Articles tagged with Rheumatoid Arthritis
A first-in-human Phase 1/Phase II study demonstrates the safety and efficacy of intravenous administration of technetium-99m tilmanocept for monitoring rheumatoid arthritis disease activity. The imaging agent binds to activated macrophages, providing joint-specific information on RA disease involvement.
Research supported by the Accelerating Medicines Partnership has provided new insights into tissue damage in rheumatoid arthritis and lupus. Novel molecular signatures have been identified in kidney cells and specific white blood cells may reflect their active role in disease process.
A pilot study presented at EULAR 2019 suggests that electro stimulation of the vagus nerve can reduce signs and symptoms of rheumatoid arthritis. The study showed a significant reduction in disease activity and improved response criteria, with two-thirds of patients meeting good or moderate response criteria.
A study at EULAR 2019 found that RA patients with IBD and type I diabetes have higher rates of venous thromboembolism, epilepsy, and heart attacks compared to controls. These findings suggest that these conditions may be novel comorbidities for patients with RA.
A survey of over 900 RMD patients revealed that pain caused one in ten to have suicidal thoughts, highlighting the huge impact of pain on mental health. Poor sleep quality also had a negative influence on pain, with two thirds of patients rarely or never feeling fully rested.
Researchers attach a removable lock to an arthritis drug to reduce systemic immune suppression and neutralization, making it safer and more effective. The modified form of the antibody shows promise in treating rheumatoid arthritis with fewer infections and less development of anti-infliximab antibodies.
A three-year study found that patients with rheumatoid arthritis in remission had an 80% reduced risk of clinical and pre-clinical cardiovascular disease. Type II diabetes was significantly associated with both cardiovascular outcomes and pre-clinical cardiovascular disease.
Research highlights the impact of obesity on disease severity and impact in patients with psoriatic arthritis, emphasizing the need for weight loss interventions alongside symptomatic treatment. The study also explores the relationship between adipokines and predicting rheumatoid arthritis onset in overweight subjects.
Researchers review aspects of RA detection and intervention, highlighting potential for early screening and prevention. Studies discuss the development of effective preventive measures, which could significantly alter disease course and quality of life.
A team of researchers has developed a nano-sized hydrogel that can scavenge nitric oxide and effectively treat rheumatoid arthritis. The hydrogel was shown to be more effective than current therapeutic drugs in suppressing the onset of the disease, with minimal side effects.
Researchers found that glucocorticoid use, especially above 10mg/d, was associated with increased risk for infections, readmission, and prosthetic joint infections among RA patients undergoing joint replacement surgery. Biologics had similar risks across treatments.
Researchers identified a new molecular mechanism causing rheumatoid arthritis, finding that death of macrophages triggers the disease. The protein A20 was found to prevent macrophage death and protect against arthritis.
Researchers have identified 18 unique cell populations in RA joint tissue, including a fibroblast subset that produces pro-inflammatory cytokine interleukin-6. COX inhibitors like NSAIDs also alter these macrophages, but not TNF responses, suggesting new treatment approaches may be needed.
Research suggests that daily activities such as eating and walking are affected early in the course of rheumatoid arthritis, with most patients experiencing functional disabilities. The study also found that persistent excess in functional disability continued even after diagnosis and treatment.
Researchers developed a novel bioelectronic treatment that significantly reduces swelling and inflammation in rheumatoid arthritis patients. The non-invasive vagus nerve stimulation treatment inhibits the production of cytokines, proteins that mediate inflammation.
A large clinical trial found that statins reduce the risk of cardiovascular events in moderate-risk rheumatoid arthritis patients by 40%, but the difference was not statistically significant. Statins also lower LDL cholesterol and C-reactive protein levels, making them a safe treatment option for these patients.
A comprehensive profile of B cells in rheumatoid arthritis reveals their involvement in the disease's progression. Researchers identified two specific differences in B cells that contribute to the condition, including the inclusion of interleukin 15 receptor subunit alpha and high levels of amphiregulin.
A new study reveals that osteoarthritis (OA) and rheumatoid arthritis (RA) have comparable impacts on patients when first visiting rheumatologists. Treatment significantly improves RA outcomes, whereas OA experiences a higher burden of disease, highlighting an urgent need for improved treatments.
A new study suggests that moderate alcohol consumption may not be beneficial for patients with rheumatoid arthritis. The research found no association between drinking and reduced disease severity or improved quality of life.
Researchers identified ELMO1 as a surprising contributor to rheumatoid arthritis, which may lead to a new treatment and blood test for early detection. The discovery also challenges the understanding of genes' roles in the body.
A study of 230,732 women found that long-term smoking cessation reduces the risk of a certain form of rheumatoid arthritis by 37%. This type of RA tends to have a more severe disease course with joint deformities and disability.
A new study finds that sustained smoking cessation can delay or prevent the development of seropositive RA, a more severe form of rheumatoid arthritis. Quitting smoking for good reduces risk by 37% after 30 years.
A study published in Restorative Neurology and Neuroscience found that eight weeks of intensive yoga practice significantly decreases the severity of physical and psychological symptoms in patients with active rheumatoid arthritis. The results show marked improvements in inflammatory biomarkers, functional status, and disease activity.
A new AI-powered app will monitor patients' symptoms between medical appointments and predict flare-ups using video and thermal imaging technology. The Flare Profiler aims to provide earlier detection of issues, allow earlier clinical intervention, and reduce the need for costly acute treatments.
Researchers discovered rare subsets of unconventional T cells in SpA patients, which produce pro-inflammatory cytokines like IL-17. These cells can be targeted with RORγt inhibitors, potentially treating IL-17 driven diseases, including spondyloarthritis.
The University of Colorado Anschutz Medical Campus will partner with the Allen Institute for Immunology to understand the human immune system and find novel mechanisms to halt or reverse rheumatoid arthritis. The research program aims to identify biomarkers for early detection and develop new treatments for this debilitating disease.
Biomechanical forces play a key role in the development of joint inflammation and erosions in chronic inflammatory rheumatic diseases. The study identifies hot spots in the musculoskeletal system where mechanical loading leads to increased inflammation and tissue damage.
Researchers from Osaka University established a new analytical approach, MIGWAS, that integrates genetic and molecular data to reveal tissue-specific features associated with diseases. The study successfully identified novel cellular components linked to traits and diseases.
A team of CU researchers has identified a genetic connection between rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis. The study found that patients with RA are at risk of developing progressive pulmonary fibrosis, enabling potential interventions to prevent this condition.
A new study has found a strong association between diabetes and an increased risk of developing osteoarthritis, rheumatoid arthritis, and osteoporosis. People with diabetes were 33% more likely to suffer from osteoarthritis than their counterparts without diabetes.
Researchers at the University of California San Diego have developed nanosponges that can safely absorb and neutralize a variety of proteins involved in rheumatoid arthritis progression. These nanosponges effectively treated severe rheumatoid arthritis in two mouse models, reducing swelling and minimizing cartilage damage.
A new drug, upadacitinib, has been shown to be effective in patients with moderate to severe forms of rheumatoid arthritis who have not responded to conventional treatments. The drug, a selective inhibitor of Janus kinase 1, has been found to improve joint swelling and pain symptoms in a phase III clinical trial.
A new study published in Rheumatology indicates that exposure to secondhand smoke in childhood increases the risk of developing rheumatoid arthritis as an adult. The study found that passive smoking during childhood can lead to an increased risk of arthritis and earlier onset, even in non-smokers.
The Women's Preventive Services Initiative recommends annual screening for urinary incontinence in all women, assessing symptom presence and impact on activities. Early intervention may reduce symptom progression and limit costly treatment needs.
Researchers at FAU have identified ILC2 as a key player in the development of rheumatoid arthritis. By increasing ILC2 levels during therapy, symptoms can be reduced. However, treatment must start before disease onset to be effective.
Researchers at Mount Sinai Hospital discovered a new gene, HIP1, linked to disease severity in rheumatoid arthritis. The study found that knocking out the gene reduced synovial fibroblast invasiveness and protected against arthritis progression.
A new PET imaging method evaluates the extent of rheumatoid arthritis inflammation by targeting translocator protein (TSPO) expression in joint lining tissue. The study demonstrates that TSPO PET can image not only synovial macrophages but also activated synovial fibroblasts, a critical process in RA pathogenesis.
A new study found that rheumatoid arthritis inflammation alters brain connectivity and structure, contributing to cognitive symptoms. Higher levels of peripheral inflammation were associated with changes in the inferior parietal lobule and medial prefrontal cortex.
A study found significantly higher gum disease prevalence in at-risk RA individuals compared to healthy controls. Increased abundance of bacteria, particularly Porphyromonas gingivalis, was also detected in at-risk individuals.
A study found that 46% of women with early rheumatoid arthritis did not achieve remission within a year, while 38% of men experienced the same issue. Lifestyle changes such as smoking cessation and weight reduction may facilitate rapid reduction of inflammation in early RA.
A recent study presented at EULAR 2018 reveals an increased risk of acute coronary syndrome in siblings of individuals with rheumatoid arthritis. The findings show a significant association between RA and ACS, suggesting shared susceptibility between the two diseases.
A 23-year follow-up study suggests early, intensive treatment of rheumatoid arthritis can lead to long-term benefits, including normalization of mortality rates. The study found that patients treated with a combination of medications had lower mortality rates compared to those treated with a single medication.
The frequency of joint replacements in rheumatoid arthritis patients decreased by 51.9% over the past decade, suggesting improved treatment strategies. Biological therapy was found to have a limited impact on this reduction, with no significant association with total hip replacement or knee replacement procedures.
A study suggests that rates of depression and anxiety in early RA patients correlate with measures of disease activity, particularly inflammation. Depression scores were significantly associated with inflammatory markers like c-reactive protein, while anxiety scores were linked to female gender, younger age, and low body mass index.
Two studies provide insight into molecular changes prior to arthritis onset, identifying gene signatures associated with disease development. Researchers found that specific autoantibodies and B-cell receptor clones can predict imminent onset of rheumatoid arthritis in at-risk individuals.
A study examining the rate of incident malignancy in patients with RA who newly started on tocilizumab or a TNFi found no significant differences. The incidence of malignancy per 100 person-years ranged from 0.83 to 2.32 in TCZ patients and from 0.96 to 2.15 in TNFi patients.
Pregnancies in women with rheumatoid arthritis are associated with an increased risk of low birth weight, prematurity, and small size at birth. However, there were no reported adverse outcomes for the mothers themselves, except for premature delivery.
A population study shows that individuals with AS are almost twice as likely to self-harm compared to their comparators. The most frequent method of self-harm is poisoning or self-mutilation. This study highlights the need for routine evaluation of self-harm behavior in patients with chronic inflammatory arthritis.
A new study from Uppsala University reveals that a wide range of anti-citrullinated protein antibodies (ACPA) in immune complexes from the joints can cause local inflammation and drive joint damage in rheumatoid arthritis. This finding supports the suspicion that ACPAs are pathogenic by forming immune complexes in the joints.
A recent review of over 70 clinical trials found that rheumatoid arthritis treatments alone are unlikely to improve mental health outcomes. Instead, integrated psychological support alongside routine care may achieve optimal mental health outcomes for patients with rheumatoid arthritis and depression.
Researchers at Osaka University identified a cellular network involving Th17 cells and stromal cells that secretes inflammatory cytokines to initiate and maintain rheumatoid arthritis. By targeting this network, a novel immunotherapeutic approach has been proposed to reduce chronic joint inflammation.
New research suggests that rheumatoid arthritis drugs taken during pregnancy are unlikely to cause a large increase in serious infections in children. The study found no marked excess risk of serious infections among RA offspring exposed to TNFi drugs compared to unexposed control children and offspring from the general population.
A study found that pregnant women with rheumatoid arthritis using certain RA drugs did not have a marked excess risk of serious side effects compared to unexposed children. The research showed that TNF inhibitors may not compromise the child's ability to fight infections.
A study published in Nature Communications has found an unexpected overlap between the causes of rheumatoid arthritis and Huntington's disease. The researchers developed a novel algorithm to analyze epigenetic data, identifying new cell signaling pathways and potential treatment options for both conditions.
Stopping expensive biological drugs for patients in remission or with low disease activity can save €7,133 per patient. This results in a small loss of 0.022 quality-adjusted life years and an increase in arthritis flares by 0.41 flares per year.
A team of University of Tsukuba-centered researchers discovered a novel biomarker, citrullinated ITIH4 protein, that is highly specific to patients with rheumatoid arthritis. The levels of this protein decreased in correlation with the reduction of disease activity score after effective treatment.
Researchers developed a novel PET tracer that targets joint inflammation and can visualize active inflammation sites in arthritic joints. The tracer, fluorine-18 F-FEDAC, shows promise for early detection of rheumatoid arthritis, potentially improving treatment outcomes.
A new study published in Arthritis Care & Research reveals that severe obesity is linked to faster progression of disability in patients with rheumatoid arthritis. Intentional weight loss may help prevent worsening disability, but unintentional weight loss can be a poor prognostic sign.
A new mouse study reveals that environmental pollutants like dioxin and cigarette smoke interact with the HLA gene variant to cause more severe rheumatoid arthritis. The disease leads to excessive bone destruction through overactive osteoclasts, a process targeted by researchers for potential new treatments.
Researchers used joint tissue biopsy to identify genes linked to disease progression and response to treatment in rheumatoid arthritis patients. This new technique holds promise for personalized therapy and improved patient outcomes.