Articles tagged with Stomach Cancer
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Researchers developed an AI tool called ONCO-ACS to predict the risk of secondary heart attacks in cancer patients after a heart attack. The tool combines cancer-related factors with standard clinical data to provide reliable information for doctors to balance treatment benefits and harms.
Researchers found no association between long term use of proton pump inhibitors and increased risk of stomach cancer. The study, which analyzed data from five Nordic countries over 26 years, suggests that patients needing long term proton pump inhibitor therapy may not need to worry about a higher risk of stomach cancer.
Research found that genetic mutations, age-related blood changes, smoking, and infection by oral bacteria increase the risk of stomach cancer. The study identified 47 significantly mutated genes in intestinal metaplasia cells, including a gene linked to poorer prognosis.
Predictions for lung cancer death rates among EU and UK women indicate stabilization of mortality rates at 12.5 deaths per 100,000 in 2026. Lung cancer remains the leading cause of cancer death for both sexes in the EU, with mortality rates continuing to decline among men.
A new dry simulator revolutionizes training for complex endoscopic cancer resection by accurately reproducing tactile sensations and simulating bleeding. The multilayered 'ESD sheet' model eliminates the need for animal tissues and reduces patient risk, standardizing high-level endoscopic training globally.
A new clinical trial, PAGODA, seeks to minimize treatment interruptions and help patients complete their chemotherapy as planned. The trial will test a structured plan to guide doctors in making small, proactive changes to chemotherapy doses to prevent treatment delays.
Early gastric cancer cells become self-sufficient by producing WNT7B, creating a self-sustaining loop and activating WNT signaling internally. This mechanism is triggered by MAPK signaling activation and has been validated in genetically engineered mouse models and human patient-derived organoids.
Research from Florida Atlantic University strengthens evidence that alcohol consumption increases cancer risk, particularly for breast, colorectal, and liver cancers. Higher intake and specific groups, such as African Americans and those with obesity or diabetes, are found to be more vulnerable to the risks.
Researchers developed a model using DNA methylation biomarkers and CT imaging to predict lymph node metastasis in early-stage gastric cancer patients. The tool helped reduce unnecessary invasive surgeries by up to 44%.
The American Society for Radiation Oncology (ASTRO) has published its first clinical guideline on radiation therapy for gastric cancer. The guidelines provide evidence-based recommendations for the role of radiation therapy in multidisciplinary care, including patient selection, integration with systemic therapy and treatment delivery.
Researchers at UC Riverside and City of Hope have developed a novel Pin1 degrading compound that suppresses pancreatic cancer peritoneal metastases. The treatment targets not only cancer cells but also tumor-supporting cells, potentially overcoming treatment resistance.
The bioactive components of Scleromitrion diffusum exhibit potent anticancer activity by inhibiting proliferation, inducing apoptosis, and suppressing metastasis. Its multi-compound, multi-pathway approach targets several critical pathways in gastric cancer pathogenesis.
A prospective cohort study found that increased lymphocyte counts, decreased serum LPS levels, and specific mucin expression patterns are associated with antralization. The study suggests that acid reflux is closely linked to antralization.
Researchers at MD Anderson have made significant advancements in treating kidney cancer, including the use of metastasis-directed targeted radiation therapy to delay systemic treatments. Additionally, preliminary data from an ELI-002 vaccine trial showed promise in delaying relapse of KRAS-mutated pancreatic and colorectal cancers.
Researchers have discovered a promising new approach to suppress the growth of aggressive cancers by targeting minor splicing, a specialized molecular process. By blocking minor splicing, cancer cells accumulate DNA damage and trigger cell death, while healthy cells remain largely unaffected.
Early-onset gastrointestinal cancers are rising globally, particularly among younger adults. Colorectal cancer is the most common early-onset GI cancer, accounting for over half of cases, and its incidence is increasing faster than any other type of early-onset cancer.
A recent analysis of 16 years of data on Japanese adults reveals a strong association between socioeconomic status and the incidence of five common cancers. Communities with low employment rates or low incomes show higher cancer rates compared to those with higher socioeconomic status.
A new prototype imaging system combines light-emitting diodes (LEDs) with hyperspectral imaging technology to create detailed maps of tissue properties invisible to conventional cameras. The system shows promise for cancer detection during endoscopy, achieving real-time speeds and high-quality data comparable to reference systems.
The study highlights a significant increase in early-onset colorectal cancer rates globally, particularly in high-income countries. Younger patients are more likely to receive aggressive treatment without survival advantage, and survivors often report problems with anxiety, body image, and sexual dysfunction.
Researchers found that CBR3-AS1 and PCA3 were significantly overexpressed in gastric cancer tissues, suggesting their involvement in GC development. The study supports the use of these lncRNAs as diagnostic biomarkers.
Researchers discovered biomarkers in gut bacteria and metabolites that can help diagnose and treat gastrointestinal diseases. The study found that certain biomarkers could predict multiple diseases, including gastric cancer and inflammatory bowel disease.
A 25-year review highlights the stomach cancer-fighting potential of Brazilian plant species, which contain bioactive compounds with potential anticancer properties. The studies suggest that regular consumption of fruits and vegetables rich in polyphenols and flavonoids may help lower the risk of stomach cancer.
A recent study found that early-stage stomach cancer diagnoses are increasing, marking a major progress in detecting this deadliest form of cancer. The study suggests advancements in endoscopic imaging and more widespread use of upper endoscopy may be contributing to these shifts.
Researchers from the University of Southampton engineered a new type of super-strong antibody that triggers a stronger response from the immune system compared to naturally produced antibodies. The study confirms that making subtle increases in rigidity stimulates immune activity, creating a powerful immune response against disease.
Researchers identified four specific genes linked to lethal stomach cancers, enabling potential targeted treatments and less aggressive procedures for some patients. The study's findings support a more personalized approach to treatment based on each patient's tumor biology.
Liquid biopsy analyzes circulating tumor components in body fluids to detect cancer at early stages, offering a safer and more dynamic alternative to traditional tissue biopsies. This non-invasive approach has shown promise in detecting various types of cancer, including lung, breast, colorectal, prostate, and gastric cancers.
Researchers from HKUMed identified early mutations and risk factors for stomach cancer, laying the foundation for improved prevention and early detection. The study also developed a biobank of 'intestinal metaplasia' organoid models to study early cancer development.
Researchers created a highly detailed map of gastric cancer tissues using advanced mapping technologies, identifying distinct subgroups of cancer cells and evolutionary pathways that influence tumour behaviour. These insights could lead to more precise, targeted treatments that improve survival rates and reduce side effects.
Scientists analyzed somatic mutations in stomach lining tissue to explore cancer development, finding that cells with 'driver' mutations occupy almost 10% of the gastric lining by age 60. An unusual discovery suggests exposure to an unknown mutagen led to trisomy of chromosomes 13, 18 and 20, increasing the risk of gastric cancer.
The Asia-Pacific region's H. pylori treatment practices show a growing consensus on primary and secondary prevention, but differences in antimicrobial resistance and medical resources persist. Establishing uniform standards for gastric cancer prevention will be crucial to addressing these disparities.
A team of researchers discovered a long intergentic non-coding RNA molecule, lincPRKD, that may provide a new target to prevent and treat gastric cancer. The study aims to determine how often this molecule is activated in gastric cancers and test whether it can be used for early detection.
Excessive alcohol consumption causes severe digestive problems, including liver damage, stomach disorders, and increased cancer risk. Chronic alcohol use can lead to conditions like cirrhosis, pancreatitis, and colorectal cancer.
A pioneering study identified a crucial interaction between Helicobacter pylori and non-H. pylori bacteria in pre-cancerous stage of gastric cancer. Researchers found that bacterial leakage into deeper gastric tissues may represent a previously overlooked factor in cancer progression.
Researchers at UCSF have identified unique, cancer-specific proteins created through mistakes in RNA splicing. These antigens could be used to create potent immunotherapies that recognize and attack hard-to-treat tumors. The discovery offers new hope for glioma patients and expands the number of targets available for cancer therapy.
Researchers discovered that stomach cancers form electrical connections with sensory nerves, stimulating growth and spread. CGRP inhibitors may be a potential treatment option for stomach cancer, targeting the electrical connection between tumors and neurons. The study suggests a new understanding of how nerves drive tumor growth.
Researchers at Pusan National University have developed a novel drug delivery system that uses nanoparticles to target and kill colorectal cancer cells. The system, which involves encapsulating cancer cell-activated nanoconjugates in an alginate matrix, can selectively deliver drugs to tumor cells while minimizing side effects.
A recent study found that U.S. soldiers are 10 times more likely to use nicotine pouches, which can cause serious health issues, compared to the general population. The study analyzed anonymous responses from 1,957 soldiers and found that 23.8% reported using nicotine pouches in the previous 30 days.
Sylvester researchers will present over 130 studies at ASH 2024, addressing disparities in gastric cancer. Frank J. Penedo's research highlights worse outcomes for patients with unmet supportive needs, while Shria Kumar's work seeks answers for disparities in gastric cancer among specific minorities.
Research suggests ferroptosis, a cell death pathway regulated by iron metabolism and lipid peroxidation, holds potential to counter resistance in cancer cells. Ferroptosis targets defense mechanisms in persisting and cancer stem cells, offering new therapeutic strategies.
A new study introduces a multi-omics-based molecular classification of gastrointestinal stromal tumors, categorizing them into four distinct subtypes. The findings identify key genetic signatures and tumor suppressor genes that influence treatment response, providing a roadmap for personalized therapy strategies.
A recent clinical trial found that the Nivolumab and Anlotinib combination therapy significantly reduced tumor size in nearly one-third of patients, while most experienced stability in their condition. The treatment also showed improved survival outcomes compared to historical data, with a manageable safety profile.
A groundbreaking study has provided novel insights into the molecular underpinnings of gastric cancer peritoneal spread, paving the way for more effective treatments. The research also demonstrated the safety and potential efficacy of a new treatment approach in a clinical trial.
The underwater endoscopic mucosal resection (UEMR) technique demonstrates promising outcomes in the treatment of gastrointestinal neuroendocrine tumors, particularly in rectal tumors. UEMR achieves complete histological resection at a lower cost with minimal requirement for advanced endoscopic skills.
Researchers have found that natural killer cells instinctively recognize and attack the XPO1 protein, which drives cancer growth. By targeting this protein, scientists may be able to activate more killer cells to destroy cancer cells. The study suggests that this approach could lead to personalized cancer treatment with less side effects.
Researchers found that abnormal results from routine blood tests were linked to a higher risk of being diagnosed with cancer within a year. The study estimated that taking these results into account could lead to an extra six people with undiagnosed cancer being urgently referred for treatment.
Researchers at MedUni Vienna have identified AF1Q as a promising biomarker to predict gastric cancer recurrence risk. The study found that 97.8% of tumour samples had elevated AF1Q levels, associated with higher recurrence risk and lower survival chances.
Researchers found that regorafenib synergizes with TAS102 to inhibit cancer growth, angiogenesis, and microvessel density in preclinical models of colorectal and gastric cancers. The combination also suppresses ERK1/2 activation regardless of KRAS or BRAF mutational status.
Gastrointestinal cancers represent a significant global health burden due to high incidence and mortality rates. The review analyzes molecular characteristics, prognosis, and current therapeutic strategies for these malignancies, including esophageal, gastric, small bowel, and colorectal carcinomas.
Families with germline CDH1 P/LP variants show a cumulative risk of gastric cancer between 7-10% and breast cancer in female carriers at 37%
Researchers from USC Viterbi School of Engineering have developed ingestible sensors that track gastrointestinal health in real-time. These 'smart pills' use AI and wearable technology to detect gases associated with gastritis and gastric cancers, offering a significant step forward in ingestible technology.
A Korea University study reveals that gastrectomy decreases the risk of major adverse cardiovascular events in patients with gastric cancer. The research analyzed data from 2004 to 2013 and found a significantly lowered risk of cardiovascular disease in those who underwent gastrectomy.
Researchers found that ARID1A mutation renders tumors sensitive to immunotherapy by triggering an antiviral immune response. This could lead to improved patient outcomes and the development of targeted therapies.
A study of over 470,000 adults found that those who frequently add salt to their food are 39-40% more likely to develop stomach cancer. The research highlights the connection between high salt consumption and stomach cancer in Western countries, raising awareness of the negative effects of extremely high salt consumption.
The newly updated guidelines provide clinicians with the latest recommendations for staging and management of neuroendocrine tumors. The guidelines highlight recent changes for treating these tumors, including emerging molecular imaging techniques known as theranostics.
A new study from the University of Miami Miller School of Medicine shows that community-based screening and treatment for Helicobacter pylori bacterium infection can identify and eliminate high-risk individuals. The approach aims to prevent gastric cancer in vulnerable populations, including Blacks, Asians, and Latinos.
A population-wide observational study found an association between tuberculosis (TB) and a higher incidence of various cancers. TB patients were more likely to be diagnosed with lung, blood, gynaecological, colorectal, thyroid, oesophagus, and stomach cancers compared to the general population.
A new study has discovered that Streptococcus anginosus bacteria play a significant role in causing stomach cancer. The research showed that S. anginosus infection led to gastric inflammation, cell damage, and the growth of stomach cancer cells, doubling tumour size and weight in some cases.
Scientists at Northwestern University and UCSF have developed a new technique to enhance the potency of human T cells against cancer. By studying mutations in malignant T cells, they were able to create T cells that can kill tumors derived from skin, lung, and stomach cancers in mice.
Researchers have engineered T cells with a mutation found in malignant lymphoma cells, making them more than 100 times potent at killing cancer cells. The new approach shows promise against solid tumors and could provide long-term immunity against cancer.
Researchers identified 26 'driver genes' that play a pivotal role in the transition to stomach cancer, providing a critical window for early detection and targeted prevention. The study's findings offer new insights into the mechanisms governing the transformation of intestinal metaplasia into stomach cancer.