Articles tagged with Metabolic Disorders
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The collaboration aims to accelerate the development of small molecule inhibitors for treating metabolic diseases. Insilico will utilize its Pharma.AI platform to design and optimize novel molecules, while Qilu will handle subsequent development and commercialization.
A phase 2 clinical trial is comparing three strategies to protect heart health in prostate cancer patients undergoing hormone therapy. The study will assess the impact of intermittent fasting, GLP-1 medication, and nutritional counseling on cardiovascular and metabolic risks associated with androgen deprivation therapy.
Researchers have found a nonlinear dose-response relationship between exercise and hepatic steatosis, indicating that a combination of aerobic and resistance exercises can produce clinically meaningful improvements. The study suggests that exercising above 130 MET-min/week can lead to significant reductions in hepatic steatosis.
The W8Buddy study, a major real-world evaluation of digitally delivered specialist weight management pathways, is recruiting 450 participants from 4 Specialist Weight Management Services across England and Wales. The study aims to assess the long-term health benefits and economic impact of digital tools for obesity care.
Researchers explore microneedle technology as a novel delivery system for efficient and minimally invasive intradermal drug delivery. The review highlights the design of functional microneedles with specific structures to overcome biological barriers in various tissues, improving therapeutic outcomes.
Researchers found that CD47 knockdown improves glucose homeostasis and alleviates dyslipidemia in aged male mice by reducing visceral fat and enhancing brown fat tissue function. This breakthrough suggests CD47 as a key regulator of age-related metabolic dysfunction.
Obesity is a chronic health condition associated with harm to health, affecting more than one-third of the US population. A new American Heart Association scientific statement emphasizes socioeconomic and structural barriers to obesity prevention and management.
Researchers have discovered a novel drug candidate that can reverse metabolic liver disease and fibrosis, addressing a critical gap in treatment options. The compound, EVT0185, has been shown to control blood sugar levels, reduce cholesterol, and destroy fat build-up that causes liver fibrosis.
Research reveals that fat located near the colon contains an unusually high number of inflammatory fat cells and immune cells, suggesting a unique function in communicating with the immune system in the gut region. This tissue may be an adaptation to the gut microbiome and could contribute to amplifying or sustaining inflammation.
A study published in PNAS found that over 60% of pairs of damaging genetic variants can restore enzyme activity when combined, challenging long-held assumptions about genetics. This phenomenon, known as intragenic complementation, has implications for rare disease diagnosis and treatment.
A new study reveals that people with an unexpectedly high metabolic BMI have up to a five times higher risk level for diseases such as diabetes and fatty liver. Metabolic BMI is based on advanced metabolomic analyses and identifies obesity-linked changes in metabolism that can be present even at normal weight.
A new study has identified unique protein signatures linked to ethnicity and changes in physical activity, which may influence cardiometabolic health. The research found that South Asian individuals may face a higher risk of cardiometabolic disorders due to distinct immune, inflammatory, and metabolic pathways.
A new study found that light intensity activities, such as walking or household chores, were associated with a lower risk of death for people with CKM syndrome. The researchers used data from the National Health and Nutrition Examination Survey to compare activity level duration for each CKM syndrome stage.
Researchers discovered that natural light exposure improves blood glucose levels and reduces variability in people with type 2 diabetes. The study also found that melatonin levels increased and fat oxidative metabolism improved when participants were exposed to natural light.
A new study reveals the emotional challenges faced by siblings of people with Prader-Willi syndrome, including feelings of stress, loneliness, and sadness. Siblings often take on extra responsibilities at home and struggle to cope with their brother or sister's behavior and hunger.
A comprehensive review reveals the therapeutic effects of Borago officinalis, a plant with diverse compounds targeting inflammation and metabolic pathways. The study highlights its potential in treating cardiovascular disease, diabetes, and neurodegenerative disorders.
A new study found that higher levels of PFAS in the blood are linked to an increased risk of early onset of metabolic dysfunction-associated steatotic liver disease (MASLD) in adolescents. MASLD affects up to 40% of children with obesity and increases long-term risk for type 2 diabetes, heart disease, and liver cancer.
A recent study by University of Eastern Finland found that prediabetes has increased significantly in Finnish children living with overweight or obesity, rising from 11% to 50% over two decades. The study suggests a potential link between maternal overweight and the rise in child prediabetes prevalence.
A study led by UC Riverside scientists found that a father's microplastic exposure can trigger metabolic dysfunctions in his offspring, with female offspring being more susceptible. The research used mouse models and found altered sperm small non-coding RNA profiles and increased risk of diabetes in female offspring.
A new MIT study shows that high-fat diets cause liver cells to revert to an immature state, making them more susceptible to cancer-causing mutations. This reversion is driven by genes that help the cells survive stressful conditions, but ultimately increases their likelihood of becoming cancerous.
Researchers have identified an effective strategy to reduce structural liver damage and improve hepatic vascular function in cirrhosis. Blocking the PAF-R receptor can help rebalance immune and inflammatory responses within the liver.
The University of Texas at San Antonio has received a $7 million gift commitment from Ed and Linda Whitacre to advance research, student success, and athletics. The gift will fuel groundbreaking discovery in metabolic health and strengthen the institution's role in improving health outcomes for South Texans.
Researchers identified a specific type of gut bacteria, Turicibacter, that promotes metabolic health and reduces weight gain in mice. The bacterium produces fatty molecules that are absorbed by the small intestine, improving ceramide levels and preventing excessive weight gain.
According to a recent survey by the Physicians Committee for Responsible Medicine, nearly half of US adults resolve to start a new diet in 2026. More than 80% say cost is an important factor when choosing a weight-loss plan. Despite evidence that plant-based diets are effective and less expensive, only 6% plan to try this approach. Res...
Researchers discover RFP's role in adipogenesis, a process that forms fat-storing cells. The study found that high RFP levels promote easy fat cell formation and weight gain, while low levels resist weight gain.
Pennington Biomedical Research Center launched its first international scientific symposium in Riyadh, Saudi Arabia, exceeding expectations with distinguished audience engagement and new institutional contacts.
Researchers developed a method to measure insulin function in the brain, finding patterns that can identify women at higher risk for metabolic syndrome. Childhood stress affects women's metabolic health risks differently than men, suggesting a sex-specific process.
A study found that mitochondria in people with type 2 diabetes and fatty liver disease have impaired ability to utilize ketone bodies for energy production. This defect was greater than the overall decline in mitochondrial function, suggesting a potential new target for improving energy metabolism in diabetes.
A study published in Environmental Endocrinology found that teens with higher blood levels of PFAS before bariatric surgery had smaller improvements in blood sugar over five years. This could lead to the metabolic benefits of the surgery fading within a decade.
Research finds that sorbitol, a common sugar substitute, can induce similar effects on the liver as fructose, leading to steatotic liver disease. The study also shows that gut bacteria play a crucial role in clearing sorbitol, and that excessive consumption can overwhelm them.
A randomized clinical trial shows that semaglutide improves glycemic control and weight outcomes in individuals with schizophrenia. The study suggests using glucagon-like peptide-1 receptor agonists as an early intervention strategy to reduce cardiometabolic risk in this population.
A research team at Max-Planck-Gesellschaft found that pregnant mice exposed to fatty food smells developed more pronounced obesity and insulin resistance in their offspring. The brains of the offspring showed similarities to those of obese adult mice, suggesting a potential link between maternal diet and child health.
A new trial found that increasing or decreasing sugar intake in a person's diet has no effect on their preference for sweet foods. Researchers suggest that public health advice may need to focus on reducing sugar and energy-dense foods, rather than eliminating all sweet options.
Researchers at University of Cologne identify p35-mediated CDK5 hyperactivity as a central mechanism limiting nerve regeneration in diabetes. Targeted interventions using peptides restore nerve fiber growth, leading to significant motor and sensory improvements.
A study conducted at the University of California, Riverside, has uncovered a link between soybean oil consumption and obesity in mice. The research found that a genetically engineered group of mice on a high-fat diet rich in soybean oil did not gain weight, suggesting that the liver protein HNF4α plays a crucial role in fat metabolism.
Researchers identified biological markers of inflammation, liver stress, and early damage to brain cells in young adults with obesity. Low blood levels of choline, essential for liver health and long-term brain function, were also found. These findings suggest that metabolic stress and inflammation may begin far earlier than expected.
Withdrawal of tirzepatide after 36-week treatment led to 25% or greater weight regain in most participants within a year, reversing initial cardiometabolic parameter improvements. Continued obesity treatment is crucial for sustained benefits.
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
A study by the German Diabetes Center found that people with type 2 diabetes and fatty liver disease have impaired mitochondrial ketone body oxidation, reducing their ability to produce energy from ketones. This defect suggests a potential new target for improving energy metabolism in diabetes.
A nationwide survey by the American Gastroenterological Association found that nearly two-thirds of Americans recognize obesity as a chronic disease, while over 80% believe insurance should cover its treatment. However, barriers such as high out-of-pocket costs and lack of coverage for procedures or medications hinder access to weight-...
Researchers found a significant link between type 1 diabetes and an increased risk of bladder cancer, with people being 4.29 times more likely to develop the disease. The new analysis controlled for tobacco smoking, a factor that obscured the heightened risk in earlier studies.
Research highlights CNDP enzymes as key regulators of metabolic disorders and oncogenic pathways. Genetic polymorphisms and molecular mechanisms revealed, linking CNDP function to energy balance and obesity management. Future studies focus on developing targeted therapies and diagnostic tools.
A human clinical trial found that consuming black cumin seed powder daily for 8 weeks significantly reduced blood triglycerides, LDL and total cholesterol levels. The study also showed an increase in HDL cholesterol levels, associated with a lower risk of heart problems.
Dr. Leanne Redman joins the Charles Perkins Centre to lead research on obesity, diet, and exercise, building on her extensive experience in women's health issues and translational research. With over 300 publications and numerous awards, she will expand the centre's impact on global health.
Researchers found that an elevated one-hour blood glucose level after an oral glucose tolerance test can signal a critical metabolic state. Participants with this value responded well to lifestyle interventions, improving insulin sensitivity and beta-cell function, and reducing the risk of type 2 diabetes.
A study found that eating earlier in the day leads to significant changes in fat metabolism, whereas late eating has no measurable effect. The researchers used lipidomics and analyzed gene activity in fat tissue to understand the origin of these effects.
Researchers have found that a one-hour plasma glucose concentration is a more sensitive marker for early detection of impaired glucose tolerance than traditional methods. This biomarker can help identify at-risk individuals and enable targeted prevention strategies.
A recent USC study tracked 85 young adults over four years and found that increased ultra-processed food consumption was linked to elevated blood sugar and early signs of diabetes risk. The researchers also discovered that limiting UPF intake can help prevent disease.
Exercise promotes angiogenesis and lymphangiogenesis through molecular signaling pathways, enhancing vascular function and immune response. This process offers potential interventions to combat age-related decline and disease, including cardiovascular diseases, muscle atrophy, and metabolic disorders.
A new study found that time-restricted eating without calorie restriction does not improve metabolic health in women with overweight or obesity, but shifting the body's internal clocks. The study also revealed that participants who followed a late-eating schedule went to bed and woke up later.
Researchers explore the link between senescent cells and metabolic diseases, highlighting potential treatments known as senotherapeutics. Senolytics, senomorphics, and senosensitizers are interventions aimed at eliminating or suppressing senescent cells to mitigate metabolic disease.
A recent study from Houston Methodist reveals how Alzheimer's can disrupt the connection between nerves and blood vessels in fat tissue, worsening heart and metabolic conditions. The research highlights a potential link between neurodegeneration and cardiovascular and metabolic disorders.
The Louisiana ECHO program, which focuses on pre-, peri- and postnatal outcomes, obesity, and other areas, will continue its efforts to expand access to clinical trials for Louisiana children. The grant renewal supports the collaboration between researchers from Pennington Biomedical and Ochsner Health System, as well as two free-stand...
A new study from Virginia Tech found that weightlifting outmuscles running for blood sugar control in diabetes models. The research compared the effects of endurance and resistance exercise in mice fed a high-fat diet and found that weightlifting was more effective in reducing subcutaneous and visceral fat, improving glucose tolerance,...
Pennington Biomedical researchers will participate in numerous panels and presentations during the conference, sharing their latest findings on obesity treatment and prevention. The institution is well-represented at the event, with faculty members among the experts leading courses, presentations, and speaker panels.
The European Society of Endocrinology (ESE) has announced the winners of the 2026 ESE Awards, which recognize outstanding contributions to improving knowledge and expertise in endocrinology. This year's winners include Martin Reincke for his work on neuroendocrinology and Maria-Christina Zennaro for her research on hypertension.
Researchers have discovered that HSL plays an unexpected role in the nucleus of fat cells, helping maintain healthy adipose tissue. This new understanding challenges 60 years of certainty about fat metabolism and offers avenues for better understanding metabolic diseases such as obesity.
The National Institutes of Health has renewed Pennington Biomedical's Metabolic Basis of Disease Center for five years, providing $2.2M per year to support research on the mechanisms of metabolic health. The center aims to address the obesity epidemic and its related illnesses.
Researchers developed innovative 3D dynamic cell co-culture models to simulate MASLD progression stages, addressing traditional 2D culture limitations. Pro-inflammatory macrophages were identified as drivers of hepatocyte lipid metabolism disruption.
A study published in Science Advances found that the ketogenic diet can have potentially dangerous impacts on metabolic health, including impaired blood sugar regulation and fatty liver disease. Mice fed the diet developed severe metabolic complications, with some changes starting within days.