Articles tagged with Rheumatoid Arthritis
A study of women with rheumatoid arthritis found that weight gain, not loss, was associated with a lower mortality risk. Those who experienced severe unintentional weight loss had the highest risk of death decades later.
Research from Umea University shows that jawbone loss caused by periodontitis precedes and correlates with rheumatoid arthritis. Elevated levels of RANKL in the blood also indicate a causal link between the two conditions.
Researchers found that weight loss, particularly severe unintentional weight loss, increases the risk of death in patients with rheumatoid arthritis. In contrast, healthy weight gain has no effect on mortality risk for these patients.
Research indicates that being overweight or obese can lead to poorer RA treatment outcomes and higher mortality risk. Studies show that patients with healthy weights are more likely to achieve remission, while those who are overweight or obese face a 25-47% lower chance of sustained remission despite similar treatments.
Researchers found that vitamin D is effective in preventing the onset of inflammation but less effective once inflammatory disease is established. The study suggests that patients with rheumatoid arthritis may require higher doses of vitamin D or a new treatment to bypass vitamin D insensitivity in immune cells.
Researchers have discovered a potent drug-like compound that inhibits Toll-like receptor 8, a key player in autoimmune diseases. The compound, CU-CPT8m, exerts potent anti-inflammatory effects on tissue, offering a potential breakthrough for treating rheumatoid arthritis and other autoimmune conditions.
Researchers have identified a peptide called θ-defensin 1 (RTD-1) found in Old World monkeys that has the potential to stop or reverse rheumatoid arthritis progression. RTD-1 treatment resulted in greater disease resolution and higher complete disease resolution rates compared to established treatments.
A new study lists beneficial foods for managing rheumatoid arthritis symptoms and progression, including blueberries, ginger, and green tea. Patients can support disease management through food and diet without harmful side effects.
A new study suggests that biologic therapies for rheumatoid arthritis during pregnancy do not significantly increase the risk of opportunistic infections in infants. Researchers found no significant difference in infection rates among infants whose mothers used biologics compared to those who did not.
A study found that temporarily pausing methotrexate use for two weeks after flu vaccination improves the immune response in RA patients, with a higher rate of satisfactory responses and seroprotection rates. This approach has potential clinical implications, including improved vaccine efficacy without increasing disease activity.
Research found associations between opioids and SSRIs with increased osteoporotic fracture risk in RA patients, particularly with long-term use. Patients who developed fractures had higher disease activity, longer disease duration, and more comorbidity at baseline compared to those who did not experience fractures.
Researchers have developed a new method to preserve tissue samples for rheumatoid arthritis research, allowing for the analysis of multiple samples in a uniform way. This approach has the potential to identify specific inflammatory pathways and guide treatment decisions.
A digital health coaching program improved RA patients' well-being, decreased symptoms, and reduced flare frequency. The program showed significant increases in physical activity, sleep hours, and medication adherence.
Researchers developed a new tool to analyze cellular and molecular profiles of synovial tissue and peripheral blood, which may help unlock clues about rheumatoid arthritis. The study found that robust cell yield from synovial tissue enables mass and flow cytometric data.
Research reveals obesity is associated with reduced rates of remission and increased rates of disability in RA patients. Effective weight screening and management should be a central feature of RA treatment plans.
Research finds that obesity is associated with a higher degree of synovitis in RA patients, leading to worse clinical responses to treatment. Patients who are overweight or obese tend to have higher histological scores and more inflammation in their joints.
Research finds that RA patients who meet certain factors, including younger age and low CRP levels, are more likely to successfully taper their biologic drugs. Patients without concomitant steroid use also tend to have better outcomes.
A study of 1,678 RA patients found no increased risk of second malignancy among those treated with biologics after a primary cancer diagnosis. Hazard ratios showed a slightly higher mortality rate among RA patients who received biologics before their cancer diagnosis.
Research reveals that rheumatoid arthritis may increase the risk of developing chronic obstructive pulmonary disease (COPD). Individuals with chronic inflammatory conditions are at a higher risk, emphasizing the need for controlled inflammation and early symptom monitoring.
Patients who experience negative symptoms during biosimilar treatment attribute them incorrectly to the new medication. Effective communication between clinicians and patients is crucial for successful transitioning.
Scientists developed a hydrogel that detects nitric oxide and absorbs excess fluids, delivering drugs to treat rheumatoid arthritis. The gel uses acrylamide as a base material and NOCCL crosslinker to trap drug molecules.
A six-year study of nearly 1 million people found that autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel diseases increase cardiovascular risk and mortality. The study's results highlight the need for better tools to predict cardiovascular events in these populations.
Research shows that administering shingles vaccine several weeks prior to starting tofacitinib for rheumatoid arthritis results in robust immune responses. This is particularly beneficial for patients with rheumatoid arthritis who are at a higher risk of developing shingles.
Research published in Annals of the Rheumatic Diseases found a link between prolonged use of oral contraceptives and reduced risk of developing rheumatoid arthritis. However, breastfeeding was not associated with a significant protective effect after accounting for influential factors.
A new study published in Arthritis Care & Research found that male workers in the manufacturing sector have a higher risk of developing rheumatoid arthritis than those in other sectors. Women working in certain occupations, such as assistant nurses and attendants, also showed a slightly increased risk of rheumatoid arthritis.
A new study introduces a finger prick test for patients with rheumatoid arthritis and other autoimmune conditions taking adalimumab, enabling easy monitoring of drug levels without full blood draws. This method simplifies therapeutic drug monitoring, potentially benefiting patient care.
Researchers identified two proteins derived from common gut bacteria that trigger immune responses in RA patients, supporting a link between intestinal and synovial autoimmunity. The discovery provides a potential pathway for improving diagnosis and treatment of rheumatoid arthritis.
Finnish researchers discovered gene mutations in white blood cells of patients with rheumatoid arthritis, which accumulate similarly to cancer-causing mutations. The mutations were found only in mature T cells and had a permanent impact on the disease.
A recent study found that individuals with rheumatoid arthritis who consumed fish at least 2 times a week had lower disease activity compared to those who ate fish less than once a month. The study, which assessed 176 patients, suggests that fish consumption may lower inflammation related to rheumatoid arthritis.
A new analysis of 2006-2014 Medicare data found that 41% of rheumatoid arthritis patients were regular opioid users by 2014. Factors associated with regular opioid use included younger age, female sex, and back pain.
A new relapse prediction tool has been developed to reduce the cost of rheumatoid arthritis treatment. The tool, which combines two measurements to predict the risk of relapse in patients with RA, allows for successful dose reduction of disease-modifying anti-rheumatic drugs (DMARDs), resulting in significant cost savings.
A meta-analysis found that the excess risk of cardiovascular events in RA patients has decreased since the year 2000. The reduced risk appears to be related to better management of cardiovascular risk and control of chronic systemic inflammation.
A large population study found that passive smoking in childhood increased the risk of developing rheumatoid arthritis (RA) in adulthood. Smoking also speeds up disease progression in ankylosing spondylitis, a painful and disabling form of arthritis.
A Danish study found a clear downward trend in knee and hip replacements in RA patients since the introduction of biological DMARDs to treatment protocols. The incidence of total knee replacements decreased by 0.20 per year after 2003, while the incidence of total hip replacements also showed a downward trend.
A population study found that being overweight or obese, as defined by body mass index, abdominal obesity, and higher body fat percentage, is associated with a higher risk of developing rheumatoid arthritis in women. In contrast, no clear association was found between RA risk and BMI criteria for men.
A meta-analysis published at EULAR 2017 found that early treatment of pre-rheumatoid arthritis (pre-RA) significantly reduces the risk of developing rheumatoid arthritis (RA). Patients who received active treatment had a lower risk of RA at 52 weeks or more compared to those on placebo.
The study suggests that patients with rheumatoid arthritis should use a combination of drugs known as triple therapy instead of biologic therapy, due to the high costs involved. The analysis found that triple therapy is as effective as switching directly to biologics, but at a significantly lower cost.
A randomized study found that group-based quality improvement sessions improved TTT scores from 11% to 57% in intervention patients, while control patients saw a decline to 25%. The learning collaborative positively impacted implementation of the recommended care approach.
New studies examine rheumatoid arthritis patients' mortality, disease activity, and physical function over 20 years. Early treatment has been shown to have a significant impact on long-term outcomes, with patients experiencing relatively good results.
New research reveals that obesity influences blood tests for C-reactive protein and erythrocyte sedimentation rate, particularly in women with rheumatoid arthritis. The study found greater BMI was associated with increased CRP levels in these individuals.
Providing pedometers to individuals with rheumatoid arthritis increased activity levels and decreased fatigue. The study's findings suggest that simple increases in physical activity can help manage fatigue.
Researchers at Uppsala University have discovered that antibodies against cartilage protein collagen II are associated with a good prognosis in rheumatoid arthritis. The study found that patients with these antibodies showed increased signs of inflammation during the first six months after diagnosis, but no difference later on.
Researchers found that IL-21 producing CD4+ T cells contribute to joint inflammation by activating synovial fibroblasts. This discovery holds promise for targeted therapies to decrease inflammation and improve quality of life for patients.
Researchers at University of Pittsburgh found a potential inverse relationship between schizophrenia and rheumatoid arthritis, with eight genes showing opposing effects on risk. The study suggests that immune system dysfunction may play a role in both disorders.
Researchers developed an assay to detect autoantibodies present in rheumatoid arthritis patients, finding that memory B cells secrete these molecules. The study suggests targeting these immune system cells could lead to a cure for the disease.
A research team at Brigham and Women's Hospital has identified a unique subset of T-cells that collaborate with other immune cells to drive inflammation in peripheral tissues. These cells display unusual biological features and stimulate B-cells to produce antibodies, contributing to tissue damage in autoimmune diseases.
A new subset of helper T-cells, called peripheral helper T-cells (Tph cells), has been identified as a key player in the development of rheumatoid arthritis. These genetically distinct T-cells are found in tissues affected by RA and can induce plasma cell differentiation and inflammation.
Research found no association between high monitoring (health detail oriented) and more information receipt for RA patients, while high blunting was linked to more info for OA patients. This challenges typical patterns in acute and chronic disease coping literature.
The review highlights the need for personalized biologic dosing in rheumatoid arthritis treatment due to varying patient responses and drug concentrations. Implementing individualized doses can improve therapeutic outcomes while reducing costs.
Researchers found a common bacterial cause of gum disease may trigger rheumatoid arthritis by inducing hypercitrullination, leading to inflammation and tissue damage. A study published in Science Translational Medicine identified Aggregatibacter actinomycetemcomitans as the primary pathogen responsible for this process.
Researchers at the University of Birmingham identified two types of synovial fibroblast cells responsible for cartilage damage in RA patients. The study suggests targeting these cell processes could lead to more effective and manageable treatments.
Researchers identified a gene variant that raises risk of severe rheumatoid arthritis, potentially leading to targeted treatment. The study found that the variant correlates with increased MIF production and structural changes in cells, resembling cancerous tissues.
A study published in Neurology shows a link between mothers with rheumatoid arthritis and children with epilepsy. Children born to mothers with rheumatoid arthritis were up to 90% more likely to develop epilepsy than those without RA. The study suggests changes in the environment for the fetus may play a role in developing epilepsy.
Researchers found that smoking and excess weight hindered the ability of RA patients to achieve optimal control of inflammation and symptoms. Patients who were overweight or obese saw less symptom relief compared to those with a healthy weight.
A global survey found that patients with RA are often not involved in decision-making, despite doctors acknowledging the importance of patient engagement. The study highlights gaps in communication between healthcare providers and their patients, with few patients having shared treatment goals or feeling comfortable voicing concerns.
A 10-year precision trial involving 24,081 patients in 13 countries investigated the cardiovascular safety of widely used nonsteroidal anti-inflammatory drugs and COX-2-specific inhibitors. The trial found that celecoxib shares similar cardiovascular toxicity with rofecoxib, leading to increased nuance in analgesic recommendations for ...
Researchers found that patients treated with rituximab as their first biologic had a lower mortality risk compared to those treated with TNFi. The study included 353 patients with RA-ILD and analyzed five-year mortality rates, with RTX-treated patients showing numerically lower but not statistically significant risks.
Researchers identified three gene expression signatures that can help rheumatologists predict which patients are more likely to respond to certain therapies. The findings could lead to higher response rates and reduced likelihood of ineffective treatment, ultimately improving patient care.
Researchers found that people with RA have double the risk of CV events as those in the general population, rates similar to those with type-2 diabetes. Chronic inflammation in RA contributes independently to cardiovascular risks for these patients.
Researchers found that statin initiation was associated with a 33% reduction in all-cause mortality among AS and PsA patients. The study suggests that statins' dual benefits of lowering lipids and reducing inflammation may be the reason for this significant benefit.