Articles tagged with Rheumatoid Arthritis
Researchers identified genes overexpressed in mouse models of arthritis, showing that TARM1 suppresses immune system response and collagen-induced arthritis. TARM1 inhibition weakens autoimmune arthritis, suggesting a new treatment target for autoimmune diseases.
Scientists create magnesium-based micromotors that produce hydrogen bubbles, which propel the motors and release hydrogen gas into inflamed joints. This therapy shows promise in reducing joint pain, swelling, and bone erosion in animal models of rheumatoid arthritis.
A growing body of evidence suggests that losing helminth parasites could contribute to aging-associated inflammation. Intentional infection with helminths or helminth-derived proteins may have anti-inflammaging properties, potentially preventing age-related diseases such as heart disease and dementia.
Autoimmune diseases like T1D, SLE, MS, and RA exhibit common genetic risk, chronic inflammation, and tissue damage mechanisms. Target tissues participate in a deleterious dialogue with the immune system, contributing to disease progression.
Researchers update current research focus from 'immune-centric-only' view to better understand autoimmune diseases like type 1 diabetes and multiple sclerosis. The study identifies common gene expression changes at target tissues, highlighting the importance of studying both immune system and target tissues.
A new study analyzed medical claims data from Taiwan, finding that patients with rheumatoid arthritis live longer after disease-modifying antirheumatic drugs called biologics became available in 2003. The estimated lifetime cost was $72,953, highlighting the need for cost-effectiveness evaluation.
A study published in PLOS ONE found that patients with rheumatoid arthritis in remission display significantly higher temperatures in the forefoot regions compared to healthy adults. The research used thermal imaging to analyze temperature patterns in over 31 patients and more than 52 healthy individuals.
A new drug treatment, otilimab, has shown promising results in reducing both inflammation and pain in people with rheumatoid arthritis. In a multicentre trial, patients who received otilimab demonstrated significant improvements in pain scores, while also experiencing reduced tender and swollen joints.
Individuals with rheumatoid arthritis are more likely to develop atherosclerosis when exposed to certain bacteria causing periodontal disease. Studies suggest that immune responses to these bacteria may play a role in the increased cardiovascular disease risk associated with rheumatoid arthritis.
Researchers have pinpointed two new potential therapeutic targets for rheumatoid arthritis, a painful inflammatory disease affecting millions worldwide. The study reveals a novel cell population and mechanism driving joint inflammation, offering new avenues for therapy development.
A new study found that patients with rheumatoid arthritis taking biologic DMARDs have a 17% lower risk of developing dementia compared to those on conventional synthetic DMARDs. The treatment reduces inflammation, which may explain the decreased risk.
The new RA guideline recommends starting patients on methotrexate and continuing with treatment, rather than rapidly switching to other drugs. The guideline also aims to minimize the use of glucocorticoids due to their serious side effects.
A new study from Queen Mary University of London discovers that certain small molecules in patients' blood can predict response to disease-modifying anti-rheumatic drugs (DMARDs). Up to 50% of RA patients are unresponsive to treatment, and the research provides potential solutions for predicting patient responsiveness.
A new study identifies four profiles of 24-hour physical activity and sleep among adults with rheumatoid arthritis, lupus, and knee osteoarthritis. Younger age, lack of sitting jobs, and outside walking habits are associated with balanced activity.
The study found that patients who participated in the SMART program made more informed decisions about their medical treatment options six months later. The SMART protocol helps improve gist reasoning abilities, enabling patients to focus on key facts and make decisions aligned with their personal values.
A genetic analysis of over 850,000 Europeans found a link between obesity-related genes and an increased risk of rheumatoid arthritis. Obesity was shown to be associated with a higher risk of rheumatoid arthritis for both men and women.
A new study published in PLOS Medicine suggests that rheumatoid arthritis patients with and without autoantibodies have distinct conditions. Longitudinal data from 1,285 RA patients showed improved disease activity but varying long-term outcomes depending on autoantibody status.
A new study found that rheumatoid arthritis is associated with a 23% increased risk of developing type 2 diabetes. The research suggests that systemic inflammation may contribute to the development of diabetes in individuals with RA, highlighting the need for more intensive screening and management of diabetes risk factors.
The analysis found that adherence to the Mediterranean diet was associated with a decreased risk of rheumatoid arthritis in women who smoked or used to smoke. Among these individuals, high adherence to the Mediterranean diet resulted in 383 cases per 1 million people per year compared to 515 cases per 1 million people per year.
A two-year study by the University of Leeds has linked treatment of rheumatoid arthritis (RA) with improvements in vascular stiffness, an indicator of cardiovascular disease. The findings could inform management strategy for patients with RA and highlight the need to consider increased CVD risk factors.
A global study of over 320,000 patients found that hydroxychloroquine plus azithromycin increases cardiovascular risks, including mortality, in the short and long term. The combination therapy was associated with a 65% relative increase in cardiovascular-related mortality compared to sulfasalazine.
Researchers at Case Western Reserve University found that hydroxychloroquine is not effective in preventing COVID-19 in patients with lupus and rheumatoid arthritis. The study, which analyzed data from over 159 patients, suggests that HCQ may not be active against the SARS-CoV-2 virus in humans.
A study published in Annals of the Rheumatic Diseases identified a genetic variant associated with an increased risk of interstitial lung disease among Japanese rheumatoid arthritis patients. The variant, located in the RPA3 gene, is linked to fibrosis and triggers complications in RA patients.
A recent analysis found that adults with rheumatoid arthritis had a lower risk of developing type 2 diabetes compared to other individuals. The study, published in Arthritis Care & Research, used a US commercial insurance database and included over 449,000 people.
The SEMIRA trial found that continuous glucocorticoid regimens controlled disease activity better than discontinuation, but the latter was also effective in preventing long-term side effects. Treatment success rates were 77% for continued prednisone and 65% for tapering regimen.
Researchers at Rockefeller University have identified a new type of cell, known as PRIME cells, whose presence in the bloodstream increases before a flare-up, allowing for potential early warnings. The discovery may hold key to understanding rheumatoid arthritis root causes and developing therapies to prevent flares.
Researchers have discovered a novel cell type called PRIME cells that accumulate in the blood before rheumatoid arthritis flares, allowing for potential early prediction of disease onset. The findings could lead to better management of the condition and its symptoms.
Two studies found that methotrexate treatment does not increase the risk of chronic interstitial lung disease in RA patients, but may even delay its development. This is significant as ILD is a common complication of RA and can be life-threatening.
Patients with high disease activity in rheumatoid arthritis are at a higher risk of developing venous thromboembolism. Treatment with biologic disease-modifying antirheumatic drugs (bDMARDs) such as TNF inhibitors can reduce this risk by nearly half compared to conventional synthetic drugs.
The EULAR 2020 study investigates the connection between breast cancer, anti-hormonal therapy, and rheumatoid arthritis. The results show that the risk of breast cancer in women with RA is lower than in women with healthy joints, and no association was found between anti-hormonal breast cancer prophylaxis and later RA.
A new study finds that Medicare patients with rheumatoid arthritis are seeing higher out-of-pocket spending for specialty biologic medications, despite the closure of the Part D coverage gap. The annual average cost has dropped only 21% between 2010 and 2019.
A team of Russian researchers from the Moscow Institute of Physics and Technology analyzed a 1789 portrait by Dmitry Levitsky, revealing that the two extension pieces were indeed painted by the artist. The study used modern methods for local analysis of materials and nanomaterials to confirm the painter's involvement.
Researchers discovered how protein A20 prevents inflammation through a non-enzymatic mechanism, opening up new possibilities for treatment. The study builds upon earlier work demonstrating A20's anti-inflammatory activity and reveals its role in preventing disease development.
A recent study published in Arthritis & Rheumatology found that asthma and chronic obstructive pulmonary disease (COPD) are associated with a higher risk of developing rheumatoid arthritis. Women with asthma were 53% more likely to develop rheumatoid arthritis, while those with COPD were 89% more likely.
Patients new to rheumatology care and those in rural community health systems were more likely to quit smoking, while seropositive patients faced greater challenges. Healthcare teams supporting tobacco cessation play a crucial role in helping these patients overcome their addiction.
Researchers found that patients with rheumatoid arthritis who had adequate folate levels were less likely to die from cardiovascular disease. The study suggests that maintaining optimal folate levels through diet and supplements could help reduce this risk in these patients.
Walter and Eliza Hall Institute researchers have pinpointed immune cells called natural killer (NK) cells as an unexpected source of the inflammatory protein GM-CSF in rheumatoid arthritis. The discovery may indicate potential new therapeutic targets for reducing joint inflammation in this autoimmune disease.
A study of 443 women with RA found that those who followed an ideal clinical pathway had a 40% lower risk of complicated birth or miscarriage. This suggests that simple interventions can positively impact pregnancy outcomes in women with rheumatoid arthritis.
Researchers at UC Riverside found that the drug tofacitinib repairs permeability defects in the gut's epithelium, reducing inflammation and improving mucosal healing. The study is the first to show the direct effect of tofacitinib on intestinal epithelial cell functions.
Recent expert reviews provide valuable updates on vitamin D's role in maternal health, rheumatoid arthritis, respiratory disease, and muscle. Key findings include the importance of routine vitamin D supplementation in childhood and pregnancy to support calcium metabolism.
A recent study published in Annals of the Rheumatic Diseases reveals a novel link between the gut microbiome and host genome in the pathology of rheumatoid arthritis. The research found that bacteria belonging to the genus Prevotella were abundant in the gut microbiota of Japanese patients with rheumatoid arthritis.
Researchers used thermal imaging to assess rheumatoid arthritis, finding increased palm and finger temperatures in patients. The study suggests thermal imaging could aid in early detection of the disease, which affects over 400,000 adults in the UK.
A Mayo Clinic-led study found that people with inflammatory bowel disease, Type 1 diabetes or blood clots may be at increased risk of developing rheumatoid arthritis. Comorbidities are linked to poorer outcomes for patients with rheumatoid arthritis, including worsened physical disability and increased mortality.
Researchers at Osaka University have discovered a previously unknown type of RA-causing cell within arthritic joints that could be a target for new treatments. The newly discovered cells, dubbed 'AtoMs', have properties that make them amenable to therapeutic targeting.
Researchers at Penn Medicine have discovered that a higher dose of rituximab is more likely to put patients with pemphigus into complete remission compared to the standard treatment regimen. The study found that patients over 65 had a nearly 10-fold greater chance of achieving complete remission, while those with moderate to severe obe...
A new study found that tocilizumab is more effective than rituximab in reducing disease activity in patients with rheumatoid arthritis who have low B-cell infiltration in their synovial tissue. Tocilizumab achieved significant improvements in both low levels and falls in disease activity, particularly in the B-cell poor patient subgroup.
A new study found that biologics improve clinical disease activity in both elderly-onset and young-onset rheumatoid arthritis patients similarly at 48 weeks. The researchers also discovered similar drug maintenance and adverse event discontinuation rates between the two age groups.
Researchers found that using ultrasound to guide treatment strategy does not improve treatment decisions in patients with early rheumatoid arthritis. The study used MRI imaging to assess inflammatory activity and structural damage progression, but found no significant difference between the two groups.
A study found that RA patients receiving immune checkpoint inhibitors for cancer experience flares, with a 50% rate. The researchers also noted that the rate of immune-related adverse events was comparable to those without autoimmune diseases.
Researchers found a significant increase in opioid-use disorder hospitalizations among patients with common rheumatic conditions like gout, osteoarthritis, and fibromyalgia. The study suggests that these patients are at risk of developing an opioid use disorder due to chronic musculoskeletal diseases.
A plant-based diet has been shown to reduce inflammation and improve symptoms of rheumatoid arthritis through various mechanisms. Studies have found that plant-based diets are low in fat and high in fiber, which can reduce inflammatory markers and promote healthy gut bacteria.
A University of Tsukuba-led study found that OX40-expressing follicular helper T cells control rheumatoid arthritis by promoting inflammation through autoantibody sialylation. The interaction between OX40 on T cells and OX40L on antibody-producing B cells led to reduced sialylation, increasing autoimmune inflammation.
In a large 24-week study, rheumatoid arthritis patients saw substantial improvement from daily use of an experimental compound. Filgotinib, a selective JAK-1 inhibitor, showed significant benefits in reducing joint swelling and improving disease activity compared to placebo.
Researchers develop a new method to detect rheumatoid arthritis by analyzing hand blood content using infrared spectroscopy. The technique can provide an early diagnosis and assess treatment effectiveness, potentially leading to better long-term outcomes for patients.
A first-in-human Phase 1/Phase II study demonstrates the safety and efficacy of intravenous administration of technetium-99m tilmanocept for monitoring rheumatoid arthritis disease activity. The imaging agent binds to activated macrophages, providing joint-specific information on RA disease involvement.
Research supported by the Accelerating Medicines Partnership has provided new insights into tissue damage in rheumatoid arthritis and lupus. Novel molecular signatures have been identified in kidney cells and specific white blood cells may reflect their active role in disease process.
A pilot study presented at EULAR 2019 suggests that electro stimulation of the vagus nerve can reduce signs and symptoms of rheumatoid arthritis. The study showed a significant reduction in disease activity and improved response criteria, with two-thirds of patients meeting good or moderate response criteria.
A study at EULAR 2019 found that RA patients with IBD and type I diabetes have higher rates of venous thromboembolism, epilepsy, and heart attacks compared to controls. These findings suggest that these conditions may be novel comorbidities for patients with RA.
A survey of over 900 RMD patients revealed that pain caused one in ten to have suicidal thoughts, highlighting the huge impact of pain on mental health. Poor sleep quality also had a negative influence on pain, with two thirds of patients rarely or never feeling fully rested.
Researchers attach a removable lock to an arthritis drug to reduce systemic immune suppression and neutralization, making it safer and more effective. The modified form of the antibody shows promise in treating rheumatoid arthritis with fewer infections and less development of anti-infliximab antibodies.