Articles tagged with Immune Response
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A recent study published in Immunity reveals that human T-cell receptor genes exhibit unexpectedly high variability among individuals, with each person having a unique set of gene variants. The researchers identified 175 new gene variants originating from Neanderthals, which are present in up to 20% of modern humans in Europe and Asia.
A new Northwestern University study suggests that COVID-19 boosters may be less effective due to pre-existing antibodies from initial vaccinations. The study found that these antibodies can rapidly clear the booster from the body, limiting its efficacy. Increasing time between vaccinations is also beneficial for the immune response.
Researchers at Osaka University found that male patients with COVID-19 have a faster loss of circulating Treg cells, leading to dysregulated antibody responses. Females, on the other hand, have higher levels of these cells, which may help protect them from infection.
Researchers found that white guests are less likely to book with non-white hosts if they see featured reviews from previous white guests, but this effect is more pronounced for Black and Asian guests. Same-race endorsements on Airbnb can actually reduce racial discrimination in host selection.
Researchers highlight CD200's role in regulating immunosuppressive tumor microenvironments and propose alternative strategies for its neutralization. Unbiased genomic- and proteomic-based approaches may help clarify CD200 expression regulation across various human cancers.
A high-fat diet allows the immune system to eliminate a parasitic worm that causes long-lasting infections in the large intestine. This discovery may lead to new treatments for millions suffering from intestinal parasitic infections worldwide.
Researchers at Rice University have developed light-activated nanoscale drills that can kill pathogenic fungi, providing a potential new treatment option for fungal infections. The molecular machines target the mitochondria of fungal cells, disrupting cellular metabolism and leading to cell death.
Researchers at La Jolla Institute for Immunology have discovered the detailed mechanism of action of Inmazeb, a three-antibody cocktail designed to combat Ebola virus infection. The study reveals new information about how the drug interacts with the virus and its potential effectiveness against additional species of Ebolavirus.
A new study published in The American Journal of Pathology suggests that promoting autophagy with rapamycin restores intestinal barrier function during sepsis. The study also identifies the PLK1-mTOR axis as a crucial regulator of autophagy and intestinal barrier dysfunction, providing novel insights for treatment of sepsis.
A study by OHSU researchers found that immunity from COVID-19 gathers strength over time, indicating that vaccination should not be delayed. The study suggests that vaccine boosters can be spaced no more frequently than a year apart among healthy individuals.
Research suggests that avoiding or withdrawing from tough conversations can lead to emotional distress, bad feelings about the relationship, chronic inflammation, and lowered immune function. Couples who exhibit negative communication patterns report fewer positive emotions and slower wound healing.
Research reveals that commonly used antiretroviral drugs TAF and TDF directly impact mitochondria's energy production in immune cells. The study suggests a larger energy reduction when combined with other antiretrovirals, sparking concerns about potential long-term effects on human cells.
A new study reveals that high-affinity B cells trigger a change in the criteria for admission to germinal centers, allowing low-affinity B cells to join, increasing the diversity of the immune response. This process is crucial for fighting off viruses like SARS-CoV-2 but may hinder efforts against HIV.
Researchers found that high levels of mucosal IgA antibodies in the airways protect against SARS-CoV-2 infection for at least eight months, with a 90% lower risk of re-infection. Participants with prior infections generated stronger mucosal immune responses to Omicron breakthrough infections.
A recent study found that transfusion of COVID-19 convalescent plasma is associated with reduced mortality in immunocompromised patients. The research suggests this therapy may be beneficial for these patients, who are at high risk of severe illness and death from COVID-19.
New research finds Filamin A positions GABA-B receptors to control brain activity and slow down electric impulses. This discovery could lead to new therapies for neurological disorders such as Multiple Sclerosis and epilepsy.
A multicenter study found that COVID-19 vaccination following multisystem inflammatory syndrome (MIS-C) is safe, with mild reactions and no serious complications. The study included 385 patients aged 5 years or older, all of whom received at least one vaccine dose without any reports of myocarditis or MIS-C reoccurrence.
Research from Michigan Medicine reveals that high levels of ammonia in colon tumors can lead to reduced T cell growth and immunotherapy resistance. A study published in Cell Metabolism found that using an FDA-approved drug to lower ammonia levels made tumors more sensitive to treatment.
A study by Osaka University tracked the survival of antibody-producing plasma cells, finding that most die shortly after immune response, but a small population can survive for months or years. The researchers identified molecular markers distinguishing these long-lived plasma cells from short-lived ones.
A recent study published in the American Journal of Obstetrics & Gynecology MFM found that pregnant individuals have a similar long-term immune response to SARS-CoV-2 mRNA vaccination as non-pregnant individuals. The study also showed that vaccination during pregnancy provides protection to unborn babies, which is essential for their C...
Researchers at Lund University discovered an antibody with potential to protect against Strep A infection and a rare form of binding that leads to effective immune response. The finding could explain why many Group A strep vaccines have failed.
Researchers found that graphene oxide exposure altered the gut microbiome and triggered a type 2 immune response in zebrafish, which could inform strategies to mitigate adverse effects of nanomaterials.
Researchers found that Covid vaccines effectively protect HIV-positive individuals, particularly after a third booster shot. The study also revealed a surprisingly strong cellular immune response in HIV-positive people, similar to those in healthy individuals.
A recent study found that Denisovan DNA sequences near immune-related genes in modern Papuans regulate their activity, affecting how people respond to infections. The research suggests that Denisovan DNA contributed to the adaptation of early modern humans living in New Guinea and nearby islands.
A study found that genetic variants near ERAP2 and TICAM2 provided protection against Yersinia pestis, the bacterium responsible for the Black Death. These variants were also associated with improved detection and resistance to other pathogens, but at a cost: increased risk of autoimmune disorders like Crohn's disease.
Researchers uncovered distinct DNA methylation profiles in ocean microbes, shedding light on population dynamics and interactions. The study's findings have significant implications for understanding pathogenicity and developing new approaches to monitoring environmental health.
A newly discovered immune response inside the nose fights off viruses, but is suppressed by colder temperatures, making an infection more likely to occur. The study offers the first biological mechanism to explain why viruses like COVID-19 spike in colder seasons.
Research finds that individuals who received monoclonal antibodies before COVID vaccination exhibit a diverse antibody response, increasing the coverage provided by vaccines. This phenomenon, known as antibody feedback inhibition, is beneficial for diversifying immune responses to viruses.
A new study by RCSI University of Medicine and Health Sciences found that the circadian body clock influences immune responses to vaccines. The research discovered that the shape of mitochondria in dendritic cells changes throughout the day, impacting their ability to break down vaccines.
Johannes Gutenberg University Mainz has been awarded funding for three Collaborative Research Centers in the life sciences, including CRC 1551 and CRC/Transregio 355. The centers will focus on investigating polymer concepts in cellular function and heterogeneity of regulatory T cells in distinct microenvironments.
The German Research Foundation has approved a new Collaborative Research Center at the University Medical Center Mainz, exploring regulatory T cells in immune-related and tissue-specific diseases. The project aims to develop tailored immunotherapies using Treg cells, which could lead to breakthroughs in patient care.
Researchers analyzed a child's genetic data to identify novel mutations in the GTF3A gene, which impair the innate immune response. The study found that these mutations make cells more susceptible to HSV-1 infection and loss of antiviral immune response.
Researchers review myeloid-derived suppressor cells' phenotypes, mechanisms of immunosuppression, and roles in cancer treatment. Studies on non-malignant diseases, such as autoimmune disorders and obesity, are lacking, highlighting the need for further investigation.
Researchers at the University Hospital Bonn have discovered a new function of CRISPR/Cas9 gene scissors, which produce small signal molecules that bind to proteins, activating an emergency response. This discovery opens up new possibilities for treating diseases using CRISPR technology.
Researchers identified four partially hidden binding pockets on the SARS-CoV-2 virus's Nsp1 protein that could be targeted with drugs. These pockets are found to halt virus replication and prevent immune system shut-down, providing a promising lead for future coronavirus treatments.
A recent study from Linköping University found that COVID-19 reactivated several latent viruses, including the Epstein-Barr virus, in people with chronic fatigue syndrome (ME/CFS). The study suggests that these reactivated viruses may contribute to the disease's symptoms and could potentially be used as a diagnostic tool.
The study reveals that coronin proteins regulate T cell population size by promoting survival signals when cells are not too crowded. This mechanism is evolutionarily conserved in both humans and slime molds, opening up new avenues for research.
Co-infection with gut parasites increases shedding of respiratory bugs like Bordetella bacterium, leading to higher probability of onward transmission. This study in rabbits has broad implications for human populations and suggests targeting treatment of helminths could be an effective way to reduce disease outbreaks.
A new study reveals that urolithin A from pomegranates can rejuvenate T cells by recycling and renewing mitochondria, enhancing their ability to fight tumors. The researchers plan to investigate the application of urolithin A in clinical trials for colorectal cancer.
Researchers found a significant association between NTM infection and increased mortality in patients with end-stage renal disease. Early diagnosis and treatment may improve survival. NTM can cause nonspecific symptoms like fever and weight loss, and patients with compromised immune systems are at higher risk.
Researchers have identified two distinct molecular subgroups of cervical cancer, C1 and C2, which differ in their clinical aggressiveness and response to treatment. The study suggests that determining the subgroup of a patient's cervical cancer could provide additional prognostic information for planning treatment.
A recent analysis found that individuals at risk for rheumatoid arthritis and those with the disease have higher blood levels of antibodies against Prevotella copri, a bacterial strain typically found in the gut. This study suggests that targeted therapies may be developed to prevent or treat the disease.
Researchers developed a new machine-learning approach to classify macrophages, which are key immune cells involved in pro- or anti-inflammatory responses. This technology could be used as a diagnosis tool or to highlight the role of specific cell types in disease environments.
Researchers identified urolithin A as a compound that improves function of immune cells against cancer. The study found that urolithin A induces mitophagy in T cells, recycling and renewing mitochondria to enhance tumor-fighting capabilities.
Researchers analyzed 408 patients receiving immune checkpoint inhibitor therapy and found no increased risk of side effects from receiving both immunotherapy and the vaccine. The study supports NCCN's recommendations for COVID-19 vaccination in people with cancer, citing strong protection against severe COVID-19 for all variants.
A VUB study has mapped the immune system's response to brain infections, revealing that resident macrophages play a key role in defending against pathogens. The researchers found that blood-derived immune cells can eliminate parasites, but may retain 'memory' of past infections, altering their ability to respond to future insults.
A recent study led by Dr. Luis Cuello and Alain J. Labro found that a known Shaker channel mutation differs structurally from its human counterparts, with implications for drug development and ion transport mechanisms. The research reveals a unique conformation of the W434F mutant that is distinct from wild-type channels.
A new study shows that COVID-19 booster jabs significantly improve immunity against SARS-CoV-2 variants in elderly Singaporeans. The study found that a third vaccine dose boosts low antibody responses and T cell responses in older adults, providing better protection against severe disease.
Researchers found that elderly Japanese individuals show a low immune response to the third mRNA COVID-19 booster vaccine. The study revealed that nearly 10% of participants had negligible antibody production despite receiving an additional dose. The findings suggest that elderly people may require specialized serological testing proto...
Researchers analyzed eight patients who experienced COVID-19 rebound after taking Paxlovid and found robust T-cell responses. The study suggests that rebound symptoms could be driven by the cellular immune response to residual viral RNA rather than an impaired immune response.
Researchers at Karolinska Institutet found that intravenous omega-3 treatment improved immune function and stimulated healing of inflammation without compromising the body's response to COVID-19. The study suggests a potential new, cost-effective low-risk treatment for severe COVID-19.
A new study led by Erika Pearce at Johns Hopkins Medicine found that the shape and function of mitochondria in Th17 cells play a crucial role in controlling their autoimmune activity. The researchers identified several molecules, including LKB1, that can influence this process, paving the way for potential therapeutic modifications.
A study by MedUni Vienna's Department of Dermatology reveals that tick saliva inhibits the skin's defense function, making it easier for pathogens to multiply. Climate change increases the danger from ticks, which now pose a threat in higher-altitude regions of Austria and well into late autumn.
Researchers at University of Liège discovered a carp virus's ability to inhibit host cell defense mechanisms through the Zα protein domain. This finding broadens our understanding of Zα domain-containing proteins involved in immune system diseases such as cancers and autoimmune diseases.
A recent study finds that exposure to proteins in common foods, vaccines, bacteria, and viruses can prime the immune system to attack SARS-CoV-2, potentially providing protection against COVID-19. The study's findings suggest that individuals with a history of exposure to these agents may be less susceptible to severe illness.
A new study from OHSU reveals that breakthrough infections following vaccination can provide a potent immune response against COVID-19, with increased protection for those 65 and older. The research found an equally strong immune response among people who received a third vaccine booster dose three months prior.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
Researchers found that getting enough sleep influences the environment where monocytes form, develop, and get primed to support immune function. This process, hematopoiesis, occurs in the bone marrow and can accelerate clonal hematopoiesis, an age-related condition linked to cardiovascular disease.
A team of scientists from SMART and NTU Singapore has developed a rapid point-of-care test kit that measures antibodies against SARS-COV-2 and its variants, offering personalized vaccination strategies. The test kit requires just 10 minutes to show results and has up to 93% accuracy.
Research at Karolinska Institutet shows that people with diabetes have lower levels of psoriasin, a key peptide that weakens the bladder's protective barrier function. This increases the risk of urinary tract infections. Oestrogen therapy may help regulate the immune response to UTIs in patients with diabetes.