Articles tagged with Type 2 Diabetes
Researchers developed a novel HTS assay and miniaturized it to identify small molecule modulators of GPR119, a promising target for treating type 2 diabetes. The study screened over 500,000 compounds and identified 200 modulators, paving the way for new treatments.
University of Tokyo researchers have developed a trans-omics approach that maps the interactions between molecules inside cells in response to insulin. This comprehensive understanding may lead to better therapies for type 2 diabetes by identifying potential drug targets and optimizing insulin regimens.
Research finds cardiorespiratory fitness, high-intensity physical activity and low sedentary time all lower type 2 diabetes risk. The study, published in Diabetologia, suggests that a combination of these traits may be more beneficial than individual components.
A comprehensive study from Chalmers University of Technology confirms whole grains as a crucial food group for preventing type 2 diabetes. The study found that consuming more than 50g of whole grain per day can reduce the risk of developing the disease by up to 34%.
The NIH grant will aid research in understanding how to prevent kidney damage and failure caused by type 2 diabetes. Tubular epithelial cells play a crucial role in kidney function and require high amounts of lipids and fatty acids to work correctly, but people with type 2 diabetes have lipid metabolism derailments.
A recent study found that statins do not reduce cardiovascular disease or death in healthy individuals aged 75 and older. However, in people with type 2 diabetes aged 75-84 years, statins were associated with a significant reduction in cardiovascular disease and death. The protective effect declined after age 85.
Researchers found that nalbuphine effectively treated opioid-induced urine retention in a patient, suggesting it as a potential solution for those unable to use catheters. WHO guidelines also recently made recommendations on treatment intensification for type 2 diabetes and insulin use for type 1 and type 2 diabetes.
Researchers discovered a protein called HIF helps heart cells survive after a heart attack, but its effect is blocked by fats accumulating within the heart muscle in people with diabetes. Repurposed drugs that activate HIF may help prevent lasting heart muscle damage and improve recovery in Type 2 diabetics.
Research analyzed data from over 25,000 individuals in China to determine early life nutrition's role in metabolic disorders. The study found significant associations between low birth weight and increased risk of obesity, diabetes, and hypertension.
A new study found that overweight mice with Type 2 diabetes who don't sleep well need more time to heal their wounds compared to healthy mice. The research suggests that sleep plays a crucial role in wound healing among obese mice with Type 2 diabetes.
A study of 300,000 type 2 diabetes patients found that those with controlled risk factors had a significantly low risk of premature death, heart attack, and stroke. Optimizing medication, not smoking, and managing other risk factors can greatly reduce the risk.
A new expert review outlines the clinical characteristics of bone fragility in adults with diabetes and provides valuable insights for diagnosis and treatment. The review highlights recent studies on bone mineral density, biochemical markers, and fracture prediction to inform clinicians about the optimal approach to managing bone healt...
Researchers found that a blood test conducted as early as the 10th week of pregnancy may help identify women at risk for gestational diabetes. The study suggests that measuring HbA1c levels in early pregnancy could determine a woman's later risk for the condition, allowing for lifestyle changes to reduce the risk.
A new study from Harvard T.H. Chan School of Public Health found that people who gain weight after quitting smoking may face a temporary increase in type 2 diabetes risk, directly proportional to the weight gain. However, quitters can still reap significant health benefits, including lower cardiovascular disease and cancer risks.
A study in Guatemala finds type 2 diabetes and pre-diabetes affect 25% of the indigenous population, with age being a significant risk factor rather than obesity. The prevalence has more than doubled since 2003, and researchers attribute this to aging, increased physical inactivity, and insulin resistance.
Researchers found that fat fibrosis in subcutaneous fat is predictive of unhealthy belly fat and insulin resistance in Asian participants. This difference could help explain why Asians develop type 2 diabetes at a lower body weight than Caucasians.
A recent study found that nearly half of individuals with type 2 diabetes achieved remission after a weight-loss intervention. The research suggests that substantial weight loss at diagnosis can rescue beta cells and reverse the condition. However, only those who experienced early and sustained improvement in beta-cell function were ab...
A new study by the University of Exeter found that considering patient characteristics such as sex and BMI can significantly improve treatment outcomes in type 2 diabetes. The research suggests that obese females are more likely to have good blood glucose control on thiazolidinediones, while non-obese males benefit from sulfonylureas.
A recent study found that just two weeks of inactivity can hasten the onset of Type 2 diabetes and elevate blood sugar levels among pre-diabetic patients. The study's findings suggest that seniors who experience periods of physical inactivity are more likely to suffer harmful consequences to their overall health.
Experts from the University of Stirling have made a breakthrough in understanding how people respond to lifestyle treatment for preventing Type 2 diabetes. A new genomic signature has been discovered that indicates improved insulin sensitivity in individuals whose Type 2 diabetes status improves following a treatment intervention.
A two-day intermittent calorie restriction diet was found to be effective for glycemic control in patients with type 2 diabetes, comparable to a daily calorie restriction diet. The study suggests that this approach may be more sustainable than traditional daily calorie restriction diets.
A recent study published in Respiration has found that people with type 2 diabetes are significantly more likely to suffer from breathlessness and restrictive lung disease. The research team also discovered an association between albuminuria and RLD, suggesting a possible link between lung and kidney diseases.
Despite lack of evidence, physicians recommend self-monitoring due to its potential for lifestyle change and patient activation. However, opponents cite concerns over efficacy and office-based education's negative impact on patients.
Researchers at Wake Forest Baptist will investigate lifestyle interventions on cognitive resilience in older adults with type 2 diabetes and obesity. The four-year study aims to confirm earlier findings that intensive lifestyle intervention may decrease cognitive impairment, but paradoxically increase it in those with severe obesity.
A study suggests that abnormal metabolism of three essential amino acids may contribute to the development of type 2 diabetes in women who have a history of gestational diabetes. Women with a history of gestational diabetes had higher levels of branched-chain amino acids in their blood, regardless of their dietary intake.
A new study from the University of Eastern Finland found that self-monitoring of type 2 diabetes can reduce healthcare costs by nearly 60% by replacing follow-up visits with electronic feedback. This results in significant savings on travel and healthcare costs, particularly in sparsely populated areas.
A new study found that consuming walnuts may reduce the risk of developing type 2 diabetes by half compared to non-consumers. The research, based on data from over 34,000 American adults, also suggests a link between walnut consumption and lower blood pressure, cholesterol, and triglycerides.
A study by Yale School of Medicine researchers found that human insulin is comparable to insulin analogs in terms of safety and effectiveness. The use of more expensive analog insulins did not result in better blood sugar control or reduced risk of hypoglycemia, suggesting they may be unnecessary for many patients with type 2 diabetes.
A NIH-funded study of 91 youth ages 10-19 found that neither initial treatment with long-acting insulin followed by metformin, nor metformin alone preserved the body's ability to make insulin. Metformin did show modest improvement in blood glucose levels.
A major study found that medications used to treat diabetes in adults are not effective on youth. The disease is progressing rapidly in young people due to the growing obesity epidemic.
A recent study has linked increased risk of autism spectrum disorder (ASD) in children born to mothers with the three main types of diabetes. The research, published in JAMA Network, suggests a higher risk for children exposed in utero to maternal preexisting type 1 diabetes and gestational diabetes diagnosed by 26 weeks.
A pilot study found crystalline particles of titanium dioxide in pancreas specimens with Type 2 diabetes, suggesting a possible link between the white pigment and the disease. The study suggests that increased use of titanium dioxide may contribute to the global rise in T2D cases.
The American College of Physicians' 2018 guidance statement suggests a new target hemoglobin A1c (HbA1c) level for most patients with type 2 diabetes, ranging from 7% to 8%. This range is higher than previous guidelines and may have significant implications for diabetes treatment.
A new review study published in Clinical Nutrition found that plant-based diets improve glycemic control, lead to weight loss, and lower cholesterol levels in people with type 2 diabetes. The results suggest that a diet rich in fruits, vegetables, grains, and legumes can reduce the risk of heart problems and improve type 2 diabetes.
A new study by UCSF found that people with severe mental illness are more than twice as likely to have Type 2 diabetes. Racial minorities face even higher risks, with Hispanic patients having a 36.9% incidence rate.
A large study found a strong link between type 2 diabetes and Parkinson's disease, with a 31% greater risk for those with diabetes. Younger people and those with diabetes complications had even higher risks, highlighting potential protective effects of insulin use on the brain.
Research suggests breastfeeding has long-term benefits for mothers and babies, including reducing the risk of type 2 diabetes and metabolic syndrome. Breast milk composition varies depending on a mother's weight, with obese women producing higher levels of fat and inflammatory markers.
Research finds that inefficient breakdown of fats in fat cells predicts later weight gain and metabolic complications such as type 2 diabetes. An algorithm based on clinical and blood measures can detect impairments in hormone-stimulated lipolysis, identifying women at high risk of becoming overweight or obese.
A new study from Karolinska Institutet suggests that individuals with inefficient fat metabolism are more likely to develop overweight and type 2 diabetes. The research found that women who were able to efficiently break down fat in their cells had a lower risk of weight gain and impaired glucose metabolism.
The new guidance, developed by experts at the University of Exeter Medical School, aims to improve quality of life for older adults with type 2 diabetes. For the first time, it provides guidance on stopping treatment in particularly frail adults, a move welcomed by Diabetes UK.
A 16-week study found that combining recreational football training with dietary guidance significantly improves physical fitness, reduces blood pressure, and promotes healthier weight loss. This innovative intervention demonstrates the potential for exercise and diet to prevent type 2 diabetes in middle-aged and elderly individuals.
A clinical trial found that comparable diabetes care eliminates racial disparities in kidney function decline and chronic kidney disease among patients with type 2 diabetes. The study suggests that delivering standardized care can reduce racial disparities in diabetes-related complications.
A large study published in Diabetologia found that consuming two ounces of tree nuts daily can improve glycemic control and blood lipid levels in individuals with type 2 diabetes. The research, funded by the International Tree Nut Council, showed a modest but significant improvement in blood glucose control despite higher fat intake.
Researchers discovered that a person's risk of developing type 2 diabetes can be predicted based on their partner's BMI. The study, published in Diabetologia, found that women have a heightened risk due to their husband's BMI, regardless of the woman's own weight.
New research projects that nearly a quarter of the world's population will be obese and 1 in 8 will have type 2 diabetes by 2045. To prevent this, global obesity levels must be reduced by 25% to stabilise global diabetes prevalence at 10%.
Research by Dr. Fernanda De Felice reveals a disease mechanism common to Alzheimer's disease and Type 2 diabetes, leading to new strategies for preserving brain health. The discovery identifies a pathway causing inflammation in the brain, affecting insulin signaling and endoplasmic reticulum stress.
A 6-week CrossFit exercise programme improved blood sugar control and reduced heart disease risk in people with Type 2 diabetes. Participants showed significant improvements in insulin sensitivity and heart disease risk factors, even with shorter exercise sessions than traditional guidelines recommend.
A new study published in Diabetes Care found that lesbian and bisexual women have a significantly higher risk of developing type 2 diabetes, with a 27% higher incidence than heterosexual women. The study also found that stress related to discrimination and violence victimization may contribute to these disparities.
Researchers discovered six cytokine signatures associated with Type 2 diabetes risk in vulnerable African American women. These biomarkers could help personalize disease risk profiles for clinical decision making.
A new study by University of Sydney researchers found that eating up to 12 eggs per week does not increase cardiovascular risk factors in people with pre-diabetes and type 2 diabetes. The study also showed no impact on weight loss or cholesterol levels in participants.
Diabetes UK has committed £2.6 million to 19 new research projects investigating medieval remedies for foot ulcers, sleep disturbances as a predictor of Type 2 diabetes, and other forms of diabetes. The funding aims to reduce amputations, sepsis cases, and improve treatment options.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that girls with recently diagnosed type 2 diabetes had a high rate of menstrual irregularities. Many of these girls also had high testosterone levels, suggesting PCOS as an underlying cause.
Bariatric surgery induces changes in alpha cells to produce beneficial GLP-1, combating insulin resistance and islet dysfunction associated with type 2 diabetes. Researchers aim to develop a drug mimicking this effect, making surgery's benefits more accessible.
Researchers found that fat cells from obese patients with type 2 diabetes were epigenetically reprogrammed after exposure to palmitate and TNF-alpha. Healthy precursor fat cells also exhibited reprogramming after 24 hours of exposure, suggesting a potential link between diet and metabolic health.
The Building a Healthy Temple Diabetes Self-Management Support program integrates spirituality and health education to help Hispanics with type 2 diabetes manage the disease. The 14-week program aims to prevent complications such as amputation, kidney failure, and blindness by providing a supportive community.
A new report from the Academy of Medical Sciences warns of the urgent need to address the global burden of multiple serious illnesses. The report suggests that millions worldwide suffer from life-long disability and premature death due to ineffective treatment of people with multiple health conditions.
A naturally occurring gene variation affecting women's body fat distribution puts them at significantly higher risk of type 2 diabetes. The discovery could lead to the development of drugs targeting this specific gene variation.
A study published in the Endocrine Society's Journal of the Endocrine Society finds higher rates of type 1 diabetes in areas with a high proportion of fast food restaurants and convenience stores. The research suggests that an adverse food environment may contribute to the development of type 1 diabetes, particularly among adults.
A network meta-analysis found that SGLT-2 inhibitors and GLP-1 agonists improved survival rates compared to DPP-4 inhibitors in patients with type 2 diabetes. The study analyzed data from 236 clinical trials involving 176,310 participants.
Research found that having an evening preference is linked to a higher BMI among people with Type 2 diabetes. Participants with late breakfast times had a BMI of 28.4 kg/m^2, compared to those who ate earlier, who had a lower BMI by 0.37 kg/m^2.