Articles tagged with Dna
The Predictive Phenomics Initiative and the Exposome Moonshot aim to understand the impact of molecular signaling on organisms. Environmental factors, such as diet and lifestyle, can significantly affect biological processes, influencing traits like height, disease risk, and even eye color.
A study published in Pediatric Investigation found that microbial cell-free DNA testing predicted infectious organisms consistent with traditional culturing tests in 26.9% of pediatric patients, but its utility was variable due to factors like antibiotic exposure and contamination.
A University of Oklahoma research team has developed a breakthrough method of adding a single nitrogen atom to bioactive molecules, transforming them into new pharmacophores. This process, called skeletal editing, could open up uncharted regions of chemical space in drug discovery, making existing drugs cheaper and more accessible.
Researchers at University of California San Diego School of Medicine have discovered that fatty liver disease can lead to liver cancer through DNA damage in liver cells. The study suggests that developing new drugs to prevent or reverse DNA damage could be a promising approach for preventing liver cancer.
Researchers found a specific magnesium concentration range where DNA wraps around polyphosphate-magnesium ion condensates, forming flexible structures. This discovery could lead to new methods for tuning cellular responses and has potential applications in translational medicine.
Researchers identified a vulnerability in the bacterial machinery driving antibiotic resistance adaptation, which could lead to new counter-strategies. The study found that a genetic toolbox called integron system plays a crucial role in adapting resistance genes.
Researchers have developed a fast and rewritable DNA computing method that uses DNA origami registers to process digital files. This method has the potential to be more powerful than current silicon-based machines.
Researchers at the University of Ottawa have developed a nanoparticle strategy to deliver both mRNA and siRNA, enhancing and interfering with multiple gene and protein expressions. This approach holds significant promise for treating major diseases like cancer and cardiovascular diseases.
Researchers used ancient DNA to uncover novel signatures of adaptation in early Europeans, tracing genetic changes in response to lifestyle shifts. The study identified 14 regions of the genome that underwent significant natural selection, including traits related to vitamin D production and dairy digestion.
A groundbreaking metagenomic sequencing test has proven effective in rapidly diagnosing almost any kind of pathogen, including viruses, bacteria, fungus or parasite. The test analyzes all nucleic acids present in a sample, replacing multiple tests with a single one and speeding up diagnosis.
A team of biologists at UT Arlington has discovered a new species of gecko, Pseudogonatodes fuscofortunatus, with distinct skeletal features and genetic data. The discovery highlights the unique characteristics of this tiny lizard, found in the Paria Peninsula of Venezuela.
Scientists have engineered synthetic genes that can assemble into complex biomaterials like nanoscale tubes, using a modular approach similar to building furniture. This breakthrough enables the creation of distinct materials that can spontaneously develop from a finite set of parts by rewiring the timing of molecular instructions.
Researchers used DNA barcoding to identify 31,800 insect samples from 37 habitats in Sweden, discovering 175 new species of scuttle flies. The study provides insights into the diversity and distribution of these species, which are influenced by climate factors and habitat changes.
Researchers at Colorado State University have identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast. This new approach provides a less toxic and quickly reversible alternative to hydroxyurea, allowing for better insight into cell cycle arrest mechanisms.
A team of scientists developed an advanced computational technique to predict gene architecture through nucleosome position, combining experimental approaches with machine learning techniques. The study demonstrates that nucleosomal architecture is greatly influenced by DNA sequence information and physical signals.
Researchers have identified a new epigenetic mark, 5-formylcytosine, which plays a crucial role in activating genes during early embryonic development. This discovery sheds light on the regulation of gene expression in vertebrates and has implications for our understanding of human development and disease.
A UCL-led research team has crystallized the first alternative DNA structure from the insulin gene, revealing its shape and structure. The discovery suggests that different variants in the insulin gene can form different DNA structures, which could affect insulin function and potentially play a role in diabetes development.
A new approach developed by researchers could streamline the forensic analysis pipeline and reduce delays in processing DNA evidence. The technique, using differential digestion with digital microfluidics, simplifies the process of isolating an assailant's DNA from a single sample, reducing manual steps from 13 to five.
Scientists have discovered over 50,000 unusual DNA structures called i-motifs in the human genome, which are concentrated in key functional areas and may play a role in regulating gene activity. This finding offers new possibilities for diagnostic and therapeutic approaches to diseases such as cancer.
Researchers at Osaka Metropolitan University found compounds in nucleic acids from salmon DNA and torula yeast RNA inhibit cancer cell growth. These compounds may prevent cancer by stopping cell replication.
Silent gene mutations may have significant consequences beyond their own gene, according to a study published in the Proceedings of the National Academy of Sciences. Researchers found that synonymous mutations in one gene can increase the production of a neighboring gene by recruiting RNA polymerase to cryptic transcription sites.
Researchers from Sweden and Spain have identified an endogamous community in northern Iberia that remained relatively isolated despite centuries of turbulent regional history. The study also revealed the presence of the variola virus, which can offer a new explanation on how smallpox entered Iberia.
Researchers propose a novel approach using CRISPR to stabilize DNA G4s at specific genomic locations, enabling precise investigation into biological processes and disease associations. The method leverages CRISPR-guided biotin-conjugated compounds to target specific G4s with reduced off-target effects.
A team of scientists at Gladstone Institutes has developed a new method that enables them to make precise edits in multiple locations within a cell—all at once. They created a tool using molecules called retrons to efficiently modify DNA in bacteria, yeast, and human cells.
Researchers identified nidogen-2 as a key driver of pancreatic cancer progression and metastasis. Blocking this molecule enhanced chemotherapy effectiveness and reduced spread in mouse models, suggesting a promising new treatment approach.
Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.
Researchers found a correlation between protein folding and evolution in certain globular protein families, with most conserved exons corresponding to better foldons. However, the general trend did not hold for all protein families, suggesting other biological factors may influence protein folding and evolution.
Professor Helle Ulrich will investigate how a small regulatory protein called ubiquitin contributes to DNA replication and repair, and decipher how cells direct different pathways. The ERC Advanced Grant aims to gain a deeper mechanistic understanding of ubiquitin's function in preventing mutations that can cause ageing and cancer.
Telo-seq reveals dynamic mechanisms of telomeres in aging and cancer, providing new insights into their role in health and disease. The breakthrough method determines telomere length and sequence on individual chromosomes.
A noncoding gene has been identified as the deciding factor in determining sex in Argentine ants, with a specific genomic region being crucial to this process. The gene does not encode a protein but rather produces an RNA that influences sex determination.
A mysterious plasmid, pBI143, found in 90% of human intestines, could be used to identify faecal contamination and offer insights into intestinal diseases. The discovery also highlights the prevalence of 'cryptic' plasmids in human gut microbiota.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
Researchers have uncovered novel perspectives on domestic and wild cat evolution through the use of cutting-edge genome sequencing and assembly technologies. The study highlights distinct genetic changes that will aid in future disease studies and provide crucial information for those studying feline diseases, behavior, and conservation.
The IntelliGenes software combines conventional statistical methods with cutting-edge machine learning algorithms to produce personalized patient predictions and visualize significant biomarkers for disease prediction. Researchers applied the software to discover novel biomarkers and predict cardiovascular disease with high accuracy.
Scientists have developed a method to study bobcats using only their pawprints, allowing for extensive data collection and analysis of ancestral background and microbial communities. This technique has the potential to inform better management and conservation of rare or endangered species.
Researchers from National University of Singapore have synthesised a redesigned yeast chromosome XV, comprising 1.05 million base pairs. The novel technology, CRISPR/Cas9-mediated mitotic recombination with endoreduplication (CRIMiRE), speeds up the assembly process, allowing for rapid reconfiguration of the synthetic chromosome.
A new compartment in mammalian cells, the exclusome, has been discovered to house DNA rings that can be ejected from the nucleus. This process helps protect chromosomes from foreign DNA that could disrupt cellular function. The discovery sheds light on a potential link between the exclusome and autoimmune diseases.
Researchers identified PUCH, a novel enzyme that produces small molecules called piRNAs to detect and prevent parasitic DNA from replicating in our genomes. This discovery sheds light on how our immune system works and may have implications for understanding innate immunity.
Cancer cells exploit enhancer DNA to accelerate tumor growth, according to researchers at the University of Toronto. The study found that specific proteins regulate this process, suggesting potential treatments through FOXA1 or NFIB suppression.
A new CRISPR-based diagnostic tool, MPXV-CRISPR, has been developed in Australia to detect the monkeypox virus with high precision and speed. The tool can detect the virus in clinical samples in just 45 minutes, making it faster than current methods.
CityU and AFCR have signed a MoU to promote cutting-edge cancer-related innovative inventions and commercialization. The partnership aims to foster the development of biomedicine and related innovation, with world-leading scholars from Harvard Medical School attending the inaugural 'Innovation Series in Biomedicine' forum.
Researchers found that the OsMATL2 gene triggers haploid induction when inactivated, resulting in plants with half the normal chromosome number and reduced seed setting. This discovery could revolutionize rice cultivation by accelerating breeding processes.
Researchers at UC Santa Cruz have created a device that mimics biological channels to detect biomolecules indicative of human disease. The bioprotonic system uses electrical currents of protons to translate biomolecule presence into electronic signals, with potential applications for in-vitro and clinical settings.
Researchers at the University of Pennsylvania School of Engineering and Applied Science have discovered dozens of small protein sequences with antibiotic qualities in extinct organisms like Neanderthals and Denisovans. They then synthesized these molecules using artificial intelligence and tested their efficacy against pathogens.
Researchers develop a new method to assemble arrays of quantum rods onto patterned DNA scaffolds, enabling precise control over light emission and polarization. This breakthrough could enhance virtual reality devices and microLEDs with improved depth and dimensionality.
Using plasma circulating tumor DNA testing can expedite biomarker testing and time to treatment for patients with suspected advanced lung cancer. The study suggests that this approach may improve patient outcomes.
Researchers have discovered that gene editing technologies may introduce unintended mutations and damage to DNA in early human embryos. The study found that most cells repair breaks in the DNA using non-homologous end joining, which can lead to additional genetic abnormalities.
Researchers have developed a new method to manipulate the shape of double-stranded DNA, known as triplex origami, which can create compacted structures with unique properties. This breakthrough has implications for gene therapy, nanoscale materials engineering, and our understanding of biological processes.
A new study using CRISPR/Cas9 technology has identified a critical gene, SLC4γ, required for young coral colonies to build their skeletons. This gene is unique to stony corals and may have evolved to support skeleton formation.
Researchers created a novel map of protein assemblies in DNA damage response, capturing canonical repair mechanisms and proposing new DDR-associated proteins linked to stress, transport, and chromatin functions. The study provides new therapeutic opportunities for diseases caused by defects in DNA damage response.
Researchers detected chicken, cow, and human eDNA at all altitudes, as well as common plant-based allergens and pathogenic bacteria. The sterilizable probe enabled mapping of genetic material from potentially all species using aircraft.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
Researchers have designed a new nanoparticle sensor that can detect cancer with a simple urine test. The sensors use DNA barcodes to analyze urine samples, which can reveal distinguishing features of a particular patient's tumor.
A University of Colorado at Boulder research team has discovered a protein crucial for repairing DNA in cancer cells, which they found can be selectively targeted to kill cancer cells without harming healthy ones.
A DNA designer drug restored levels of stathmin-2, a protein necessary for motor neurons to function, in both mouse and human studies. This finding could lead to clinical trials to delay paralysis in ALS patients by maintaining stathmin-2 levels.
A new study assesses DNA metabarcoding's performance in identifying fish eggs on the West Florida Shelf, highlighting its value for long-term monitoring of spawning sites and habitats. The technique can identify multiple species from a single sample, but may introduce biases by excluding rare species.
Researchers at Rice University's Center for Theoretical Biological Physics discovered Aedes aegypti's chromosomes have a unique 'liquid crystal' structure, unlike other species. This finding may provide insights into the functioning of genomes and gene regulation.
A new DNA biosensor developed by NIST, Brown University, and the French government-funded research institute CEA-Leti boasts accurate and inexpensive design. The modular device can measure biomarkers in a scalable and high-sensitivity manner.
Researchers at the University of Tokyo have developed artificial DNA that can target and kill cancer cells by binding to microRNA molecules. The DNA triggers an immune response that not only kills cancer cells but also prevents further growth of cancerous tissue.
A global registry for gene-drive modified organisms could facilitate transparent communication, monitor ecological impacts, and inform local decision-making. Experts agree that a registry is necessary for the fair development, testing, and use of gene-drive technologies.