Articles tagged with Genetic Analysis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers from McGill University and Italy found that blocking neutrophils can prolong pain, even with anti-inflammatory drugs. The study suggests reconsidering acute pain treatment, and findings are supported by a large UK analysis.
A study by Rice University bioscientists has revealed the presence of a central metal ion critical to DNA replication and implicated in misincorporation. The research found that three metal ions are involved in the process, with the first supporting nucleotide binding and the second stabilizing the binding of loose nucleotides. This di...
A new genetic analysis suggests that vaquitas can recover if deaths from gillnets are halted, despite initial concerns about inbreeding depression. The species' natural resilience and genetic diversity provide a high probability of survival.
A new lab test has been developed by Rutgers scientists to identify COVID-19 variants. The test uses molecular beacon technology and can detect eight different mutations in the spike protein, increasing the transmissibility of the virus and evading immune defenses.
Researchers developed a comprehensive regional diagnostic method using DNA testing, allowing for precise identification of microorganisms and estimation of their abundance. The technique has the potential to revolutionize our understanding of the ocean's food web and its role in removing greenhouse gases.
A new study found a consistent increase in PHGDH expression among Alzheimer's patients and asymptomatic individuals, suggesting increased serine production in the brain. The findings prompt caution against taking serine supplements for Alzheimer's disease treatment or prevention.
Researchers have used a data-sharing innovation to categorise 16 uncertain BRCA variants as benign or likely benign, potentially allowing women with these variants to skip invasive surgeries. This could lead to thousands of people avoiding difficult treatments for no reason.
Researchers discover that type 1 TPCs encode SV channels in plant vacuoles, while type 2 TPCs likely encode distinct ion channels. This study provides functional and evolutionary insights into the TPC family in plants, shedding light on their role in plant growth and defence mechanisms.
A large-scale study found genetic links between COVID-19 severity and various medical conditions, including venous embolism, type 2 diabetes, and ischemic heart disease. The analysis also revealed shared genetic architecture with idiopathic pulmonary fibrosis and reduced risk of autoimmune conditions.
A research team from the Max Planck Institute for Terrestrial Microbiology has identified 1,000 biosynthetic gene clusters, over half of which are previously unknown. These natural products have been found to be eukaryotic proteasome inhibitors that suppress the immune system of insects, as well as other virulence factors.
A study from the Healthy Nevada Project found that only 10% of patients with electronic health records containing genetic diagnosis experienced a change in care, emphasizing the need for follow-up education and conversations. The study also highlights the importance of including genetic diagnoses into electronic health records to maxim...
A comprehensive genetic analysis of the native people in China's southwestern region reveals a more complex peopling and migration history than previously thought. The study found that all ethnic groups are genetically similar, suggesting a common ancestor, but with closer relationships to Tibetan Highlanders and southeast Asians.
Researchers identified two genes associated with recovery within the first 24 hours after stroke, linking neuronal excitability to stroke outcomes. Genetic evidence suggests that calming overexcited neurons may protect the brain after a stroke.
Researchers analyzed ancient corn roots to understand the transformation of wild grass teosinte into modern corn. The study found that early corn specimens lacked seminal roots, a key adaptation for drought tolerance, and had different root anatomy than modern corn.
A study found that small genetic variations impact an organism's ability to utilize energy from various nutrients. Researchers identified several genes contributing to sugar tolerance in fruit flies, which are also present in humans and linked to obesity and type 2 diabetes.
A new study found that newborn brains are already organized into functional networks, with five networks operating at birth. Individual variability in these networks may be related to genetic differences and could have implications for behavior in adults.
Researchers analyzed genomic profiles of over one million cells from 1,000 people, identifying a link between specific genes and immune cell types in autoimmune diseases. The discovery could lead to tailored treatments and refine clinical trials.
An international team of researchers has identified 5,500 new RNA virus species that represent all five known RNA virus phyla. The study suggests there are at least five new RNA virus phyla needed to capture them and highlights the importance of marine microbes in ocean adaptation to climate change.
Researchers discover medusavirus undergoes four stages of maturation within host cells, with unique particle structures and DNA-protein exchange mechanisms. The findings provide new insights into giant viruses' biology and behavior.
Researchers use stem cells from people with extra X chromosomes to identify key genes contributing to symptoms like infertility and intellectual disability. The study's findings could lead to new treatments for these conditions.
A recent study led by the University of Zurich found that well-integrated male dolphins with strong social bonds to many alliance partners produce the most offspring. The researchers analyzed 30 years of behavioral data from 85 male dolphins and used genetic data to conduct paternity analyses for more than 400 dolphins.
Researchers used single cell RNA-sequencing to identify specific cells and genes in maize roots responsible for nitrate uptake. The study provides valuable insights into optimizing root nutrient uptake ability in crops.
Researchers developed a computational approach called CellTrek to combine parallel gene-expression profiling methods, creating spatial maps at single-cell resolution. The tool provides detailed information on individual cell types' location within tissues, enabling unique biological insights.
Scientists have identified a clear genetic signature of Parkinson's disease in people's memory T cells, which could lead to new therapies and diagnostics. The study found that targeting these genes may help stop T cells from attacking brain cells in Parkinson's.
The study highlights the need to analyze molecular markers, such as genetic sequences or brain proteins, to obtain more accurate assays, diagnoses and therapies. The results show changes in astrocytes attempting to adapt to toxic environments from the disease, worsening its progression.
A study has decoded the DNA of the Arabian Oryx, a vulnerable species that was on the brink of extinction. The researchers analyzed the genetic data to inform breeding programs and found moderate diversity in the population's gene pool.
Researchers found early and persistent activation of neutrophils in patients who developed severe COVID-19. The study suggests that identifying specific gene signatures could lead to effective treatments targeting high-risk patients. This discovery may also inform the development of simple blood tests to prioritize treatment.
Researchers sequenced bacteria associated with Fucus vesiculosus, finding tissue-specific bacteria important for alga's health. The study revealed new insights into the relationships between marine bacteria and algae, shedding light on the impact of climate change on ecosystem services.
Researchers developed a new genomic technology to analyze DNA, RNA and chromatin from a single cell, providing a comprehensive database for better understanding of brain diseases. The technology helped identify 63 cell types in the human frontal cortex region.
Researchers found that obstructive sleep apnea (OSA) accelerates the biological aging process and causes epigenetic age acceleration, leading to increased mortality risk. However, one year of CPAP treatment significantly slows down biological age acceleration in OSA patients, suggesting a potential reversal of age-related trends.
Scientists developed a novel approach to securely share and analyze genomic data, enabling a more nuanced understanding of heritable diseases like cancer. This 'federated analysis' method allows researchers to analyze large amounts of genomic and clinical data without compromising patient privacy.
Researchers discovered two WOX genes controlling lateral root primordium size in rice, improving drought stress tolerance and crop production. QHB/OsWOX5 regulates S-type roots, while OsWOX10 mediates L-type root development, enhancing water uptake under drought conditions.
A new study found that traditional Chinese medicine Shengmai Yin increases the sensitivity of cancer cells to radiation, reducing radioresistance. By altering DNA methylation status, SMY enhances the efficacy of radiation therapy and reduces side effects.
Researchers discover new species of burrowing frog, Synapturanus danta, in Amazon peatlands. The frogs' unique calls and adaptations make them an important part of their underground ecosystem, contributing to nutrient cycling and soil structure.
Researchers discovered a bZIP23-PER1A module that regulates rice seed vigor, improving crop quality. They found two cultivars with huge phenotypic differences, Kasalath and Jigeng88, and identified a novel detoxification pathway to enhance seed vigor.
Researchers uncovered bone remains of a first-generation African individual from Senegambia, buried in a Portuguese shell midden 350 years ago. The genetic signature and dietary analysis indicate that he was forcibly translocated to Portugal via the Trans-Atlantic Slave Trade.
A new genetic study found evidence of South Asian genetic admixture in several mainland Southeast Asian populations influenced by Indian culture. The researchers also discovered close genetic links between languages from different families, supporting an earlier hypothesis about their common origin.
A new method of optical genome mapping has been developed to provide more precise information on types of leukemia. The technique reveals additional prognostic information compared to conventional cytogenetics in AML/MDS patients, facilitating more accurate diagnosis and therapy.
A new bacterial strain, Noda2021, belonging to Candidatus phylum Dependentiae has been isolated and sequenced, revealing its genetic material and potential ecological significance. This discovery sheds light on the diversity of microorganisms in Japan's microbiological hotspots.
A new study identifies at least 16 distinct wasp species previously grouped as one, Ormyrus labotus, which lays eggs in over 65 insect species. The discovery highlights the importance of seeking out hidden diversity and underscores the need for precise identification to understand ecosystem health.
A recent study by researchers from Ritsumeikan University found that athletes with a history of sprained ankle showed reduced gut bacteria diversity compared to those without such a history. This suggests that musculoskeletal injury may have a negative impact on the gut microbiota, potentially leading to long-term health consequences.
Researchers at Karolinska Institutet used spatial transcriptomics to create a map of gene expression in the mouse colon, gaining new insights into inflammatory bowel disease. The study's findings suggest that the colon is divided into more segments than previously thought and could lead to the development of new treatments.
A new DNA benchmark, developed by NIST and collaborators, enables more accurate detection of genetic variants linked to diseases such as spinal muscular atrophy. The benchmark, based on HiFi sequencing technology, helps labs and clinics sequence genes with high accuracy, critical for disease diagnosis and treatment.
A study found that humans have evolved less sensitive noses compared to other primates, with genetic variations affecting scent perception. Researchers screened the genomes of over 1,000 Han Chinese people and an ethnically diverse population to identify novel genetic variants associated with odor detection.
A new DNA metabarcoding technique identifies nearly 3,000 insect species in European forests, revealing that forest dieback affects insect community composition and ecological functions. The study highlights the importance of preserving environmental features supporting biodiversity.
Researchers use environmental DNA to monitor aquatic species near hydropower facilities, while also developing a novel method for printing full-strength steel components using additive manufacturing. These advancements could lead to more efficient and cost-effective monitoring and renewable energy production.
A study led by Clemson University geneticist Allison Hickman has identified 11 high-priority genes associated with uterine cancer. These genes are potential targets for drug therapies, offering new hope for effective treatment options.
Researchers discovered all-female, forest-dwelling drywood termite colonies in Japan and found they evolved through human-assisted hybridization, leading to stronger offspring and double breeding. This can outcompete incumbent species, posing a risk to homeowners with drywood termite infestations.
A new analysis links genetic variants associated with high blood levels of lipoprotein A to a higher risk of prostate cancer, including advanced or early-age-onset cases. The study found no significant associations for other blood lipids.
The use of polygenic risk scores in pre-implantation genetic testing is unproven and can lead to discrimination and stigmatization. ESHG argues that there is no evidence PRSs can predict disease likelihood in unborn children, making their application premature.
A new species of angel shark, Squatina mapama, has been identified in the Central American Caribbean, shedding light on the region's biodiversity. Genetic analyses reveal distinct characteristics from other related species, emphasizing the importance of forensic science in understanding cryptic species within the genus.
Researchers developed unprecedented insights into the natural and commercial flow of fish, highlighting the importance of inclusive approaches to fisheries management and conservation. The study's findings indicate a strong connection between larval dispersal and catch distribution in Hawaii, emphasizing the need for community-based ma...
A new study published in Mammalian Biology analyzed the life history data of 13 North Atlantic right whales using genetic samples and photo identification. The researchers found that four calves previously thought to be dead survived, revealing a significant variation in calf separation time from mothers and physical development.
Epidemiologists have developed a new blood test, DunedinPACE, to measure biological aging. The test uses DNA methylation marks to track changes in organ-system integrity over time, predicting future disease and mortality.
A new machine learning model, RefMap, has identified 690 genetic risk factors for motor neurone disease, a five-fold increase from previous estimates. This discovery could lead to the development of new treatments and personalized medicine for patients with MND.
Researchers confirm that Chevalier barley came from a single plant, analyzing seed samples older than 150 years. The study reveals how the single plant's genetic signature was preserved and used to create modern malting barley varieties.
Researchers at Karolinska Institutet have identified a specific gene variant that protects against severe COVID-19 infection, found in individuals of African ancestry. The study analyzed 2,787 hospitalized patients and 130,997 people from six cohort studies, revealing an 80% prevalence of the protective variant among Africans.
Researchers have identified a previously unknown gene, goldentouch, responsible for the golden coloration in Midas cichlids. The gene, found on chromosome 11, is present in two variants: one associated with dark coloration and the other with orange/yellow coloration.
A study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by changes in hundreds of genes working together in networks across several organs. Fat processing hormones may play a central role in coordinating this activity.
Researchers from the Crump Lab created a series of atlases to study the molecular decisions of cranial neural crest cells, identifying genetic signs that point to specific destinies. Their findings reveal a new approach to understanding head development and regeneration in vertebrates.