San Diego discover Zika virus blocks dendritic cells' ability to alert T cells, while dengue virus stimulates pro-inflammatory cytokines, leading to a stronger but uncontrolled immune response. Understanding these differences is key to developing life-saving vaccines.
A new hepatitis B vaccine, Heplisav-B, was compared to standard vaccines in a study of previously vaccinated individuals. The results showed that Heplisav-B was more effective at boosting immunity, with 99.4% achieving protective levels compared to 92.7% for standard vaccines.
A TB vaccination has been shown to boost the immune system of bladder cancer patients, reducing cancer recurrence rates by up to 75% in a small pilot study. The vaccine was well-tolerated with no side effects and showed promising results in improving patient outcomes.
A study has established the importance of immunoglobulin A in generating a response to pneumonia vaccines. The research found that poor regulation of gut microbiota can lead to an inadequate immune response, leaving individuals vulnerable to respiratory infections.
The European Centre for Disease Prevention and Control reports a significant increase in measles cases across EU/EEA countries, with eight out of ten unvaccinated individuals contracting the disease. Vaccination levels fall short of the 95% target, leaving vulnerable populations susceptible to measles.
Researchers at the University of Leeds have developed a more affordable and lower-risk polio vaccine using virus-like particles (VLPs). VLPs mimic the outer protein shell of poliovirus but are empty inside, making them non-infectious yet capable of triggering an immune response.
A new study has found that sleep debt and night shifts increase the risk of several common infections in nurses. The research, which analyzed data from 1,335 Norwegian nurses, reveals a clear link between slept debt, night work, and infection risk.
Cervical cancer incidence increased in rural US counties, with higher rates among white women, likely due to lower screening coverage and diagnostic care utilization. Rural areas may experience heightened access barriers, contributing to lower HPV vaccine uptake.
Researchers at Weill Cornell Medicine develop two strains of mycobacteria with 'kill switches' that can be triggered to stop the bacteria after they activate an immune response. The new approach aims to accelerate vaccine development and overcome safety concerns.
A new study led by La Jolla Institute for Immunology scientists found that children who experience multiple dengue virus infections develop protective T cells, which help fight the virus. These T cells appear to be key to dengue virus immunity and may inform the development of a vaccine that prompts a similar response.
A new study reveals that asymptomatic neonatal HSV infections in mice can lead to persistent CNS infection and long-term cognitive decline. Maternal vaccination may prevent this cognitive impairment, suggesting a potential strategy for reducing neurological damage in infected offspring.
A study by Bar-Ilan University reveals that Israeli Arabs have high vaccination rates due to their trust in the country's healthcare system. The research also found that vaccinations are often administered in supportive environments with flexible hours and play areas for children, making it easier for families to participate.
The EU/EEA has detected circulating vaccine-derived poliovirus type 2 (cVDPV2) in sewage samples, prompting increased vigilance. To prevent a return of the disease, countries must maintain high vaccination rates and close vaccination gaps, as well as strengthen environmental surveillance.
A high number of poliovirus detections in European countries has highlighted the importance of maintaining high vaccination coverage. The virus can be imported into Europe as long as it circulates globally, posing a risk to unvaccinated populations.
A new survey finds that nearly three-quarters of US adults support requiring children to be vaccinated against preventable diseases, while over half support prohibiting unvaccinated children from attending school. However, support for this prohibition has dropped significantly since the Covid-19 pandemic, and there is growing support f...
A new longitudinal study has provided unprecedented insights into human papillomavirus (HPV) infection dynamics. The study found that non-persistent infections exhibit a plateau in viral load before rapidly declining, while chronic infections show a strong correlation between immune cells and virus production. This research could infor...
A new self-destructing vaccine provides improved safety and protection against TB in macaque monkeys, outperforming the standard BCG vaccine. The 'kill switch' mechanism eliminates the risk of accidental infection, offering a safer vaccination option for immunocompromised individuals.
Stephania Cormier and colleagues lead a Frontiers in Immunology research collaboration to explain RSV's complex interplay with host immune responses. The team identifies gaps in knowledge, hindering therapeutics and vaccines development.
According to a new survey, over half of U.S. adults believe the RSV vaccine is effective in protecting infants from the virus, up from 42% last year. The rise in perceived effectiveness comes as several politicians have cast doubt on the vaccine's safety and efficacy.
Cases of whooping cough are increasing in the US, with over 28,000 cases reported this year. A nationally representative survey found that many people lack knowledge about the disease's symptoms and vaccine effectiveness.
The study analyzed the high burden of RSV-associated acute respiratory illness among young children in the U.S. and found nirsevimab to be effective against severe cases, highlighting the potential for substantial public health impact through increased prevention coverage.
A modeling study found that HPV vaccination programs for adults aged 27-45 years are more costly and less effective than vaccinating younger people. Vaccinating subgroups at higher risk of HPV infection may improve cost-effectiveness, but overall, it's unlikely to be efficient for cancer prevention.
Researchers developed a nasal vaccine combining traditional pertussis antigens with an innovative adjuvant called T-vant to boost immune response. The new vaccine was shown to prevent the bacteria's colonization in the respiratory tract, significantly curbing whooping cough spread.
Research analyzing European survey data from 113,884 men who have sex with men reveals that only 44% report being vaccinated against both hepatitis A and B. Strong public health support and creating an open environment are crucial to reduce outbreaks among MSM and eliminate hepatitis B.
Researchers at Houston Methodist have identified a new strain of bacteria, Streptococcus dysgalactiae subspecies equisimilis (SDSE), linked to increasingly severe human infections. The study used integrative analysis to investigate the genome, transcriptome, and virulence of SDSE strains, shedding light on their molecular pathogenesis.
A new study in mice shows a unique mRNA delivery method can successfully edit faulty genes in fetal brain cells. The technology has the potential to stop progression of genetic-based neurodevelopmental conditions like Angelman syndrome and Rett syndrome before birth.
Researchers at Rice University have developed a time-release technology called PULSED that could help protect against poliomyelitis in combination vaccines. The technology would allow poliovirus-like particles to be released from microparticles after a few days, ensuring full vaccination efficacy.
A Spanish study found that the influenza vaccination campaign for children aged 6-59 months was effective in preventing acute respiratory infections and hospitalization. The study estimated the vaccine to be 70% effective against any influenza type and 77% effective against severe cases.
Researchers at Wake Forest University School of Medicine will investigate factors that facilitate or hinder conversations between physicians and patients about medical misinformation. The study aims to develop a toolkit to increase health literacy and counter misinformation among older adults, who are disproportionately affected by hea...
Participants who received 2 doses of MVA-BN vaccine showed comparable or lower mpox antibody responses at 12 months compared to those receiving 1 dose. Protective immunity may be waning in individuals vaccinated with this vaccine, according to a recent study.
A modelling study suggests that slow waning of MMR vaccine-induced immunity may contribute to rising measles cases in double-vaccinated people. However, the MMR vaccine remains the most effective measure to prevent measles infection, and community vaccination levels above 95% are essential to prevent outbreaks.
A study found that RSV vaccination significantly reduced hospitalization risk among adults 60+ in the US, offering protection against severe RSV disease. The vaccine demonstrated effectiveness in high-risk populations, including those over 75 and with immunocompromising conditions.
This study found modestly increased risks of inflammatory bowel disease and bullous skin disorders in hospitalized patients infected with the Omicron variant. Booster vaccination mitigated long-term autoimmune sequelae risk.
A new vaccine created by Mizzou researchers protects cattle from bovine anaplasmosis, a devastating tick-borne disease causing hundreds of millions of dollars in economic losses. The vaccine has been proven to give immunized cattle protection for at least a month and is being discussed with industry partners for future distribution.
A study found that men infected with high-risk types of HPV could experience sperm death from oxidative stress, leading to impaired fertility. The researchers also discovered a weakened local immune response in the urogenital tract, which may contribute to these effects.
A European study found that prior smallpox vaccination in childhood could offer protection against infections caused by monkeypox virus (MPXV) clade II in men. The estimated degree of protection varied among countries, highlighting the need for further research.
A recent study published in Clinical Infectious Diseases found that high-dose and adjuvanted flu vaccines provided better protection against flu symptoms and hospitalization for people 65 years and older during the 2022-2023 flu season. The study included nearly half a million participants and showed significant advantages of these vac...
Researchers found that a refutational approach can help overcome misinformation, leading to fewer misconceptions and improved emotional responses. The study tested students' knowledge of fluoridation and found that those who read an article with a refutation had more positive emotions toward the subject.
A recent study has confirmed the efficacy and safety of the dengue vaccine TAK-003, which reduces the risk of contracting the disease by over 50%. The vaccine has shown a high safety profile, with more than 90% of adults and children developing antibodies after administration.
A new study has found that fear of vaccines directly reduces people's intention to get vaccinated, leading to increased adoption of conspiracy beliefs. The researchers conducted three online studies with almost 1,000 participants to explore the impact of fear on vaccine hesitancy and anti-vaccine conspiracy beliefs.
A new study by Prof. Eyal Klement and PhD Student Michal Morgenstern has identified key factors influencing vaccination intentions among Israeli dairy farmers, revealing the significant impact of social pressure and underscoring the need for improved communication between veterinarians and farmers.
A comprehensive meta-analysis found that interventions increasing access to vaccines and providing transportation assistance tripled vaccination odds, particularly in low-income countries. Financial incentives also showed a moderate effect, but were less impactful.
Dr. Pamela Rendi-Wagner, new ECDC Director, stresses the need to restore and reinforce public trust in science after the COVID-19 pandemic. She highlights challenges such as war, climate change, and social inequalities, which can lead to misinformation and reversed medical advances. ECDC is taking steps to implement its expanded mandat...
Researchers have identified microproteins exclusive to liver tumors that can stimulate the immune system against cancer cells. These small molecules, generated from previously non-coding genes, could be used to develop new treatments, including vaccines that stop or reduce tumor growth.
Rural residents with head and neck cancer experience higher mortality rates due to factors like alcohol use, tobacco consumption, and lower HPV vaccination rates. This disparity widens the rural-urban mortality gap.