Scientists at Mount Sinai Hospital have mapped the complete structure of the AASS enzyme, revealing how its activity can be controlled. The findings provide a new avenue for developing treatments for glutaric aciduria type 1 (GA1), a rare genetic disorder that causes toxic substances to accumulate in the body.
Pennington Biomedical researchers will present scientific findings and participate in expert discussions at ObesityWeek 2026, highlighting advances in obesity science and treatment. The institution will also contribute to educational and early-career programming.
A new tool, ASAP, rapidly and reversibly turns autophagy on and off, confirming suspected targets, revealing new ones, and suggesting a link between protein building and breakdown. ASAP also targets nuclear pore complexes and protein condensates, shedding light on autophagy's role in maintaining cellular health.
A clinical trial found that urolithin A increased blood flow to the brain during memory tasks, suggesting potential benefits for brain health. However, the supplement did not significantly improve blood vessel function or cognitive function in participants.
A new study reveals that the decline in thermogenic fat activity with age may explain why older people feel the cold more. The research suggests that restoring thermogenic fat activity could help understand and treat age-related metabolic problems, including obesity and type 2 diabetes.
The Endocrine Society establishes the Jesse Roth Award to recognize outstanding research in hormone action, diabetes, or metabolism. C. Ronald Kahn is the inaugural winner, who will deliver a lecture at ENDO 2027 and receive an honorarium and travel grant.
PFBS exposure leads to genetic, metabolic, and morphological disruptions in zebrafish embryos, including oxidative stress, heart function impairment, and visual response deficits. The study suggests that PFBS, despite being a safer alternative, can still have negative effects on living organisms.
A recent study found that eating peanuts was associated with favorable changes in blood lipids linked to a lower risk of type 2 diabetes. The changes involved a class of lipids called sphingolipids, which contained very long-chain saturated fatty acids.
Scientists have found that certain immune cells in fat tissue may protect against obesity-related inflammation in females, but contribute to harmful metabolic changes in males. The study identified six distinct eosinophil populations in adipose tissue, each with different gene-expression patterns and potential functions.
Researchers review evidence on obesity drugs, finding potential benefits for brain function, especially for those with type 2 diabetes or obesity. They call for clinical trials to track cognitive abilities and emphasize the importance of monitoring older patients.
Exerkines, exercise-responsive signals, coordinate interorgan crosstalk to regulate glucose and lipid metabolism, insulin sensitivity, and inflammation. Exerkine-based diagnostics and therapeutics hold promise for precision management of chronic metabolic diseases.
A survey of 97 US health clinics found that most conduct basic screening for CKM syndrome, but far fewer use guideline-recommended tools like CKM staging framework and PREVENT equations. The study highlights opportunities to improve patient care by better incorporating these tools into clinical practices.
A randomized controlled trial found that adding sleep coaching to a diabetes prevention lifestyle program helped participants sleep better and feel less sleepy during the day, leading to greater weight loss. Falling asleep earlier was associated with about 1.3 pounds of weight loss over eight weeks, independent of sleep duration.
Researchers discovered sex differences in how mice brain adapts to overeating on high-fat diets, with females showing less susceptibility to obesity. The study found that female mice exhibit increased excitability in key neurons, leading to weight loss, whereas male mice show increased excitability, leading to weight gain.
Dr. Petter Bjornstad will lead Pennington Biomedical Research Center in advancing research in metabolic disease, with a focus on improving the health and well-being of Louisiana residents. He brings exceptional expertise in diabetes and kidney disease, with a vision to translate world-class science into better health outcomes.
Researchers found that sotagliflozin reduces excessive platelet activation, a process that can lead to dangerous blood clots that block flow to the heart and brain. The drug also makes platelets less likely to stick together and form blood clots, potentially lowering the risk of heart attack and stroke.
Research highlights the importance of gut microbiota in regulating various diseases, including intestinal and extra-intestinal disorders. The authors call for a shift from one-strain-fits-all approaches to personalized interventions based on host factors.
A Norwegian randomized controlled trial found that a high-saturated fat diet with low carbohydrate intake improved several cardiovascular risk markers, including triglycerides and HDL cholesterol, without increasing apoB. The study challenged the notion that high saturated fat intake inherently increases disease risk and suggests a low...
Targeting fat cells with sphingosine kinase 2 inhibitors could be a new strategy to combat obesity and lower the risk of its comorbidities like cancer. The researchers found a significant reduction in body weight, improved glucose tolerance, and reduced lipid accumulation in the liver.
A study by Carnegie Mellon University researchers reveals that gut bacteria can detect when people eat and send signals that help intestinal cells absorb nutrients at the right time of day. The findings suggest that maintaining consistent eating patterns may help support a healthy relationship between the microbiome and the body.
The grant will support Dr. Flanagan-Steet's research into understanding how metabolism and glycosylation work together during normal development and disease onset. The study aims to identify common biological pathways that contribute to rare diseases, with the ultimate goal of developing new treatments.
Researchers at ITQB NOVA are developing a portable sensor to measure phenylalanine levels for people with phenylketonuria (PKU), a rare metabolic disorder. The device aims to allow patients to adjust their diet and treatment in real-time, improving health outcomes and quality of life.
A molecular atlas of exercise-associated changes in mice reveals distinct responses to exercise varying by tissue, cell type, sex, and circadian phases. The atlas provides a comprehensive resource for understanding systemic molecular adaptations to endurance exercise, enabling the development of personalized exercise strategies.
A new analysis of US national health data found that inflammation increases across the stages of cardiovascular-kidney-metabolic syndrome, with the largest increase at the earliest stage. Average hs-CRP nearly doubled between stage 0 and stage 1, crossing the 2 mg/L threshold commonly used to signal increased cardiovascular risk.
A comprehensive study of 18,476 Chinese participants reveals 'clocks' of human aging that can predict chronic disease and mortality. The research provides clinically relevant metrics for health monitoring and disease prevention, shedding light on aging's impact on metabolism.
A new study from the Bogalusa Heart Study has found a significant association between cumulative clinical obesity and white matter changes in the brain by midlife. Researchers analyzed data from 190 participants and found that those with greater exposure to clinical obesity had worse brain health in midlife.
An international study found that variants in the IDUA gene, associated with mucopolysaccharidosis type I, can cause inherited retinal disease without broader health problems. The study highlights the importance of understanding how genetic variants affect the body, potentially leading to earlier recognition and treatment opportunities.
Research suggests that people with dementia who are overweight or obese at diagnosis tend to live longer, pointing to the importance of nutrition in the degenerative disease. Studies adjusting for biases found no significant contribution to the observed associations between weight status and mortality.
UCLA scientist Tara TeSlaa is developing a new approach to record nutrient use in specific cell types, aiming to build maps of cellular metabolism across tissues and conditions. Her lab will use stable isotope tracing to create a molecular record of nutrient use, allowing for more accurate interpretations of nutrition research.
The European Society of Endocrinology is launching a new Obesity and Endocrinology School in 2027 to support early-career clinicians in obesity research and clinical practice. The School will cover the latest developments in obesity, including genetics, adipose tissue biology, and treatments.
A clinical trial found that feijoa powder improved systolic blood pressure in people with prediabetes, which was an unexpected finding in a study designed to test its effects on weight loss and blood sugar control. Larger trials are needed to confirm these results and fully understand the potential benefits of feijoa powder.
A new study from the University of Georgia found that patients with high out-of-pocket costs for semaglutide (GLP-1) are less likely to adhere to their medication, with nonadherence rising to over 80% when costs exceed $75. This suggests that policymakers and insurers should consider restructuring out-of-pocket costs and insurance desi...
Researchers aim to identify biological mechanisms behind insulin resistance and develop therapeutic strategies. The study focuses on skeletal muscle tissue from lean and obese individuals, exploring protein modifications that distinguish insulin-sensitive from insulin-resistant muscle.
Researchers at the University of Missouri have discovered that bullfrogs can generate ketone bodies in their brains, allowing them to continue critical neural functions even when glucose levels are low. This finding could have implications for understanding human brain health and potentially treating neurological disorders.
Researchers at MIT identified a cellular pathway necessary for colorectal cancer metastasis, controlled by protein YAP1, which promotes cell proliferation and migration. A high-fat diet triggers activation of this pathway, and drugs blocking ceramide production may help prevent metastasis.
Researchers discovered that immune cells in adipose tissue require the enzyme ACC1 to maintain metabolic health, but its inhibition leads to metabolic impairment and inflammation. The study provides new insights into the complex relationship between obesity, immune cells, and metabolic health.
A new study suggests that semaglutide reduces heart disease risk beyond just weight loss, but the exact mechanism is unclear. The study analyzed data from a clinical trial of semaglutide, which found that patients taking the drug had a 20% lower risk of heart disease, but only half of this reduction could be explained by changes in kno...
A study found that adolescents with a high body mass index may age biologically faster, increasing their risk of developing obesity-related diseases and premature death. The study's findings suggest a link between genetic predisposition to high BMI and accelerated biological aging.
Researchers at the University of Basel found that a drug called fenoterol increases energy expenditure in humans without activating brown fat. This suggests that a more complex regulation of brown fat in humans may be at play, and could have implications for future obesity treatments.
Researchers found that post-transplant cirrhosis cases often reflected recurrence of the original disease, with lower long-term survival rates. The study highlights the need for lifelong surveillance of fibrosis progression after transplantation to improve outcomes.
AUB investigator Amanda Ziegler aims to make healthy lifestyle changes accessible for teens to address obesity and cardiometabolic diseases. The PrevenTeen project utilizes AI-powered mobile health tools to develop pragmatic approaches for adolescent patients.
A 12-week study found that time-restricted eating resulted in modest weight loss (median 2.7%) and improved eating habits in adults with obesity and prediabetes. The study also showed no significant differences in inflammation markers and appetite hormones between the time-restricted eating and usual eating pattern groups.
BioLife has developed a novel oral peptide delivery technology that uses a dissolvable effervescent tablet format to protect peptide medicines during digestion. Preclinical studies have demonstrated measurable systemic semaglutide exposure following oral administration, providing in vivo proof of concept.
Researchers at UTHealth Houston developed a treatment that reverses nerve pain in diabetic mice by targeting the MMP-9 enzyme, which breaks down proteins and causes immune response. The new monoclonal antibodies selectively inhibit MMP-9 activity, regenerating nerve fibers and improving wound healing.
Researchers found that meal timing programs the liver's daily rhythms and can have serious metabolic and health consequences when out of sync. The liver uses food signals to activate metabolic pathways, which can conflict with the body's natural circadian clock, leading to health issues.
Researchers identified EFHD1 as a protein driving metabolic liver disease, triggering an antiviral immune response that can be blocked to protect against liver injury. Blocking EFHD1 shows promise in preventing liver damage, even on high-fat diets.
The University of Louisville is launching the Nutrition and Metabolic Health Center to tackle chronic diseases, with a focus on prevention and new treatments. Researchers will investigate the impact of nutrition and environmental factors on health, with the goal of improving prevention and treatment options.
A study of 1.26 million bariatric surgery patients found 5.3% had extreme obesity, defined as a BMI of 60 kg/m² or higher. Despite a higher burden of health conditions, surgical risk remained relatively low, with complications occurring in 2.57% of cases.
The 2026 Childhood Obesity Conference, 'Be the Reason Kids Greaux Healthy,' will explore strategies for preventing and treating childhood obesity, bringing together healthcare professionals, researchers, educators, and community leaders. The conference will feature keynotes, sessions, and poster presentations on emerging topics in pedi...
Researchers found distinct patterns of bone density change after anatomical and reverse total shoulder arthroplasty, with significant declines in bone mineral density over time in patients with osteoporosis. These findings suggest that optimizing osteoporosis treatment and monitoring bone density may improve long-term outcomes after re...
A new molecular compound, TOFA, identified by UC Berkeley scientists, helps cells burn extra energy with no change in food intake or exercise, improving insulin sensitivity and glucose control. The treatment, which works by increasing energy expenditure, shows promise in mouse models and may be used in combination with GLP-1 medications.
A new trial will assess whether Semaglutide reduces alcohol consumption in people with alcohol use disorder, obesity, and liver disease. The four-year CURB project aims to explore the potential benefits of the weight loss drug in treating alcohol-related liver disease and obesity.
Professors Etienne Cavalier and Roland Chapurlat assume leadership as Co-Editors-in-Chief, bringing complementary expertise in laboratory science, translational research, and clinical investigation. They aim to build on the journal's strong foundations and further enhance its role in musculoskeletal research.
A key molecule released during exercise, L-β-aminoisobutyric acid (L-BAIBA), has been discovered to strengthen muscles, improve exercise performance, and protect against muscle damage in type 2 diabetes. The study reveals L-BAIBA's role in muscle adaptation, metabolism, and contraction, offering promising insights for future therapies.
Research shows a link between dollar store food quality and higher rates of obesity, high blood pressure, and type 2 diabetes. Traditional grocery store access is associated with better health metrics, according to a new study published in BMC Public Health.
Researchers highlight unanticipated benefits of GLP-1 medications, including reduced inflammation and lower risk of certain cardiovascular and musculoskeletal conditions. However, questions remain about lean body mass and nutritional health following weight loss associated with these medications.
A study by Rutgers researchers found that waist circumference measures nearly as accurately as a new obesity definition incorporating multiple body measurements, identifying potential health risks earlier. Waist measurement can provide a practical tool for clinicians and patients to detect unhealthy amounts of body fat.
A new study by King's College London reveals that proposed new obesity definitions give greater insight into the ill health of metabolic bariatric surgery candidates compared to BMI. The study found marked variation in disease burden among patients considered for surgery, despite similar BMI.
A retrospective cohort study of 16,924 men found metabolic syndrome and related abnormalities during the first year of treatment. Hypertension was the most common metabolic outcome among patients receiving concurrent androgen deprivation therapy and an androgen receptor pathway inhibitor.
A recent study published in JAMA Network Open finds a strong association between gestational diabetes and an increased risk of postpartum cardiovascular, kidney, and metabolic disorders. The research highlights the importance of monitoring and managing gestational diabetes to prevent long-term health consequences for mothers.