Articles tagged with Anesthesia
Researchers at Boston Children's Hospital developed a slow-release injectable drug delivery system that achieved pain-numbing anesthetic effects lasting two to three weeks in rats. The system uses liposomes with multiple compartments, allowing for ultra-slow release of hydrophilic drugs.
Researchers discovered how anesthesia, surgery, and intensive care stress alter gene activity in the brain, leading to cognitive impairment and delirium. A new drug, vorinostat, reversed these changes, restoring memory formation and regulating the internal biological clock.
The American Society of Anesthesiologists recommends using epidural or spinal anesthesia during external cephalic version to improve its success rate. Research suggests that anesthesia can make ECV nearly 40% more likely to succeed, reducing the need for C-sections and associated risks.
New research at ANESTHESIOLOGY 2026 reveals ketamine may ease early symptoms of postpartum depression during C-sections. Additionally, sleep medication before surgery can lead to better pain management and reduced opioid use after surgery. The event also highlights the risks associated with cannabis use during surgery.
Researchers found that female mice's microglia form prolonged contacts with neurons during recovery, leading to synaptic remodeling and plasticity. This phenomenon was not observed in male mice, highlighting differences in brain recovery processes between sexes.
A team of researchers at Kyoto University found that traveling waves in rat brains are linked to information transfer in consciousness, but the amount of transfer entropy is higher during anesthesia than wakefulness. The study suggests that the awake brain selectively regulates information for reliable communication.
A study of 9,036 mechanical thrombectomy procedures found that conscious sedation (CS)-dominant centers had faster door-to-recanalization times and lower in-hospital mortality compared to general anesthesia (GA)-dominant centers. However, the benefits of CS were only observed at centers where it was routinely used.
OYE Therapeutics announced positive Phase 1 results for OYE-101, a proprietary intravenous caffeine formulation. The study demonstrated the safety and tolerability of OYE-101 in healthy adult volunteers, supporting its planned development as a treatment to support emergence from general anesthesia and deep sedation.
A new approach to spinal surgery is gaining traction, with more than 200 surgeries performed under light sedation using local and spinal anaesthesia. This shift aims to reduce risks and speed up recovery for patients, especially the elderly and those with multiple health conditions.
Study identifies binding pocket on sodium ion channels where anesthetics like sevoflurane stabilize in inactive state, reducing neuronal activity. The findings may enable the design of safer, more selective anesthetics with fewer side effects.
A new study found that a standardized five-step anesthesia protocol can safely induce dreaming during surgery, with most patients reporting pleasant and positive dreams. The study's findings suggest that anesthesia dreaming could support emotional well-being and improve patient satisfaction.
Researchers explore how next-gen AI and sensor-rich operating rooms can enable more precise, data-driven, personalized surgery. Advances in multimodal data integration, machine learning, and robotic systems could enhance situational awareness and intraoperative decision-making.
Experts warn that AI-enhanced surgical robotics could enable true personalized surgery and enhance surgical team performance. However, regulatory reforms are needed to address risks from adaptive systems and ensure patient benefits.
Researchers have developed a new tool called Cheese3D to track subtle changes in mouse facial expression, enabling scientists to study and interpret brain function with greater accuracy. The system uses AI to quantify facial movements, opening up new possibilities for studying autism, behavioral therapy, and disease states.
OYE-101, a novel intravenous caffeine formulation, has been developed to accelerate recovery from general anesthesia and deep sedation. The company's lead program is being evaluated in a scientific bridging study to support a 505(b)(2) NDA for OYE-101.
A large randomized trial shows that continuous wearable monitoring reduces time with dangerously low oxygen levels after surgery, leading to improved composite outcomes and safety. The study found a 30-minute reduction in hypoxemia and a significant risk reduction for desaturation events.
A large randomized trial shows measurable improvements in postoperative patients who received continuous wearable monitoring, reducing time with dangerously low oxygen levels and composite outcomes. The study found a statistically significant 14% risk reduction for dangerous desaturation events and overall safety improvement.
Researchers discovered that three anesthesia drugs, propofol, ketamine, and dexmedetomidine, have the same destabilizing effect on the brain, causing a loss of consciousness. This common mechanism could lead to the development of a universal anesthesia-delivery system to monitor patients more effectively.
A study suggests ketamine may rapidly alleviate chronic fatigue symptoms in some individuals. Participants who received ketamine experienced a significant energy boost, which could be beneficial for those struggling with the debilitating condition.
OYE-101, a novel intravenous caffeine formulation, aims to accelerate recovery from general anesthesia and deep sedation in adults. The FDA-cleared treatment also seeks to address opioid-induced respiratory depression and related overdose situations.
Researchers discovered that sevoflurane impairs neurogenesis and cognitive function by inhibiting fatty acid β-oxidation in neural stem/progenitor cells. Enhancing FAO activity in NSPCs attenuates sevoflurane-induced neurogenesis impairment, suggesting a new mechanism of sevoflurane neurodevelopmental toxicity.
A recent study published in Current Molecular Pharmacology reveals CoQ2's sedative-hypnotic properties, inducing reversible loss of righting reflex and altering electroencephalogram activity. The compound disrupts mitochondrial membrane potential by inducing excessive proton leak and inhibiting electron transport chain complexes I and IV.
The company has secured $5 million in funding to support Phase 1 and pivotal trials for its therapies aimed at addressing opioid-induced respiratory depression and improving anesthesia recovery. This financing marks a transformative moment for OYE Therapeutics, positioning the company to enter clinical development with confidence.
Researchers found that tubeless anesthesia significantly reduces postoperative complications, promotes enhanced recovery, and lowers costs in selected patients. The study also showed improved respiratory function and reduced intubation times.
A new study published in Music and Medicine reveals that intraoperative music therapy significantly reduces the amount of propofol required during laparoscopic cholecystectomy. Patients who received therapeutic music experienced smoother awakenings, reduced physiological stress markers, and improved patient outcomes.
Dr. Kraig S. de Lanzac, a renowned anesthesiologist, has been elected as the first vice president of the American Society of Anesthesiologists (ASA). He will serve for one year and is committed to advocating for members on critical issues impacting their specialty.
Patrick Giam, M.D., FASA, has been named president of the American Society of Anesthesiologists (ASA), the nation's largest organization of anesthesiologists. Dr. Giam will serve for one year and is committed to advocating for anesthesiologist-led care and ensuring fair payment.
A study found that anesthesiologist-led care for patients undergoing surgery for hip fractures leads to faster surgery times and fewer complications. This approach reduces unnecessary delays, allowing patients to receive timely treatment and start recovery sooner, ultimately improving their outcomes.
A new study suggests that people over 60 who experience excessive daytime sleepiness may be at a higher risk of developing cognitive problems after surgery. The study found that those with moderate to severe daytime sleepiness had greater global cognitive decline six weeks after surgery.
Research suggests that individuals experiencing social isolation or food insecurity are more likely to develop chronic pain following surgery. Limited access to nutritious food can slow wound healing, while stress from loneliness can overstimulate the nervous system and increase pain severity.
A new study suggests that women who give birth via cesarean delivery are more likely to experience severe pain that disrupts sleep and activities of daily living. The study also found a higher risk of developing sleep disorders, such as insomnia or obstructive sleep apnea, after giving birth by C-section.
A new study found that speaking a non-English primary language increases the risk of postoperative delirium in U.S. patients, particularly those with lower estimated household incomes. The study, which analyzed 49,588 patients, suggests that language barriers and confusion may contribute to this increased risk.
Most children, including nearly 80% of infants, do not follow recommended guidelines for pre-surgery fasting from clear liquids. Prolonged fasting can be harmful and increase dehydration, pain, anxiety, and nausea. The study suggests allowing healthy children to drink clear liquids up to two hours before surgery.
Research highlights how limited access to healthcare in rural areas affects newborn health, with babies born to rural mothers more likely to experience complications at birth. The study also found that women without prenatal care are 2.6 times more likely to have infants with non-reassuring Apgar scores.
John M. Zerwas, M.D., FASA, received the American Society of Anesthesiologists' Distinguished Service Award for his lifelong dedication to advancing anesthesia care. As chancellor of The University of Texas System, Dr. Zerwas has led efforts to expand access to higher education and graduate medical education.
A systematic review suggests AI improves accuracy and decision-making in pediatric anesthesia, enabling anesthesiologists to intervene sooner when complications occur. AI offers personalized, real-time decision support, potentially reducing complications and outcomes in children.
Fentanyl-stimulant overdose deaths among adults aged 65 and older have surged 9,000% over the past eight years, matching rates found among younger adults. Chronic health conditions, multiple medications, and slower drug processing contribute to increased vulnerability in this age group.
Researchers at Penn Medicine have identified specific brain circuits impacted by psilocybin, which could lead to new paths forward for pain and mental health management options. The study found that psilocybin reduces both pain and depression-like behaviors with benefits lasting almost two weeks.
A new study by Universidad Miguel Hernandez de Elche researchers reveals that brain slow waves are guided by neuronal excitability, not anatomy. The discovery uses advanced computational models to analyze local and global brain activity, shedding light on states like deep sleep and anesthesia.
Researchers at Boston Children's Hospital report an alternative local anesthetic, 2',6'-pipecolylxylidine (PPX), that selectively blocks pain while leaving motor function intact. PPX has been found to be less toxic than conventional anesthetics and may enable longer-lasting pain relief.
A new clinical trial found no significant neurodevelopmental effects on infants and young children after brief inhaled anesthesia and surgery. The study used a balanced strategy with lower doses of sevoflurane and did not show meaningful short-term differences in IQ or child behavior problems.
The new book Spinal Surgery Biomechanics: Principles for Residents offers a comprehensive exploration of core biomechanical concepts essential for mastering spinal surgical procedures. It bridges the gap between theory and practice, providing a biomechanical framework that supports surgical planning and patient safety.
A new study published in PNAS found that prolonged and repeated exposure to GABA anesthetic agents in infants under two months leads to accelerated visual cortical development. This may suggest the use of non-GABA-active anesthetics for newborns, as a large multicenter clinical trial is currently underway.
A large clinical study found that high-tech oxygen level monitoring during heart surgery did not lower the risk of serious complications afterward. Fewer pneumonia cases were reported in patients with advanced monitoring, but this difference may have been coincidental.
An analysis of National Poison Data System reports found a near tripling in US reported lidocaine local anesthetic poisonings/deaths over the past decade, contrasting with a substantial fall in reports associated with other local anesthetics. The increase was primarily driven by a rise in reports of death associated with lidocaine.
SURGhub has transformed surgical education in low-resource and conflict-affected regions by reaching over 19,000 healthcare workers with high-quality training. The platform's accessibility and culturally relevant content are bridging a gap that has left millions without access to safe surgical care when needed.
A new analysis of published data finds no association between pre-surgery fasting and post-procedure vomiting, contradicting long-standing recommendations. Research included 801 patients in experimental groups and 990 control group patients, with results showing that aspiration pneumonia is rare.
The American Society of Anesthesiologists (ASA) recommends that tattoos following the same safety standards as elective surgery. Patients opting for anesthesia or sedation should be administered by a qualified anesthesia professional in an equipped facility to handle emergencies and monitor patient safety.
The research aims to improve the survivability of wounded soldiers, enhance combat safety, and accelerate postoperative recovery in a multicenter pivotal clinical study. OYE's technology has shown promise in reducing mortality rates, lowering healthcare costs, and improving surgical workflow efficiency.
A recent MIT study identified a potential signature of unconsciousness that can be measured to improve anesthesiology care. Researchers found that different anesthetics affect brain wave phase in the same way, leading to misaligned local communications and functions.
A clinical trial found that using EEG to monitor consciousness safely reduced anesthetic use in children, resulting in quicker recovery, reduced delirium, and lower healthcare costs. The study also showed a significant reduction in pediatric anesthesia emergence delirium.
Combining dexmedetomidine with spinal anesthesia prolongs pain relief and reduces shivering during surgery, suggesting improved recovery outcomes. However, it may slightly increase the risk of a slower heart rate.
Charité has reduced annual CO2 emissions from anesthesia by over 80% since 2018 by switching to more environmentally friendly anesthetics. The hospital's efforts have resulted in significant savings and no medical drawbacks for patients.
A study at Michigan Medicine found that using less polluting inhaled anesthetic agents reduced CO2 equivalents by over 14 kg per case. This resulted in a 50% decrease in harmful emissions without impacting patient safety or outcomes.
A multidisciplinary team led by the Wyss Institute aims to create novel anesthesia-inducing drugs that can safely induce an anesthesia-like state without compromising vital functions. The project leverages expertise from Harvard's MCB, MIT, and Tufts University to develop safe battlefield-ready anesthetics.
A randomized clinical study found that an opioid-free treatment pathway is both safe and effective for bariatric surgery patients. The alternative method, which combines three different medicines, significantly reduces the need for opioids during treatment.
A new practice advisory from the American Society of Anesthesiologists recommends strategies to reduce postoperative neurocognitive disorders in older adults. The evidence-based guidelines aim to minimize cognitive and functional changes after surgery, which can lead to loss of independence.
Anthem's revised policy reverses its previous plan to stop paying for anesthesia care after a certain time limit, a move that would have compromised patient safety. The American Society of Anesthesiologists welcomed the decision, highlighting the need for fair payment for anesthesiologists to ensure adequate care for vulnerable patients.
The American Society of Anesthesiologists recommends fostering better work environments to combat harassment, incivility, and disrespect. These behaviors negatively affect clinician well-being, patient health, and disproportionately impact anesthesiology.
Researchers developed a new AI-powered diagnostic system, FastGlioma, which reveals invisible cancerous tissue in brain tumor surgery. The technique may delay or prevent recurrence of high-grade tumors and improve patient survival.