Overdiagnosis of papillary thyroid cancer
This study found that US thyroid cancer overdiagnosis persists even after accounting for possible true incidence rises, highlighting opportunities to reduce unnecessary referrals and diagnoses
Thyroid Cancer
Articles tagged with Thyroid Cancer
ESE and ESPE launch joint transition of care guidance to improve outcomes for young people moving from child to adult endocrine care
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
New AI tool helps doctors treat cancer patients after heart attack
Researchers developed an AI tool called ONCO-ACS to predict the risk of secondary heart attacks in cancer patients after a heart attack. The tool combines cancer-related factors with standard clinical data to provide reliable information for doctors to balance treatment benefits and harms.
Seeing thyroid cancer in a new light: when AI meets label-free imaging in the operating room
Researchers combined Dynamic Optical Contrast Imaging (DOCI) with machine learning to identify thyroid cancer during surgery. The AI analysis framework accurately classified samples across three categories and generated tumor probability maps for precise location identification.
Next-generation targeted alpha therapy using astatine shows promise in thyroid cancer resistant to conventional treatment
A first-in-human study found that a single dose of the alpha-emitting radionuclide <sup> 211 </sup> At was both well-tolerated and effective in achieving disease control without molecularly targeted drugs. The therapy has potential to reduce treatment burden and broaden access to effective care for patients with refractory disease.
Researchers unleash the power of a new tool in canine cancer treatment
A new study from Mizzou's College of Veterinary Medicine analyzed the effects of radioactive iodine therapy on thyroid cancer in dogs. The research found that tailoring the dose of radiation more precisely for each dog could improve outcomes and potentially lead to more targeted care.
New ATA management guidelines for adult patients with differentiated thyroid cancer
The American Thyroid Association has released new guidelines for managing adult patients with differentiated thyroid cancer, emphasizing evidence-based recommendations for diagnosis, treatment, and monitoring. The guidelines highlight the importance of patient-reported outcomes and areas for further research.
Cancer screenings continue years after guidelines change to limit unnecessary tests, study finds
Researchers found that it took 13 years for cervical cancer screenings to halve among women over 65, and even longer for prostate cancer screenings to decrease significantly. The study emphasizes the need for more effective tracking mechanisms to identify and reduce inappropriate screening practices.
ASCO: Pre-surgical combination therapy boosts survival in patients with rare thyroid cancer
A new therapy combining pembrolizumab with targeted therapies before surgery improved tumor removal and overall survival for patients with BRAF-mutated anaplastic thyroid cancer. The treatment increased response rates and showed better outcomes compared to standard therapy.
Scientists develop super strong antibodies for new cancer treatment
Researchers from the University of Southampton engineered a new type of super-strong antibody that triggers a stronger response from the immune system compared to naturally produced antibodies. The study confirms that making subtle increases in rigidity stimulates immune activity, creating a powerful immune response against disease.
AACR: New CAR T cell therapy benefits patients with advanced thyroid cancers
AIC100 demonstrated encouraging responses and an acceptable safety profile in patients with two types of advanced thyroid cancer, including anaplastic thyroid cancer (ATC) and relapsed/refractory poorly differentiated thyroid cancer (PTDC). The therapy showed significant tumor shrinkage and disease control in 56% of patients.
Radioiodine therapy improves relative survival rates of differentiated thyroid cancer patients
A new study finds that radioiodine therapy significantly increases relative survival rates in differentiated thyroid cancer patients, with benefits observed across low-, intermediate-, and high-risk subgroups. The treatment reduces recurrence rates and improves long-term survival in high-risk groups, while also showing promise for low-...
IGTP-led study identifies an epigenetic signature with prognostic value in metastatic thyroid cancer
A study led by IGTP identifies an epigenetic signature of 156 altered CpG sites in primary tumours that can help stratify patients according to their risk of developing distant metastases. The findings contribute to a better understanding of the disease and open new avenues for patient stratification and personalised treatment strategies.
HKUMed develops world’s first AI model for thyroid cancer diagnosis, with over 90% accuracy and reduced consultation preparation time
The HKUMed AI model achieves over 90% accuracy in classifying both thyroid cancer stage and risk category. The model reduces pre-consultation preparation time for frontline clinicians by approximately 50%, making it a significant advancement in precision management of the disease.
World Hormone Day 2025 – global endocrine community unites to raise public awareness of the small steps everyone can take towards good hormone health
The European Society of Endocrinology and the European Hormone and Metabolism Foundation launch a global campaign to raise awareness about hormone balance and its impact on chronic diseases. Small steps can make a big difference in improving hormone health.
Early-life exposure to air and light pollution linked to increased risk of pediatric thyroid cancer
A new study by Yale University researchers suggests that early-life exposure to small particle air pollution and outdoor artificial light at night may increase the risk of pediatric thyroid cancer. The study found a significant association between these exposures and increased risk of papillary thyroid cancer in children and young adults.
Popular CT scans could account for 5% of all cancer cases a year
A new study suggests that CT scans could account for 5% of all cancer cases each year, primarily due to radiation exposure. The largest risk is among infants, followed by children and adolescents. To mitigate this risk, reducing the number of scans and doses per scan can help save lives.
UTHealth Houston research: Children born to young men with cancer have slight increases in preterm birth, low-birth-weight children, but not birth defects
According to UTHealth Houston research, adolescent and young adult men with cancer have a slightly elevated risk of having preterm birth and children with low birth weight. However, the likelihood of live birth was highest for fathers who had thyroid cancer and lowest for those with gastrointestinal cancer.
Study links PFAS contamination of drinking water to a range of rare cancers
Researchers from the Keck School of Medicine of USC found an association between levels of manmade “forever chemicals” in drinking water and certain digestive, endocrine, respiratory, and mouth and throat cancers. The study estimated that PFAS contamination contributes to 6,864 cancer cases per year.
Risk of thyroid cancer among GLP1-RA users
A large international study of GLP1-RA users and dipeptidyl peptidase-4 inhibitors (DPP-4i) found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer. The study, published in the Thyroid journal, analyzed data from 92,497 GLP1-RA users and 2,484,408 DPP-4i users.
MD Anderson Research Highlights for December 18, 2024
Researchers at MD Anderson Cancer Center have made significant breakthroughs in smoking cessation treatments, with a study finding that varenicline plus counseling is the most effective treatment for individuals with major depressive disorder. Additionally, a new radiotherapy technique demonstrates effectiveness in treating metastatic ...
Sleep deprivation in dementia: Heart disease, diabetes, anxiety, and thyroid disorders
A new review reveals how sleep disturbances exacerbate dementia symptoms, impacting overall health and caregiver well-being. The study emphasizes the need for holistic approaches to address coexisting conditions like cardiovascular disease and diabetes.
Combining targeted therapy and immunotherapy improves overall survival in patients with anaplastic thyroid cancer
Researchers at the University of Texas MD Anderson Cancer Center demonstrated that combining anti-PD-L1 immunotherapy with mutation-directed targeted therapy extended overall survival in patients with anaplastic thyroid carcinoma. The median OS across all cohorts was 19 months, compared to five months for historical data.
Chinese Medical Journal study reveals key insights on the global burden of thyroid cancer in 2022
A study published in the Chinese Medical Journal projects a significant rise in global thyroid cancer burden, with 821,214 new cases and 47,507 related deaths reported worldwide in 2022. The incidence is expected to increase by 44.1% from 2019 to 2030, with women experiencing higher rates than men.
Scientists discover how the body's killer cells attack cancer
Researchers have found that natural killer cells instinctively recognize and attack the XPO1 protein, which drives cancer growth. By targeting this protein, scientists may be able to activate more killer cells to destroy cancer cells. The study suggests that this approach could lead to personalized cancer treatment with less side effects.
Rates of obesity-related cancer are rising sharply in young Chinese people
Obesity-related cancer rates in China have risen sharply among young people, with an alarming 3.6% annual increase between 2007 and 2021. The trend is particularly pronounced among those aged 25-29, highlighting the urgent need for better public health policies to address China's growing overweight and obesity rates.
New directions in targeting the multifaceted BRAF in cancer
Researchers discuss diverse BRAF alterations found in human cancers and strategies to inhibit them. Class I BRAF inhibitors represent a landmark achievement in precision oncology, with FDA-approved dabrafenib/trametinib for metastatic BRAF p.V600E-mutant solid tumors.
Subclinical hypothyroidism during first half of pregnancy is associated with hypothyroidism 1-5 years after delivery
A new study found that subclinical hypothyroidism diagnosed before 21 weeks of pregnancy is associated with higher rates of overt hypothyroidism or thyroid replacement therapy within 5 years after delivery. Women with high TSH values and elevated TPO antibodies were at increased risk.
Mayo Clinic marks medical milestone with world’s first known successful total larynx transplant performed in a patient with an active cancer as part of a clinical trial
Mayo Clinic's surgical team successfully performed the rare procedure, which included multiple organs, on a Massachusetts man with a rare form of laryngeal cancer. The landmark surgery, conducted as part of a clinical trial, marks a significant step towards making larynx transplantation available to a wider population.
Thyroid eye disease patients report maintained improvement 2 years after teprotumumab infusions
A study analyzing pooled clinical trial data found that teprotumumab maintained improvements in signs and symptoms of thyroid eye disease in most patients after 51 weeks. Nearly two years after the final infusion, 82% of patients did not require further treatment.
Accessibility issues in cancer care
Researchers found that only 41.5% of cancer patients could successfully book a new appointment at a clinic due to various barriers, including language issues and workflow challenges.
Popular diabetes drugs do not increase thyroid cancer risk, study suggests
A comprehensive Scandinavian study has found no evidence that popular diabetes medications GLP-1 analogues increase the risk of thyroid cancer. The research analysed data from over 145,000 patients treated with these drugs and compared them to other patient groups.
Minimally invasive procedure may spare patients from thyroid surgery
A 10-center study found that microwave ablation is associated with similar progression-free survival rates to surgery but with fewer complications and a greater potential for preserving thyroid function. The procedure resulted in less blood loss, shorter incision length, and shorter procedure and hospitalization durations.
Study finds association between TB infection and increased risk of various cancers
A population-wide observational study found an association between tuberculosis (TB) and a higher incidence of various cancers. TB patients were more likely to be diagnosed with lung, blood, gynaecological, colorectal, thyroid, oesophagus, and stomach cancers compared to the general population.
Morality among low-risk differentiated thyroid cancer survivors in the U.S.
A new study published in Thyroid found that individuals with low-risk differentiated thyroid cancer (DTC) in the US experience lower mortality rates compared to the general population. The most common causes of death were malignancies and cardiovascular disease.
Families of men with fertility problems show distinct patterns of increased risk for several types of cancer
Men with low sperm count or none have a higher risk of developing cancer, including at younger ages, compared to fertile men. Families of azoospermic men have a significantly increased risk of five cancers, while families of oligozoospermic men have a higher risk of colon, bone and joint, and testicular cancers.
NTRK gene fusion in papillary thyroid cancer: A clinicogenomic biobank and record linkage study from Finland
Researchers identified NTRK gene fusion in 1.5% of Finnish papillary thyroid cancer patients, with notable co-occurring genetic alterations and favorable treatment outcomes. The study highlights the potential for biobank samples linked to electronic health records to describe patient characteristics and outcomes.
Genetic alterations in thyroid cancer mediate resistance to BRAF inhibition and anaplastic transformation
A study reveals thyroid cancer's genetic changes contribute to resistance to BRAF inhibitors and can lead to tumor dedifferentiation. Researchers identify potential targets for new therapies, including dual-targeted treatments and immunotherapy combinations.
Novel PET tracer enhances lesion detection in medullary thyroid cancer, offers potential for targeted therapy
A novel PET imaging agent has been found to effectively identify medullary thyroid cancer (MTC) in preclinical and clinical studies. The compound demonstrates favorable tumor uptake and improved activity clearance from off-target tissues, potentially enhancing lesion detection and enabling targeted MTC radioligand therapy.
Higher risk of 17 cancers after high BMI in late teens
Men who are overweight or obese at age 18 have a higher risk of developing 17 different cancers later in life. Higher BMI is also associated with an increased risk of mortality after cancer diagnosis for certain types of cancer.
Certain per- and polyfluoroalkyl “forever chemicals” identified as potential risk factor for thyroid cancer
A recent study published in eBioMedicine found an association between certain per- and polyfluoroalkyl substances (PFAS) and an increased risk of thyroid cancer. The researchers investigated plasma PFAS levels in thyroid cancer patients and non-cancer controls, finding a significant positive association with exposure to n-PFOS.
A cancer survival calculator is being developed using artificial intelligence
A new AI-based tool estimates patient-specific cancer survival rates using machine learning, offering personalized prognosis for patients with breast, thyroid, and pancreatic cancers. The Cancer Survival Calculator differs from existing estimators by incorporating multiple factors beyond disease stage.
Offspring of teen, young adult women with cancer history more likely to have birth defects
A recent study by UTHealth Houston found that the offspring of adolescent and young adult women with a history of cancer face a higher risk of birth defects. The study examined 6,882 offspring ages 12 months and younger and found an increased risk of specific types of defects in the offspring of women with a history of cancer.
Adding immune modulator to targeted therapy does not improve survival in difficult-to-treat thyroid cancer
A phase II clinical trial shows that adding an immunomodulatory agent to treatment with a targeted tyrosine kinase inhibitor did not improve disease-free survival for patients with advanced differentiated thyroid cancer. The study found cediranib to be an active agent, but combining it with lenalidomide didn't yield better results.
Case Report: Intrathoracic synovial sarcoma with BRAF V600E mutation
Researchers report a case of a 15-year-old boy with recurrent intrathoracic synovial sarcoma who achieved partial response with BRAF inhibitor Vemurafenib treatment. The study highlights the importance of routine next-generation sequencing to drive treatment choice and investigate BRAF mutations in SS tumors.
ERβ as a mediator of estrogen signaling in inflammatory breast cancer
Inflammatory breast cancer is a rare and aggressive form of breast cancer with poor outcomes. Research highlights the role of ERβ as a mediator of estrogen signaling, demonstrating its tumor suppressive effects in preclinical models. ERβ's antimetastatic activity may hold promise for improving treatment options for IBC.
A new generic treatment for multiple types of cancer
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
Pretherapy imaging and dosimetry offer personalized treatment planning for thyroid cancer patients
A new approach uses pretherapy imaging and dosimetry to personalize radioactive iodine treatment for refractory differentiated thyroid cancer patients. The method allows researchers to calculate personalized dosage of treatment, resulting in improved outcomes.
Microcalcification ‘fingerprints’ can yield info about cancer
Researchers used materials science to analyze microcalcifications in breast tissue, revealing groups that reflect tissue type and malignancy. The study also found variations in mineral composition and trace metals in malignant calcifications.
Genomic screening can help detect thyroid cancer, Geisinger study finds
A Geisinger study found that genomic screening can help detect medullary thyroid cancer (MTC) in patients with RET gene variants. The research evaluated 75 patients who had the genetic results, and 12 were found to have cancer after undergoing surgery. Genomic screening provides opportunities for early detection and treatment of MTC.
Bariatric surgery decreases risk of heart disease
A Rutgers study of 86,964 adults with obesity and NAFLD found that bariatric surgery reduced the risk of major cardiovascular events by 49% compared to nonsurgical care. This is significant because heart disease is a leading cause of death in the US, and NAFLD can lead to liver damage and inflammation.
Concern over unregulated high street health checks that may be putting extra pressure on the NHS
A recent investigation by The BMJ reveals dozens of UK companies offering private blood tests with misleading claims, contradicting official medical guidance and potentially harming individuals. Experts argue for regulation to protect consumers and prevent unnecessary costs for the NHS.
A special issue of the Journal of Nuclear Medicine Technology highlights the new frontier of theranostics
The Journal of Nuclear Medicine Technology special issue highlights the potential of theranostics to tailor cancer treatment to individual patients. The innovation uses targeted radiopharmaceuticals for both diagnosis and treatment of tumors.
Revealing one of the mechanisms by which thyroid cancer becomes resistant to lenvatinib-a molecularly targeted drug
A study found that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells. Inhibition of EGFR by lapatinib therapy in combination with lenvatinib enhanced growth inhibitory effect and inhibited tumor growth more remarkably than monotherapy.
RET inhibitor selpercatinib demonstrates durable responses in tumor-agnostic population
In a Phase I/II trial, selpercatinib demonstrated a 44% objective response rate across multiple tumor types, including pancreatic and colorectal cancers. The study found responses regardless of cancer type or prior treatment history, confirming RET fusions as a tissue-agnostic target.
Researchers examine link between pesticides and thyroid cancer risk in Central California area
A study examining the link between pesticide exposure and thyroid cancer risk found that 10 out of 29 reviewed pesticides were associated with an increased risk. Exposure to paraquat dichloride was consistently linked to thyroid cancer, while higher numbers of pesticides over a 20-year period proportionally increased risk.
Pralsetinib achieves tissue-agnostic benefits for patients with RET gene fusions
The study found an overall response rate of 57% and disease control rate of 83% in 23 patients with diverse cancer types. These results validate RET as a tissue-agnostic target with sensitivity to RET inhibition.
Exposure to ‘forever chemicals’ costs US billions in health costs
A new study estimates that exposure to PFAS chemicals may result in $5.5-63 billion in lifetime health costs due to conditions like low birth weight, childhood obesity, kidney cancer, and hypothyroidism. The study supports the EPA's decision to lower safe allowable levels of these substances.
Evaluating rising incidence of thyroid cancer
A study of 1,300 patients found most thyroid cancers are discovered in asymptomatic individuals, supporting the hypothesis of ongoing subclinical disease detection. The findings contradict the notion of a rising incidence of thyroid cancer.
AI can be used to identify benign thyroid nodules and reduce unnecessary biopsies
Researchers developed an AI model to analyze thyroid ultrasound images, identifying nodules unlikely to be cancerous with a sensitivity of 97%. This technology could reduce the number of unnecessary biopsies and assist radiologists in choosing which nodules should undergo biopsy.