Articles tagged with Stomach Cancer
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A simple health questionnaire could be a highly effective tool to pre-screen people for early signs of oesophageal cancer, enabling much earlier diagnosis and treatment. Eight factors were identified as markers in those individuals who had Barrett's oesophagus or went on to develop it.
Researchers propose a link between microbial infections and various cancers, centered around the mucin protein MUC1. The protein's dual role in combating bacterial attacks and triggering inflammation processes may contribute to malignancy.
Survival rates for seven cancers have improved in Australia, Canada, and Norway compared to New Zealand, Denmark, Ireland, and the UK. The largest gains were seen in patients under 75 years old with poor prognosis cancers. Improvements in cancer control suggest progress has been made in these countries.
A relaxation of UK salt regulations has been linked to 9,900 additional cases of cardiovascular disease and 1,500 stomach cancer cases. This policy change resulted in a slowdown of salt intake reductions, which are now estimated to cost the UK economy £160million.
Researchers at Hiroshima University discover that a layer of cells resembling normal stomach lining is produced by stomach cancer tissue itself, making it difficult to spot after Helicobacter pylori infection treatment. This finding highlights the need for continued check-ups even after H. pylori eradication.
Researchers discover that gastric stem cells release a protein called intelectin 1 to bind to Helicobacter pylori bacteria, preventing damage. This mechanism is triggered by the presence of H. pylori and stimulates stem cell proliferation and tissue regeneration.
A San Diego State University study finds that lumping all Hispanic-Americans together masks the differences in cancer outcomes. The study reveals subtle and sometimes significant differences in cancer risk among Cuban, Mexican, Puerto Rican, and Central and South American groups.
A Cancer Research UK-funded study found that less chemotherapy is as effective at controlling disease for elderly or frail patients with advanced stomach or oesophagus cancer. The study showed that lower doses of chemotherapy resulted in fewer side effects and improved quality of life.
Researchers found curcumin has potential to prevent or treat stomach cancer by inhibiting histone modifications. Compounds like cholecalciferol, resveratrol and quercetin also show promise in modulating histone activity.
Researchers found that the medicine DFMO not only blocks cell growth but also directly targets H. pylori to reduce its virulence. This could lead to a new strategy for preventing stomach cancer. The study supports further research into using DFMO to prevent stomach cancer.
Scientists have isolated a gene, miR-I35B, linked to both inflammation and gastric cancer. The study suggests that miR-135B plays a role in the development of gastric abnormalities and may help develop diagnostic tools for early detection.
Researchers predict a decline in cancer death rates in Australasian countries and Russia in 2018. However, the largest number of deaths are predicted for Russia, mainly due to high rates among men who still smoke. The study highlights the need for urgent measures on tobacco control in Russia.
Michael Hall's discovery of the TOR protein as a central controller of cell growth and metabolism has contributed to our understanding of cancer development. Rapamycin and its derivatives are now used in targeted cancer treatment, extending life expectancy for some patients with advanced cancer.
ZW25, an antibody targeting the HER2 receptor, has shown encouraging anti-tumour activity in patients with advanced cancers driven by HER2. The median time patients survived without disease progression was 6.21 months, and 13 experienced tumour shrinkage.
Researchers at Fred Hutchinson Cancer Center have found a specific strain of Helicobacter pylori strongly correlated with stomach cancer. The study suggests that the EPIYA D variant of the cagA gene may be used to identify high-risk patients and improve screening and treatment plans.
Researchers at McGill University have made a groundbreaking discovery linking stomach tumours in patients with Peutz-Jeghers Syndrome to immune system inflammation. The study suggests targeting inflammatory pathways may lead to potential new treatments for this rare genetic disorder.
A new study published in Diabetologia reveals that diabetes is a significant risk factor for all-site and site-specific cancers, with a higher risk in women than men. Women with diabetes have a 27% higher risk of all-site cancer compared to women without diabetes.
A global review of almost 20 million people found that diabetes significantly raises the risk of developing cancer, with women at even greater likelihood. The study highlights the need for more research into the role diabetes plays in cancer development and the importance of sex-specific research.
A new study found that Helicobacter pylori bacteria can shut down the energy production in host cells to evade the immune system, leading to an increased risk of gastritis, ulcers, and stomach cancer.
A new report from WCRF shows that overweight or obesity increases cancer risk by at least 12 types of cancer. Regularly drinking sugar-sweetened drinks increases cancer risk due to weight gain, while being physically active can help protect against three cancers: bowel, breast, and womb.
A breath analysis test showed good diagnostic accuracy for esophagogastric cancer in a study of 335 patients, including those already diagnosed with the disease. The test identified abnormally regulated volatile organic compounds in the breath associated with esophagogastric cancer.
A Melbourne research team discovered that a protein called NF-kB1, which was previously thought to drive cancer development, actually plays a critical role in preventing stomach cancers. The study also found that immunotherapy may be a significant tool for treating stomach cancers driven by chronic inflammation.
Researchers have identified two genes, PIAS1 and IRF8, that play a crucial role in regulating the replication of Epstein-Barr virus. By understanding how these genes interact with the virus, scientists may develop new treatments for cancer types associated with EBV infection.
Researchers found that mature cells in different organs activate the same genes and undergo similar processes when dividing again, leading to potential new targets for cancer treatment. This discovery could support using universal strategies to treat or prevent cancer in various organs.
A new genetic study has better predicted stomach cancer risk by analyzing intestinal metaplasia, a known risk factor for the disease. The study identified biomarkers that can be used to detect patients at high risk of progression.
Researchers found that mature cells can revert to a stem cell-like state, carrying accumulated mutations that predispose them to developing into precancerous lesions. This new understanding could lead to the development of treatments targeting mature cells, potentially preventing cancer recurrence.
Researchers discovered H. pylori's two additional strategies to target mitochondria, which maintain an environment conducive to bacterial proliferation and worsen gastric lesions in mice. The findings suggest new avenues for developing effective strategies to combat H. pylori infection and reduce its pathogenic potential.
A new study found that elevated oral pathogens and decreased bacterial diversity are associated with precancerous stomach cancer lesions. The researchers suggest that treating chronic periodontal disease and controlling pathogen infections may help prevent stomach cancer.
Research published in Gut found a significant association between long-term proton pump inhibitor (PPI) use and an increased risk of developing stomach cancer. The study, which monitored over 63,000 adults, revealed that the longer PPIs were used, the greater the risk, with daily use linked to a quadrupling in risk compared to weekly use.
A population-based study found a 22% reduction in stomach cancer risk among those aged 60 and over who received antibiotic-based treatment for H. pylori infection compared to the general population. The study suggests that treating this type of bacterial infection in older adults can help reduce their risk of developing gastric cancer.
Researchers have found that Helicobacter pylori infection increases stem cell turnover in the stomach, leading to increased cell division and cancer risk. The bacteria sends a signal to stem cells, putting them into overdrive, which may explain why chronic infections with H. pylori are linked to stomach cancer.
Cancer survivors can enjoy kefir as a fortifying post-exercise drink without digestive issues. Kefir's health benefits include improved lactose tolerance and anticarcinogenic activity.
Researchers will test drug Selumetinib on patients after endoscopic removal of stage I gastric cancer. The goal is to reverse pre-cancerous metaplasia and prevent cancer recurrence.
Sub-Saharan African-born blacks experience a higher incidence of infection-related cancers and blood cancers compared to US-born non-Hispanic blacks. In contrast, prostate cancer is more prevalent among Western African-born black men, while Eastern African-born blacks have higher rates of liver and thyroid cancer.
A study published in the AACR Annual Meeting found that longer-than-expected telomeres are associated with an increased risk of cancer. The research analyzed blood samples from over 28,000 Chinese people and found a significant link between telomere length and cancer incidence.
A recent study found that people who gained weight over their lifetime were more likely to develop esophageal and stomach cancers. The researchers analyzed data from over 400,000 people and discovered that those who became obese after a healthy weight had nearly tripled the risk of developing these cancers.
A breath test measuring five chemicals has shown promising results for detecting oesophagus and stomach cancers in a large patient trial. The test achieved an overall accuracy of 85%, outperforming the current method of endoscopy.
Prolonged exposure to work-related stress has been linked to an increased likelihood of lung, colon, rectal, and stomach cancer and non-Hodgkin lymphoma in men. Researchers found a significant link between work-related stress and cancer in men who held stressful jobs for 15-30 years or more.
Researchers found that nerve growth factor and tuft cells stimulate gastric tumor growth through aberrant cholinergic signaling, providing a potential therapeutic target for stomach cancer. Blocking nerve growth factor receptor inhibited stomach cancer growth in mice.
The USC Cancer Report Card highlights the decline of prostate and lung cancer among men, while stomach cancer is on the rise globally. Breast cancer risk increases for women, particularly Korean women, due to westernized lifestyles. The report also shows that many cancers are preventable and curable if caught early.
Researchers at Hiroshima University have linked stomach (gastric) and prostate cancer to a specific type of DNA called T-UCRs. The study identifies a potential regulatory pathway of stomach (gastric) cancer, providing new insights into cancer genetics.
A new report estimates 4.3 million new cancer cases and 2.8 million deaths in China in 2015, with lung cancer the leading cause of cancer death. The study highlights the need to reduce risk factors and improve clinical care delivery to prevent avoidable cancer deaths.
A novel protein has been identified as a key player in preventing bowel inflammation, which is a major cause of Crohn's disease and ulcerative colitis. The discovery could lead to the development of targeted therapies for these conditions.
Men in China face increasing tobacco-related cancer risks due to high cigarette smoking rates among teenagers and continued use in adulthood. The country now produces and consumes nearly 40% of the world's cigarettes, primarily driven by men's smoking habits.
Researchers found that miR-7 directly targets and suppresses the activity of growth factor receptor IGF1R, as well as the pro-oncogenic NF-κB pathway. Increasing miR-7 levels reduced tumor growth in mice and correlated with improved patient survival.
Researchers found that H. pylori infection causes distinct DNA damage patterns in human cells, resembling those seen in gastric cancer. The study suggests a causal link between the bacterium and cancer development.
New cancer cases are increasing globally, with significant rises in prostate and breast cancer since 1990. However, death rates from cancer are falling in many countries due to prevention and treatment progress.
Researchers have developed a new technology that accurately identifies high-risk changes in exhaled breath, indicating stomach cancer development. The nanoarray analysis method shows promise for non-invasive screening and monitoring of those at risk.
A study analyzing medical professional liability claims related to esophageal cancer screening found that the risks of claims arising from acts of commission and omission are similarly low. The authors suggest that physicians balance the risk of complications from diagnostic procedures, even if those complications are rare.
Scientists have discovered that blocking nerve signals using surgery or Botox can slow stomach cancer growth and increase survival rates in mice. This finding offers a promising new treatment approach for this devastating disease, which affects over 2 million people worldwide.
Taking aspirin daily for at least 10 years can significantly cut the risk of major digestive tract cancers. Rates of bowel, stomach, and oesophageal cancer are reduced by around 35% and deaths by 40%, according to a new study. However, long-term use increases the risk of bleeding and other side effects.
Scientists have identified four biological subtypes of stomach cancer based on shared mutations and molecular abnormalities, promising to guide clinical trials for improved therapies. The new classification could lead to targeted treatments for aggressive cancers with a high five-year survival rate below 25 percent.
A team of scientists discovered a protein named IL23A that is produced as an immune response to bacterial infection, which leads to gastric cancer. The production of IL23A by stomach cells requires the tumour suppressor gene RUNX3.
A new AGA/GCF Research Scholar Award will support Mohamed El-Zaatari's research into the role of myeloid cells in gastric pre-neoplasia. Gastric cancer is a deadly disease with limited funding, but this grant may lead to new targets for drug development and ultimately a cure.
Researchers have discovered that JAK inhibitors, currently used to treat blood disorders, can reduce the growth of inflammation-associated stomach and bowel cancer. The study provides evidence supporting their use in treating these cancers.
Researchers have developed a tiny capsule that can detect occult blood in the stomach at very low levels, enabling early diagnosis of stomach cancer. The device is non-toxic and acid-safe, and has been shown to be reliable and simple to use.
A peptide fragment derived from cow's milk, lactoferricin B25, exhibits potent anticancer capability against human stomach cancer cell cultures. This finding provides support for the potential therapeutic agent for gastric cancer treatment.
Cancer is the leading cause of death among Hispanic Texans under 76, with lower rates of breast and colon cancer screenings. Despite advanced cancer stages at diagnosis, Hispanics experience higher survival rates than non-Hispanic whites.
Researchers discover how Helicobacter pylori suppresses human beta defensin 1 production, allowing bacteria to colonize and cause tissue damage. The study found that patients infected with H. pylori had ten times less hβD1 than uninfected patients.
Researchers identified three distinct molecular classifications of gastric cancer that respond differently to therapies, offering a promising new approach to treatment. The study found that tumors can be grouped into proliferative, metabolic and mesenchymal subtypes, each with unique genomic and epigenomic properties.