Articles tagged with Respiratory Disorders
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Researchers at UVA Health System created an 'atlas of atherosclerosis' revealing critical processes that form harmful plaque buildup. The study provides unprecedented insights into atherosclerosis and its impact on coronary artery disease, heart attacks, and strokes.
A novel study has implicated granulocyte colony-stimulating factor (G-CSF) in both bronchopulmonary dysplasia and retinopathy of prematurity, making it a promising therapeutic candidate. G-CSF deficiency was shown to protect against these diseases, suggesting wide-ranging protection.
The European Union has approved vaccines for pregnant women and monoclonal antibodies to prevent respiratory syncytial virus (RSV) among young children. New sequencing tools have also been developed to track the genetic diversity of RSV and inform vaccine effectiveness and treatment strategies.
A new study from Gladstone Institutes has greatly expanded the scientific body of knowledge about how the body responds to too much oxygen. The research highlights a particular protein, MYBBP1A, that may play a central role in regulating cells' response to hyperoxia.
New research found that less than five minutes of daily physical activity can be beneficial for people living with inoperable lung cancer, reducing mortality rates by 60% compared to those who were largely inactive. Healthcare providers should investigate a person's levels of physical activity in early management of the disease.
Researchers discovered how biological information travels between mothers and babies during pregnancy. Microscopic extracellular vesicles, produced by placental cells, act as a protective mechanism transporting important biological information to emerging neurons.
The Cre-LoxP system's specificity is compromised due to non-specific promoters driving Cre expression, leading to inaccurate results. This limitation requires careful consideration for proper interpretation of experimental outcomes.
A recent study analyzed asthma mortality rates in China and the US from 1990 to 2019, revealing substantial differences in mortality rates and risk factors. The study found that smoking was a leading risk factor for asthma mortality in China, while high body mass index (BMI) was a larger public health challenge in the US.
A significant post-COVID resurgence in invasive meningococcal disease has been observed in France, with a notable increase in cases among young people aged 16-24. The study reveals that the disease has returned to pre-pandemic levels, with some serogroups targeting different age groups.
Researchers developed soft, miniaturized wearables that continuously track subtle body sounds wirelessly across the body. The devices offer new functionalities and provide highly accurate, real-time evaluation of patient health.
The November issue of CHEST journal features cutting-edge research on asthma, COPD, diffuse lung disease, and thoracic oncology. A new guideline provides updated recommendations for patients with stable COPD, while home spirometry is shown to be less consistent than clinic spirometry in monitoring lung function in patients with asthma.
The POLINA project will develop new materials and technologies for medical applications, aiming to revolutionize bioprinting for safer, smarter and affordable medical devices. The project will create micropatterned cell surface models to help study lung diseases and design new tracheal implants.
A study of 139,000 Canadian children found a substantial decrease in severe respiratory disease hospitalizations and ICU admissions during the first two years of the pandemic compared to pre-pandemic periods. This suggests that public health interventions may be warranted for future evaluations of respiratory illness.
A new study published in BMJ Mental Health reveals that people with severe mental health issues are almost twice as likely to experience multimorbidity, a combination of chronic diseases. The research emphasizes the urgent need for a comprehensive and integrated approach to address this critical issue.
The new American Thoracic Society Clinical Practice Guideline provides evidence-based recommendations for treating patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). The guideline recommends using specific immune modulating and antifibrotic medications, such as mycophenolate, cyclophosphamide, nintedanib, ...
Researchers at Gwangju Institute of Science and Technology developed metal-enhanced fluorescence probes for rapid and accurate detection of influenza viruses. The probes showed high sensitivity and specificity, detecting the virus even at low concentrations, with a remarkable accuracy of over 99%.
Researchers have developed AI tools that can effectively detect heart valve disease and predict cardiovascular risk using digital stethoscopes. A study found that AI-powered digital stethoscopes predicted nearly 90% of valve disease diagnoses, offering a promising tool for transforming CVD care.
A new study by RCSI University of Medicine and Health Sciences found that boosting levels of a deficient protein improves survival rates for people with severe alpha-1 antitrypsin deficiency. The research, which tracked health data from over 600 patients, showed a clear survival benefit from augmentation therapy.
Dr. Alan Jobe, MD, PhD, is recognized for his pioneering work in neonatal lung diseases, advancing the field of bronchopulmonary dysplasia research. The APS John Howland Award acknowledges his commitment to improving global health outcomes, particularly in low-income countries.
The updated guideline recommends yearly low-dose CT scan screening for people aged 50-80 years old with a 20+ pack-year history of smoking. This expansion aims to detect lung cancer early, potentially saving lives.
The Children's Environmental Health Center will investigate the cumulative health impacts of early exposure to pollutants and non-chemical stressors among children in underserved communities. The center aims to reduce environmental health disparities and promote environmental justice for children.
Researchers found that DNA damage accumulates in arteries with aging and contributes to impaired vascular function. In mice lacking or heterozygous for the double-strand DNA break repair protein ATM kinase, aging accelerated vascular dysfunction, including increased arterial stiffness and oxidative stress.
A new study reveals a reversal in the trend of early-onset lung cancer, now affecting younger women and middle-aged adults. The increased incidence in women is attributed to rising rates among those born in the 1960s, without higher smoking prevalence.
A new study published in the Journal of the American Heart Association found that chronic kidney disease may increase the risk of sudden cardiac arrest among Hispanic/Latino adults. Heavy drinking and preexisting heart disease were also linked to an increased risk of sudden cardiac arrest.
A Singaporean study found that unvaccinated COVID-19 survivors are at a heightened risk of heart complications almost a year after recovery. The study revealed a 56% higher risk of developing new heart complications among unvaccinated survivors compared to uninfected individuals.
A substantial burden of RSV-associated hospitalizations was found in Canadian pediatric hospitals, especially among infants under six months. The study suggests that preventive strategies for these young infants could lead to decreased RSV disease burden in children.
A new model developed by Cleveland Clinic researchers can more accurately prioritize patients waiting for a lung transplant, taking into account their disease severity and time on the waiting list. This approach may help reduce waitlist mortality for patients with end-stage lung disease.
An observational study of nearly 70,000 COVID-19 patients found that Paxlovid lowered risk of death by 84% and Legevrio by 77%, reducing combined risk of hospitalization and death by over 40%. The treatments were effective across all patient subgroups and against newer Omicron subvariants.
Researchers discovered that a mutation in the gene ACTA2 causes moyamoya disease and strokes in young children. The mutation leads to dysfunctional smooth muscle cells in arteries, resulting in blockages and increased risk of stroke. Understanding this mechanism could lead to new treatments for moyamoya disease.
A new editorial paper highlights the importance of including older patients in lung cancer clinical trials, where they are often undertreated due to age-related factors. The paper emphasizes the need for increased collaboration among stakeholders to enhance enrollment and retention of older cancer patients.
A recent study published in Radiology: Artificial Intelligence found significant racial and sex-related biases in an AI chest X-ray foundation model, affecting its performance across patient subgroups. The researchers highlighted the need for comprehensive bias analysis to ensure diversity and representativeness in dataset collection.
The 'Crystal Ribcage' technology enables scientists to study lung function at a cellular level while maintaining physiological processes. This innovation holds immense potential for understanding lung diseases and developing new treatments.
Veterinary researchers used 3D organoids to investigate lung cancer in dogs, finding that canine primary lung cancer organoids faithfully mirrored tumor tissues. The study identified correlations between organoid cell viability and specific target molecules, paving the way for personalized treatment approaches.
A systematic review and meta-analysis of 195 clinical trials found that cell therapy can reduce the risk of death from COVID-19 by 60%. The studies, conducted in 30 countries between January 2020 and December 2021, used various types of cells, including mesenchymal stem cells and natural killer cells.
A study at the Technical University of Munich found that people with long Covid experience altered blood vessels in the eye, which could be used to diagnose the condition. Persistent inflammatory responses were also linked to symptom severity and chronic inflammation.
A recent study has found that particular combinations of bacteria in day care dust are linked to an increased risk of wheezing in young children. Researchers identified four categories of microbiota, one of which was associated with a higher incidence of wheezing in children under three years old.
A phase 2 study of idrevloride in hypertonic saline has shown significant improvement in lung function for individuals with primary ciliary dyskinesia. The treatment, an epithelial sodium channel blocker, is safe and well-tolerated, offering hope for newly developed treatments for the rare disease.
A study published in NPJ Aging reveals that COVID-19 exacerbates production of auto-antibodies associated with blood clotting disorders and aging. Researchers found that severe COVID-19 cases display a significant age-related increase in auto-antibodies, which can lead to tissue injury and organ damage.
A study of nearly 500,000 participants found that smoking shortens telomere length in white blood cells, a indicator of aging and cell regeneration. The more cigarettes smoked, the stronger the shortening effect, suggesting a link between smoking and accelerated aging.
Research shows city living, day care attendance, damp homes, and traffic pollution increase the risk of chest infections in young children. Breastfeeding reduces this risk. Urban environments also affect immune systems before exposure to illnesses.
Research presented at the European Respiratory Society International Congress suggests that CPAP machines can prevent deaths from heart disease and reduce cardiovascular problems in people with obstructive sleep apnea (OSA). A pilot study also found that CPAP may be more effective than a weight-loss drug in tackling clogged arteries.
Research found that women exposed to air pollution give birth to smaller babies, with PM2.5 and other pollutants associated with average reductions in birth weight. However, living in greener areas was linked to slightly higher birth weights, suggesting a potential mitigation effect.
Researchers at Helmholtz Munich developed a non-invasive method using MR imaging to detect early signs of vascular disease associated with chronic pulmonary impairment in premature infants. The study presents a new tool for risk stratification and potential prevention of complications later in life.
A new global definition of acute respiratory distress syndrome (ARDS) has been proposed by experts, expanding the criteria to include non-invasive ventilation and pulse oximetry. The updated definition aims to improve recognition of ARDS at an earlier stage, allowing for more effective interventions.
People with asthma and COPD face increased breathing difficulties due to climate change's effects on heatwaves, wildfires, and flooding. Experts urge governments to reduce greenhouse gas emissions to mitigate these risks.
Researchers aim to identify genetic risk factors and mechanisms underlying virus-induced asthma, using artificial intelligence-based techniques and patient-derived models. The study may lead to personalized prevention campaigns and mechanism-targeted drugs.
A new study found that voluntary collective isolation was unlikely to prevent rapid spread of COVID-19 among the Tsimané, a small-scale Indigenous society in remote Amazonia. The simulation predicted nearly identical rates of infection in real-world data, highlighting the need for targeted interventions and medical resources
The August issue of CHEST journal features a new clinical practice guideline for managing patients with neuromuscular weakness and a multisociety evidence review on the effect of race and ethnicity on pulmonary function testing interpretation. This is complemented by other research and reviews covering various aspects of chest medicine.
Researchers found that young vapers are at risk of respiratory symptoms such as bronchitic symptoms and shortness of breath, even if they or others around them smoke cigarettes or cannabis. The study also highlights the need for regulatory oversight of vaping products.
Most infants admitted to the intensive care unit (ICU) for RSV infections were previously healthy and born at term. Preventative interventions targeting all infants can reduce the burden of severe RSV illness. New treatments such as palivizumab and nirsevimab are being considered.
A growing number of studies highlights the power of dogs in detecting COVID-19 and its variants, even when obscured by other viruses. Trained scent dogs are as effective and often more effective than antigen tests and RT-PCR tests, detecting the virus faster and without environmental impact.
A new imaging method developed by UC researchers can identify specific lung infections in real time, reducing diagnosis time from 2-3 days to hours. The method uses injectable probes that light up under a nuclear imaging machine, enabling faster treatment for critically ill patients.
A network meta-analysis found that breathing training combined with aerobic exercise, and yoga training, enhance lung function in adults with asthma. The study highlights the importance of integrating appropriate exercise training into asthma management plans.
A new study found consistent increases in premature cardiovascular disease (CVD) death and disability due to particulate matter air pollution globally. The analysis, published in the Journal of the American Heart Association, revealed a 8.1% rise in age-standardized CVD deaths attributed to outdoor PM pollution between 1990 and 2019.
Researchers at TUM develop an RNA agent for a lung spray that slows macrophage activity, reducing lung inflammation and fibrosis. The active substance RCS-21 is delivered via an inhaler through a special sugar molecule, showing promise in treating acute inflammatory lung damage.
Researchers at the Institute for Systems Biology have identified a signaling system called MtrA that helps Mycobacterium tuberculosis grow in response to host signals. Disrupting this system compromises the pathogen's cell wall, making it unable to divide and ultimately compromising its survival.
Researchers at McMaster University developed a new rapid test that can quickly identify eosinophils, key drivers of severe asthma, in complex biological samples. The test uses DNAzymes to track protein signatures and is designed to be simple and adaptable for mass manufacturing.
Researchers developed AirGels, bioengineered models of human lung tissue, to study airway infections in a more realistic manner. They found that Pseudomonas aeruginosa induces contraction of the host's mucus using type IV pili, contributing to biofilm formation.
The study reveals altered magnitudes and coherence between oscillations in brain vasculature and brain waves in older adults. This finding has significant implications for the assessment of Alzheimer's disease and monitoring of neurodegenerative disorders.
Researchers found that human senescent fibroblasts trigger progressive lung fibrosis in immunodeficient mice by inducing paracrine senescence and pro-fibrotic activities. The study also suggests that senolytic compounds like navitoclax can ameliorate lung fibrosis induced by senescent human fibroblasts.