Articles tagged with Human Biology
Researchers discover a novel metabolic pathway, glyoxalase system, that regulates excessive immune responses by targeting a previously underexplored metabolic pathway. The GLO2-SLG-D-lactylation pathway suppresses inflammatory signaling, reducing inflammation in acute and autoimmune disease settings.
A recent study found that women with polycystic ovary syndrome (PCOS) have embryos carrying a unique 'epigenetic memory' that could explain why the condition often runs in families. Treating affected embryos with certain inhibitors showed promise in restoring normal gene activity, suggesting a potential therapeutic avenue.
Pregnancy rates remained stable for IVF and IUI cycles in 2022, while single embryo transfer usage increased. Clinical pregnancy rates were stable, with singleton delivery rates improving to 91.5%. The use of ART rose by 15.6% despite a slight decline in total treatment cycles.
A new study shows that a simple blood test taken in the first trimester of pregnancy can accurately identify women at risk of developing preeclampsia five months before clinical diagnosis. The test uses cell-free RNA, or cfRNA, to capture subtle molecular signals from multiple maternal tissues.
Scientists at Xi'an Jiaotong-Liverpool University developed a new nanoparticle capable of carrying high doses of chemotherapy drugs while staying stable for extended periods. This innovation could make treatments more effective and reduce side effects.
Researchers used a premature aging mouse model to study the effects of age and sex on osteocyte networks and bone structure. Aged PolgA mice showed accelerated skeletal aging, reduced osteocyte connectivity, and increased frailty, with males exhibiting more pronounced changes.
Researchers developed an improved biological ageing clock, LinAge2, that offers doctors a practical way to assess how quickly a person is ageing and what can be done to slow it down. The new algorithm-powered tool outperforms other clinical models in predicting long-term mortality and health outcomes.
A University of Otago study found that prolactin helps regulate core body temperature during pregnancy, reducing the risk of hyperthermia. This adaptation promotes a safe environment for the fetus and enhances maternal survival and wellbeing.
The CIAO study found that centenarians in Cilento, Italy, adhere to a Mediterranean diet rich in fresh fruits, vegetables, and olive oil, which pays health dividends. They also exhibit coordinated immune responses and social engagement, maintaining cognitive integrity and emotional stability.
Researchers at University of Virginia Health System discovered that an immune molecule called STING drives the formation of harmful plaques and protein tangles associated with Alzheimer's. Blocking STING protected lab mice from mental decline, suggesting a promising treatment target for neurodegenerative diseases.
MenstruAI analyzes menstrual blood to detect disease biomarkers, offering an early warning system for women's health. The technology uses a paper-based test strip and smartphone app to analyze protein concentrations.
As women age, more genes on their X chromosomes escape silencing, potentially influencing disease. This epigenetic change may explain sex-based differences in age-related diseases.
Researchers at Stanford University have developed a modular biosensor called SENSBIT that can continuously track drug concentration profiles in real time. The device has remained functional for up to seven days when implanted directly into the blood vessels of live rats.
Scientists have identified a brain molecule called NEAT1 that appears to play a central role in triggering light sensitivity (photophobia) during migraines. By disrupting the normal balance of nerve signaling and pain regulation, NEAT1 makes nerves more sensitive to light.
A new study found that a simple oral swab test can increase IVF success rates by identifying the best hormone treatment for each woman based on her genetic profile. The test, developed by researchers at Lund University, shows promise in reducing costs and increasing pregnancies.
Research shows that low phosphate levels in blood are associated with reduced sperm motility and poor semen quality. The findings suggest a potential link between phosphate and male fertility, highlighting the importance of understanding biological factors involved in reproductive health.
A new study from Texas A&M University found that residents' knowledge of environmental health risks is the most important factor in their decision to take a home buyout. Residents who live in areas with high levels of risk and are more concerned about environmental risks are more willing to accept a buyout.
The PEARL trial found that low-dose rapamycin improved lean muscle mass and reduced pain in women, while also showing improvements in emotional well-being. The study suggests rapamycin may offer measurable benefits for physical function and overall well-being in older adults.
A study published in Human Reproduction found that healthy childhood diets are associated with delayed onset of menstruation, independent of body mass index (BMI) or height. The research suggests that a diet high in fruits, vegetables, and whole grains may help reduce the risk of chronic diseases such as diabetes and breast cancer.
Researchers will gather in Italy to review a decade of work on promoting healthy aging and extreme longevity. The study aims to identify key factors that contribute to the remarkable health of residents over 100 years old.
A team of researchers used machine learning to analyze changes in astrocyte cells' structure, shedding light on heroin addiction and relapse. The study, published in Science Advances, found that specific subpopulations of astroglia exhibit more pronounced morphological changes during drug use.
The VAST project seeks to understand the normal human virome, the vast ecosystem of viruses living in and on humans. By analyzing tens of thousands of samples from diverse populations, researchers aim to identify how a healthy virome shifts with disease or environmental factors.
Researchers created an Experimental Beverage Marketplace to analyze the impact of taxes on sugar-sweetened beverage consumption. The study found that participants purchased significantly less of these drinks when a tax was applied, replicating standard economic principles.
A study analyzing 17,500 individuals found that immune resilience counters factors of aging and mortality through TCF7 gene regulation, reducing mortality risk by 69% in midlife. This promotes salutogenesis, actively fostering health and well-being.
A study published in PLOS Biology found that individuals who receive dynamic facial-expression feedback from an avatar's face tend to gamble more than those receiving real human feedback. The amygdala plays a key role in this facilitation, with increased valuation of uncertainty contributing to increased risk-taking behavior.
MSU is developing a computer program called MOSAIC to create holistic biological profiles from skeletal remains, making the investigative process clearer and more efficient. The project aims to leverage relationships between various structures to provide estimates without biasing results by focusing on individual components.
A team of researchers has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer. The study highlights how the metabolic environment of tumors influences T cell function, opening new possibilities for improving cancer immunotherapy by targeting tumor metabolism.
Researchers developed a method to detect epileptic seizures in humans using canine EEG data. The approach leverages feature similarities across species and modalities, reducing input space discrepancies. Euclidean alignment and knowledge distillation are key components of the proposed joint alignment mechanism.
A national study in Australia aims to understand the genetic cause of rare diseases, improving diagnoses and treatment options for those affected. The study is recruiting Australians with a known or suspected rare genetic disease to gather information and connect them with future research opportunities.
A study of European jackdaws reveals that sleep-deprived birds prioritize deep sleep over vigilant wakefulness. The findings suggest that even flexible sleep strategies have limits, highlighting the importance of understanding animal sleep patterns to better comprehend human sleep loss.
A study found that agricultural antifungals, like TBZ, can cause genomic changes in the infectious yeast Candida tropicalis, increasing its resistance. This increase in resistance poses a growing concern for human infections, as many pathogens are becoming resistant to antifungal medicines.
William Murphy, a genomicist at Texas A&M University, was named the 2025 SEC Professor of the Year. He studies genome structure, function and evolution to understand genetic basis of species traits and diseases.
A study found that mice exposed to microgravity for 37 days experienced significant bone loss, especially in weight-bearing bones. This research may inform human acclimation strategies for spaceflight.
Researchers have identified a novel mechanism of intercellular communication involving mRNA transfer between different types of stem cells. This phenomenon enables cell fate conversion and reverts human pluripotent stem cells to an earlier embryonic stage.
A team of biologists has discovered an ancient neurohormone called bombesin that controls appetite in humans and other vertebrates. The study also found that bombesin-like neurohormones are present in starfish, revealing a common ancestor of appetite regulation dating back over half a billion years.
The National Initiative for RNA Biology and Its Applications (NIRBA) aims to strengthen Singapore's RNA research capabilities, focusing on human health and diverse applications. The program will integrate leading institutions and promote interdisciplinary collaborations to achieve groundbreaking scientific discoveries.
Researchers at the University of Virginia Health System have developed a computational tool called LogiRx that can predict how drugs will affect biological processes in the body. The tool has demonstrated its potential by identifying a promising candidate to prevent heart failure, a leading cause of death worldwide.
Scientists developed a novel solvatochromic fluorescent dye that enables high-precision temperature measurements through changes in fluorescence properties. The researchers achieved exceptional sensitivity and resolution, ideal for bioimaging applications.
Researchers have discovered a common gene linked to human kidney disease is also present in sea anemones, allowing their hair cells to detect water movement. This finding suggests an evolutionarily ancient role for the gene in sensing fluid movement, predating the common ancestor of mammals and sea anemones.
A new enzyme discovered in a gut bacterium has the potential to synthesize unique glycans with prebiotic properties, supporting gut health. The novel β-galactosidase could drive innovation in prebiotic products and contribute to developing new treatments for diseases like Chagas disease.
A study of nearly 900 postmenopausal women found an association between perimenopausal symptom burden and later cognitive function and behavioral impairment. Women with higher menopausal symptom burdens were more likely to experience poorer cognitive function and mild behavioral impairments, both markers of dementia.
The Gene Ontology Consortium has published a new resource of human gene functions, combining experimental data with evolutionary modeling. The PAN-GO functionome lists known functions of over 20,000 genes, providing a complete and accurate picture of gene function.
Researchers explore cognitive foundations of cross-species social behavior using octopus and reef fish as examples. These alliances challenge traditional views of intelligence and cooperation in the animal kingdom.
Researchers discovered synovial joints in ancient fish lineages, suggesting these features first evolved in jawed vertebrates. The study's findings shed light on the origins of humans' flexible joints and provide critical information for research into vertebrate skeletal architecture.
Researchers discovered a novel mechanism of intercellular communication through mRNA transfer between stem cells, allowing for biologically significant effects such as cell fate conversion and pluripotent state maintenance.
Researchers discovered a common cognitive feedback loop used by Buddhist jhāna meditation and Christian speaking in tongues practices to achieve profound focus and joy. This 'Attention, Arousal and Release Spiral' offers insights into cultivating deep states of tranquility and bliss.
Researchers have successfully modeled a treatment-resistant form of asthma in mice, shedding light on the role of CD4+T resident memory cells and MHC-II molecules in lung inflammation. The study's findings may lead to new treatments for this severe and debilitating condition.
A new computer vision framework, YOLO-Behavior, automatically identifies animal behaviors from videos, overcoming manual annotation limitations. The method has been applied to various study systems, doubling available data for parental care behavior and enabling rapid analysis of cooperative behavior.
A study found that DNA methylation clocks used in forensic science and epigenetics are less reliable when applied to non-blood tissues, such as lungs, colon, and kidneys. The researchers suggest that organ-specific epigenetic clocks may be needed to improve biological age prediction.
A groundbreaking study analyzed data from over 78,000 cancer patients to identify nearly 800 genetic changes impacting survival outcomes. The research also discovered genes significantly associated with survival in various cancers, such as breast, ovarian, skin, and gastrointestinal cancers.
A recent study found that cold temperatures allow the bird pink eye pathogen to survive on bird feeders for up to seven days, causing more severe disease in birds compared to warmer temperatures. Regular cleaning of feeder surfaces with bleach can help mitigate the spread of the disease.
Researchers at TUM found that cystic fibrosis causes changes in the immune system as early as birth, leading to frequent inflammation and infections. These changes are not affected by CFTR modulator therapies.
Researchers tracked 131 juvenile sea turtles and found they may be active swimmers during their early life stage, challenging existing hypotheses. The study provides important data for assessing risks from human activity and informing conservation efforts.
A new study from Penn State finds that oral tissue samples significantly affect epigenetic clock accuracy, leading to older age estimates. Researchers tested five tissue types and seven epigenetic clocks, concluding that blood-based samples are more accurate in measuring biological age.
Researchers at the University of Maryland discovered multiple pathways for dsRNA molecules to enter cells, challenging previous assumptions about RNA transport. They found that a protein called SID-1 plays a key role in regulating genes across generations, which could lead to better targeted treatments for human diseases.
Neuromorphic computing is poised to emerge into full-scale commercial use, driven by the need for energy-efficient solutions. The review article proposes strategies for building large-scale neuromorphic systems that can tackle complex real-world challenges.
Antonio Bicchi's IIT-led project VSoftPro aims to create a transhumeral prosthesis with user-controlled stiffness and passive adaptability. The goal is to replicate the natural appearance and functionality of a human arm, enhancing safe and natural interactions.
A team of researchers from Penn State and the University of California, Irvine, have proposed a novel theory on the molecular basis underlying human scalp hair growth. They suggest that long scalp hair initially evolved to protect early human ancestors in equatorial Africa from intense heat and solar radiation.
Scientists from Gladstone Institutes developed a new method called RASAM, which made a surprising discovery that large sections of newly formed DNA are hyperaccessible for many hours. This finding holds important implications for basic understanding of biology and the development of new medicines.
A new longitudinal study has provided unprecedented insights into human papillomavirus (HPV) infection dynamics. The study found that non-persistent infections exhibit a plateau in viral load before rapidly declining, while chronic infections show a strong correlation between immune cells and virus production. This research could infor...