Articles tagged with Septic Shock
Researchers at UH College of Pharmacy are developing breakthroughs to combat sepsis, a leading cause of hospital deaths, and diseases such as Alzheimer's and sickle cell disease. A dual-action nanomedicine has shown a 100% survival rate in preclinical trials for sepsis treatment.
The study targets microglia, brain immune cells involved in inflammation after sepsis. Evodiamine-loaded liposomes deliver anti-inflammatory treatment to the affected areas, reducing brain inflammatory signals and protecting hippocampal neurons.
The American College of Chest Physicians' open-access journal CHEST Critical Care has received its first Journal Impact Factor of 2.7, reflecting the dedication of its authors, reviewers, and readers. This recognition highlights the journal's growing impact in critical care medicine.
Researchers at the University of Calgary have developed a new method to analyze cellular behavior in sepsis infections, identifying 18 different clusters of behaviors involved. This breakthrough could lead to targeted therapeutics and improved survival rates for patients.
Researchers found AI can accurately assess complex quality measures in seconds, providing near real-time feedback to physicians. This results in improved compliance with national sepsis quality measures and lower administrative costs.
The study found that sepsis continues to be a significant cause of mortality in China, with infections accounting for the majority of deaths. The analysis also revealed age-related differences in sepsis burden, with older adults and males consistently carrying the highest risk.
The FDA has approved an AI-based early warning system for sepsis, developed by Johns Hopkins University researchers, which detects the condition hours faster than doctors and has reduced deaths by nearly 20%. The system, known as Targeted Real-Time Early Warning System, integrates electronic health records with advanced clinical AI to ...
A large clinical trial involving thousands of patients across the US and abroad found that balanced crystalloid fluid resuscitation was as effective as saline solution in preventing major adverse kidney events after pediatric sepsis treatment. The study also revealed biochemical differences between the two fluids, including elevated bl...
A study comparing two blood purification strategies for septic shock found that both CytoSorbⓇ and oXirisⓇ improved hemodynamic status by reducing lactate levels and vasopressor requirements. However, no significant differences were found in primary outcomes, suggesting comparable clinical benefits.
The American College of Chest Physicians (CHEST) has certified its first class of critical care advanced practice providers with the CCAPP designation. This achievement recognizes their dedication to high-quality patient care and their role in supporting multidisciplinary critical care teams. The CCAPP certification is designed to vali...
A new study found that tuberculosis is a major cause of deadly sepsis among people living with HIV, particularly in Africa. Early treatment of TB has been shown to significantly reduce sepsis deaths, with a 23% reduction in mortality rate.
The study validates the use of SOFA-2 in sepsis care and research, demonstrating its ability to identify clinically meaningful organ dysfunction. The findings suggest that incorporating immune markers may not improve predictive performance, highlighting the biological complexity of sepsis.
The American College of Chest Physicians' CHEST Critical Care journal has been added to the Web of Science Core Collection through the Emerging Sources Citation Index. This indexing marks a significant milestone for the journal, increasing access to high-quality research and supporting its commitment to advancing critical care medicine.
Researchers at Tulane University have developed the first vaccine able to protect nonhuman primates from melioidosis, a long-neglected and deadly tropical disease on the rise. The vaccine uses outer membrane vesicles to trigger a powerful immune response.
A landmark trial has shown that a structured approach to infection prevention and treatment can save women's lives. The programme reduced severe maternal infections and deaths by about one-third (32%) compared to usual care.
A 47-year-old man from New Jersey died after consuming beef due to a tick-borne meat allergy caused by the Lone Star tick's alpha-gal sugar. Researchers identified the allergy and its link to fatal anaphylaxis, urging physicians to investigate severe abdominal pain after eating red meat in areas with high Lone Star tick populations.
A deep learning model developed by researchers identified subgroups of ICU patients with sepsis who could benefit from corticosteroid therapy. Patients with severe metabolic acidosis and circulatory dysfunction benefited the most from treatment.
The article argues that a universal 30 mL/kg fluid bolus is no longer appropriate and instead calls for a balanced, individualized approach to fluid management in septic shock. This approach considers the patient's comorbidities, infection source, and estimated fluid losses, and guides management by frequent reassessment.
A recent University of Michigan-led study found that almost 10% of patients with sepsis who were previously healthy died within 90 days. These patients tended to have less organ failure and more COVID-19 related sepsis than those with underlying health conditions.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
The American College of Chest Physicians (CHEST) has launched a critical care APP education and certification program, covering 11 topic areas including patient-centered care and pharmacology. The CCAPP Certification Exam is now available, with an August 5 deadline to apply for the 2025 exam.
A large cohort study has shown that supplementary treatment with statins can boost survival chances for critically ill patients with sepsis. The results indicate a 39% lower death rate over 28 days after hospital admission.
Researchers have reexamined the Ashwell-Morell receptor's functions using innovative glycoengineering techniques, clarifying its roles in sepsis and inflammation control. The study reveals that the receptor can bind to a specific type of protein glycan chain, which was previously thought to be incompatible with binding.
A pioneering study has identified interleukin-6 (IL-6) as a powerful diagnostic biomarker for the early detection of sepsis in high-risk patient groups. IL-6 outperformed traditional biomarkers in distinguishing bacterial from non-bacterial infections and stratifying sepsis severity.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed in Elsevier's Scopus database. This achievement is a testament to the high-quality research published in these journals, which provide open access content in pulmonary and critical care medicine.
A systematic review found no moderate-to-high level evidence that compliance with the Centers for Medicare & Medicaid Services' (CMS) Severe Sepsis and Septic Shock Management Bundle was associated with improved sepsis mortality. The study suggests reconsidering the inclusion of the bundle in the Hospital Value-Based Purchasing program.
Researchers at Penn Engineering and PSOM will develop AI systems to predict treatment response in breast cancer, heart attacks, and sepsis. The goal is to support clinicians with accurate and transparent predictions, leading to better health outcomes for patients.
Prolonged β-lactam antibiotic infusions associated with reduced 90-day mortality in adults with sepsis or septic shock. This standard of care approach is now supported by high certainty evidence.
Researchers have identified distinct molecular signatures associated with sepsis, enabling more accurate diagnosis and prognosis. The study's findings suggest a potential new tool to target specific therapies at patients most likely to develop severe symptoms.
An international research team developed a novel scoring system, called the Phoenix Sepsis Score, to diagnose sepsis in children. The scoring system enables physicians to quickly determine the severity of organ failure, leading to improved outcomes for affected children.
A new set of international criteria has been established to diagnose pediatric sepsis and septic shock in children, aiming to improve clinical care and research globally. The Phoenix Sepsis Score of at least 2 can identify potentially life-threatening organ dysfunction in infected children under 18 years old.
A novel score, the Phoenix Sepsis Score, predicts mortality in children with suspected or confirmed infection. The new criteria outperform existing organ dysfunction scores and International Pediatric Sepsis Consensus Conference criteria
Pediatric sepsis experts have released new diagnostic criteria that will be used worldwide to diagnose life-threatening infections in children. The updated criteria, known as the Phoenix Criteria, include measures of respiratory, cardiovascular, and coagulation dysfunction.
A randomized clinical trial involving 126 patients found that landiolol did not prevent organ failure in those with established septic shock. The study concluded that this beta-blocker is not a suitable treatment option for managing tachycardia in these patients.
A retrospective analysis of pediatric sepsis deaths found Black children were 2.5 times more likely to die from sepsis, with an overall mortality rate of 1.65% compared to 1.27% for white children. The study highlights the need to identify factors contributing to racial disparities in sepsis outcomes.
A formulation of vitamin C has been proven effective in treating sepsis, a deadly condition responsible for 35-50% of hospital deaths. The next phase of clinical trials will recruit 300 adult septic patients to receive the treatment.
Researchers found that genetic variants of the STING gene and bacterial NADase enzyme activity interact to determine disease severity. People with the risk variant of STING have a higher risk of life-threatening conditions, while those with the protective variant are less affected.
The inaugural issue of CHEST Critical Care focuses on clinically relevant research and patient management guidance for critical care medicine. The journal accepts submissions of original research, case series, and research letters, covering topics such as intensive care medicine and diverse populations.
Pharmaceutical scientists from the National University of Singapore have developed multi-functional synthetic peptide nanonets for relieving inflammation caused by bacterial infection. These nanonets trap bacterial endotoxins and pro-inflammatory cytokines, achieving anti-inflammatory activity through selective binding.
A large multicenter study finds that combining hydrocortisone and fludrocortisone reduces death rates and hospice discharge among patients with septic shock. The regimen outperformed hydrocortisone alone, with a four percent lower mortality rate.
A recent study found that adults with type 1 diabetes are at a high risk of being overweight or obese, but only half receive lifestyle recommendations to manage their weight. The study also highlighted the importance of individualized patient education in improving weight management for these patients.
Researchers at Boston Children's Hospital propose using an existing drug to prevent NET formation, which can lead to severe inflammation in conditions like COVID-19, sepsis, and ARDS. The study shows that ricolinostat inhibits histone deacetylases, reducing NET formation and inflammation.
St18 is a negative regulator of VEGF signaling, which plays a critical role in septic pathophysiology. Mice lacking St18 exhibit increased retinal vasculature and enhanced serum VEGF concentrations, highlighting the importance of St18 in regulating VEGF.
Monitoring lactate and bio-ADM levels helps identify high-risk sepsis patients. Bio-ADM measures blood vessel leakage, which can detect fatal outcomes despite low or decreasing lactate levels.
A new pediatric study found that treating septic shock with a combination of vitamin C, vitamin B1, and hydrocortisone reduces mortality in children. The treatment resulted in mortality rates of 9% at 30 days compared to 28% in control groups.
A randomized clinical trial of 200 patients with septic shock found that combining vitamin C, hydrocortisone, and thiamine did not significantly improve survival rates over seven days compared to hydrocortisone alone. The study's findings were released in conjunction with the Critical Care Reviews Meeting 2020.
A new model predicts children likely to go into septic shock, allowing for earlier treatment and potentially saving lives. The study analyzed 2,464 visits and found the model accurately predicted 90% of cases.
Research reveals that sugar released into bloodstream enters brain during septic shock, causing premature mental aging and memory loss. The study provides a clear target for drug therapy: binding to the sugar or converting it to non-impairing compounds.
The study found a significant decrease in overall mortality in septic shock from 51.7% to 39.3% between 2004 and 2014, with shorter hospital stays also observed.
A new study published in the American Journal of Respiratory and Critical Care Medicine found that New York State's sepsis reporting mandate led to improved care and reduced mortality rates for critically ill patients. Patients who received standardized treatment protocols had shorter hospital stays and lower mortality rates.
The updated 'Hour-1 Bundle' introduces five critical steps for treating sepsis immediately upon recognition, including measuring lactate levels, performing blood cultures, and administering broad-spectrum antibiotics. This revised bundle aims to further reduce mortality rates among patients with sepsis by beginning treatment promptly.
A large-scale study has shown that steroid treatment can reduce the duration of septic shock and time spent on life support therapy, but not necessarily lead to fewer deaths. The trial involved 3800 patients across five countries and found that steroids led to a more rapid resolution of shock and earlier discharge from intensive care.
A new study links HMGB1 protein to post-sepsis immunosuppression and neutrophil dysfunction. Researchers found that neutralizing HMGB1 restores neutrophil function, offering a potential therapeutic approach for sepsis recovery.
A machine-learning algorithm has been developed to predict severe sepsis and septic shock in hospitalized patients, utilizing data from electronic health records. The algorithm was validated in real-time and found to accurately identify patients at risk, with approximately 3% of all acute care patients screened as positive.
A study published in JAMA found that a nationwide norepinephrine shortage in 2011 was associated with an increased risk of in-hospital death among patients with septic shock. The shortage led to a decline in norepinephrine use, which may be related to worse outcomes and other unmeasured factors.
Researchers found that subcutaneous injection of orexin can improve survival rates in mice with endotoxin shock by restoring body temperature and increasing heart rate. Future studies aim to validate the effect of peripherally administered orexin in primates with septic shock.
Patients with septic shock who experience bradycardia (lower heart rate) have a 21% lower mortality rate compared to those without. A 13% decrease in mortality risk was observed among patients with average lower heart rates below 80 beats per minute.
Researchers compared early treatment with vasopressin to norepinephrine in septic shock patients, finding that neither improved kidney failure-free days. The study suggests that larger trials may be needed to assess potential benefits of alternative treatments.
Researchers analyzed over 7,000 patient encounters with severe sepsis or septic shock, finding that 68% of patients without shock did not receive an ICD diagnosis code. Patients assigned codes had a higher mortality rate, ICU admission rate, and hospital length of stay compared to those identified by clinical criteria alone.
Sepsis occurs when molecules released into the bloodstream to fight an injury or infection trigger inflammation throughout the body. The new definitions provide detailed measurements for identifying sepsis in adults, including the use of the Sequential Organ Failure Assessment (SOFA) score and clinical criteria such as respiratory rate...