Articles tagged with Atopic Dermatitis
Researchers have uncovered a key mechanism explaining how allergic inflammation in the skin can progress to a body-wide allergic response. IL-13 acts on dendritic cells, enhancing their ability to present allergens and promoting immune responses that produce antibodies.
People with eczema face a higher risk of developing shingles due to an altered skin immune response. Researchers analyzed UK database data and found that eczema severity was directly linked to increased shingles risk.
A review of 47 trials involving 6,230 children and adults found that adding oral antihistamines to existing treatments showed small but clinically unimportant reductions in eczema severity. First-generation antihistamines may also increase cognitive impairment and the risk of stopping treatment due to side effects.
Researchers created an optical hydration index that combines multiple inputs and measurements to track skin hydration state. The system uses near-infrared optical imaging and temperature-aware algorithm for robust at-home monitoring.
A novel study shows that adults with atopic dermatitis, particularly those with childhood onset, report significantly greater limitations in their educational and professional choices. The findings highlight the need for comprehensive, early, and multidimensional care to address the long-term impact of AD on life trajectories.
A new study reveals that facial itch sensations differ from those on the body due to distinct trigeminal and spinal pain pathways. The researchers found a functional divergence in neuropeptide signaling and central circuit engagement between the two systems, which was independent of peripheral innervation density.
Researchers created a comprehensive mapping of over 1 million cells in normal adult human skin, identifying 45 unique cell types that vary across composition and arrangement. This study brings scientists closer to developing more targeted treatments for skin diseases like eczema and psoriasis.
Researchers used nonlinear dynamics to explore why eczema flare-ups happen and how to improve treatment outcomes. They found that small physiological changes can significantly increase the maintenance burden in long-term efforts to keep eczema in remission.
Researchers found that patients with major depressive disorder share immune abnormalities with inflammatory skin diseases, including atopic dermatitis. The study suggests targeting the Th2 pathway and interleukin-4 receptor alpha as potential therapeutic strategies for psychiatric illness.
Researchers discovered that a gene called ZNF750, active in skin cells, is essential for supporting Langerhans cells and building the body's first line of immune defense. The study found that ZNF750 controls the production of IL-34, a molecule released by skin cells that acts as a survival signal for Langerhans cells.
A new study from North Carolina State University found that neutrophils play a role in the early stages of atopic dermatitis flares in dogs. The researchers compared skin samples from four dogs with house dust mite-induced AD with samples from five healthy, or control, dogs.
Rocatinlimab shows durable improvements in skin clearance, itch, and quality of life by targeting OX40 immune receptor in patients with moderate-to-severe atopic dermatitis. The treatment led to significant reductions in eczema severity, itch, pain, and sleep disturbances.
Eczema's duration and severity significantly impact a child's likelihood of outgrowing food allergies. Children with longer-lasting, more severe eczema are less likely to overcome food allergies.
A new study reveals that adults with atopic eczema are more likely to experience suicidal thoughts, with factors such as age of onset, obesity, and clinical features strongly associated with increased risk. The study highlights the need for healthcare professionals to better recognize and address these challenges.
A study found that teenage girls using multiple products on their faces increase the risk of skin irritation and allergy. The average cost of a daily skin care regimen is $168, with some costing over $500.
A groundbreaking study suggests that the skin may serve as a biomarker for pediatric eosinophilic esophagitis (EoE), a chronic allergic disease of the esophagus. The study found significant deficits in ceramides, lipid molecules essential for the skin's protective barrier, in children with EoE but without atopic dermatitis.
Researchers found that exposure to dogs in early life reduced the risk of eczema in genetically predisposed children by suppressing skin inflammation. The study identified a genetic variant near an interleukin-7 receptor gene that responded differently to dog ownership, providing potential targets for future treatment or prevention.
Research suggests that interacting with dogs can modify a child's risk of developing atopic eczema, potentially due to the impact on immune cells. The findings provide new insights into the complex relationship between genetics and environment in the development of eczema.
Researchers have identified early changes in the cheek skin barrier of infants that can predict the onset of eczema, or atopic dermatitis. The study found that these changes occur even before any clinical symptoms appear, and may be linked to maternal and environmental influences.
Researchers found that ultrafine bubble showers significantly suppressed inflammation in mice with atopic dermatitis caused by external factors. The treatment also improved skin protective barrier proteins. However, no significant effects were seen in mice with atopic dermatitis caused by genetic factors.
Researchers at NIH identified characteristic symptoms of topical steroid withdrawal (TSW), including elevated nicotinamide adenine dinucleotide (NAD+) levels, which can be diagnosed using provisional criteria. TSW treatment may involve mitochondrial complex I-blocking drugs, such as metformin or berberine.
A new study explains how scratching aggravates inflammation and swelling in a type of eczema called allergic contact dermatitis. Scratching activates mast cells, which drive itchiness and inflammation, but also triggers the release of substance P, which protects against bacteria.
A Swedish study found that topical steroid withdrawal (TSW) is characterized by symptoms such as redness, pain, and itching, often accompanied by sleep problems. The study aimed to understand the phenomenon of TSW, which many patients consider a cortisone dependence.
Researchers found comorbidities like asthma and atopic dermatitis associated with earlier onset, severity, and duration of alopecia areata. AA patients with multiple concomitant diseases reported more severe hair loss.
A study published in Advances in Therapy found that dupilumab improves signs and symptoms of atopic dermatitis in children aged 6 months to 5 years, including those with co-morbid conditions such as asthma or allergies. The research provides hope for treating pediatric patients suffering from atopic dermatitis.
A new study published in PLOS ONE suggests that air pollution exposure may be associated with an increased risk of eczema. Data from hundreds of thousands of U.S. adults found that every 10-µm/m3 increase in PM2.5 levels doubles the eczema rate among residents.
The new CAMP 2.0 tool provides personalized medicine for managing allergic contact dermatitis by generating safe lists based on individual patch testing results. It offers thousands of product options and interactive tools to help patients find safe products, track their quality of life, and understand their allergens.
A survey of 298 parents with children diagnosed with atopic dermatitis found that parents' understanding of the condition and its dietary links significantly influenced their children's diets. The most frequently identified trigger foods were milk, tree nuts/seeds/peanuts, and eggs.
A new study found that patients with asthma, allergic rhinitis, atopic dermatitis, or food allergies have a higher risk of developing EoE. Food allergy had the highest risk, with a hazard ratio of 6.31 compared to those without any of these conditions.
A large-scale study investigated the relationship between childhood obesity and immune-mediated skin diseases (IMSDs), such as atopic dermatitis and psoriasis. The study found that obese children were more likely to develop these conditions, with changes in body weight affecting their risk of developing these diseases.
Researchers have identified a crucial molecular signaling pathway in maintaining the skin barrier, which could lead to new treatments for inflammatory skin diseases. The study's findings also suggest that this pathway may contribute to certain types of cancer.
A large population-based case-control study found a small increased risk of composite adverse outcomes with long-term oral corticosteroid use among individuals with atopic dermatitis. Health professionals must weigh benefits against potential risks, and monitor for adverse events.
Scientists identified Roseomonas mucosa as a beneficial bacterium that relieves eczema symptoms in adults and children. The probiotic is available over-the-counter and has shown significant improvement in eczema severity, skin barrier function, and quality of life.
The American College of Allergy, Asthma & Immunology (ACAAI) has issued a position paper on the safety of administering live vaccines to patients treated with dupilumab. The review suggests that treatment should not be stopped, but rather, shared decision-making between doctors and patients is recommended to weigh risks and benefits.
Researchers found that eating more than one gram of sodium per day increases the likelihood of eczema flares by 22%, making it easier for patients to manage their symptoms. Eczema affects over 31 million people in the US and can be difficult to cope with when unpredictable.
This nationwide study found that allergic rhinitis and hypertension are the most prevalent comorbidities among AD patients, while dietary triggers and seasonal changes exacerbate disease severity. The study also highlights the need for improved management strategies tackling these factors.
Researchers have identified new cellular targets for a vaccine to treat eczema in children, which may limit the severity of symptoms and reduce antibiotic use. The study uncovered specific immune signatures in children with infected flares of eczema, providing a potential blueprint for future therapies.
A new Northwestern Medicine study reveals that 73% of children with skin diseases face stigma and bullying, leading to impaired relationships and mental health issues such as depression and anxiety. The study suggests that clinicians should aggressively treat skin disorders in children and consider referral to evaluation and counseling.
A study from the University of Gothenburg found that patient images are severely lacking in scientific articles on atopic dermatitis. This lack of visual aids hinders patients' ability to make informed decisions about their care, as they struggle to understand complex medical terminology and figures. The absence of images also affects ...
Children and young adults with allergies or eczema who experience difficulty swallowing may have eosinophilic esophagitis, a chronic inflammatory disease. The condition can cause injury and narrowing of the throat, and its incidence is rising in North America and Europe.
A recent study published in Allergy found that climate change has negative effects on atopic dermatitis, including increased inflammation from air pollution and stress from droughts. The researchers called for further research to address the impact of multiple climatic factors on eczema incidence and prevalence.
The new guidelines offer evidence-based recommendations for diagnosing and managing anaphylaxis and atopic dermatitis in pediatric and adult patients. The guidelines emphasize the importance of patient values and preferences in arriving at optimal recommendations, reflecting advancements in diversity, equity, and inclusion.
A recent study published in Annals of Allergy, Asthma and Immunology examines the effects of climate change on various allergic conditions, including atopic dermatitis, asthma, and seasonal allergies. The research suggests that environmental warming can lead to longer-lasting pollen seasons and increased T2 inflammation.
Researchers at Harvard Medical School have discovered a novel mechanism behind itch, revealing that Staphylococcus aureus single-handedly causes itch by instigating a molecular chain reaction. The study found that the bacterium's enzyme protease V8 activates protein PAR1 on skin neurons, leading to the sensation of itch.
A recent study found that 72% of eczema patients experienced poor mental health symptoms for 1-10 days within the past month. Additionally, 35% reported never discussing their mental health with their allergist and 57% were never asked about it.
A study found that language difficulties lead to underdiagnosis of allergic conditions like asthma and eczema in children who speak a language other than English. A case report highlights the risks of pharmacy translation software interfering with prescription filling, causing delays in securing life-saving medications.
Researchers analyzed gut and skin microbiota in Shiba Inu dogs with atopic dermatitis, finding that treatment with Oclacitinib restored balance to the microbiome. The study suggests that microbes may serve as potential therapeutic targets for canine atopic dermatitis, offering new disease management strategies.
The brain natriuretic peptide (BNP) is a peptide that plays a crucial role in activating atopic dermatitis, or eczema. In a mouse model of AD, mice without BNP exhibited reduced thickened skin and itching compared to control mice with BNP.
Researchers at UCSF found a feedback loop between immune protein IL-31 and nerve cells, which dials back nearby inflammation and promotes skin healing. This discovery could lead to new treatments for conditions like eczema, allergies, and asthma by targeting the nervous system's role in regulating the immune response.
A major European study found that almost all patients with skin diseases face embarrassment, leading to a huge psychological toll. The study also revealed that stigmatization is a major impact of skin diseases on personal and professional life.
Researchers have identified viral components of the skin's microbiome that drive the development of innovative therapies for atopic dermatitis. Bacteriophages, or 'bacteria eaters', were found to help certain bacteria grow faster in AD patients, contributing to the overpopulation of the skin microbiome.
A clinical trial has shown that methotrexate is a useful and safe treatment for children with severe atopic dermatitis, offering better objective disease control compared to ciclosporin. The study found no concerning safety signals, making methotrexate an attractive alternative for patients in settings where healthcare resources are li...
A new study from the University of Pennsylvania School of Medicine found a significant link between inflammatory bowel disease (IBD) and atopic dermatitis (AD), with adults having a 34% increased risk and children having a 44% increased risk. The severity of AD was also associated with an increased risk of developing IBD.
A study published in mSystems found associations between the gut microbiome and eczema in infancy, with alterations in gut bacteria preceding eczema development. The research revealed changes in gut microbiota composition and diversity over the first 3 years of life, influenced by mode of delivery and feeding patterns.
The study used electronic health record data from over 200,000 children to describe patterns of pediatric allergies across the US, validating the 'allergic march' pattern. It also found that eosinophilic esophagitis (EoE) is more common among non-White patients than previously reported.
A new study from Northwestern University found that only 13% of US parents and caregivers are aware of the 2017 NIH guidelines recommending early peanut introduction to prevent peanut allergy. Despite this, more work is needed to educate families and clinicians about the guidelines.
A study found that patients with atopic dermatitis have a higher proportion of proinflammatory effector T cells and lower suppressive Tregs specific to a particular mite antigen, leading to the development of atopic symptoms.
A recent study published by National Jewish Health has found that children who live close to highly trafficked roads are more likely to develop atopic dermatitis. The study, which analyzed data from 2008-2021, revealed that living within 500 meters of a highly trafficked road increased the risk of developing atopic dermatitis in children.
Researchers developed a non-invasive diagnostic method that analyzes sebum for biomarkers of early-onset atopic dermatitis in infants. The study revealed distinct gene expression profiles associated with AD, allowing for early detection and potential treatment monitoring.
A new study finds that rare helper T cells called Th9 can drive allergic disease and may hold the key to precision medicine approaches for treating severe allergies. Th9 cells are activated by specific transcription factors and can produce inflammatory cytokines without antigen stimulation.