Articles tagged with Thyroid Cancer
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Two studies and an editorial report confirm that firefighters exposed to the World Trade Center's aftermath are at a heightened risk of developing cancer. The research highlights the environmental exposures to carcinogens in the wreckage, which poses significant health concerns for those who responded to the 9/11 attacks.
A phase I clinical trial of BLU-667, a novel precision-targeted drug, reports significant durable disease control in patients with RET-driven cancers. The study reveals an overall response rate of 37% for RET-driven cancers, with responses of 45% for non-small cell lung cancer.
A new study of 45 years reveals that Alaska Natives have a similar incidence of thyroid cancer as the U.S. white population, but their tumors tend to be larger and have spread beyond a localized area. The study suggests that differences in access to healthcare may contribute to these discrepancies.
In a Penn-led trial, cabozantinib significantly shrunk tumors in 34 out of 35 patients with metastatic, radioactive iodine-resistant thyroid cancer. The median time on the study was 35 weeks, and 54% of patients achieved a partial response.
Researchers have identified 52 microRNAs that are decreased in expression as thyroid cancer becomes more aggressive. Restoring these molecules' levels in tumors may be a novel treatment strategy.
Researchers in Japan propose updated diagnostic criteria, revised patient management and treatment guidelines, and new algorithms for thyroid storm. The most common cause of death is multiple organ failure, highlighting the need for further studies on TS outcomes and prognosis.
Researchers detected a high rate of thyroid cancer in young individuals from Fukushima Prefecture after the 2011 nuclear accident. However, no clear evidence suggests an increased incidence of thyroid carcinomas following the accident, contrasting with Chernobyl's findings.
Researchers at Harvard Medical School have discovered a novel therapeutic strategy to treat drug-resistant thyroid cancers by combining vemurafenib with palbociclib, a CDK4/6 inhibitor. The treatment was shown to induce stronger cell death than when used alone, offering new hope for patients with papillary thyroid carcinoma.
A review article reveals that thyroid hormones and biochemical pathways drive seasonal reproduction in some mammals. The study suggests that increased triiodothyronine (T3) levels regulate gonadotropin-releasing hormone secretion in a seasonal fashion.
A 10-year study of over 1,200 patients with low-risk PMC of the thyroid found that close monitoring is an acceptable first-line approach, reducing unnecessary surgery. The study showed that only 8% of patients experienced tumor growth or new metastasis, and older patients were least likely to grow.
A study found that thyroid cancer survivors are at increased risk of many aging-related diseases, including diabetes, heart disease, and osteoporosis. Those diagnosed with thyroid cancer before age 40 had the highest risk for some of these diseases.
A new ultrasound scoring system has been developed to identify thyroid nodules that require biopsy or follow-up. The system uses a risk stratification approach to classify nodule appearance and size, reducing unnecessary biopsies and improving cancer diagnosis accuracy.
New research from the University of Pennsylvania School of Medicine finds that lenvatinib improves overall survival rates in older thyroid cancer patients who are resistant to standard radioiodine treatment. The drug is well-tolerated and has a significant impact on patient outcomes.
A study published in the New England Journal of Medicine found that wealthier individuals are more likely to receive cancer diagnoses due to increased testing. However, mortality rates from these cancers have been decreasing, largely due to improved treatments. The authors suggest alternative payment models and reduced financial confli...
Researchers found that two FDA-approved immunotherapy drugs, dabrafenib and trametinib, are well-tolerated and result in a 50-54% response rate among patients with advanced BRAF-mutated papillary thyroid cancer. This breakthrough could change the standard of care for this rare but aggressive form of thyroid cancer.
A study by Penn State researchers suggests a possible link between the partial meltdown at Three Mile Island Nuclear Power Plant and thyroid cancer cases in nearby areas. The study found an increase in genetic mutations caused by low-dose radiation exposure in patients who developed thyroid cancer after living in at-risk regions.
A large population-based study found that 6.5% of thyroid cancer patients experienced general post-operative complications, while 12% had complications specific to thyroid surgery within a year after their operation. Patients over 65 and those with more advanced thyroid cancer were at higher risk for these complications.
The USPSTF concludes that screening for thyroid cancer in asymptomatic persons results in harms that outweigh the benefits due to overdiagnosis and overtreatment. Most cases of thyroid cancer have a good prognosis with a 98.1% 5-year survival rate.
A new study published in the Journal of the American College of Surgeons found that pancreatic cancer patients who travel to academic medical centers for surgery have longer overall survival rates and better quality care. For thyroid cancer patients, traveling also results in more adherence to evidence-based treatment guidelines.
A large study found patients with follicular and medullary thyroid cancer had the highest rate of bone lesions and fractures, and increased risk of death. Researchers suggest targeting this high-risk population with specific drugs to prevent or treat complications.
Sub-Saharan African-born blacks experience a higher incidence of infection-related cancers and blood cancers compared to US-born non-Hispanic blacks. In contrast, prostate cancer is more prevalent among Western African-born black men, while Eastern African-born blacks have higher rates of liver and thyroid cancer.
A study found that the 2006 Massachusetts health reform led to a significant increase in surgical intervention for thyroid cancer, particularly among nonwhite patients. The researchers discovered a 26% rise in thyroidectomy rates and a 22% increase in neck dissections among these patients compared to those with private insurance.
A combination of two drugs targeting molecular pathways controlled by the RAS gene has shown promise in treating RAS-driven lung, ovarian, and thyroid cancers. Patients with heavily treated cancers have experienced long-term clinical benefit from the treatment, including one patient on treatment for over two years.
Research reveals that consuming cow's milk with levothyroxine supplement can lead to reduced absorption of the medication, potentially resulting in inadequate thyroid hormone levels. The study advises patients on managing hypothyroidism or taking levothyroxine to avoid consuming dairy products simultaneously.
Thyroid cancer incidence has increased in the US, with higher rates among Hispanics and African Americans compared to non-Hispanic Whites. The study found a significant rise in incidence among young people, particularly Hispanic females between 20-49 years old.
A study by the Endocrine Society found that higher exposure to certain flame retardants may be associated with an increased risk of papillary thyroid cancer. The researchers collected dust samples from homes and analyzed participants' blood samples to assess long-term exposure to these environmental chemicals.
A new study by Cleveland Clinic researchers found that the rarely studied gene USF3 is associated with an increased risk of developing differentiated thyroid cancer. The team discovered a compound heterozygous deletion in USF3 linked to the disease, which may lead to a potential therapeutic strategy by removing glutamine.
Patients with thyroid cancer who choose not to intervene report feeling isolated and anxious, despite lack of support from healthcare providers. Many keep diagnosis a secret to avoid negative feedback, but only a few find satisfactory support from others.
Researchers at the University of Pittsburgh School of Medicine have identified a novel genetic mechanism and marker that may predict response to a class of drugs in many cancer types. Elevated levels of IGF2BP3 protein were found in both thyroid and other common cancers, suggesting its potential as a biomarker for treatment response.
The American Thyroid Association has published new evidence-based recommendations for diagnosing and managing thyroid disease during pregnancy. The Guidelines cover thyroid function testing, iodine nutrition, and treatment of thyroid disease during pregnancy and lactation.
A study found a sixfold increase in thyroid cancer incidence in South Korea between 1999 and 2008, mainly due to overdetection by screening. The researchers call for reduced ultrasound examinations in the general population to mitigate the economic burden of unnecessary treatments.
A team of scientists at the University of Alberta has discovered a protein marker, PDGFRA, that can help diagnose and treat aggressive papillary thyroid cancer. This finding could lead to more targeted treatments and reduce the need for unnecessary surgeries.
For patients with suspicious papillary thyroid cancer, lobectomy is associated with better outcomes and lower costs compared to total thyroidectomy. The study used a Markov model to determine the effectiveness of each procedure in terms of quality-adjusted life years.
Researchers discovered a nearly 4-fold increase in thyroid cancer among WTC-exposed firefighters, but this increased risk was not significant after controlling for biases. A separate finding showed a 1.4-fold increase in prostate cancer among WTC-exposed firefighters from 2005 to 2009.
Research by Australian National University has found that diagnoses of differentiated thyroid cancer have increased three-fold in 25 years despite no change to death rates. Over-meticulous examinations are leading to unnecessary surgeries, causing substantial medical costs and complications for patients.
The new Guidelines, published in Thyroid Journal, offer a detailed framework for the diagnosis and management of patients with different etiologies of thyrotoxicosis. The guidelines integrate recent studies and developments in practice trends, providing a comprehensive set of recommendations.
A phase II clinical study found that treating metastatic thyroid cancer patients with the BRAF mutation showed promising anti-tumor activity in a third of patients, with an overall response rate of 38%. The therapy vemurafenib joins other effective treatments for this patient population.
A study of 28,000 patients found that increased imaging after initial treatment for thyroid cancer did not lead to better survival rates, but rather more aggressive treatment for recurrence. The researchers emphasize the importance of curbing unnecessary imaging and tailoring care to individual patient risk.
A new study found that while more imaging after thyroid cancer treatment identifies recurrence, it does not always lead to improved survival. Radioiodine scans, however, were associated with better outcomes.
A type of thyroid cancer, EFVPTC, is being reclassified as non-invasive and low-risk due to its low recurrence rate. The new name, NIFTP, guides pathologists in diagnosis and reduces aggressive treatment, potentially saving lives and reducing healthcare costs.
A recent study published by The Endocrine Society found that radioactive iodine treatment can impair a woman's remaining egg supply, known as ovarian reserve. Women who received high doses of radiation had significantly lower levels of anti-Müllerian hormone (AMH) after treatment.
A new study from Duke Health reveals that patients undergoing thyroidectomy should seek surgeons who perform at least 25 operations annually to minimize risks. The study analyzed data from over 16,000 patients and found an association between surgeon case volume and complication rates.
Researchers developed a new method called ADAP to detect antibodies in small blood samples, increasing sensitivity for early disease diagnosis. The approach could also be applied to saliva testing, offering a simpler and more accessible alternative to current methods.
Men and women in Appalachia continue to have higher cancer incidence rates compared with those in the rest of the United States. Lifestyle changes and improved healthcare are helping narrow the gap between Appalachian and non-Appalachian populations.
The new guidelines provide a comprehensive framework for the evaluation, treatment, and surveillance of patients with thyroid nodules and thyroid cancer. The updated guidelines integrate new information and advances in the field, but also highlight areas that need further investigation and refinements.
Thyroid cancer patients report poor quality of life after diagnosis and treatment compared to other patients with more lethal cancers. Researchers found that thyroid cancer survivors reported an average quality of life score of 5.56 out of 10, which is worse than other cancer types.
Researchers at Michigan Technological University found that thyroid cancer detection assays may not accurately measure two major biomarkers. The proteins tend to clump together, making it difficult to detect the true levels of thyroglobulin and galectin-3. By adding a step to break up these clumps, the tests could be made more accurate.
Researchers have identified a new cancer-predisposing gene, SEC23B, associated with thyroid cancer and Cowden syndrome. This gene is involved in protein transport within cells and has been found to promote aggressive growth of thyroid cells.
A new study discovered that patient-derived human cells can be used to regenerate thyroid function in patients with cancer who have had their thyroids surgically removed. This breakthrough could lead to the development of a cell-based regenerative therapy to treat thyroid diseases.
The new guidelines focus on initial evaluation, biopsy criteria, molecular marker studies, risk assessment, and cancer screening for patients with thyroid nodules. For differentiated thyroid cancer, the guidelines emphasize screening, staging, and surveillance strategies, as well as long-term management and treatment options.
A new study has identified a minimum surgeon volume threshold of 25 cases per year associated with improved patient outcomes for total thyroidectomy. High-volume surgeons had significantly lower complication rates, with only a 4.2% chance of experiencing complications compared to 6.4% for low-volume surgeons.
A recent Mayo Clinic study found that the number of new thyroid cancer cases is doubling, driven by the detection of previously undiagnosed low-risk tumors. These silent cancers often require unnecessary treatments, leading to financial and physical hardship for patients.
A 30-year study of 4,941 thyroid cancer patients found that moderate TSH suppression can bring benefits comparable to more extreme approaches, with potentially fewer side effects. The research supports a shift towards more tailored hormone suppression strategies for high-risk patients.
A team of Pitt scientists has developed consensus guidelines for thyroid cancer molecular testing to help clinicians make informed decisions about diagnosing the condition. The new guidelines incorporate newly available tests that better incorporate personalized medicine into diagnosing thyroid cancer.
A nationwide study in Taiwan found a strong association between Parkinson's disease and most types of cancer, including malignant brain tumors and gastrointestinal tract cancers. However, breast, ovarian, and thyroid cancers showed no significant link to PD.
Researchers found that younger thyroid cancer patients with lymph node involvement have a lower survival rate compared to those with no spread. The number of lymph nodes involved plays a role in survival, with six or more nodes increasing the risk of death.
The new guidelines provide a broader scope of therapeutic options for pediatric patients with differentiated thyroid cancer, aiming to limit aggressive therapy when it's unlikely to offer benefit. The guidelines specifically address the differences in biological behavior and management of these entities in children.
The updated guidelines offer a state-of-the-art basis for clinical care of patients with MTC, highlighting areas in need of further investigation. The revised recommendations aim to improve overall survival for these patients by developing more effective drugs or combinations of drugs.
A phase 2 clinical trial found that sunitinib significantly improved progression-free survival in patients with advanced differentiated thyroid cancer. The study showed that 83% of patients benefited from treatment, with either tumor shrinkage or slowed disease progression.
A new analysis of a large national database found that breast cancer survivors have an increased risk of developing thyroid cancer, especially within five years of their diagnosis. Women who received radiation therapy for breast cancer were more likely to develop aggressive thyroid cancer, but with smaller tumors and fewer treatments.