Articles tagged with Rheumatoid Arthritis
A recent review of over 70 clinical trials found that rheumatoid arthritis treatments alone are unlikely to improve mental health outcomes. Instead, integrated psychological support alongside routine care may achieve optimal mental health outcomes for patients with rheumatoid arthritis and depression.
Researchers at Osaka University identified a cellular network involving Th17 cells and stromal cells that secretes inflammatory cytokines to initiate and maintain rheumatoid arthritis. By targeting this network, a novel immunotherapeutic approach has been proposed to reduce chronic joint inflammation.
New research suggests that rheumatoid arthritis drugs taken during pregnancy are unlikely to cause a large increase in serious infections in children. The study found no marked excess risk of serious infections among RA offspring exposed to TNFi drugs compared to unexposed control children and offspring from the general population.
A study found that pregnant women with rheumatoid arthritis using certain RA drugs did not have a marked excess risk of serious side effects compared to unexposed children. The research showed that TNF inhibitors may not compromise the child's ability to fight infections.
A study published in Nature Communications has found an unexpected overlap between the causes of rheumatoid arthritis and Huntington's disease. The researchers developed a novel algorithm to analyze epigenetic data, identifying new cell signaling pathways and potential treatment options for both conditions.
Stopping expensive biological drugs for patients in remission or with low disease activity can save €7,133 per patient. This results in a small loss of 0.022 quality-adjusted life years and an increase in arthritis flares by 0.41 flares per year.
A team of University of Tsukuba-centered researchers discovered a novel biomarker, citrullinated ITIH4 protein, that is highly specific to patients with rheumatoid arthritis. The levels of this protein decreased in correlation with the reduction of disease activity score after effective treatment.
Researchers developed a novel PET tracer that targets joint inflammation and can visualize active inflammation sites in arthritic joints. The tracer, fluorine-18 F-FEDAC, shows promise for early detection of rheumatoid arthritis, potentially improving treatment outcomes.
A new study published in Arthritis Care & Research reveals that severe obesity is linked to faster progression of disability in patients with rheumatoid arthritis. Intentional weight loss may help prevent worsening disability, but unintentional weight loss can be a poor prognostic sign.
A new mouse study reveals that environmental pollutants like dioxin and cigarette smoke interact with the HLA gene variant to cause more severe rheumatoid arthritis. The disease leads to excessive bone destruction through overactive osteoclasts, a process targeted by researchers for potential new treatments.
Researchers used joint tissue biopsy to identify genes linked to disease progression and response to treatment in rheumatoid arthritis patients. This new technique holds promise for personalized therapy and improved patient outcomes.
Rheumatoid arthritis patients have higher mortality rates due to complications from the disease and its treatment. Cardiovascular and respiratory conditions, including pneumonia, are major contributors to these deaths.
Researchers found that only 15% of patients with rheumatoid arthritis could use a HandiHaler inhaler correctly, while 94% of healthy controls could. The study highlights the importance of ensuring patients can properly use their prescribed inhalers to manage their respiratory disease.
A new, portable microfluidic device has been developed to facilitate single-cell analysis and identify fibroblast subtypes in rheumatoid arthritis (RA) patients. The device, which can be assembled for $600, enables researchers to profile joint synovial tissue from RA patients on-site, optimizing sample quality.
Researchers identified distinct patterns in gene expression in synovial tissue samples, revealing differences in pain mechanisms among rheumatoid arthritis patients. These findings may help clinicians develop targeted treatment strategies for patients with minimal inflammation but high disease activity scores.
The NIH has released datasets for rheumatoid arthritis and systemic lupus erythematosus disease tissue, providing clues about potential research targets. Researchers can access the data to explore new approaches to understanding autoimmunity and developing medicines.
Researchers at the University of Central Florida have discovered a link between Mycobacterium avium subspecies paratuberculosis (MAP) and rheumatoid arthritis. The bacteria, commonly found in milk and beef, can trigger autoimmune responses in genetically predisposed individuals.
A recent study published in Rheumatology found that menopause worsens physical function and functional decline in women with rheumatoid arthritis, leading to a significant impact on quality of life. Women experience rheumatoid arthritis at a rate three times greater than men, with more severe declines and increased disability.
A study published in Immunity reveals that the immunomodulatory cytokine IL-23's pro-inflammatory activity critically depends on structural activation of the cytokine by its receptor, IL-23R. The findings provide new insights into autoimmune and inflammatory diseases such as psoriasis, rheumatoid arthritis, and Crohn's disease.
ViLim Ball technology created by Lithuanian startup company Fidens helps reduce uncontrollable shaking hands and morning stiffness associated with essential tremor and rheumatoid arthritis. The device is effective in 7 out of 10 cases and has been tested with human subjects.
A nationwide cohort study found a link between maternal rheumatoid arthritis and increased risks of thyroid disease, epilepsy, and rheumatoid arthritis in offspring. The study's results highlight the importance of monitoring child development if exposed to rheumatoid arthritis in utero.
A study of women with rheumatoid arthritis found that weight gain, not loss, was associated with a lower mortality risk. Those who experienced severe unintentional weight loss had the highest risk of death decades later.
Research from Umea University shows that jawbone loss caused by periodontitis precedes and correlates with rheumatoid arthritis. Elevated levels of RANKL in the blood also indicate a causal link between the two conditions.
Research indicates that being overweight or obese can lead to poorer RA treatment outcomes and higher mortality risk. Studies show that patients with healthy weights are more likely to achieve remission, while those who are overweight or obese face a 25-47% lower chance of sustained remission despite similar treatments.
Researchers found that weight loss, particularly severe unintentional weight loss, increases the risk of death in patients with rheumatoid arthritis. In contrast, healthy weight gain has no effect on mortality risk for these patients.
Researchers found that vitamin D is effective in preventing the onset of inflammation but less effective once inflammatory disease is established. The study suggests that patients with rheumatoid arthritis may require higher doses of vitamin D or a new treatment to bypass vitamin D insensitivity in immune cells.
Researchers have discovered a potent drug-like compound that inhibits Toll-like receptor 8, a key player in autoimmune diseases. The compound, CU-CPT8m, exerts potent anti-inflammatory effects on tissue, offering a potential breakthrough for treating rheumatoid arthritis and other autoimmune conditions.
Researchers have identified a peptide called θ-defensin 1 (RTD-1) found in Old World monkeys that has the potential to stop or reverse rheumatoid arthritis progression. RTD-1 treatment resulted in greater disease resolution and higher complete disease resolution rates compared to established treatments.
A new study lists beneficial foods for managing rheumatoid arthritis symptoms and progression, including blueberries, ginger, and green tea. Patients can support disease management through food and diet without harmful side effects.
A new study suggests that biologic therapies for rheumatoid arthritis during pregnancy do not significantly increase the risk of opportunistic infections in infants. Researchers found no significant difference in infection rates among infants whose mothers used biologics compared to those who did not.
A study found that temporarily pausing methotrexate use for two weeks after flu vaccination improves the immune response in RA patients, with a higher rate of satisfactory responses and seroprotection rates. This approach has potential clinical implications, including improved vaccine efficacy without increasing disease activity.
Research found associations between opioids and SSRIs with increased osteoporotic fracture risk in RA patients, particularly with long-term use. Patients who developed fractures had higher disease activity, longer disease duration, and more comorbidity at baseline compared to those who did not experience fractures.
Researchers have developed a new method to preserve tissue samples for rheumatoid arthritis research, allowing for the analysis of multiple samples in a uniform way. This approach has the potential to identify specific inflammatory pathways and guide treatment decisions.
A digital health coaching program improved RA patients' well-being, decreased symptoms, and reduced flare frequency. The program showed significant increases in physical activity, sleep hours, and medication adherence.
Researchers developed a new tool to analyze cellular and molecular profiles of synovial tissue and peripheral blood, which may help unlock clues about rheumatoid arthritis. The study found that robust cell yield from synovial tissue enables mass and flow cytometric data.
Research reveals obesity is associated with reduced rates of remission and increased rates of disability in RA patients. Effective weight screening and management should be a central feature of RA treatment plans.
Research finds that obesity is associated with a higher degree of synovitis in RA patients, leading to worse clinical responses to treatment. Patients who are overweight or obese tend to have higher histological scores and more inflammation in their joints.
Research finds that RA patients who meet certain factors, including younger age and low CRP levels, are more likely to successfully taper their biologic drugs. Patients without concomitant steroid use also tend to have better outcomes.
A study of 1,678 RA patients found no increased risk of second malignancy among those treated with biologics after a primary cancer diagnosis. Hazard ratios showed a slightly higher mortality rate among RA patients who received biologics before their cancer diagnosis.
Research reveals that rheumatoid arthritis may increase the risk of developing chronic obstructive pulmonary disease (COPD). Individuals with chronic inflammatory conditions are at a higher risk, emphasizing the need for controlled inflammation and early symptom monitoring.
Patients who experience negative symptoms during biosimilar treatment attribute them incorrectly to the new medication. Effective communication between clinicians and patients is crucial for successful transitioning.
Scientists developed a hydrogel that detects nitric oxide and absorbs excess fluids, delivering drugs to treat rheumatoid arthritis. The gel uses acrylamide as a base material and NOCCL crosslinker to trap drug molecules.
A six-year study of nearly 1 million people found that autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel diseases increase cardiovascular risk and mortality. The study's results highlight the need for better tools to predict cardiovascular events in these populations.
Research shows that administering shingles vaccine several weeks prior to starting tofacitinib for rheumatoid arthritis results in robust immune responses. This is particularly beneficial for patients with rheumatoid arthritis who are at a higher risk of developing shingles.
Research published in Annals of the Rheumatic Diseases found a link between prolonged use of oral contraceptives and reduced risk of developing rheumatoid arthritis. However, breastfeeding was not associated with a significant protective effect after accounting for influential factors.
A new study published in Arthritis Care & Research found that male workers in the manufacturing sector have a higher risk of developing rheumatoid arthritis than those in other sectors. Women working in certain occupations, such as assistant nurses and attendants, also showed a slightly increased risk of rheumatoid arthritis.
A new study introduces a finger prick test for patients with rheumatoid arthritis and other autoimmune conditions taking adalimumab, enabling easy monitoring of drug levels without full blood draws. This method simplifies therapeutic drug monitoring, potentially benefiting patient care.
Researchers identified two proteins derived from common gut bacteria that trigger immune responses in RA patients, supporting a link between intestinal and synovial autoimmunity. The discovery provides a potential pathway for improving diagnosis and treatment of rheumatoid arthritis.
A new analysis of 2006-2014 Medicare data found that 41% of rheumatoid arthritis patients were regular opioid users by 2014. Factors associated with regular opioid use included younger age, female sex, and back pain.
Finnish researchers discovered gene mutations in white blood cells of patients with rheumatoid arthritis, which accumulate similarly to cancer-causing mutations. The mutations were found only in mature T cells and had a permanent impact on the disease.
A recent study found that individuals with rheumatoid arthritis who consumed fish at least 2 times a week had lower disease activity compared to those who ate fish less than once a month. The study, which assessed 176 patients, suggests that fish consumption may lower inflammation related to rheumatoid arthritis.
A large population study found that passive smoking in childhood increased the risk of developing rheumatoid arthritis (RA) in adulthood. Smoking also speeds up disease progression in ankylosing spondylitis, a painful and disabling form of arthritis.
A new relapse prediction tool has been developed to reduce the cost of rheumatoid arthritis treatment. The tool, which combines two measurements to predict the risk of relapse in patients with RA, allows for successful dose reduction of disease-modifying anti-rheumatic drugs (DMARDs), resulting in significant cost savings.
A meta-analysis found that the excess risk of cardiovascular events in RA patients has decreased since the year 2000. The reduced risk appears to be related to better management of cardiovascular risk and control of chronic systemic inflammation.
A Danish study found a clear downward trend in knee and hip replacements in RA patients since the introduction of biological DMARDs to treatment protocols. The incidence of total knee replacements decreased by 0.20 per year after 2003, while the incidence of total hip replacements also showed a downward trend.
A meta-analysis published at EULAR 2017 found that early treatment of pre-rheumatoid arthritis (pre-RA) significantly reduces the risk of developing rheumatoid arthritis (RA). Patients who received active treatment had a lower risk of RA at 52 weeks or more compared to those on placebo.
A population study found that being overweight or obese, as defined by body mass index, abdominal obesity, and higher body fat percentage, is associated with a higher risk of developing rheumatoid arthritis in women. In contrast, no clear association was found between RA risk and BMI criteria for men.
The study suggests that patients with rheumatoid arthritis should use a combination of drugs known as triple therapy instead of biologic therapy, due to the high costs involved. The analysis found that triple therapy is as effective as switching directly to biologics, but at a significantly lower cost.
A randomized study found that group-based quality improvement sessions improved TTT scores from 11% to 57% in intervention patients, while control patients saw a decline to 25%. The learning collaborative positively impacted implementation of the recommended care approach.
New studies examine rheumatoid arthritis patients' mortality, disease activity, and physical function over 20 years. Early treatment has been shown to have a significant impact on long-term outcomes, with patients experiencing relatively good results.