An international study has established age-specific ultrasound reference values to distinguish normal joint changes from early signs of inflammatory arthritis. The study analysed over 28,000 joints from 802 healthy volunteers and developed new thresholds for normal and abnormal findings, which will help clinicians identify inflammatory...
A study of 60,980 US adults with autoimmune rheumatic conditions found that those who received updated COVID-19 vaccines had a 69% lower adjusted odds of COVID-19-related hospitalization compared to those who received only the initial series vaccines or were unvaccinated. The completion of the initial series and booster vaccination als...
Researchers from Children's Hospital of Philadelphia have found distinct genetic architecture in pediatric-onset rheumatic and inflammatory diseases compared to adults. The study identified 39 genome-wide significant variants associated with immune responses, including previously unreported variants.
The new guidelines focus on referral and assessment, treatment, relapse and re-evaluation, and possible endovascular interventions. Regular follow-up and monitoring should be based on symptoms, clinical findings, and acute phase markers.
The EULAR RheumaFacts project reveals large disparities in workforce density, non-pharmacological care availability, and access to modern treatments such as biologics. The study aims to drive policy and advocacy for improving the quality of life of people with rheumatoid arthritis and other RMDs.
A new international consensus statement provides practical guidance for clinicians to identify, monitor, and treat RA-ILD. The experts outline key risk factors and recommend a team-based approach involving rheumatologists, pulmonologists, and other specialists.
A new approach to managing fatigue in inflammatory arthritis combines physical activity and cognitive behavioral techniques. Digital patient education is shown to be cost-effective and efficient in improving patient outcomes. Caregiver-focused interventions are also crucial in supporting daily functioning and disease management.
Researchers present findings on a novel therapeutic strategy for PsA, using synovial biopsy-driven treatment with biologics targeting IL-17/23 axis. A separate study evaluates the effectiveness of personalized dietary interventions in improving clinical outcomes.
The updated ASAS-SPARTAN revised classification criteria for axSpA prioritize MRI of the sacroiliac joints and incorporate a focused set of clinical variables. The new recommendations also emphasize the role of imaging in diagnosing and managing both axial and peripheral SpA.
A new study presented at EULAR 2026 highlights the importance of structured cardiac evaluation in systemic sclerosis, particularly for patients with multi-system disease. The research also identified PDE4B as a promising therapeutic target across various tissues and cell subsets, offering potential benefits for patients with early dise...
A population-based cohort study found that IIM subtypes differ in incidence, particularly by sex and ethnicity. Automated quantitative nailfold videocapillaroscopy (NVC) model shows superior discriminative capacity for predicting disease activity compared to traditional serum biomarkers.
A multidisciplinary patient organisation provides accessible, person-centred support through professional counselling, offering a non-clinical setting to discuss everyday challenges and work-related issues. The service also offers unique insights into unmet needs, such as medication shortages and administrative barriers.
New AI algorithms demonstrate improved accuracy in evaluating radiographic data and assessing joint inflammation. These innovations include the RADAR algorithm, ADMIRA, and thermography-based systems, offering promising alternatives to traditional imaging methods.
The study evaluated digital platforms and AI chatbots for improving health literacy in patients with RMDs. The results showed high usability, perceived usefulness, and trust among participants, suggesting a promising approach to patient education.
A new study suggests that adding low-dose glucocorticoids to maintenance treatment for ANCA-associated vasculitis (AAV) does not reduce the risk of major flares, but is associated with an increased risk of chronic damage and hospitalization. In contrast, rituximab use was linked to a lower risk of major flares.
A new study using the EUSTAR database found that patients with active disease at baseline had higher cumulative incidence rates of organ and multi-system involvement. Early disease activity monitoring is crucial for identifying patients at risk, guiding treatment decisions, and improving patient outcomes.
Researchers have developed operational definitions of srSLE based on disease activity and treatment exposure, showing strong predictive performance. A novel autoantibody signature has also been identified to predict atherosclerosis progression in juvenile-onset systemic lupus erythematosus
Comorbidities such as cardiovascular disease, cognitive impairment, and osteoporotic fractures are common in RMD patients. Systemic autoimmune diseases increase the risk of cardiac arrhythmias and mortality. PPI use is linked to a higher risk of major osteoporotic fractures, while JAKi therapy may pose a risk of venous thromboembolism.
A study found that patients continuing ULT remained flare-free for longer over 24 months, with a cumulative flare incidence of 12.3% compared to 31.8% in the ULT discontinuation attempt group. Effective weight management and exercise are key to managing gout and rheumatoid arthritis.
Research studies reveal suboptimal adherence to treat-to-target strategies in rheumatoid arthritis, with lower rates among spondyloarthritis patients. Additionally, data from registries show the potential benefits of glucagon-like peptide-1 receptor agonists for weight loss and disease activity management in RMD.
Researchers present results from Phase 1 trials of CAR-T cell therapies in patients with refractory rheumatoid arthritis and systemic sclerosis, showing improved disease activity and clinical remission. The findings suggest an immunological 'reset' strategy may offer true curative potential for these severe diseases.
Researchers have found a widely available drug combination to be an effective treatment for patients with systemically active Sjögren's disease. The combination of leflunomide and hydroxychloroquine reduced disease activity while maintaining a favorable safety profile.
A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.
A new study suggests that ultrasound stimulation can bring about functionally meaningful changes in pain perception and brain connectivity. The research found a delayed analgesic effect, with participants reporting reduced pain intensity after 28-55 minutes following TUS application.
In patients with symptomatic rheumatic heart disease, digoxin significantly reduced the risk of a composite of all-cause death or new-onset or worsening heart failure. The treatment had little risk of toxicity, making it a promising therapeutic option for these patients.
The EULAR recommends a multidisciplinary approach to managing Behçet's syndrome, aiming to prevent irreversible organ damage and maximize quality of life. The updated guidelines prioritize monoclonal TNFi for patients with eye, vascular, or nervous system involvement, promoting earlier recognition and more consistent care.
A study found that using SGLT2i drugs in patients with gout and type 2 diabetes can lead to lower rates of starting urate-lowering therapy, NSAIDs, and diuretics. This could streamline care and reduce medication burden for these patients.
The European Alliance of Associations for Rheumatology (EULAR) has introduced three overarching principles and 11 points to consider for assessing disease activity in AOSD. The guidelines emphasize the importance of adopting a valid, reliable, and easily transferable definition of disease activity, which includes fever, skin rash, arth...
The European Alliance of Associations for Rheumatology has developed a new disease activity score (EAPSDAS) to assess clinical manifestations in antiphospholipid syndrome (APS). The score evaluates thrombotic, obstetric, microvascular, and non-thrombotic symptoms, providing insights into disease activity and treatment response.
Two first-in-class antibodies, C01 and C04, have been developed to inhibit inflammation in autoimmune diseases by blocking the high-affinity IgG receptor FcγRI. The antibodies were discovered using a unique immunization method and exhibit higher affinity for FcγRI than human IgG.
A new review provides simplified criteria for defining gout remission and proposes integrated management strategies for sustained disease control. The authors highlight the importance of individualized urate-lowering therapy and proactive flare prevention, using imaging to show patients visual proof of crystal dissolution.
Researchers at UMC Utrecht are developing a predictive model to accurately predict disease progress in juvenile dermatomyositis. The Interferon Score aims to identify which children can safely reduce medication and which require intensified treatment.
Researchers developed a points-based classification model using eight variables to assess joint pain, genetic mutations, and iron loading. The criteria show promise in diagnosing haemochromatosis arthropathy with high specificity and sensitivity, paving the way for new treatment options.
The European Alliance of Associations for Rheumatology (EULAR) is hosting the EULAR 2026 Congress in London, featuring a scientific program with new clinical data and updated treatment guidelines. The congress will also provide exclusive media opportunities, including a press conference and one-on-one interviews with expert panelists.
A University of Houston researcher identifies a protein that may reduce high ketone levels in diabetic patients, potentially improving health outcomes. The study also shows that the protein promotes muscle ketolysis and running capacity in mice.
EULAR has established new points to consider and consensus definitions for managing difficult-to-treat psoriatic arthritis, aiming to improve treatment options and care for patients. The guidelines focus on identifying the biology behind treatment non-response and promote personalized treatment approaches.
A recent study from Karolinska Institutet reveals how a gene associated with several rheumatic diseases affects cell movement. The researchers discovered that the DIORA1 gene regulates cell movement by interacting with MRCK kinases, which are important for the cell's skeleton and ability to move.
Researchers analyzed immune cell transcriptomes to understand JIA's pathogenesis. Monocytes, monocyte-derived dendritic cells, and platelets are increased in JIA patients, while B-cell responses differ between sJIA and non-sJIA subtypes.
The European Alliance of Associations for Rheumatology (EULAR) journal Annals of the Rheumatic Diseases (ARD) has achieved a notable increase in its impact factor to 20.6, surpassing 58 other titles in rheumatology and reaffirming its status as the leading journal for original research in both basic and clinical fields. This recognitio...
Recent studies suggest that early biologics in severe psoriatic arthritis may not significantly benefit patients compared to standard step-up care with methotrexate. However, a study found that intensive therapy with early biologics or combination csDMARDs can rapidly control disease activity and maintain better outcomes at 1 year.
The recombinant zoster vaccine was found to be well-tolerated in patients with inflammatory rheumatic musculoskeletal diseases, with only a few reports of flare and serious AEs. The majority of patients tolerated the vaccine without significant adverse events.
Research discovers mitochondrial respiration impairment accelerates skeletal ageing by altering cell metabolism and reducing regenerative abilities. The study highlights the role of mitochondria in skeletal health and potential therapeutic avenues.
Pusan National University researchers have identified genes that are overexpressed in peri-implantitis, a condition similar to periodontitis but with higher recurrence rates. The study's findings may help diagnose and treat the disease with targeted therapies.
Women with infertility are at higher risk of developing SARD, including lupus and Sjögren's syndrome, even after accounting for pre-eclampsia and other pregnancy complications. Infertility treatments do not appear to increase this risk, suggesting that women may be undiagnosed or untreated.
A scoping review found associations between myositis disease activity and gluten exposure in patients with inflammatory myopathies and celiac disease. The study suggests that gluten may act as an exogenous antigen driving myositis in genetically predisposed patients.
A retrospective cohort study found associations between COVID-19 and the long-term risk of various autoimmune and autoinflammatory connective tissue disorders. Long-term monitoring and care are crucial to mitigate these risks, taking into account demographic factors, disease severity, and vaccination status.
Researchers at Umeå University have identified unique inflammatory protein profiles in the blood of individuals with severe periodontitis, which is associated with lower levels of EGF and OLR-1 proteins. The study provides a promising lead for developing biomarkers and treatments for the disease.
Dr. Melissa Grunlan's team creates regenerative osteochondral plugs, a potential off-the-shelf device to treat OCDs and avoid total knee replacement surgery. The technology offers an alternative to autografting or total knee replacement, providing immediate support for joint function and potentially reducing post-operative complications.
A Charité study found that taking proton pump inhibitors (PPIs) simultaneously with cortisone preparations is associated with a higher risk of osteoporosis in patients with inflammatory rheumatic conditions. The study analyzed the bone health of over 1,500 patients and found that PPI use led to significantly lower bone density.
Professor Leith Zakraoui was awarded the 2024 IOF CNS Medal for his dedicated work in advancing musculoskeletal health at both national and international levels. He has been a key figure in strengthening IOF activities in Africa and promoting education and awareness within the region.
A new study published in the Journal of the American Heart Association suggests that treating gum disease after a heart rhythm ablation procedure can lower oral inflammation and reduce the risk of AFib recurrence. Researchers found that an index measuring the severity of gum inflammation was associated with the return of AFib, highligh...
Women with selected rheumatic diseases experience a higher prevalence of childlessness, while risks for pre-eclampsia, low birth weight, and preterm delivery are increased for many conditions. Men with rheumatic conditions also face a higher risk of childlessness, although the impact on fertility varies among different diseases.
This study found that SIRT6 activation improves DNA damage repair efficiency and reduces baseline DNA damage in chondrocytes from older donors. MDL-800 treatment also lowered p16 promoter activity and decreased DNA damage in murine cartilage explants, supporting the concept of SIRT6 as a critical regulator of DNA repair.
A NSF-funded project, MABLE, is developing a digital app using crowdsensing, AI, and robotics to empower individuals with responsive maps and turn-by-turn instructions. The app aims to improve accessibility and navigation for persons with visual or mobility impairments, such as those with low vision and wheelchair users.
The European Alliance of Associations for Rheumatology (EULAR) has developed new recommendations for managing fatigue in people with inflammatory rheumatic and musculoskeletal diseases. The guidelines emphasize the importance of monitoring fatigue and offering management options based on a shared decision between patients and healthcar...
The updated EULAR recommendations for managing SLE emphasize individualized, multidisciplinary care and consider patient education and societal costs. Non-pharmacological interventions and careful drug selection based on disease type and severity are also key to improving long-term outcomes.
A systematic review and meta-analysis of 16 studies involving 875 patients with knee osteoarthritis found significant reductions in patient-reported pain from the third month onwards. Stem cell treatment was most effective when using patient's own fat-derived stem cells, leading to better pain alleviation and recovery of joint function.
A clinical trial found that high levels of anti-Ro/SSA antibodies in pregnant women are associated with an increased risk of fetal atrioventricular block (AVB), a condition that can be fatal. Home-based fetal heart rate monitoring reliably detects conduction abnormalities, potentially reducing the need for serial echocardiograms.
A recent study found that transient inflammatory pain causes persistent mitochondrial and metabolic disturbances in sensory neurons, leading to failure in pain resolution. Targeting the cellular redox balance prevents and treats chronic inflammatory pain in rodents.
Researchers propose a new approach to testing treatments for osteoarthritis by focusing on individuals who sustain knee trauma, such as ACL tears. This approach identifies a high-risk group of patients with early disease, allowing for targeted treatment and prevention strategies.