A new study from the University of Miami Miller School of Medicine shows that community-based screening and treatment for Helicobacter pylori bacterium infection can identify and eliminate high-risk individuals. The approach aims to prevent gastric cancer in vulnerable populations, including Blacks, Asians, and Latinos.
A population-wide observational study found an association between tuberculosis (TB) and a higher incidence of various cancers. TB patients were more likely to be diagnosed with lung, blood, gynaecological, colorectal, thyroid, oesophagus, and stomach cancers compared to the general population.
A new study has discovered that Streptococcus anginosus bacteria play a significant role in causing stomach cancer. The research showed that S. anginosus infection led to gastric inflammation, cell damage, and the growth of stomach cancer cells, doubling tumour size and weight in some cases.
Researchers have engineered T cells with a mutation found in malignant lymphoma cells, making them more than 100 times potent at killing cancer cells. The new approach shows promise against solid tumors and could provide long-term immunity against cancer.
Scientists at Northwestern University and UCSF have developed a new technique to enhance the potency of human T cells against cancer. By studying mutations in malignant T cells, they were able to create T cells that can kill tumors derived from skin, lung, and stomach cancers in mice.
Researchers identified 26 'driver genes' that play a pivotal role in the transition to stomach cancer, providing a critical window for early detection and targeted prevention. The study's findings offer new insights into the mechanisms governing the transformation of intestinal metaplasia into stomach cancer.
A recent study from Drexel University's College of Nursing and Health Professions aimed to understand the challenges and supports affecting individuals with GI cancer and their caregivers when it comes to maintaining a healthy diet and avoiding malnutrition. The research highlighted the importance of creating dietary interventions that...
A study found country of birth to be a significant risk factor for gastric intestinal metaplasia, a precursor to stomach cancer. Countries in Latin America and the Caribbean showed varying rates of risk.
Researchers found that cancer cells with multiple mutations alter cell competition, allowing them to infiltrate and form highly invasive tumors. The study identified a key mechanism, MMP21, which promotes the production of diffusely invasive cancer cells.
A long-term study published in Environmental Epidemiology shows a slightly increased incidence of cancer, particularly colon, pancreas, and stomach cancer in men, as well as lymphoma in women. The researchers used new calculation methods to analyze radiation doses from Chernobyl fallout.
Scientists at Nagoya University have discovered a reliable cancer marker, stromal cell-derived factor 4 (SDF-4), that detects gastric cancer with high accuracy. The protein is found in high levels even in patients with stage I gastric cancer, suggesting its potential for early detection.
Men who are overweight or obese at age 18 have a higher risk of developing 17 different cancers later in life. Higher BMI is also associated with an increased risk of mortality after cancer diagnosis for certain types of cancer.
A study by Chiba University researchers reveals that DNA methylation and lifestyle data can improve gastric cancer risk assessment. High levels of DNA methylation in the stomach mucosa years before gastric cancer onset are associated with higher risk, while tobacco and alcohol consumption amplify pro-carcinogenic alterations.
A study published in Gastroenterology validated pyrvinium as a potential preventative treatment for stomach cancer. The drug induces cell death in precancerous lesions by targeting specific stem cells through dual MEK/ERK and STAT3 inhibition, suggesting lower adverse effects on tissue regeneration.
Research published in BMJ Oncology reveals a global increase of 79% in new cancer cases among those under 50 between 1990 and 2019. Breast cancer accounted for the highest number of early onset cases, while cancers of the windpipe and prostate rose the fastest.
A new targeted treatment called zolbetuximab has been shown to extend survival for patients with advanced gastric or gastroesophageal junction cancer that overexpresses a specific biomarker. The treatment significantly increased progression-free and overall survival, with improved results compared to standard chemotherapy.
Patients with cancer who live in rural Pennsylvania counties are more likely to receive complex surgeries at high-volume hospitals due to their perceived better outcomes. However, for less complex surgeries, rural patients are less likely to opt for high-volume hospitals despite potential benefits from centralization.
A large long-term study found that good cardiorespiratory fitness in young men is associated with a significantly lower risk of developing nine specific cancers, including a 40% reduced risk of liver cancer. Higher fitness was also linked to lower risks of rectal, pancreatic, and bowel cancers.
A new single-cell study provides deeper understanding of the evolution of the tumor microenvironment in gastric cancer. Researchers identified six unique ecotypes, or collections of cell states, within the tumor microenvironment and discovered a potential new therapeutic target, SDC2.
Three University Hospitals and Case Western Reserve University research teams received $50,000 Collaborative Science Pilot Awards to explore innovative research projects. The awards aim to increase competitiveness and capacity for major external funding opportunities in key areas such as cancer, brain health and genetics.
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
Erdafitinib achieves tumor-agnostic benefits across 16 cancer types, including urothelial, lung, and other cancers. The trial demonstrated a disease control rate of 73.7% and clinical benefit rate of 45.6%, with notable improvements in pancreatic and cholangiocarcinoma patients.
The study revealed lower age-standardized rate of NENs incidence in China (1.14 per 100,000) compared to the USA (6.26 per 100,000). The most common sites for primary NEN tumors progressed were found to be the pancreas, stomach, lungs, and rectum.
A large case-control study identified nine genes associated with stomach cancer risk and found that pathogenic genetic variations exacerbate the damage caused by H. pylori infection, significantly increasing the risk of gastric cancer. The study suggests that screening for pathogenic variants can help prioritize interventions.
SourceRIKEN·JournalNew England Journal of Medicine·TypeExperimental study·DateMar 29, 2023
A team of researchers developed a novel cancer therapeutic combining antibody fragments with molecularly engineered nanoparticles, permanently eradicating gastric cancer in treated mice. The 'hit and run' drug delivery system targets HER2 proteins associated with gastric cancer.
Researchers from China conducted a comprehensive review of dual therapy (DT) for H. pylori eradication, highlighting its high efficacy and patient compliance with minimal adverse events. High-dose DT administered over 14 days has emerged as the most effective treatment option.
Lung cancer death rates are projected to decrease overall in the EU and UK in 2023, however, a concerning trend is observed among women in France, Italy, and Spain. Meanwhile, pancreatic cancer death rates are forecasted to rise among women due to continued smoking habits.
The use of AI is improving diagnostic accuracy for digestive cancers, but challenges in data sharing and standardization hinder its widespread application. Researchers surveyed recent applications of AI to these deadly cancers, finding that AI can automate complex processes and detect patterns not visible to humans.
Researchers have developed a novel prognostic index to predict survival outcomes in gastric cancer patients. The inflammation-combined prognostic index (ICPI) combines three biomarkers - lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio - to provide a personalized prognosis for each patient.
Researchers found that arginine levels are limited in human cancers, prompting cancer cells to manipulate proteins to take up the amino acid. Starving cancer cells of arginine may lead to mutations that make them more recognizable to the immune system.
Johns Hopkins researchers have developed a three-dimensional organoid model derived from human tissue to study gastroesophageal junction (GEJ) cancer. The dual knockout of genes in the model has identified key biological targets for treating GEJ cancers with existing drugs.
A study found that Medicare Advantage patients are more likely to be treated by less experienced surgeons and have higher mortality rates after complex cancer surgeries. They also experience longer delays in diagnosis and treatment due to prior authorization requirements.
The ESMO Asia Congress 2022 will focus on the latest scientific and clinical advances in oncology, with a special emphasis on the Asia-Pacific region. Media representatives can register for coverage through the official media registration form.
A trial involving 1000 patients with Lynch syndrome found that a daily dose of resistant starch reduced cancers in other parts of the body by over half, particularly upper GI cancers. The effect persisted for 10 years after stopping the supplement.
Scientists have discovered that oxidative stress, a process disrupting genetic code by damaging DNA, is the culprit behind inflammation's link to cancer. The study provides crucial insights into roles of inflammation and oxidative stress in certain cancers.
Adults aged 45-64 experienced a nearly doubled rate of esophageal cancer and a 50% increase in Barrett's esophagus between 2012 and 2019. Researchers recommend more frequent screening for middle-aged patients with multiple risk factors.
A molecular switch, p57, enables stomach stem cells to change allegiance from normal digestion to injury response, potentially leading to new treatments for gastric pathologies. The study's findings suggest that p57 is a key regulator of reserve stem cell state in gastric chief cells.
Researchers at Charité - Universitätsmedizin Berlin have discovered a novel mechanism that restricts cell division in healthy stomach tissue, protecting against cancerous changes. However, Helicobacter pylori infection deactivates this mechanism, enabling cells to grow uncontrollably and increasing the risk of stomach cancer.
The study reveals a narrowing gap between cancer profiles in China and the USA, with converging trends in lung, breast, and colorectal cancers. China's cancer burden is expected to rise, while the US has seen reduced rates since the 1990s due to effective prevention strategies.
A study by University of New South Wales has found that one in five future thyroid cancers in Australia is attributable to current levels of overweight and obesity. The prevalence of obesity has doubled in the last two decades, with 75% of Australian men and 60% of women being overweight or obese.
Researchers have developed new preclinical models to understand gastric cancer development and spread. Using these models, they identified Lgr5-expressing tumour cells as responsible for driving gastric cancer growth and spread, establishing them as a potential therapeutic target.
Gastric cancer is the sixth most common cancer worldwide, with 1.09 million new cases in 2020. Recent research offers hope for improved treatment options, making it a critical area of focus for medical oncologists like Dr. Mohamad Sonbol.
Research at Uppsala University found a correlation between specific genes and prognosis in Chinese patients with cardia cancer. Focal amplification of the ERBB2 gene was linked to better prognosis, while EGFR amplification had worse outcomes.
A new imaging technique using PET/MR and a PET tracer directed against CXCR4 shows high accuracy in detecting MALT lymphomas of the stomach, potentially reducing the need for repeated gastroscopies. The study found that [68Ga]Pentixafor PET/MR achieved 97% accuracy in detecting tumours compared to gastroscopy.
A systematic review of epidemiological studies found that muscle strengthening exercises associated with aerobic activities can significantly reduce cancer mortality. The analysis suggested that strength training twice a week can protect against cancer, with the benefit being even greater when combined with aerobic activities.
A new trial will evaluate a blood test for personalized cancer treatment, targeting oesophageal, stomach and bowel cancers. The test detects DNA changes specific to cancer and may offer an earlier indication of treatment effectiveness.
A new study by West Virginia University researcher Jonathan Busada found that testosterone can help regulate the immune response and prevent stomach inflammation. The study suggests that androgens may act as a 'brake pedal' on the immune system, protecting men from chronic inflammatory diseases such as celiac disease, multiple sclerosi...
The cancer burden in China has undergone a paradigm shift, with rising cases of breast and lung cancers. The country's high incidence rate makes it a priority for policymakers to implement tailored preventive measures, including health education, vaccination programs, and tobacco-control policies.
Researchers at Osaka University identify HPnc4160 as a key regulator of Helicobacter pylori adaptation to the human stomach. The study found that strains with lower levels of this molecule are more infectious and produce higher levels of CagA, an oncoprotein linked to cancer development.
A recent study reveals an increase in cancer incidence and mortality rates in China, with rising rates seen in colorectal, pancreatic, and breast cancers. The study highlights the importance of implementing cost-effective approaches for primary prevention and collaborative efforts to reduce the cancer burden.
MSK scientists found that tissue damage synergizes with specific genetic changes to promote the earliest stages of pancreatic cancer. The researchers identified epigenetic changes that distinguish normal repair processes from cancer-initiating ones at the molecular level.
A new study published in JAMA Network Open shows that deep learning can help predict occult peritoneal metastasis in stomach cancer. The researchers developed a deep learning model called Peritoneal Metastasis Network (PMetNet) to predict clinically occult peritoneal metastasis using preoperative computed tomography images.
Stomach cancers may respond to medicines that inhibit TNF, a protein involved in inflammation and disease progression. The discovery was made using a laboratory model of stomach cancer and suggests a potential new therapeutic target for this devastating disease.
The UC Santa Cruz Genomics Institute is teaming up with No Stomach For Cancer to release a web portal that combines vast amounts of gene variant data with corresponding clinical data. This collaboration aims to advance science and patient survival by identifying individuals at risk of hereditary stomach cancers.
Researchers found that administering immunotherapy in combination with chemotherapy earlier in the course of disease can slow cancer progression. Combining the therapies also kills myeloid-derived suppressor cells, which appear to overpower immunotherapies, thereby improving response rates.
Researchers at UArizona Health Sciences have identified a biomarker, MiR130b, that appears in patients before stomach cancer develops. The biomarker can be detected through a simple blood test, potentially saving time and lowering costs compared to current diagnostic procedures.
A new study reveals that non-white Americans, especially Asian Americans, are at a higher risk of gastric cancer compared to non-Hispanic whites. The risk is highest among Korean Americans age 50 and older, who have a 12-fold to 14.5-fold higher risk of developing stomach cancer.
Researchers reveal a novel paradigm in EBV-associated gastric cancer where the viral genome alters the host epigenetic landscape, promoting proto-oncogene activation and tumorigenesis. The 'enhancer infestation' model identifies a new mechanism of cancer development that does not require genetic alterations.
MIPT bioinformaticians have developed a method to tailor drug prescriptions for stomach cancer patients using RNA sequencing. By analyzing gene expression levels, researchers can predict an individual's response to ramucirumab, increasing treatment efficacy.
A study found that patients experienced higher rates of infections in the years leading up to a cancer diagnosis compared to those without cancer. The researchers discovered an association between specific infections and increased risk of certain types of cancer.