Articles tagged with Metabolic Disorders
Researchers aim to identify biological mechanisms behind insulin resistance and develop therapeutic strategies. The study focuses on skeletal muscle tissue from lean and obese individuals, exploring protein modifications that distinguish insulin-sensitive from insulin-resistant muscle.
Researchers at the University of Missouri have discovered that bullfrogs can generate ketone bodies in their brains, allowing them to continue critical neural functions even when glucose levels are low. This finding could have implications for understanding human brain health and potentially treating neurological disorders.
Researchers at MIT identified a cellular pathway necessary for colorectal cancer metastasis, controlled by protein YAP1, which promotes cell proliferation and migration. A high-fat diet triggers activation of this pathway, and drugs blocking ceramide production may help prevent metastasis.
A new study suggests that semaglutide reduces heart disease risk beyond just weight loss, but the exact mechanism is unclear. The study analyzed data from a clinical trial of semaglutide, which found that patients taking the drug had a 20% lower risk of heart disease, but only half of this reduction could be explained by changes in kno...
Researchers discovered that immune cells in adipose tissue require the enzyme ACC1 to maintain metabolic health, but its inhibition leads to metabolic impairment and inflammation. The study provides new insights into the complex relationship between obesity, immune cells, and metabolic health.
A study found that adolescents with a high body mass index may age biologically faster, increasing their risk of developing obesity-related diseases and premature death. The study's findings suggest a link between genetic predisposition to high BMI and accelerated biological aging.
Researchers at the University of Basel found that a drug called fenoterol increases energy expenditure in humans without activating brown fat. This suggests that a more complex regulation of brown fat in humans may be at play, and could have implications for future obesity treatments.
Researchers found that post-transplant cirrhosis cases often reflected recurrence of the original disease, with lower long-term survival rates. The study highlights the need for lifelong surveillance of fibrosis progression after transplantation to improve outcomes.
AUB investigator Amanda Ziegler aims to make healthy lifestyle changes accessible for teens to address obesity and cardiometabolic diseases. The PrevenTeen project utilizes AI-powered mobile health tools to develop pragmatic approaches for adolescent patients.
A 12-week study found that time-restricted eating resulted in modest weight loss (median 2.7%) and improved eating habits in adults with obesity and prediabetes. The study also showed no significant differences in inflammation markers and appetite hormones between the time-restricted eating and usual eating pattern groups.
BioLife has developed a novel oral peptide delivery technology that uses a dissolvable effervescent tablet format to protect peptide medicines during digestion. Preclinical studies have demonstrated measurable systemic semaglutide exposure following oral administration, providing in vivo proof of concept.
Researchers at UTHealth Houston developed a treatment that reverses nerve pain in diabetic mice by targeting the MMP-9 enzyme, which breaks down proteins and causes immune response. The new monoclonal antibodies selectively inhibit MMP-9 activity, regenerating nerve fibers and improving wound healing.
Researchers found that meal timing programs the liver's daily rhythms and can have serious metabolic and health consequences when out of sync. The liver uses food signals to activate metabolic pathways, which can conflict with the body's natural circadian clock, leading to health issues.
Researchers identified EFHD1 as a protein driving metabolic liver disease, triggering an antiviral immune response that can be blocked to protect against liver injury. Blocking EFHD1 shows promise in preventing liver damage, even on high-fat diets.
The University of Louisville is launching the Nutrition and Metabolic Health Center to tackle chronic diseases, with a focus on prevention and new treatments. Researchers will investigate the impact of nutrition and environmental factors on health, with the goal of improving prevention and treatment options.
A study of 1.26 million bariatric surgery patients found 5.3% had extreme obesity, defined as a BMI of 60 kg/m² or higher. Despite a higher burden of health conditions, surgical risk remained relatively low, with complications occurring in 2.57% of cases.
The 2026 Childhood Obesity Conference, 'Be the Reason Kids Greaux Healthy,' will explore strategies for preventing and treating childhood obesity, bringing together healthcare professionals, researchers, educators, and community leaders. The conference will feature keynotes, sessions, and poster presentations on emerging topics in pedi...
Researchers found distinct patterns of bone density change after anatomical and reverse total shoulder arthroplasty, with significant declines in bone mineral density over time in patients with osteoporosis. These findings suggest that optimizing osteoporosis treatment and monitoring bone density may improve long-term outcomes after re...
A new molecular compound, TOFA, identified by UC Berkeley scientists, helps cells burn extra energy with no change in food intake or exercise, improving insulin sensitivity and glucose control. The treatment, which works by increasing energy expenditure, shows promise in mouse models and may be used in combination with GLP-1 medications.
Professors Etienne Cavalier and Roland Chapurlat assume leadership as Co-Editors-in-Chief, bringing complementary expertise in laboratory science, translational research, and clinical investigation. They aim to build on the journal's strong foundations and further enhance its role in musculoskeletal research.
A new trial will assess whether Semaglutide reduces alcohol consumption in people with alcohol use disorder, obesity, and liver disease. The four-year CURB project aims to explore the potential benefits of the weight loss drug in treating alcohol-related liver disease and obesity.
Research shows a link between dollar store food quality and higher rates of obesity, high blood pressure, and type 2 diabetes. Traditional grocery store access is associated with better health metrics, according to a new study published in BMC Public Health.
A key molecule released during exercise, L-β-aminoisobutyric acid (L-BAIBA), has been discovered to strengthen muscles, improve exercise performance, and protect against muscle damage in type 2 diabetes. The study reveals L-BAIBA's role in muscle adaptation, metabolism, and contraction, offering promising insights for future therapies.
A study by Rutgers researchers found that waist circumference measures nearly as accurately as a new obesity definition incorporating multiple body measurements, identifying potential health risks earlier. Waist measurement can provide a practical tool for clinicians and patients to detect unhealthy amounts of body fat.
Researchers highlight unanticipated benefits of GLP-1 medications, including reduced inflammation and lower risk of certain cardiovascular and musculoskeletal conditions. However, questions remain about lean body mass and nutritional health following weight loss associated with these medications.
A retrospective cohort study of 16,924 men found metabolic syndrome and related abnormalities during the first year of treatment. Hypertension was the most common metabolic outcome among patients receiving concurrent androgen deprivation therapy and an androgen receptor pathway inhibitor.
A new study by King's College London reveals that proposed new obesity definitions give greater insight into the ill health of metabolic bariatric surgery candidates compared to BMI. The study found marked variation in disease burden among patients considered for surgery, despite similar BMI.
A recent study published in JAMA Network Open finds a strong association between gestational diabetes and an increased risk of postpartum cardiovascular, kidney, and metabolic disorders. The research highlights the importance of monitoring and managing gestational diabetes to prevent long-term health consequences for mothers.
A new theory proposes that critical illness arises from loss of physiological coordination, not just organ failure. The Entropic Critical Illness Theory views living organisms as open systems with a continuous need to regulate entropy.
A new study reveals that patients with metabolic dysfunction-associated steatotic liver disease (MASLD) have elevated lipocalin-2 levels and exhibit early signs of cardiovascular and cognitive impairment. The findings highlight the importance of considering MASLD as a systemic condition affecting multiple organ systems.
A study published in the Journal of Cachexia, Sarcopenia and Muscle reveals that deleting transforming growth factor-beta 1 (TGF-β1) from macrophages enhances muscle regeneration and mitochondrial function. The research found that this approach protected against obesity-related muscle wasting and improved exercise performance.
Researchers from Pennington Biomedical Research Center propose a new framework for defining and diagnosing obesity, which considers the effects of excess adiposity on organs and tissues. This approach provides a more biologically grounded and clinically actionable method for guiding treatment decisions.
Researchers found that Bofutsushosan reduced fibrosis in fat tissue and liver of mice with obesity, and identified herbal components with anti-fibrotic activity. The study suggests that Bofutsushosan may have benefits beyond weight control, providing a scientific basis for studying Kampo medicines.
A new study published in the Journal of Inherited Metabolic Disease found that high-dose niacin therapy can improve survival outcomes in children with NAXD deficiency, a rare genetic disorder. The treatment has been shown to halt significant deterioration and reduce life-threatening complications.
The IOF Musculoskeletal Rare Diseases Training Course bridges latest scientific advances with current clinical guidance, covering disorders-specific programs. Clinicians can access high-quality educational content at their own pace to deepen expertise in rare skeletal conditions diagnosis and management.
A new analysis of 19 randomized controlled trials found that different GLP-1 medications have distinct effects on heart and metabolic health, suggesting a need for personalized treatment selection. Oral GLP-1 therapies are emerging as strong options that could expand accessibility and flexibility.
Researchers at the University of Cambridge solved the puzzle of why stimulating and blocking a specific 'switch' in the brain can help people lose weight. By targeting distinct regions of the brain, they found that GIPR agonists suppress appetite, while GIPR antagonists boost weight loss by releasing a 'brake'.
Researchers identified endotrophin as a biological marker that rises and falls with changes in body fat, reflecting changes in metabolic health. The study suggests endotrophin could serve as a valuable biomarker and therapeutic target for reducing obesity-related health risks.
The Pennington-Louisiana Nutrition Obesity Research Center has received a five-year, $5.66 million renewal grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The award reaffirms Pennington Biomedical's position as a national leader in nutrition, obesity, and metabolic health research. The center su...
Dr. Kaja Falkenhain receives the Peter J. Reeds Early Career Investigator Award for her groundbreaking work on human nutrition and metabolism. Her research focuses on cardiometabolic health and glycemic control, highlighting the impact of nutritional exposures on energy expenditure.
A new review calls on Mexico to add liver health to its existing chronic disease programs, citing the country's high liver disease prevalence. Liver disease affects nearly half of Mexican adults and is linked to diabetes and obesity.
A new study published in Hepatobiliary Communications reveals that standard CT scans can detect stage-specific tissue patterns predicting severe liver complications in chronic hepatitis B-related cirrhosis. Visceral fat and muscle shifts carry different warning meanings based on the patient's disease stage.
Researchers propose using the glucose ketone index (GKI) to track metabolic health in non-communicable diseases, which cause three in four deaths worldwide. The GKI measures blood glucose and ketones and may indicate metabolic state, assess long-term nutritional adherence, and support mitochondrial function improvement.
A new study from Pennington Biomedical Research Center in Louisiana demonstrates safe and effective bariatric surgery outcomes for young patients with severe obesity. The study found significant improvements in weight loss and obesity-related health conditions, highlighting the importance of multidisciplinary care models.
Researchers developed a new mouse model that closely reproduces eosinophilic gastritis, identifying key immune pathways and mechanisms behind the disease. The study provides a biological explanation for therapies targeting IL-4Rα, suggesting potential improvements in treatment precision.
Dr. Joe Northup, a renowned metabolic and bariatric surgeon, has been elected the 40th president of ASMBS. He aims to ensure patients understand the role of surgery in comprehensive obesity care.
Researchers found that yeast-based supplements can reprogram early-stage immune cells to produce enhanced anti-tumor responses. The study suggests a potential solution for obesity-related immune dysfunction and cancer, using a food-grade supplement with an excellent safety record.
The study demonstrated sustained improvements in disease features in mouse models with effects lasting throughout their lifespan. Genespire's approach has the potential to translate into human health as a single-administration treatment for patients with MMA.
The study found a 37% increase in obesity and a two-fold increase in severe obesity among both adults and youth over 20 years. Obesity rates have major implications for cardiovascular disease and mortality, highlighting the need for targeted initiatives to address the rising epidemic.
A large Swedish study found that certain bacteria in the gut microbiota can be seen in people who develop type 2 diabetes years later. Fluctuations in metabolism and low fibre intake may also contribute to the risk. The discovery paves the way for early identification of at-risk individuals.
The NUTRITION 2026 meeting will present over 1,650 scientific presentations on topics including food additives, GLP-1 therapies, and ultra-processed foods. Experts will discuss the latest research on potential risks and clinical considerations of these substances.
Researchers have identified high rates of overweight/obesity (82%) and hypertension (higher than statewide average) in Franklin Parish, with income levels linked to lower hypertension rates. Older residents are also more likely to have undiagnosed high cholesterol and diabetes.
A new study by Thales Papagiannakopoulos and colleagues found that lung cancer tumors talk directly to the nervous system through sensory neurons in the lungs, promoting cachexia. Silencing these nerves or blocking the production of prostaglandin E2 (PGE2) reduced cachexia, suggesting a potential therapeutic strategy.
Researchers have developed a gene-editing tool that unlocks the secrets of fungi, a kingdom rich in antibacterial compounds. The tool, called fPE7max, enables precise control over DNA sequences and has identified three novel molecules with anti-cancer properties.
A new study from the University of Copenhagen suggests that longer sleep is linked to more stable blood sugar levels in healthy 18-year-olds, even among those with no previous health issues. The researchers tracked participants over two weeks and found a two-way relationship between sleep duration and blood sugar stability.
A CU Anschutz study reveals reduced mitochondrial efficiency in healthy yet sedentary individuals, which may precede the development of major diseases like cancer, diabetes, and Alzheimer's. Regular exercise acts as a literal shield for cellular health, helping mitochondria seamlessly switch between burning fat and carbohydrates.
Researchers at the University of Zurich have developed epigenetic drugs that can reprogram perivascular fat cells to reduce inflammation and improve blood vessel health. By targeting specific gene-expression regulators, these drugs aim to prevent vascular damage in people with obesity and metabolic disease.
Researchers found that over-the-counter probiotics contain only 36 unique species of bacteria, with most common species being forms of Lactobacillus. The analysis suggests a lack of consistency in the combination of species used to support gut health and vaginal health claims.
A survey of over 5,700 Chinese adolescents found significant associations between screen time, body weight, and mental health with sleep quality. Rural adolescents and girls fared worse overall, highlighting the need to address these factors to improve sleep.
A cohort study found that demographic, clinical, and healthcare factors influence the uptake of metabolic bariatric surgery among US adults with obesity. The study suggests improving access to this life-changing procedure through targeted policies and interventions could have a significant impact.