A recent study identified novel genes that influence PARP inhibitor response in prostate cancer, including MMS22L and RNASEH2B. The research found that loss of CHEK2, a previously approved biomarker, confers resistance to PARP inhibition, highlighting the need for comprehensive genomic analysis to improve treatment decisions.
SourceBrigham and Women's Hospital·JournalNature Communications·TypeExperimental study·DateApr 4, 2023
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers have developed a non-invasive method to track human aging using retinal scans, which are less expensive and more accurate than other aging clocks. The study found that changes in the eye can provide an actionable evaluation of gero-protective therapeutics, offering a new tool for tracking aging.
SourceBuck Institute for Research on Aging·JournaleLife·TypeImaging analysis·DateMar 28, 2023
High blood pressure damages specific brain regions, including the putamen and white matter areas, leading to cognitive decline and increased risk of dementia. The study uses a combination of MRI, genetic analyses, and observational data to identify these affected regions.
SourceEuropean Society of Cardiology·JournalEuropean Heart Journal·TypeObservational study·DateMar 27, 2023
Chinese scientists have identified a key gene involved in crop alkaline tolerance, which may greatly improve crop yield in sodic environments. The study found that the gene negatively regulates alkaline stress by modulating the efflux of H2O2 under environmental stress.
SourceChinese Academy of Sciences Headquarters·JournalScience·TypeExperimental study·DateMar 23, 2023
Researchers identified over 1,000 genes with age-related methylation changes in human sperm. These changes are associated with increased offspring disease susceptibility for neurodevelopmental disorders. The study found no correlation between paternal BMI or semen quality and age-related methylation changes.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateMar 21, 2023
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers used UK Biobank image and genomic data to uncover insights into rare retinal dystrophies, a leading cause of blindness in working-age adults. The study identified new genetic associations with the thickness of photoreceptor cell layers, offering new avenues for research and diagnosis.
SourceEuropean Molecular Biology Laboratory·JournalPLOS Genetics·TypeData/statistical analysis·DateMar 9, 2023
Mutant mice lacking FADS1/2 genes exhibit bipolar swings in behavior, featuring phases of abnormally low activity and hyperactivity. Omega-3 fatty acid supplements and a mood stabilizer reverse behavioral changes, suggesting these mice as a valuable model for studying BD.
SourceJuntendo University Research Promotion Center·JournalMolecular Psychiatry·TypeExperimental study·DateMar 7, 2023
A recent study has identified nine new genetic variants that increase the risk of prostate cancer in men of African descent, including a variant linked to aggressive forms. The findings can be used to refine polygenic risk scores and identify high-risk patients for earlier screenings.
SourceKeck School of Medicine of USC·JournalEuropean Urology·TypeMeta-analysis·DateMar 3, 2023
A new study published in Diabetologia found that childhood obesity is associated with a higher risk of four out of the five recently proposed subtypes of adult-onset diabetes. The study used Mendelian randomization to investigate the link between childhood body size and the risk of different diabetes subtypes occurring in adults.
Researchers created a network of interacting proteins to understand the function of genes and link specific biological processes to diseases. They identified groups of proteins interacting with genes linked to over 1,000 human traits, providing insights into new targets for drug discovery and potential repurposing opportunities.
SourceEuropean Molecular Biology Laboratory·JournalNature Genetics·DateFeb 23, 2023
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
A recent study found that metformin users had distinct DNA methylation profiles compared to non-users, potentially revealing its role in longevity. The research identified several pathways related to delirium and aging, highlighting the need for further investigation into metformin's mechanism of action.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateFeb 22, 2023
A new study published in Genes, Brain and Behavior found that genetic variants in LINGO2, OAS1, and HECTD1 are associated with different mathematical abilities in Chinese children. The study refined genome-wide association studies of math skills and added population diversity to the literature.
Researchers found 270 distinct differentially methylated regions (DMRs) in AD brains compared to normal controls, validating their key findings using an independent cohort. The study offers a novel approach to investigating the relationship between DNA methylation and gene/protein expression.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalAlzheimer s & Dementia·DateFeb 22, 2023
Researchers found associations between cancer treatments and accumulated mutations in blood cells, a sign of accelerated aging called clonal hematopoiesis. This accumulation increases the risk of blood cancer and death in long-term childhood cancer survivors.
SourceSt. Jude Children's Research Hospital·JournalCancer Discovery·DateFeb 8, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A recent study published in Nature has discovered several new disease genes and provided new insights into the effects of known genetic factors on disease. The study highlights an underappreciated complexity in dosage effects of genetic variants, challenging traditional Mendelian inheritance laws.
A new toolkit enables researchers to map individual RNA data to a more diverse 'pantranscriptome', addressing reference bias and increasing the accuracy of gene expression mapping. This approach builds on pangenomics, allowing for the comparison of an individual's genome to genetically diverse cohorts of reference sequences.
SourceUniversity of California - Santa Cruz·JournalNature Methods·DateJan 16, 2023
Researchers have identified a new genetic pathway involved in regulating sleep from fruit flies to humans. The Pig-Q gene is associated with sleep regulation in both humans and animals, providing a novel insight into the genetics of insomnia.
SourceTexas A&M University·JournalScience Advances·DateJan 10, 2023
A recent study has revealed a novel cold domesticated repair mechanism for DNA damage in rice, providing elite modules for improving chilling tolerance. The discovery of GCG codon repeats in the first exon of COLD11, a DNA repair protein, has opened the way for fine regulation of rice chilling tolerance with a single site.
SourceChinese Academy of Sciences Headquarters·JournalScience Advances·TypeMeta-analysis·DateJan 6, 2023
Researchers identified six genes associated with dementia risk in people of African ancestry, differing from those found in European populations. The study highlights the need for increased representation of non-European ancestry groups in genetic research to address health disparities.
SourceVeterans Affairs Research Communications·JournalMolecular Psychiatry·TypeMeta-analysis·DateDec 22, 2022
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A massive international data analysis uncovered hundreds of signals for new treatment and prevention targets in colorectal cancer. The study identified 250 independent risk associations, including 50 newly discovered ones, through analyzing genomic, transcriptomic, and methylomic data.
SourceCleveland Clinic·JournalNature Genetics·DateDec 20, 2022
Researchers confirmed smoking and obesity increase COVID-19 severity, with ACE2 mediating detrimental effects. Lower socioeconomic position also increases COVID-19 risk, highlighting social inequalities.
SourceThe University of Hong Kong·JournalJournal of Medical Virology·TypeExperimental study·DateDec 14, 2022
Researchers used WGS data of 10,585 people from China to construct the first blood virological profile of the Chinese population. The study identified 14 viruses widely present in the population, including hepatitis B virus, which was detected in 1.69% of individuals.
SourceBGI Genomics·JournalCell Discovery·TypeObservational study·DateDec 7, 2022
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers uncovered distinct DNA methylation profiles in ocean microbes, shedding light on population dynamics and interactions. The study's findings have significant implications for understanding pathogenicity and developing new approaches to monitoring environmental health.
SourceChung Ang University·JournalMicrobiome·TypeExperimental study·DateDec 7, 2022
Researchers discovered 10 novel genetic loci associated with osteoarthritis, which are robustly found in every population ancestry studied. The study also identified genes expected to contribute to OA included targets for existing drugs against cancer, epilepsy and acne.
SourceUniversity of Alabama at Birmingham·JournalNature Genetics·TypeData/statistical analysis·DateDec 6, 2022
A new AI-powered blood test, DELFI, has been developed to detect liver cancer with high accuracy. The test detected over 80% of liver cancers in a study of 724 individuals, with an overall sensitivity of 88% and specificity of 98%.
SourceJohns Hopkins Medicine·JournalCancer Discovery·DateNov 18, 2022
Researchers identified five genetic variants that progressively increase the risk of becoming nearsighted with more schooling, especially for university-level education. These findings provide new insights into biological pathways causing nearsightedness and its interaction with lifestyle factors.
SourcePLOS·JournalPLOS Genetics·TypeExperimental study·DateNov 17, 2022
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
A genetic variant associated with low levels of HDL 'good' cholesterol and high triglycerides has been identified in Polynesian people. This discovery provides new insights into the genetic causes of high cholesterol and may lead to the development of more effective treatment options.
SourceUniversity of Pittsburgh·JournalHuman Genetics and Genomics Advances·DateOct 20, 2022
A recent study identifies a specific gene, GNL3, that regulates neural proliferation in response to lithium, which is used to treat bipolar disorder. This gene plays an important role in brain function and has been implicated in risk for bipolar disorder, schizophrenia, and inter-individual variations in intelligence.
SourceElsevier·JournalBiological Psychiatry·TypeExperimental study·DateOct 18, 2022
Researchers have analyzed data from 5.4 million people to uncover 12,000 genetic variants influencing height, explaining 40% of differences. This breakthrough enables the prediction of height with greater accuracy, particularly for children, and has implications for medical investigation and police investigations.
SourceUniversity of Queensland·JournalNature·TypeData/statistical analysis·DateOct 12, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
The Global Biobank Meta-analysis Initiative has made significant advancements in expanding genome-wide association studies (GWASs) to include more diverse and representative data from around the world. By analyzing genomic data from over 2 million individuals across four continents, researchers have identified new genetic variants asso...
SourceCell Press·JournalCell Genomics·TypeMeta-analysis·DateOct 12, 2022
The study found that genetic variants associated with height are concentrated in regions covering just over 20% of the genome. The variants identified explain 40% of the variation in height for people of European ancestry, and around 10-20% for those of non-European ancestry.
SourceQueen Mary University of London·JournalNature·TypeMeta-analysis·DateOct 12, 2022
Researchers identified 257 rhizoplane microbial biomarkers associated with six key agronomic traits, revealing a complex association between millet genotype, root microbiome, and crop growth. The study provides insights into precision agriculture based on genotype-dependent microbial effects in foxtail millet.
SourceBGI Genomics·JournalNature Communications·TypeData/statistical analysis·DateOct 10, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers have discovered two genes contributing to a paradoxical drug effect in Aspergillus fumigatus, a fungus that causes deadly infections. The findings could lead to the development of new treatments and improve patient outcomes.
SourceUniversity of Massachusetts Amherst·JournalMicrobiology Spectrum·TypeCase study·DateOct 6, 2022
A genome-wide study has identified two genetic variants and structural changes in chromosomes associated with posterior urethral valves, a condition that affects 1 in 4,000 males. The study highlights the importance of including diverse populations in genetic studies to identify genetic contributors to rare conditions.
Researchers from Children's Hospital of Philadelphia used advanced mapping techniques to identify causal genes and target pairings in the pancreas linked to type 2 diabetes. The study revealed alpha and acinar cells play a greater role in disease development than previously thought.
SourceChildren's Hospital of Philadelphia·JournalCell Metabolism·DateSep 6, 2022
The expanded 1000 Genomes Project resource now includes nearly all parent-child trios alongside the original samples, sequenced at high coverage using Illumina NovaSeq instruments. This comprehensive analysis presents significant improvements in variant calls, especially among rare SNVs, INDELs, and SVs.
SourceNew York Genome Center·JournalCell·TypeData/statistical analysis·DateSep 1, 2022
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
The study developed a high-throughput method for screening non-photochemical quenching rates in field-grown plants using pulse amplitude modulated chlorophyll fluorescence analysis. This approach enables testing hundreds of genotypes within a day, paving the way for genome-wide association studies.
SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalJournal of Visualized Experiments·TypeExperimental study·DateAug 29, 2022
A new UCLA-led study has identified multiple new risk genes for Alzheimer's disease and progressive supranuclear palsy (PSP) by combining new testing methods. The researchers used high-throughput testing to simultaneously test 5,706 genetic variants in 25 loci associated with Alzheimer's and nine loci associated with PSP.
SourceUniversity of California - Los Angeles Health Sciences·JournalScience·DateAug 18, 2022
A massive analysis of over 10,000 Mycobacterium tuberculosis isolates revealed new genes associated with resistance to 13 antibiotics. The study provides a comprehensive framework for understanding the genetic mechanisms of resistance and identifying diagnostic gaps.
SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateAug 9, 2022
A team of researchers from The Mount Sinai Hospital has made a groundbreaking discovery into the genetic and molecular mechanisms that predispose individuals to Alzheimer's disease. They identified 21 candidate risk genes, including SPI1, which regulates microglia and AD risk.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNature Genetics·DateAug 5, 2022
Researchers examine the genomic variations of 191 microbial strains paired with their host plants to understand cooperation and conflict. They found that 80% of symbiont genes align with the host's interest, often paying for them to be beneficial despite competing interests.
SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalProceedings of the Royal Society B Biological Sciences·TypeExperimental study·DateAug 3, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers at Boyce Thompson Institute have created the first comprehensive annotation of long intergenic non-coding RNAs (lincRNAs) in four mustard species. The study identifies locations across all four genomes that encoded lincRNAs, proposed functions for them, and confirmed the function of some lincRNAs involved in germination. Th...
SourceBoyce Thompson Institute·JournalThe Plant Cell·TypeExperimental study·DateJul 19, 2022
Researchers found global redistribution of histone H3 modifications with time, particularly in intergenic regions and near transcription start sites. Caloric restriction diet feeding reduced the extent of changes occurring during the first year of life in these genomic regions.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateJun 30, 2022
Researchers at Gladstone Institutes and Stanford University identified key genes linked to T cell exhaustion. They discovered how to block these genes, resulting in healthier T cells and smaller tumors in mice with cancer. This breakthrough may lead to improved immune-based treatments for cancer patients.
SourceGladstone Institutes·JournalCancer Cell·DateJun 28, 2022
A new study reveals that over half of human populations worldwide have experienced sharp dips in population size due to founder events, associated with geographic isolation, hunter-gatherer lifestyle, or cultural practices. This analysis technique, ASCEND, will help identify groups at high risk of genetic diseases.
SourcePLOS·JournalPLOS Genetics·TypeObservational study·DateJun 23, 2022
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers have developed a new method to assess the three-dimensional structure of the human genome, revealing that groups of simultaneously interacting regulatory elements may affect gene expression. The study found that cooperative groupings of DNA elements occurred around genes associated with cell identity.
SourceWeill Cornell Medicine·JournalNature Biotechnology·DateJun 23, 2022
Scientists have discovered a significant genetic link to humans' ability to move in sync with music. The study identified 69 genetic variants related to beat synchronization and found connections between rhythm and health, while acknowledging that environment also plays a crucial role.
SourceVanderbilt University Medical Center·JournalNature Human Behaviour·DateJun 17, 2022
A new study found that genes tied to perception of five basic tastes may influence diet quality and cardiometabolic risk factors. Researchers identified associations between taste-related genes with specific food groups and risk factors, suggesting personalized nutrition guidance could improve diet quality.
Researchers developed an in vitro stem cell model to map disease risk variants in human neurons, which could provide insights into the biological mechanisms underlying neuropsychiatric disorders. The study focuses on mapping cis-regulatory elements linked to psychiatric disease heritability.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalCell Reports·TypeComputational simulation/modeling·DateJun 1, 2022
A massive global study of diverse populations has significantly advanced the understanding of type 2 diabetes by identifying 117 genes that contribute to the disease. The research used genetic data from almost 181,000 people with type 2 diabetes and 1.16 million without it.
SourceUniversity of Massachusetts Amherst·JournalNature Genetics·TypeMeta-analysis·DateMay 12, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A large study has found six predictors that can help determine the optimal lithium dose for patients with bipolar disorder. The predictors include age, sex, kidney function, and medication use. The researchers hope to develop a digital app to aid psychiatrists in finding the right dose.
SourceKarolinska Institutet·JournalThe Lancet Psychiatry·DateMay 12, 2022
Researchers found a genetic link between long repeated DNA sequences and schizophrenia. The study discovered rare tandem repeat expansions near genes associated with the disorder, contributing to dysfunction at synapses and disrupting gene function.
SourceThe Hospital for Sick Children·JournalMolecular Psychiatry·DateMay 11, 2022
Researchers have mapped the connections between DNA and blood proteins in two large populations, providing insights into disease causes and potential treatment targets. The study's findings could shed light on health disparities and help develop new therapies.
SourceJohns Hopkins Bloomberg School of Public Health·JournalNature Genetics·DateMay 2, 2022
Researchers from The University of Texas Health Science Center at San Antonio have identified 33 genes associated with Alzheimer's disease, doubling the known list. This discovery adds 42 new genetic variants to the existing gene list, shedding light on emerging pathways of Alzheimer's biology and potential treatment targets.
SourceUniversity of Texas Health Science Center at San Antonio·JournalNature Genetics·TypeMeta-analysis·DateApr 20, 2022
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A study found that small genetic variations impact an organism's ability to utilize energy from various nutrients. Researchers identified several genes contributing to sugar tolerance in fruit flies, which are also present in humans and linked to obesity and type 2 diabetes.
SourceUniversity of Helsinki·JournalNature Communications·DateApr 19, 2022
A large-scale genetic study has identified 287 genomic regions associated with schizophrenia and 120 specific genes linked to the disorder. These findings provide new insights into the biological processes underlying schizophrenia, offering potential avenues for novel therapies.
SourceCharité - Universitätsmedizin Berlin·JournalNature·DateApr 7, 2022
A National Jewish Health-led study found that over a third of identified genetic risk factors for asthma are associated with altered function of airway epithelium. The research discovered genetic changes in genes related to mucus production and type 2 inflammatory pathways, increasing asthma risk.
SourceNational Jewish Health·JournalNature Communications·TypeComputational simulation/modeling·DateMar 28, 2022
A new study confirms that abnormalities in the GDF15 gene are involved in hyperemesis gravidarum, a condition causing severe nausea and vomiting during pregnancy. The discovery may lead to targeted treatments and improved care for women with HG.
SourceKeck School of Medicine of USC·JournalBJOG An International Journal of Obstetrics & Gynaecology·TypeExperimental study·DateMar 16, 2022
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers at Clemson University have identified a genetic variation associated with congenital idiopathic megaesophagus (CIM) in German shepherd dogs, which is often fatal if left untreated. A genetic test using melanin-concentrating hormone receptor 2 and dog's sex can predict the risk of CIM with 75% accuracy.
SourceClemson University·JournalPLOS Genetics·TypeData/statistical analysis·DateMar 10, 2022
A new study predicts rheumatoid arthritis progression using a polygenic risk score. The score, generated from genetic variants associated with the disease, significantly differed between severe and non-severe progression groups. Higher scores were linked to higher risks of severe progression, particularly among younger patients.
SourceTokyo Medical and Dental University·JournalArthritis & Rheumatology·DateMar 7, 2022